Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Therapie & Reha · Seite 141

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
11.08.2026journal-article

Journal of Shahid Sadoughi University of Medical Sciences

A Cornerstone of Modern Rehabilitation

Mohammadreza Vafaeinasab

Introduction: Musculoskeletal disorders are among the leading causes of pain, disability, and reduced quality of life worldwide, imposing a substantial burden on individuals, healthcare systems, and society. In recent decades, advances in rehabilitation science and the growing adoption of evidence-based practice have shifted the focus of rehabilitation from merely alleviating symptoms to restoring function, enhancing participation, improving quality of life, and promoting patient independence. Within this framework …

11.08.2026journal-article

Pharmaceutics

Lipid Nanoparticles for Gene Therapy: Unresolved Challenges in Manufacturing, Transdermal Delivery, Machine Learning, Endosomal Escape, and the Protein Corona

Ognjen Milić, Sanela M. Savić, Melanija Zurković, Boban Stanojević, Snežana Savić

Lipid nanoparticles (LNPs) are now the leading delivery platform for nucleic acid therapeutics, but progress in the field is measured almost entirely by physicochemical and computational proxies rather than by functional properties that determine therapeutic outcomes. This review examines six interconnected areas of LNP development: microfluidic manufacturing, lyophilization, transdermal microneedle delivery, machine learning-guided formulation design, endosomal escape biology, and protein corona-mediated organ tar …

11.08.2026journal-article

Jurnal Jamu Indonesia

Network Pharmacology and Molecular Docking Analysis of Zingiberaceae Bioactive Compounds as Candidate Adjuncts for Hypertension Therapy

Asarini Asarini, Gemini Alam, Hermanus Ehe Hurit

Hypertension remains a major cardiovascular risk factor, and plant-derived compounds may provide leads for adjunctive therapeutic development. This study evaluated bioactive compounds from six Zingiberaceae species using ADMET screening, network pharmacology, and molecular docking. Thirty-two compounds were screened with DeepPK using predicted human oral bioavailability (≥20%) and selected toxicity endpoints. Six compounds met the screening criteria: zingerone, isoborneol, terpinyl acetate, 1,8-cineole, linalool, a …

11.08.2026journal-article

Medicine: theory and practice

Практическое использование лечебно - реабилитационной программы у пациента с локальным дефицитом мягких тканей полости рта в области установленных имплантов

Михаил Арменакович Власов, Евгений Васильевич Яковлев, Дмитрий Юрьевич Бутко, Наталья Вячеславовна Корнева, Владимир Станиславович Василенко, Лариса Андреевна Даниленко, Марина Васильевна Калинина, Эльнур Эльданиз Оглы Гулиев, Сергей Степанович Рогозин, Ксения Сергеевна Скирчук

Разработка новых программ реабилитации пациентов с патологией зубо - челюстной системы, сочетающих цифровое планирование, 3D - моделирование и физиотерапевтические методы восстановления, имеет важное значение в стоматологии. Цель — представлениеклинического наблюдения при проведении вестибулопластики с применением комплексной про-граммы медицинской реабилитации. Клиническое наблюдение. Мужчина (36 лет) обратился поповоду протезирования дентальных имплантов с диагнозом «Локальный дефицит мягких тканейв области устан …

11.08.2026journal-article

Immunotherapy Advances

Safety and Efficacy of PRaG Therapy in Elderly Cancer Patients

Xiangrong Zhao, MengMeng Yang, Junjun Zhang, Yuehong Kong, Meiling Xu, Rongzheng Chen, Qian Yin, Pengfei Xing, Liyuan Zhang

Abstract Introduction PD-1/PD-L1 inhibitors lack evidence-based support in patients aged ≥75 years due to their frequent exclusion from clinical trials. This study aimed to evaluate the safety and efficacy of PRaG therapy—combining PD-1/PD-L1 inhibitors with radiotherapy—specifically in this elderly demographic. Methods Data were collected from patients aged ≥75 years who received PRaG therapy at our center between January 1, 2019, and December 31, 2024. Eligible patients were required to have at least one post-bas …

11.08.2026journal-article

Clinical Infectious Diseases

First-in-Human Adjunctive Bacteriophage Therapy for Malakoplakia

Saima Aslam, Aleah Brubaker, Mita Shah, Thomas C S Martin, Tyler Mandt, Austin-Marley Windham-Herman, Haiyan Zhang, Tina Bryde, Yilmaz Emre Gençay, Aurelie Gram, Christian Grøndahl, Jakob Krause Haaber, Björn Hallström, Eric van der Helm, Jonas Hink, Lorrie Maccario, Anders Østergaard, Alice Troy, Niloofar Yavari, Robert T Schooley, Sanjay Mehta

Abstract We report the first use of adjunctive bacteriophage therapy for Escherichia coli related malakoplakia in a kidney transplant recipient with progressive disease. Adjunctive CRISPR-enhanced phage cocktail SNIPR001 combined with prolonged antibiotics, ascorbic acid, and bethanechol was associated with cutaneous lesion resolution and sustained radiographic regression without phage-related adverse events.

11.08.2026journal-article

Diabetology

Weight and Glycemic Outcomes Following GLP-1 Receptor Agonist Therapy in People Living with HIV: A Retrospective Study at a Bronx Hospital

Dimitrios Raptis, Natalia Nazarenko, Raksheeth Agarwal, Mandar Kalpesh Shah, Yiqi Gao, Panagiotis Theodoropoulos, Pawel Borkowski, Maisha Maliha, Maria Alyssa Yee Policarpio, Shreyas Yakkali, Yi-Yun Chen, Jason Leider, Preeti Kishore, Naomi Friedman

Background/Objectives: People living with HIV (PLWH) who undergo prolonged antiretroviral therapy (ART) may experience weight gain as a potential side effect. Many of these individuals are prescribed glucagon-like peptide 1 (GLP-1) receptor agonists (RAs), or dual GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) RAs, which are known for their weight-reducing effects and positive impact on metabolic health. However, studies investigating their effects on PLWH are limited. Methods: We conducted a retrospe …

11.08.2026journal-article

Bioengineering

NO-Responsive Oleanolic Acid Self-Assembled Micelles Co-Loaded with BAY 11-7082 for Synergistic Chondroprotection and Anti-Osteoarthritis Therapy

Dandan Zhang, Zhigang Zhang, Dingxing Huang, Zhuoran Sun, Jiamin Huang, Chi Zhang, Qingyang Zeng, Qiling Liu, Wenzhuo Chen

Osteoarthritis is an irreversible degenerative joint disease driven by sustained NF-κB-mediated inflammatory responses, and conventional intra-articular hyaluronic acid or small-molecule NF-κB inhibitors cannot achieve targeted on-demand treatment due to poor solubility, rapid clearance and lack of lesion microenvironment responsiveness. OA with inherent anti-chondrolytic activity can self-assemble into nanocarriers in water, yet it lacks stimuli-responsive capacity. Herein, we rationally designed and synthesized a …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Clinical Reasoning Under Uncertainty in Speech-Language Pathology When Measures, Labels, and Best-Practice Claims Get Ahead of Evidence

Salim Alani

Purpose: Speech-language pathologists often have to make consequential decisions with evidence that is incomplete, indirect, or mixed. The risk is not uncertainty itself, but the way an indirect measure, a familiar label, or a best-practice statement can begin to carry more interpretive weight than it can support. This tutorial focuses on the point where observations are turned into claims and claims are turned into recommendations. Method: The tutorial draws on scholarship in measurement and assessment showing tha …

11.08.2026journal-article

Journal of Occupational & Environmental Medicine

Occupational access to firearms and firearm-related suicide among US workers.

Victor A. Soupene, Jonathan M Platt, Jonathan Davis, Joseph E Cavanaugh, Paul A Romitti, Carri Casteel

Objective: To examine the association between occupational access to firearms and firearm-related suicide, adjusting for worker demographics and rural residence. Methods: We conducted a mortality case-control study using National Violent Death Reporting System data (2013-2023). Occupational access was defined as employment in jobs involving firearm use. Firearm-related suicides were compared with non-firearm suicides using multivariable logistic regression, with sex-stratified models estimating odds ratios (ORs) an …

11.08.2026journal-article

Journal of Occupational & Environmental Medicine

Use of a Personalized Digital Wellness App to Increase Employee Engagement Without Financial Incentives

Calissa J. Leslie-Miller, Shellen R. Goltz, Katherine H. Page, Christopher C. Cushing, Tristin D. Brisbois

Objectives: Human resources (HR) initiatives can reduce healthcare costs and improve productivity, yet participation remains low. This study evaluated usability and predictors of engagement for Aspire2B, a personalized wellness application leveraging behavior change principles, alongside a 6-week HR-led movement challenge. Methods: Participants were US-based, salaried PepsiCo employees, aged 21-68. Aspire2B integrated step data and provided heart rate, stress index, and biological age via transdermal optical imagin …

11.08.2026journal-article

BMC Pulmonary Medicine

Noninvasive prediction of classic EGFR-activating mutations in non-small cell lung cancer using a combined spectral computed tomography model: an auxiliary tool for preoperative stratification of candidates for EGFR-TKI therapy

Qianqian Zhan, Hui Lin, Dandan Lin, Xueyan Liao

Abstract Background EGFR genotyping is essential for EGFR-TKI therapy in non-small cell lung cancer (NSCLC), but invasive biopsy has limitations. Noninvasive preoperative stratification tools are urgently needed. Methods We retrospectively enrolled 129 NSCLC patients to develop and internally validate a combined model integrating clinical features, conventional CT findings, and dual-layer spectral CT parameters for predicting classic EGFR-activating mutations. Performance was evaluated by ROC, DeLong test, DCA, and …

11.08.2026journal-article

Theoretical and Natural Science

Closing the Loop: An Integrated Vision-Calibration-Actuation System with LLM-Assisted Diagnostic Interface for Autonomous Topical Therapy of Urticaria

Zhilin Sui

Urticaria is common, recurrent, and often managed outside the clinic, where patients must repeatedly localize lesions and apply topical agents themselves. Current AI dermatology systems mainly stop at diagnosis, while dermatologic robots remain procedure-specific and rarely combine reasoning with physical delivery. This paper reports a feasibility study of an integrated topical-therapy pipeline for urticaria. The system combines (i) ResNet-50 U-Net segmentation trained on 98 manually annotated lesion photographs, ( …

11.08.2026journal-article

Russian Journal of Occupational Health and Industrial Ecology

The effect of intermittent vibration on the morpho-functional state of the nervous system in rats

Anna G. Zhukova, Larisa G. Gorokhova, Ekaterina P. Gostyaeva, Anna A. Koltynova, Anastasiуa S. Kazitskaya, Maria S. Bugaeva, Oleg I. Bondarev

Introduction. Prolonged intense vibration exposure is a chronic stress factor for animals and humans, which causes disorders at both the neurohumoral and molecular cellular levels. During experimental studies on animals, the authors found that prolonged vibration has a negative effect on the neurons of the cerebral cortex and, as a result, on the state of bioelectric activity of the brain and behavioral reactions of rats. However, little is known about the relationship of pain sensitivity indices with morphological …

11.08.2026journal-article

Journal of Occupational & Environmental Medicine

Protective role of dietary antioxidant intake on long-term effects of extreme PM2.5 exposure on respiratory health

Thara Govindaraju, Catherine L Smith, Jillian Ikin, Alice J Owen, Matthew Carroll, Brigitte M. Borg, Caroline X Gao, David Brown, David Poland, Shantelle Allgood, Michael J Abramson, Karen Walker-Bone, Tracy A McCaffrey, Tyler J Lane

Objective: To test whether dietary antioxidants moderated effects of PM 2.5 from coal mine fire smoke on respiratory symptoms. Methods: We conducted cross-sectional analyses of diet and respiratory symptom data from 448 members of the Hazelwood Health Study Adult cohort. Individual-level exposure to PM 2.5 from the 2014 coal mine fire was determined by combining modelled fire-related PM 2.5 estimates and time-location diaries from the time of the fire. Data were evaluated using logistic regressions to evaluate asso …

11.08.2026journal-article

BMC Health Services Research

Cost and economic evidence of stroke technology-assisted rehabilitation: a scoping review

Tengiz Samkharadze, Olivier Lambercy, Roger Gassert, Karen Sui Geok Chua, David Bruce Matchar, Simone Kager, Nicole Wenderoth, Hsiao-ju Cheng

Abstract Introduction In recent years, the growing demand for cost-effective rehabilitation after stroke has motivated the development of novel technologies to support high-intensity rehabilitation. However, available knowledge on the economic benefits of stroke technology-assisted rehabilitation (TAR) is relatively scarce and fragmented. Therefore, this scoping review aimed to review evidence on the economic benefits of TAR in laboratory, clinical, and home settings, as well as the methodologies used to evaluate t …

11.08.2026journal-article

Muscles, Ligaments and Tendons Journal

Hydrocortisone: A Timeless Milestone in Clinical Therapy

Caterina Dieni, Marco Pinzerato, Isabella Giacomini, Veronica Cocetta, Mattia Tinazzi, Maurizio Barca, Antonio Frizziero, Monica Montopoli

First isolated in 1949 and introduced into clinical practice in the early 1950s, hydrocortisone revolutionized the treatment of inflammatory and endocrine disorders. Despite the development of more potent and longer-acting glucocorticoids, it remains indispensable in modern medicine. This review explores hydrocortisone’s enduring relevance by examining its pharmacokinetic properties, therapeutic indications, and versatility across clinical contexts. The favorable safety profile of hydrocortisone and its predictable …

11.08.2026journal-article

Boletim de Conjuntura (BOCA)

SÍNDROME DE BURNOUT ENTRE CIRURGIÕES GERAIS: REPERCUSSÕES NA SAÚDE OCUPACIONAL, SEGURANÇA DO PACIENTE E QUALIDADE ASSISTENCIAL

Tayrone Nayara Soares de Oliveira, Carla Beatriz Bezerra Melo, Natalia do Nascimento Ferreira, Bianca Luzia Cavalcante do Couto, Amanda de Souza Pantoja, Ingrid Dias da Silva Correa, Luiza Cavalcante Couto Felipe, Roberta Leonor Mendes de Lima Leal, Rita de Cássia Monteiro, Eitor Morais Alves de Toledo, Vinicius Veloso Cavassani, Juan Francisco Xavier Tapia Burgos, Nicole Guedes Barros, Remita Viegas Vieira

A Síndrome de Burnout é um fenômeno ocupacional caracterizado por exaustão emocional, despersonalização e redução da realização profissional, sendo considerada um importante problema de saúde entre médicos, especialmente cirurgiões gerais. Em virtude das elevadas demandas assistenciais, jornadas prolongadas, pressão por resultados e exposição frequente a situações de alta complexidade, esses profissionais apresentam maior vulnerabilidade ao desenvolvimento da síndrome. O presente estudo teve como objetivo analisar …

11.08.2026journal-article

Asian Journal of Medicine and Health

Occupational Safety and Health Awareness and Compliance with Safe Work Practices among Morgue Workers in Kiambu County, Kenya

Lucy Mithu, Matthews Ciira Kiiyukia, Benson Karanja

Background: Morgue workers are routinely exposed to biological, chemical, physical, ergonomic, and psychosocial hazards while handling human remains. Although Kenya's Occupational Safety and Health Act (OSHA), 2007, provides a legal framework for workplace safety, limited evidence exists on occupational safety and health (OSH) awareness and compliance with safe work practices among morgue workers. Understanding these factors is important for improving workplace safety and reducing occupational injuries. Aim: This s …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Cross-Linguistic Perspectives on Aging and Sentence Processing: The Role of Word Order and Semantic Plausibility

Jee Eun Sung, Gayle DeDe, Seunghun J. Lee, Jimin Park

Purpose: This cross-linguistic study investigates how healthy aging affects sentence comprehension across three typologically distinct languages—English (head-initial), Korean, and Japanese (both head-final). It explores how syntactic word order and semantic plausibility interact with aging and whether these effects differ across languages with varying structural characteristics. Method: A total of 290 adults participated: 103 English speakers (49 younger, 54 older), 98 Korean speakers (50 younger, 48 older), and 8 …

11.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

“A Transformational redesign of the global clinical workforce decision-making processes: Novel cognitive schemes embracing modern healthcare paradigms”

Imad Salah Hassan, MohammedElfatih MohammedElamin, Roa Awadalla Ibrahim Ahmed, Abdelhakam Abuelbasher Yousif, Ahmed Hani Mubarak Awad, Mukhtar Mohamedsalih Mukhtar Abdelgadir, Mustafa Awadalla Ibrahim Ahmed, Fatima Abdalrahman Adam Ali Ayyad, Khadija Bushra Salim Salih, Rayan Mohammed Abdullah Ishag

Background Global healthcare systems continue to face a persistent quality gap driven by fragmented and inconsistent clinical decision-making. Although competency-based medical education (CBME) frameworks define clinician roles, they provide limited practical guidance and tools for real-time decision-making. Additionally, contemporary literature failed to incorporate modern healthcare paradigms into everyday clinical decision-making. Objective To develop a structured, competency-aligned, seven-step cognitive roadma …

11.08.2026journal-article

Exploring Science Academic Conference Series

Impact of Early Mobilization on Clinical Outcomes of Mechanically Ventilated Patients During Critical Care Rehabilitation and Related Nursing Practices

Lianghao Zhao

Objective To systematically review the effects of early mobilization in critical care rehabilitation on the key clinical outcomes of mechanically ventilated patients, and deeply explore the key points, challenges and countermeasures of nursing practice under the cur rent evidence-based background. Methods A systematic literature search was conducted in PubMed, CINAHL, the Cochrane Library, CNKI, and Wanfang Database. Covering clinical practice guidelines, systematic evaluation, randomized controlled trials and high …

11.08.2026journal-article

Advances in Community Services Research

Legal Protection for Occupational Safety and Health for Workers in the Informal Sector in Indonesia

Michelle Nabila Andaista Bangsu, Dicky Ega Brahmanto, Alia Shifa

Purpose: This study aims to analyze legal protections for occupational safety and health (OSH) for workers in the informal sector within the Indonesian legal system and to identify normative gaps in the relevant regulations. Research Method: This study employs a normative legal approach (doctrinal legal research) through legislative and conceptual analyses. The analysis was conducted through grammatical, systematic, and teleological interpretations of the 1945 Constitution, Law No. 1 of 1970, Law No. 13 of 2003 as …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Associations Between Ultrasonographic Hyoid Motion Parameters and Penetration, Aspiration, and Pharyngeal Residue Across International Dysphagia Diet Standardisation Initiative Food Textures

Shu-Mei Yang, Ting-Ju Lai, Tyng-Guey Wang, Ming-Yen Hsiao

Purpose: The clinical swallow examination, including palpation of hyo-laryngeal motion, is an important screening technique for dysphagia. However, this method lacks objectivity and precision, and it cannot reliably quantify hyoid movement velocity, which may be more closely associated with the risk of penetration and aspiration. This prospective observational study aimed to evaluate the predictive value of ultrasonographic hyoid motion parameters for identifying penetration, aspiration, and pharyngeal residue acro …