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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
22.08.2026journal-article

Diseases of the Esophagus

P1.159. Long-Term and Perioperative Outcomes of Ivor-Lewis Single-Incision Minimally Invasive Esophagectomy (SIMIE) for Esophageal Cancer: Comparison With McKeown MIE

Jang-Ming Mail, Pei-Ming Huang, Shuenn-Wen Kuo, Ke-Cheng Chen, Mong-Wei Lin

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Minimally invasive esophagectomy has been gradually adopted as an effective surgical option for the treatment of esophageal cancer. However, the optimal surgical approach, including port placement and anastomotic site, remains to be determined. Methods In the present study, we evaluated the perioperative and long-term survival outcomes of single-incision Ivor Lewis minimally invasive esophagectomy with intrathoracic esophagogastros …

22.08.2026journal-article

Internal Medicine Journal

Development and application of a frailty index derived from patient‐reported outcome measures and comorbidities in oncology patients

Divya Mathew, Heather Lane, David Ward, Rosemary Saunders, Lesley Millar, Christopher Etherton‐Beer

Abstract Background Emerging evidence supports the use of a frailty index as an objective measure of frailty. We constructed a frailty index from patient‐derived outcome measures, as well as self‐reported comorbidity data, and tested its correlation with survival. Method Data from 464 patients with lung, breast and colorectal cancer were obtained from the Continuous Improvement in Care – Cancer Project database, and a 42‐variable frailty index was generated by dividing the total number of deficits present by the to …

22.08.2026journal-article

Japanese Journal of Clinical Oncology

Stage-specific prognostic impact and recurrence patterns according to tumor location in upper tract urothelial carcinoma following radical nephroureterectomy: a propensity score-matched analysis

Yue Ogihara, Fumihiko Urabe, Masataka Kubo, Naoki Uchida, Hirokazu Kagawa, Masaki Hashimoto, Yuhei Koike, Yuya Iwamoto, Shota Kawano, Mimu Ishikawa, Sotaro Kayano, Juria Nakano, Yuzo Inaba, Kosuke Iwatani, Yu Imai, Minoru Nakazono, Keiji Yasue, Kojiro Tashiro, Masaya Murakami, Takaya Sasaki, Shunsuke Tsuzuki, Jun Miki, Takahiro Kimura, the JIKEI-YAYOI Collaborative Group

Abstract Background The prognostic significance of the location of the primary tumor in upper tract urothelial carcinoma (UTUC) remains controversial. We evaluated the impact of ureteral urothelial carcinoma (UUC) versus renal pelvic urothelial carcinoma (RPUC) on oncological outcomes and recurrence patterns following radical nephroureterectomy (RNU). Methods We retrospectively analysed 779 patients with UTUC who underwent RNU between 2012 and 2021 within the JIKEI-YAYOI Collaborative Group. Propensity score matchi …

22.08.2026journal-article

Journal of Ayurveda and Holistic Medicine (JAHM)

Natural Compounds as Oral Remedies for the Treatment of Oral Diseases: A Narrative Review

Swetha Mathiyazhagan, Vinitha Packirisamy

Background: The aim of this narrative review is to inform the key role of natural products in the prevention and treatment of common oral diseases such as dental caries‚ gingivitis‚ periodontitis‚ oral candidiasis and oral cancer with the underlying mechanisms. Method: Reporting of this narrative review followed the Scale for the Assessment of Narrative Review Articles (SANRA) guideline․ Review of the literature was conducted on PubMed‚ PubMed Central (PMC)‚ Scopus‚ Web of Science and Google Scholar․ The search per …

22.08.2026journal-article

Journal of Clinical Medicine

Evaluating the Performance of Mammogram-Based AI Risk Model in Predicting Subsequent Breast Cancer in Women with a Prior History of Breast Cancer

Samuel B. Ogunlade, Andrew Dakkak, Amie Leon, Kristin A. Robinson, Santo Maimone, Michael Villalba, Haley P. Letter

Objectives: Women with a history of breast cancer are at increased risk of developing subsequent breast cancer, including ipsilateral recurrence and contralateral new primary breast cancer. This study evaluated the discriminatory performance of a mammogram-based artificial intelligence (AI) risk model for predicting subsequent breast cancer within one year after a negative screening mammogram. Methods: This enriched retrospective case–control study included women with a prior history of breast cancer who underwent …

22.08.2026journal-article

Diseases of the Esophagus

OA05.4. Consensus-Based Treatment of Anastomotic Leakage After Esophagectomy

Gijs van Dongen, Irene Fleur Kramer, Sander Ubels, Bastiaan Klarenbeek

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Recently, an international consensus guideline for management of anastomotic leakage (AL) after esophagectomy was published in collaboration with the ISDE1. An expert panel formulated 23 evidence-based recommendations for clinical care. This study aimed to investigate the extent to which these guidelines are reflected in clinical practice. Methods For this study, data of the TENTACLE - Esophagus w …

22.08.2026journal-article

Diseases of the Esophagus

PD03.08. Impact of Proton Pump Inhibitor Treatment on T-Cell Subgroups in Eosinophilic Esophagitis

Helen Larsson, Christine Lingblom, John Plate

Abstract Topic Benign Disease: Eosinophilic Esophagitis Background Eosinophilic esophagitis (EoE) is a chronic, allergy-related inflammatory disease of the esophagus causing dysphagia and food impaction. Untreated, it may lead to fibrosis. This study investigated changes in T-cell subgroups before and after proton pump inhibitor therapy and evaluated blood-based T-cell markers as less invasive indicators of treatment response. Methods Blood samples from patients with EoE (n=17; 87% men, 53% allergic) were collected …

22.08.2026journal-article

Diseases of the Esophagus

P1.189. A Case of Laparoscopy-Assisted Distal Esophagectomy for a 6.5-cm Esophageal Gastrointestinal Stromal Tumor

Hiroki Kato

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Case Submission (GISTs) are extremely rare and account for less than 1% of all GISTs. Their clinical behavior, optimal surgical approach, and postoperative management remain unclear due to limited reported cases. Rapid tumor growth may indicate aggressive biological potential and increased risk of recurrence. Early diagnosis and appropriate treatment are therefore essential. We report a case of rapidly growing esophageal GIST successfully tre …

22.08.2026journal-article

Diseases of the Esophagus

P1.107. Macrophage Infiltration and FoxP3 Density Predict Treatment Response and Survival in Esophageal Cancer Patients

Hugo Teixeira Farinha, François Fasquelle, Raphaël Marangon, Christine Sempoux, Markus Schäfer, Fulvia Serra, Styliani Mantziari

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background The tumor microenvironment (TME) holds an important role in the biological behaviour of the esophageal cancer, influenced by neoadjuvant treatment (NAT). However, its correlation to patient outcomes remains poorly defined. The aim of this study was to assess the prognostic value of TME in terms of long-term recurrence and survival. Methods All eligible patients with esophageal adenocarcinoma (EAC) and squamous cell carcinoma (SCC), treated wit …

22.08.2026journal-article

Diseases of the Esophagus

P1.145. The pCR Paradox: Unmasking Systemic Failure in Esophageal Cancer Following Neoadjuvant CROSS Therapy

Manish Jethani, Ganesh Jadhav, Rajesh Mistry, Imran Shaikh, Pranav Chadha

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background While neoadjuvant chemoradiotherapy (nCTRT) followed by esophagectomy has established itself as the global standard for locally advanced esophageal cancer - predominant squamous histology, the "Achilles' heel" remains disease recurrence. Although achieving a pathological complete response (pCR) suggests a favourable prognosis, it does not guarantee a cure. We aimed to characterize the specific timing and patter …

21.08.2026journal-article

PLOS One

Integrated optimization of electroplating wastewater treatment: A comparative assessment of physicochemical treatment configurations and process enhancement using response surface methodology

Soumaya Ibrahimi, Aicha Gasmi, Karim Kriaa, Farid Fadhillah, Majeed Ali Habeeb, Djamel Ghernaout, Noureddine Elboughdiri, Ahmed Hannachi

This study assesses physicochemical treatment methods for industrial electroplating wastewater (EPW). Monitoring at a full-scale Tunisian facility revealed considerable instability in conventional systems. Residual nickel concentrations ranged from 0.02 ± 0.01 to 60 ± 0.4 mg/L. Chloride levels consistently exceeded regulatory thresholds, ranging from 442 ± 9–1418 ± 10 mg/L. Over 24 weeks, three treatment configurations were evaluated: ferric chloride-based coagulation (Configuration 1), polyaluminum chloride coagul …

21.08.2026journal-article

Dermatologica Sinica

Systemic treatment for hidradenitis suppurativa: A narrative review of current evidence

Chu-Fei Tsai, Yang Lo

Abstract Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disease characterized by painful nodules, abscesses, and draining tunnels that severely impair the quality of life. Management is multifaceted, with systemic antibiotics like oral tetracyclines and clindamycin-rifampicin commonly used as first-line therapy, although growing concerns regarding relapse and antibiotic resistance persist. Retinoids such as acitretin show benefit in select phenotypes but are limited by side effects. Immunom …

21.08.2026journal-article

Advanced Functional Materials

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang

ABSTRACT Extracellular vesicles (EVs) from immune cells represent a novel drug delivery system with inherent anti‐tumor properties. To remodel the immunosuppressive tumor microenvironment and mediate multimodal therapy, we produced neutrophil nanovesicles at high yield and loaded them with drug (doxorubicin, DOX), near‐infrared region II fluorescent dye (FD1080), and PD‐1 inhibitor (TFA) through a simple extrusion method and further modified them with DSPE‐PEG2000‐cRGD to enhance their tumor‐targeting ability. The …

21.08.2026journal-article

Clinical and Translational Imaging

The role of prostate-specific membrane antigen positron emission tomography in detecting recurrence in patients with biochemical relapse after primary radiotherapy for localised prostate cancer: a systematic review and meta-analysis

Omar Alghazo, Thomas Milton, Kate Wilson, Mrunal Hiwase, Michael S. Hofman, Matthew Hong, Alex Jay, Michael O’Callaghan

Abstract Objective To evaluate the diagnostic efficacy of prostate-specific membrane antigen positron emission tomography–computed tomography (PSMA PET–CT) in detecting and localising recurrence in patients with biochemical relapse (BCR) following definitive radiotherapy for prostate cancer. Methods A systematic review and meta-analysis was conducted according to PRISMA guidelines. Comprehensive searches of Ovid MEDLINE, Ovid Embase, and the Cochrane Library identified studies reporting PSMA PET–CT findings in pati …

21.08.2026journal-article

The Ukrainian Journal of Clinical Surgery

Clinical Predictors of Severe Calcification of the Lower Limb Arteries and Characteristics of the Intraoperative Course of Endovascular Treatment

Yu. M. Hupalo, S. Y. Denysov

Objective. To identify clinical predictors associated with the presence of severe calcification of the lower extremity arteries and to evaluate the impact of the chosen endovascular strategy on intraoperative parameters of the procedure.Materials and Methods. The study included 150 patients with peripheral arterial disease of the lower extremities, who were divided into three groups based on the degree of calcification and treatment strategy. The degree of calcification was assessed using the Agatston index. Logist …

21.08.2026journal-article

JNCI Cancer Spectrum

Neighborhood Gentrification, Income Inequality, and Cancer Incidence Among Hispanic/Latino Adults

Yaiza Diaz-De-Durana, Corinne McDaniels-Davidson, Krista M Perreira, En Cheng, Gregory A Talavera, Linda C Gallo, Humberto Parada

Abstract Background Neighborhood gentrification leads to displacement of people, networks, and resources, and to differences in how income is distributed in the community. Few studies, however, have examined the roles of neighborhood gentrification and income inequality in relation to cancer incidence, particularly among Hispanic/Latino populations. We examined measures of neighborhood gentrification and income distribution in association with cancer risk among Hispanic/Latino adults. Methods We included 14,303 adu …

21.08.2026journal-article

The Oncologist

IUC26674-90 Impact of delayed radical cystectomy following neoadjuvant chemotherapy on oncological outcomes in Muscle-invasive bladder cancer

J Bondjeke Nkumindamu, L Afani, O Zouiten, M El Fadli, R Belbaraka

Abstract Background Radical cystectomy (RC) following neoadjuvant chemotherapy (NAC) remains the standard of care for muscle-invasive bladder cancer (MIBC), yet the optimal interval between completion of NAC and surgery remains debated. A prolonged delay may compromise the oncological benefit of NAC, particularly in resource-limited settings with constrained operating room access. Methods This retrospective single-center study included 75 patients with MIBC (cT2-T4a N0-N1 M0) who received platinum-based NAC followe …

21.08.2026journal-article

Periódicos Brasil. Pesquisa Científica

PERFIL EPIDEMIOLÓGICO E ANÁLISE DESCRITIVA TEMPORAL DO CÂNCER DE COLO DO ÚTERO NO ESTADO DO PARÁ DE 2015 A 2024

Jenniffer Luanna Lima Costa, Maria Júlia Quezado Andrade de Melo, Carlos Henrique Xavier Conceição, Victória Rodrigues Cipriano, Ana Beatriz Belém Cardoso, Thalya De Sousa Veloso, Mônica Borchart Nicolau, Kecyani Lima dos Reis, Simone Argentino, Luciana Marinho e Silva Silvestre

O câncer do colo do útero (CCU) permanece como um grave problema de saúde pública, sendo uma das neoplasias de maior morbimortalidade entre mulheres, com acentuadas desigualdades regionais no Brasil, especialmente no estado do Pará. O objetivo deste estudo foi analisar o perfil epidemiológico e a distribuição temporal do CCU no Pará, entre 2015 e 2024. Trata-se de um estudo descritivo, quantitativo e retrospectivo, realizado a partir de dados secundários obtidos no Departamento de Informática do Sistema Único de Sa …

21.08.2026journal-article

Journal of Physiology and Biochemistry

The endocannabinoidome–microbiota axis in obesity: a potential link to colorectal cancer development

Gabriela Ávila Alpino, Poliana Guiomar Brasiel, Mariana M. Almeida, Sheila C. P. Dutra Luquetti

Abstract Colorectal cancer (CRC) is a multifactorial disease strongly influenced by genetic and environmental factors, as well as by immune and metabolic disorders such as obesity and gut dysbiosis. Recent evidence highlights the interplay between the endocannabinoidome (eCBome) and the gut microbiota as a central regulatory axis of intestinal homeostasis, metabolism, and immune responses. Although no studies have directly investigated this functional interaction in the CRC context, recent evidence suggests that dy …

21.08.2026journal-article

Frontiers in Oncology

Pretreatment prognostic nutritional index and immune status for response to preoperative neoadjuvant chemotherapy in cervical squamous cell carcinoma: an exploratory retrospective study

Zhou-Le Li, Jian-Bin He, Xue Liu, Hui-Ting Hao, Han-Xiao Zhu, Min Wang, Xiao-Ming Wu, Chun-Qiang Lu

Introduction Pretreatment nutritional and immune status may be associated with response to preoperative neoadjuvant chemotherapy (NACT) in cervical squamous cell carcinoma (CSCC), but its clinical utility remains uncertain. Methods This exploratory retrospective study evaluated the association of pretreatment immunonutritional and tumor-related factors with short-term radiologic response to NACT. Ninety-two patients with histopathologically confirmed CSCC who received paclitaxel plus platinum-based NACT followed by …

21.08.2026journal-article

Clinical and Experimental Dermatology

Skin Oncology

Cristina Grechin, Patrick Ormond, Máirín McMenamin, Jennifer Boggs

A 79-year-old male presented to dermatology with a solitary, painless nodular lesion on the chest that had been present for over 20 years with gradual enlargement over the last 6 years. His past medical history included a mild IgM lambda paraproteinemia, chronic kidney disease, hypertension and COPD.

21.08.2026journal-article

Cancers

Breast-Conserving Surgery in Multicentric Breast Cancer: Evolving Evidence and Patient Selection

Mariam Rizk, Kefah Mokbel

Multicentric breast cancer—two or more biopsy-proven tumor foci in anatomically distinct regions of the same breast—has historically been treated as a near-automatic indication for mastectomy, reflecting concerns about occult residual disease, achievability of negative margins at every focus, and unacceptable cosmetic outcome. This narrative review synthesizes the evidence underlying that historical position and the more recent data that have begun to qualify it. The single-arm ACOSOG Z11102 (Alliance) trial report …

21.08.2026journal-article

MD-Onco

Robot-assisted retroperitoneal lymph node dissection for stage IIA–IIB testicular germ cell tumor

E. M. Mamizhev, R. V. Orlova, D. I. Rumyantseva, R. A. Melikov, N. F. Krotov, P. M. Gorlin, A. K. Nosov

Background. For a long time, open retroperitoneal lymph node dissection remained the gold standard for the treatment of testicular germ cell tumors. A minimally invasive approach using endoscopic technologies made it possible to solve a number of problems reducing surgical risks for the patient and the perioperative burden for the operating team. Due to the widespread use of robotic surgery in urology, robot-assisted retroperitoneal lymph node dissection (RA-RPLND) has been gaining popularity since its introduction …

21.08.2026journal-article

World Journal of Gastroenterology

Spatiotemporal trends in pancreatic cancer incidence from 2013 to 2023 in Gansu Province, Northwest China: A regional study

Yan-Mei Gu, Jie Liu, Ying-Ying Wang, Gang-Li Liu, Yuan-Yuan Li, Xiao-Mei Li, Yang Zhao, Hui-Juan Cheng, Jun Zhao, Yu-Min Li

BACKGROUND Pancreatic cancer (PC) is a malignant neoplasm with a rising incidence, yet long-term provincial trends in China remain unclear. AIM To comprehensively analyze the spatiotemporal distribution of, and trends in, PC incidence in Gansu Province from 2013 to 2023. METHODS Data on PC cases were gathered from 262 hospitals in Gansu Province, focusing on age-standardized incidence rates (ASIRs) stratified by county, gender, and climate. Moran’s I was employed for spatial autocorrelation analysis to detect clust …