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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
11.08.2026journal-article

Journal of Occupational & Environmental Medicine

Retail vs Mail Order Drug Prescribing: Trends and Costs in the Workers’ Compensation System – A Preliminary Study Using Pharmacy Benefit Management Data for Ankle Sprain Claims

Edward J. Bernacki, Nicholas F. Tsourmas, Marcos A. Iglesias, Paul D. Buffone, Nimisha Kalia, Nina Leung, Judith Green-McKenzie, Xuguang (Grant) Tao

Objective: This study examines trends and cost disparities between retail and mail order pharmaceutical dispensing within the workers’ compensation system. Method: Pharmacy benefit management (PBM) data were obtained for ankle sprain claims filed with a nationwide workers’ compensation carrier between 2012-2024. Results: During the study period, the ratio of mail order versus retail pharmacies scripts increased. Mail order prescriptions demonstrated higher cost ratios per unit (pill) than retail pharmacies for opio …

11.08.2026journal-article

Medicine: theory and practice

Клинические исходы вестибулопластики при внедрении комплексной программы медицинской реабилитации у пациентов с локальным дефицитом мягких тканей полости рта: исследование типа «случай–контроль»

Михаил Арменакович Власов, Евгений Васильевич Яковлев, Дмитрий Юрьевич Бутко, Владимир Станиславович Василенко, Марина Васильевна Калинина, Лариса Андреевна Даниленко, Сергей Степанович Рогозин, Эльнур Эльданиз Оглы Гулиев

Введение. В настоящее время наблюдается рост патологии полости рта у взрослых и детей, что приводит к увеличению распространенности хирургических вмешательств в полость рта, поэтому задача апробации, разработки и внедрения комплексных методов стоматологической реабилитации является актуальной. Целью данной работы стало изучение взаимосвязи осложнений после операции вестибулопластики и применяемой программы планирования и восстановительного лечения. Материалы и методы. В исследовании приняли участие 281 пациент, муж …

11.08.2026journal-article

The Journal of Infectious Diseases

Unraveling Resistance and Thresholds in Phage Therapy Using In Vitro Staphylococcus aureus Experiments and Pharmacokinetic/Pharmacodynamic Models

Kévin Royet, Leslie Blazère, Emilie Helluin, Ludivine Coignet, Lucile Plumet, Mélanie Bonhomme, Camille Kolenda, Romain Garreau, Florent Valour, Mathieu Medina, Frédéric Laurent, Sylvain Goutelle

Abstract Background Phage therapy is a promising approach for infections caused by multidrug-resistant Staphylococcus aureus, but its clinical development is limited by knowledge gaps in pharmacokinetic/pharmacodynamic (PK/PD) and potential emergence of resistance. Methods We performed in vitro time-kill assays to study the effect of 3 antistaphylococcal phages (V1SA019, V1SA020, and V1SA022) against 2 S. aureus strains (SH1000 and USA300). Resistance emergence was monitored through phenotyping and whole-genome seq …

11.08.2026journal-article

Journal of Occupational & Environmental Medicine

Pulmonary inflammatory markers in workers exposed to metal dusts and fumes in ferrochromium and stainless steel production

Jukka Uitti, Markku Huvinen, Aki Kanervo, Merja Järvelä, Panu Oksa, Lauri Lehtimäki, Pauliina Toivio, Timo Tuomi, Eeva Moilanen, Riitta Sauni

Objective : Our aim was to determine the association between exposure to chromium compounds and the respiratory health of workers in ferrochromium and stainless steel production. Methods : The study included 333 workers occupationally exposed/non-exposed to chromium compounds. Respiratory health was assessed using a questionnaire and spirometry. Bronchial and alveolar nitric oxide (NO) production, inflammatory markers in exhaled breath condensate, and serum samples were analyzed. Results : There were no differences …

11.08.2026journal-article

Revista ft

Abordagem clínica do tratamento endodôntico associado a laserterapia em paciente com comorbidades sistêmicas: relato de caso.

Amanda Caroline Neves Reis, Laura Sofia Alves Araújo Reis, Keissy Helem Portela de Aguiar, Maria Ivete Formiga Relvas Neta, Leonardo Pimentel Fiori, João Bosco Formiga Relvas

Endodontic treatment in elderly patients with systemic comorbidities represents a clinical challenge due to physiological changes associated with aging and health conditions such as heart diseases, chronic respiratory diseases, and history of stroke. In this context, low-level laser therapy has been used as an adjunctive resource, contributing to root canal disinfection, pain control, and tissue repair. The aim of this study was to report a clinical case of endodontic treatment associated with laser therapy in a sy …

11.08.2026journal-article

Journal of Midwifery & Women's Health

Midwives’ Communication Practices About Risk and Racism With Black Women During Pregnancy: “We've Got to Find a Way”

Emily Dove‐Medows, Cathrine Corwin, Alison R. Walsh

Introduction A growing body of literature suggests that patient‐provider communication in perinatal care is a key factor in addressing inequities in pregnancy outcomes. The purpose of this study was to explore how a sample of midwives who provide perinatal care perceive their communication practices about racism‐related risks with Black women who are pregnant during clinical encounters. Methods Fourteen midwives from a national mixed‐methods study completed semistructured interviews about communication practices re …

11.08.2026journal-article

Medicina

Biologic Injection Therapy for Shoulder Disorders: A Narrative Review Comparing Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate

Chul Hee Jung, Seok Yeon Choi, Dong Ha Lee

Background and Objectives: Shoulder disorders—including rotator cuff disease, glenohumeral osteoarthritis (GH OA), and adhesive capsulitis—are among the most prevalent musculoskeletal conditions and are frequently refractory to conservative management. Platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) have attracted increasing clinical interest as regenerative alternatives to corticosteroid injection, but a comparative appraisal of these two principal biologics across the full spectrum of shoul …

11.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

Effects of a multimodal technology-assisted rehabilitation program in a patient undergoing total ankle and total talus replacement: A paradigmatic case report

Andrea Parente, Nicola Marotta, Andrea Demeco, Daniele Madia, Umile Giuseppe Longo, Antonio Ammendolia, Alessandro de Sire

Objective This case report aimed to describe effects in balance, gait, and functional recovery observed during a multimodal technology-assisted rehabilitation program in a patient following total ankle and total talus replacement (TATTR). Methods A 59-year-old man (history of ankle fracture-dislocation) developed persistent pain, progressive avascular necrosis of the talus, and advanced ankle osteoarthritis. He underwent TATTR on January 19th, 2025. Then, he underwent a rehabilitation program combined joint mobilit …

11.08.2026journal-article

Educational Studies in Mathematics

Listening and responding to mathematics-averse speech

Caroline Yoon

Abstract As mathematics educators, we frequently encounter problematic messages about mathematics. For example, we are often told by students, parents, and people we meet that they do not have a mathematics brain or are not a mathematics person . Such speech is inaccurate and harmful to learners, but its origins are complex and responding requires care. In this article, I discuss the ethical considerations that shaped my attempt to respond to this speech through fiction and essay. My approach is grounded in Levinas …

11.08.2026journal-article

American Journal of Health-System Pharmacy

Acetazolamide versus metolazone as adjunctive therapy to loop diuretics in hospitalized patients with volume overload: A retrospective cohort study

Phuoc (Tyler) Bui, Lizbeth Ramos

Abstract Purpose Sequential nephron blockade is commonly used to augment diuresis in patients with volume overload receiving loop diuretics. While metolazone is frequently used, acetazolamide has emerged as an alternative adjunctive agent. Real-world data comparing these strategies remain limited. This study evaluated the effectiveness and safety of acetazolamide vs metolazone as adjunctive therapy. Methods This single-center, retrospective cohort study included adult patients receiving adjunctive acetazolamide or …

11.08.2026journal-article

Alzheimer's Research & Therapy

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Julie F. H. De Houwer, Wenjie Kang, Renee van Buuren, Liset de Boer, Tine Swartenbroekx, Ana Rajicic, Arabella Bouzigues, Lucy L. Russell, Phoebe H. Foster, Eve Ferry-Bolder, John C. van Swieten, Lize C. Jiskoot, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Benedetta Nacmias, Markus Otto, Maxime Bertoux, Thibaud Lebouvier, Simon Ducharme, Chris R. Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, James B. Rowe, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Henrik Zetterberg, Yolande A. L. Pijnenburg, Charlotte Teunissen, Jonathan D. Rohrer

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories relate to one another. Defining the temporal sequence of protein abnormalities could not only improve disease staging but also help identify biomarkers most sensitive to early disease activity in pathogenic variant carriers. We aimed to apply …

11.08.2026journal-article

International Blood Research & Reviews

Geographic Disparities in Haematological and Biochemical Profiles among HIV-Positive Adults on Antiretroviral Therapy across Three Senatorial Districts of Rivers State, Nigeria

P. H. Chukwu

Background: Routine haematological and biochemical indices support monitoring of adults with HIV, but geographical variation in Rivers State is insufficiently described. Aims: To compare blood count indices, inflammatory cell ratios, biochemical parameters and physical indicators between HIV-positive adults receiving antiretroviral therapy (ART) and healthy controls across three senatorial districts of Rivers State, Nigeria. Study Design: Cross-sectional comparative study. Place and Duration of Study: Nine HIV clin …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Latent Classes of Typical and Atypical Speech Development in Low-Income Children: A Longitudinal Study From Early Childhood to Adolescence

Qingyang Liu, Victoria Tumanova, Rachel A. Razza

Purpose: This study aimed to identify distinct latent classes of speech development by differentiating typical and atypical developmental trajectories from early childhood through adolescence in children from low-income families. It also examined demographic predictors of these latent classes and explored their associations with early infant temperament. Method: We used five waves of longitudinal data from the Future of Families and Child Wellbeing Study, with families from low-income backgrounds below 200% of the …

11.08.2026journal-article

Russian Journal of Occupational Health and Industrial Ecology

Gender and age aspects of temporary disability in post-pandemic cerebrovascular diseases

Elena V. Bakhtereva, Aleksandr S. Shastin, Venera G. Gazimova, Vladimir G. Panov

Introduction. Cerebrovascular diseases (CVD) are among the leading causes of premature mortality and workplace death, which highlights the importance of studying their incidence in the working population in the post-pandemic period.The study aims to conduct a comparative analysis of the gender and age characteristics of morbidity with temporary disability due to cerebrovascular diseases of the working population of the Russian Federation in the pre-pandemic (2015–2019) and early post-pandemic (2023) periods.Materia …

11.08.2026journal-article

Russian Journal of Occupational Health and Industrial Ecology

Study of the state of the cardiovascular system in laboratory animals after chronic inhalation exposure to lead oxide nanoparticles

Ilzira A. Minigalieva, Marina P. Sutunkova, Maksim A. Kopenkin, Maria S. Unesikhina, Ekaterina M. Petrunina, Vladimir V. Bazarnyi

Introduction. Current data indicate that lead oxide nanoparticles have a more pronounced toxicity compared to microparticles, organic and inorganic lead salts. Lead intoxication is a significant risk factor for the development of cardiovascular diseases. The features of the cardiotoxic effect of lead oxide nanoparticles require further study.The study aims to evaluate changes in clinical, functional, and metabolic parameters characterizing the state of the cardiovascular system during inhalation exposure to lead ox …

11.08.2026journal-article

Current Neuropharmacology

Development and Validation of a Nomogram to Predict Minimal Symptom Expression in AChR+ gMG Patients Undergoing Efgartigimod Therapy

Chi Ma, Nan Kang, Ying Zhu, Tianying Ma, Jingyi Shen, Benqiao Wang, Ruixia Zhu

Background: Efgartigimod has emerged as an effective treatment option for acetylcholine receptor antibody-positive generalized myasthenia gravis (AChR+ gMG). This study aimed to develop and validate a predictive nomogram to evaluate the achievement of Minimal Symptom Expression (MSE) in AChR+ gMG patients following efgartigimod treatment. Methods: We retrospectively reviewed 119 patients with AChR+ gMG who received at least one cycle of efgartigimod and had ≥ 12 weeks of follow-up. Clinical response was defined as …

11.08.2026journal-article

Pharmaceutics

Lipid Nanoparticles for Gene Therapy: Unresolved Challenges in Manufacturing, Transdermal Delivery, Machine Learning, Endosomal Escape, and the Protein Corona

Ognjen Milić, Sanela M. Savić, Melanija Zurković, Boban Stanojević, Snežana Savić

Lipid nanoparticles (LNPs) are now the leading delivery platform for nucleic acid therapeutics, but progress in the field is measured almost entirely by physicochemical and computational proxies rather than by functional properties that determine therapeutic outcomes. This review examines six interconnected areas of LNP development: microfluidic manufacturing, lyophilization, transdermal microneedle delivery, machine learning-guided formulation design, endosomal escape biology, and protein corona-mediated organ tar …

11.08.2026journal-article

Journal of Shahid Sadoughi University of Medical Sciences

A Cornerstone of Modern Rehabilitation

Mohammadreza Vafaeinasab

Introduction: Musculoskeletal disorders are among the leading causes of pain, disability, and reduced quality of life worldwide, imposing a substantial burden on individuals, healthcare systems, and society. In recent decades, advances in rehabilitation science and the growing adoption of evidence-based practice have shifted the focus of rehabilitation from merely alleviating symptoms to restoring function, enhancing participation, improving quality of life, and promoting patient independence. Within this framework …

11.08.2026journal-article

International Endodontic Journal

Smart Root Canal Therapy: Intelligence Refinement of Clinical Procedures

Yu Du, Jun Tian, Maobin Yang, Xi Wei

ABSTRACT Root canal therapy (RCT) is the primary treatment modality for pulpal and periapical diseases. Although the fundamental objective of RCT has remained unchanged for over a century, its technical details have been continuously refined and transformed. Preoperative diagnostic approaches have evolved from two‐dimensional imaging to three‐dimensional volumetric reconstructions and, more recently, to artificial intelligence‐assisted analytical frameworks. Treatment modalities have progressed from manual instrume …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

“The Palest Ink Is Superior to the Strongest Memory”: Evaluating Word-Finding Therapy Outcomes of Two Orthographic Cues in Adults With Aphasia

Wei Ping Sze, Carol Sacchett, Jane Warren, Wendy Best

Purpose: Word-finding difficulties (anomia) are common in poststroke aphasia. Although recent evidence suggests that written cues may benefit anomia, their optimal use remains unclear. This study investigates two parameters of orthographic cue use: the optimal unit for cueing and the durability of cueing effects on spoken word production across three outcomes (accuracies of initial and final naming responses, together with response time). Examining multiple dimensions of naming, for example, accuracies of both init …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Measurement Variability of Peak Flow: A Laboratory Experiment Comparing Cough Testing Equipment

James C. Borders, James A. Curtis

Purpose: Cough peak flow is an important indicator of airway protection, and accurate measurement is essential for evaluating and treating individuals with hypotussic cough dysfunction. Although pneumotachographs are the gold standard for airflow measurement, their cost and complexity limit clinical feasibility. Handheld analog and digital peak flow meters (PFMs) offer practical, low-cost alternatives for measuring cough peak flow; however, measurement accuracy may vary with additional components such as bacterial …

11.08.2026journal-article

Journal of Midwifery & Women's Health

Approaches to Treating Kratom Use Disorder in the Perinatal Population

James Hardy, Amy Marietta, Nathan Mullins, Olivia Caron

Abstract Kratom is an emerging substance in the United States that is commonly used to manage chronic pain and withdrawal symptoms from opioids. Kratom products are federally unregulated and legal in many states, and prolonged use can lead to the development of a substance use disorder. For pregnant persons, there are additional risks of maternal and infant withdrawal symptoms. Treatment of kratom use disorder (KUD) is complicated by misperception of the substance's harmful effects as well as limited screening opti …

11.08.2026journal-article

Frontiers in Oncology

Feasibility of the Golf Recreational Exercise for Enhanced Survivorship in prostate cancer survivors undergoing hormone therapy

Guanrong Cai, Jacek Pinski, Lori A. Michener, E. Todd Schroeder, Daniel Kirages, Joy Tu, Kimiko Yamada, George Salem

Background Prostate cancer (PCa) survivors undergoing androgen deprivation therapy (ADT) experience significant physical and psychosocial side effects that negatively impact quality of life. Although exercise is effective in mitigating these effects, adherence to traditional programs remains low. The Golf Recreational Exercise for Enhanced Survivorship (GREENS) program was developed as a novel multimodal recreational activity (MRA) integrating structured exercise with golf to enhance engagement and sustainability. …

11.08.2026journal-article

Frontiers in Psychology

Brief therapy dog interactions may increase self-efficacy and lower perceived stress and cortisol in high school students: a preliminary study

Dawn K. Melzer, Deirdre M. Yeater, Madison DeRubis, Christiana Kohlroser, Barbara J. Pierce

The present study examined changes in high schoolers’ perceived stress, general self-efficacy and cortisol levels after a brief interaction with a certified therapy dog. High school students completed self-report measures of perceived stress and general self-efficacy and provided salivary cortisol samples both before and after a 10-min interaction with a certified therapy dog. Following the interaction, students reported reductions in perceived stress scores, exhibited lower salivary cortisol concentrations and dem …