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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Diseases of the Esophagus

P1.126. Synchronous Head and Neck Squamous Cell Carcinoma and Esophageal Squamous Cell Carcinoma Treatment Experience From CMUH

Cheng Chi

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Esophageal squamous cell carcinoma account for 53% of esophageal tumor has high mortality due to exposure of carcinogens in Asian country. Head and neck cancer had high synchronous association with esophageal cancer due to “field-cancerization” to the upper aerodigestive tract. 15–20% of patients with HNC (head and neck squamous cell carcinoma had a secondary EC (esophageal squamous cell carcinoma) in Taiwan. Treatment choice and outcomes of sy …

22.08.2026journal-article

Diseases of the Esophagus

P1.087. Advancing Immunotherapy in Oesophagogastric Cancer: A Systematic Review of CLDN18.2-Targeted CAR T-Cell and T-Cell Engager Strategies

Sachin Shenoy, Unaiza Waheed, Ayesha Noorani, Kiran Purushothaman

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Conventional immunotherapy strategies have shown limited efficacy in oesophagogastric adenocarcinomas compared to other solid tumours. CLDN18.2-targeted chimeric antigen receptor T cells (CAR-T) and bispecific T-cell engagers (TCEs) represent emerging therapeutic strategies for advanced oesophagogastric cancers, yet their safety profiles and efficacy remain poorly characterized. This systematic review integrates early-phase outcomes ac …

22.08.2026journal-article

Diseases of the Esophagus

PD09.01. Impact of Sarcopenia, Myosteatosis and Cachexia on Surgical and Oncological Outcomes in Patients With Esophageal Cancer

Irene Sole Zuin, Elisa Sefora Pierobon, Giovanni Capovilla, Gianpietro Zanchettin, Lucia Moletta, Simone Corradin, Shady Attar, Alberto Ponzoni, Alessia Scarton, Sandra Zampieri, Roberta Sartori, Marco Sandri, Michele Valmasoni, Matteo Pittacolo

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Alterations in body composition, including sarcopenia, myosteatosis and cachexia, are increasingly recognized as negative prognostic factors in oncologic patients. However, the correlation between body composition, biochemical markers, and surgical and oncological outcomes in esophageal cancer remains incompletely defined. This study aimed to evaluate the association between CT-derived body composition paramete …

22.08.2026journal-article

Veterinary and Comparative Oncology

Clinical Behaviour and Outcome of Pelvic Osteosarcoma in Dogs: A Retrospective Multicentre Analysis of 74 Cases (2007–2025)

Csilla Fejös, Felicitas Czichon, Maureen Griffin, Natalie Grillo, Quentin Fournier, Michelle L. Oblak, Mikaela Eng‐Toogood, Michael Kent, Isabelle Desmas‐Bazelle, Miriam Kleiter, Laura Marconato, Katie McNaught, Simona Vincenti, Carmit Chalfon, Petros Odatzoglou, Carla Rohrer Bley

ABSTRACT Although osteosarcoma is the most common primary bone tumour in dogs, involvement of the pelvic bones is rare. The aim of the present study was to describe clinical presentation, identify possible prognostic factors, and evaluate outcomes in dogs diagnosed with pelvic osteosarcoma. Seventy‐four dogs with cytologically or histologically diagnosed pelvic osteosarcoma were included in this multicentre retrospective study (2007–2025). The median progression‐free survival (PFS) and overall survival (OS) were es …

22.08.2026journal-article

Diseases of the Esophagus

P1.172. Comparison of Intraoperative Complications in Obese vs Non-Obese in Oesophageal Cancer Surgery

Raelene Tan, Amos Liew, Varun Jahagirdar, Eleazar Leong, Paul Cashin, Geraldine Ooi

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Obesity is a substantial public health issue. A high body mass index (BMI) can increase surgical technical challenges, resulting in higher rates of intraoperative and postoperative complications. We aimed to assess whether intraoperative complication rates, using the the ClassIntra classification, differed between BMI categories in patients undergoing oesophageal cancer surgery. Methods Retrospective review was conducted of all oes …

22.08.2026journal-article

Diseases of the Esophagus

V-27. Right Recurrent Nerve Node Dissection (Station 106r)in Lateral Decubitus Esophagectomy for Cancer Esophagus Post Chemoradiation (Cross Regime)

Abhishek Jain

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – technique Video Description THIS VIDEO SHOWS THE TECHNIQUE OF CAREFULLY DISSECTING RIGHT RECURRENT LARYNGEAL NERVE NODE DISSECTION ( STATION 106R) IN LATERAL DECUBITUS POSITION FOR A VATS ESOPHAGECTOMY FOR CANCER ESOPHAGUS ( POST NEOADJUVANT CHEMORADIATION)

22.08.2026journal-article

Urology Herald

Endovascular embolization in the surgical treatment of renal angiomyolipoma

D. S. Luzhanskiy, I. A. . Aboyan, S. P. Semitko, Yа. V. Kulikovskikh, S. M. Pakus, T. Yu. Luneva, S. V. Ten

Introduction. Angiomyolipoma (AML) is the most common benign renal tumor. Selective arterial embolization of AML-feeding vessels is currently regarded as an effective organ-preserving treatment. However, the absence of unified criteria for predicting procedural success limits its widespread adoption. Objective. To evaluate the outcomes of endovascular embolization of renal AML according to tumor angioarchitectonic type. Materials & methods. This retrospective study included 30 patients with renal AML who underwent …

22.08.2026journal-article

Journal of Clinical Medicine

A Composite Histopathologic Invasion Score Predicts Lymph Node Metastasis in Gastric Cancer

Ebru Karcı, Mahya Ahmadpour Youshanlui, Ferhat Ozden, Ozgur Acikgoz, Ömer Fatih Ölmez, Ozcan Yildiz, Hafize Uzun, Ahmet Bilici

Background: Lymph node metastasis (LNM) is a major determinant of prognosis in gastric adenocarcinoma. Although lymphovascular invasion (LVI) and perineural invasion (PNI) are established markers of aggressive tumor behavior, their combined association with nodal dissemination has not been systematically evaluated. This study investigated the relationship between invasive histopathologic features and LNM and developed a composite invasion score. Methods: This retrospective study included 395 patients with gastric a …

22.08.2026journal-article

Journal of Health Psychology

Understanding bowel cancer screening behaviour and intention across British, Indian, and Indian-Immigrant populations: A qualitative cross-cultural comparison

Soumya Shetty, Mark Conner, Chris Keyworth

Bowel cancer screening reduces mortality, yet uptake remains suboptimal across many populations. While disparities in participation are well documented, limited qualitative research has explored how cultural and healthcare contexts shape attitudes towards screening and preventive healthcare. This study examined beliefs, experiences, and screening-related decision-making among White British individuals, Indian immigrants living in the UK, and individuals residing in India. A cross-cultural qualitative design was emp …

22.08.2026journal-article

Diseases of the Esophagus

OA05.3. Gastrointestinal Symptoms, and Symptoms of Delayed Gastric Conduit Emptying, One Year After Diagnosis of Cancer in the Esophagus

Magnus Konradsson, Fredrik Klevebro, Magnus Nilsson

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Comprehensive studies on long-term gastrointestinal functional results including DGCE after gastric conduit reconstruction are lacking. The aim of this study is to describe GI symptoms and symptoms of DGCE in relation to risk factors and global quality of life 1 year after diagnosis of esophageal cancer, in a large cohort. Methods Diagnostic, surgical and follow up data including EORTC QLQ-c30 and QLQ-OG25 pati …

22.08.2026journal-article

Diseases of the Esophagus

OA03-RF01.03. Non-Cisplatin-Based Preoperative Chemotherapy for Cisplatin-Unfit Esophageal Cancer: A Multicenter Retrospective Study in Japan

Yasunobu Ishizuka, Toru Kadono, Akitoshi Hakoda, Shun Yamamoto, Taisuke Hosokai, Motoo Nomura, Masahiro Fukuoka, Takeshi Yamashita, Kunihiro Fushiki, Kazuhiro Shiraishi, Yuta Sato, Kohei Kanamori, Yohei Ozawa, Atsushi Takeno, Masaaki Iwatsuki, Yuta Itohki, Yusuke Amanuma, Kazuma Sato, Ryoma Haneda, Hisahiro Matsubara, Takeo Bamba, Hiroki Hiratsuka, Naoshi Fujiwara, Takashi Ogata, Yoshito Komatsu, Hiroshi Ichikawa, Takashi Ohta, Hiroaki Nagano, Hiroya Takeuchi, Ken Kato

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Although cisplatin-based neoadjuvant chemotherapy is the standard for resectable esophageal squamous cell carcinoma in Japan, some patients are unfit due to age, renal, or cardiac dysfunction. No established treatment option exists for cisplatin-unfit patients. We compared the efficacy between non-cisplatin-based preoperative chemotherapy (noCDDP) followed by surgery and surgery alone (Sx). Methods This multicenter retrospective study …

22.08.2026journal-article

Diseases of the Esophagus

P1.129. Predictive Value of Baseline Bioelectrical Impedance Analysis(BIA) for Chemoradiotherapy Completion in Locally Advanced Esophageal Cancer: Implications for Prehabilitation

Panpanit Sukwarodwat, Somjai Nokdee, Wilawan Tapalad

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Locally advanced esophageal cancer requires toxic chemoradiotherapy, yet no established pretreatment body composition thresholds exist to predict completion. Traditional assessment relies on subjective performance status, often overlooking occult sarcopenia. This study evaluates BIA markers against BMI to define objective cut-offs for guiding targeted prehabilitation and optimizing therapeutic resilience. Methods A retrospective cohort study an …

22.08.2026journal-article

Diseases of the Esophagus

P1.159. Long-Term and Perioperative Outcomes of Ivor-Lewis Single-Incision Minimally Invasive Esophagectomy (SIMIE) for Esophageal Cancer: Comparison With McKeown MIE

Jang-Ming Mail, Pei-Ming Huang, Shuenn-Wen Kuo, Ke-Cheng Chen, Mong-Wei Lin

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Minimally invasive esophagectomy has been gradually adopted as an effective surgical option for the treatment of esophageal cancer. However, the optimal surgical approach, including port placement and anastomotic site, remains to be determined. Methods In the present study, we evaluated the perioperative and long-term survival outcomes of single-incision Ivor Lewis minimally invasive esophagectomy with intrathoracic esophagogastros …

22.08.2026journal-article

Internal Medicine Journal

Development and application of a frailty index derived from patient‐reported outcome measures and comorbidities in oncology patients

Divya Mathew, Heather Lane, David Ward, Rosemary Saunders, Lesley Millar, Christopher Etherton‐Beer

Abstract Background Emerging evidence supports the use of a frailty index as an objective measure of frailty. We constructed a frailty index from patient‐derived outcome measures, as well as self‐reported comorbidity data, and tested its correlation with survival. Method Data from 464 patients with lung, breast and colorectal cancer were obtained from the Continuous Improvement in Care – Cancer Project database, and a 42‐variable frailty index was generated by dividing the total number of deficits present by the to …

22.08.2026journal-article

Japanese Journal of Clinical Oncology

Stage-specific prognostic impact and recurrence patterns according to tumor location in upper tract urothelial carcinoma following radical nephroureterectomy: a propensity score-matched analysis

Yue Ogihara, Fumihiko Urabe, Masataka Kubo, Naoki Uchida, Hirokazu Kagawa, Masaki Hashimoto, Yuhei Koike, Yuya Iwamoto, Shota Kawano, Mimu Ishikawa, Sotaro Kayano, Juria Nakano, Yuzo Inaba, Kosuke Iwatani, Yu Imai, Minoru Nakazono, Keiji Yasue, Kojiro Tashiro, Masaya Murakami, Takaya Sasaki, Shunsuke Tsuzuki, Jun Miki, Takahiro Kimura, the JIKEI-YAYOI Collaborative Group

Abstract Background The prognostic significance of the location of the primary tumor in upper tract urothelial carcinoma (UTUC) remains controversial. We evaluated the impact of ureteral urothelial carcinoma (UUC) versus renal pelvic urothelial carcinoma (RPUC) on oncological outcomes and recurrence patterns following radical nephroureterectomy (RNU). Methods We retrospectively analysed 779 patients with UTUC who underwent RNU between 2012 and 2021 within the JIKEI-YAYOI Collaborative Group. Propensity score matchi …

22.08.2026journal-article

Journal of Ayurveda and Holistic Medicine (JAHM)

Natural Compounds as Oral Remedies for the Treatment of Oral Diseases: A Narrative Review

Swetha Mathiyazhagan, Vinitha Packirisamy

Background: The aim of this narrative review is to inform the key role of natural products in the prevention and treatment of common oral diseases such as dental caries‚ gingivitis‚ periodontitis‚ oral candidiasis and oral cancer with the underlying mechanisms. Method: Reporting of this narrative review followed the Scale for the Assessment of Narrative Review Articles (SANRA) guideline․ Review of the literature was conducted on PubMed‚ PubMed Central (PMC)‚ Scopus‚ Web of Science and Google Scholar․ The search per …

22.08.2026journal-article

Journal of Clinical Medicine

Evaluating the Performance of Mammogram-Based AI Risk Model in Predicting Subsequent Breast Cancer in Women with a Prior History of Breast Cancer

Samuel B. Ogunlade, Andrew Dakkak, Amie Leon, Kristin A. Robinson, Santo Maimone, Michael Villalba, Haley P. Letter

Objectives: Women with a history of breast cancer are at increased risk of developing subsequent breast cancer, including ipsilateral recurrence and contralateral new primary breast cancer. This study evaluated the discriminatory performance of a mammogram-based artificial intelligence (AI) risk model for predicting subsequent breast cancer within one year after a negative screening mammogram. Methods: This enriched retrospective case–control study included women with a prior history of breast cancer who underwent …

22.08.2026journal-article

Diseases of the Esophagus

OA05.4. Consensus-Based Treatment of Anastomotic Leakage After Esophagectomy

Gijs van Dongen, Irene Fleur Kramer, Sander Ubels, Bastiaan Klarenbeek

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Recently, an international consensus guideline for management of anastomotic leakage (AL) after esophagectomy was published in collaboration with the ISDE1. An expert panel formulated 23 evidence-based recommendations for clinical care. This study aimed to investigate the extent to which these guidelines are reflected in clinical practice. Methods For this study, data of the TENTACLE - Esophagus w …

22.08.2026journal-article

Diseases of the Esophagus

PD03.08. Impact of Proton Pump Inhibitor Treatment on T-Cell Subgroups in Eosinophilic Esophagitis

Helen Larsson, Christine Lingblom, John Plate

Abstract Topic Benign Disease: Eosinophilic Esophagitis Background Eosinophilic esophagitis (EoE) is a chronic, allergy-related inflammatory disease of the esophagus causing dysphagia and food impaction. Untreated, it may lead to fibrosis. This study investigated changes in T-cell subgroups before and after proton pump inhibitor therapy and evaluated blood-based T-cell markers as less invasive indicators of treatment response. Methods Blood samples from patients with EoE (n=17; 87% men, 53% allergic) were collected …

22.08.2026journal-article

Diseases of the Esophagus

P1.189. A Case of Laparoscopy-Assisted Distal Esophagectomy for a 6.5-cm Esophageal Gastrointestinal Stromal Tumor

Hiroki Kato

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Case Submission (GISTs) are extremely rare and account for less than 1% of all GISTs. Their clinical behavior, optimal surgical approach, and postoperative management remain unclear due to limited reported cases. Rapid tumor growth may indicate aggressive biological potential and increased risk of recurrence. Early diagnosis and appropriate treatment are therefore essential. We report a case of rapidly growing esophageal GIST successfully tre …

22.08.2026journal-article

Diseases of the Esophagus

P1.107. Macrophage Infiltration and FoxP3 Density Predict Treatment Response and Survival in Esophageal Cancer Patients

Hugo Teixeira Farinha, François Fasquelle, Raphaël Marangon, Christine Sempoux, Markus Schäfer, Fulvia Serra, Styliani Mantziari

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background The tumor microenvironment (TME) holds an important role in the biological behaviour of the esophageal cancer, influenced by neoadjuvant treatment (NAT). However, its correlation to patient outcomes remains poorly defined. The aim of this study was to assess the prognostic value of TME in terms of long-term recurrence and survival. Methods All eligible patients with esophageal adenocarcinoma (EAC) and squamous cell carcinoma (SCC), treated wit …

22.08.2026journal-article

Diseases of the Esophagus

P1.145. The pCR Paradox: Unmasking Systemic Failure in Esophageal Cancer Following Neoadjuvant CROSS Therapy

Manish Jethani, Ganesh Jadhav, Rajesh Mistry, Imran Shaikh, Pranav Chadha

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background While neoadjuvant chemoradiotherapy (nCTRT) followed by esophagectomy has established itself as the global standard for locally advanced esophageal cancer - predominant squamous histology, the "Achilles' heel" remains disease recurrence. Although achieving a pathological complete response (pCR) suggests a favourable prognosis, it does not guarantee a cure. We aimed to characterize the specific timing and patter …

21.08.2026journal-article

Clinical and Experimental Dermatology

Skin Oncology

Cristina Grechin, Patrick Ormond, Máirín McMenamin, Jennifer Boggs

A 79-year-old male presented to dermatology with a solitary, painless nodular lesion on the chest that had been present for over 20 years with gradual enlargement over the last 6 years. His past medical history included a mild IgM lambda paraproteinemia, chronic kidney disease, hypertension and COPD.

21.08.2026journal-article

Cancers

Breast-Conserving Surgery in Multicentric Breast Cancer: Evolving Evidence and Patient Selection

Mariam Rizk, Kefah Mokbel

Multicentric breast cancer—two or more biopsy-proven tumor foci in anatomically distinct regions of the same breast—has historically been treated as a near-automatic indication for mastectomy, reflecting concerns about occult residual disease, achievability of negative margins at every focus, and unacceptable cosmetic outcome. This narrative review synthesizes the evidence underlying that historical position and the more recent data that have begun to qualify it. The single-arm ACOSOG Z11102 (Alliance) trial report …