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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
11.08.2026journal-article

BMC Cancer

Trials in progress: CARMAN – study protocol of a randomized controlled, international, multicenter, open-label phase II trial evaluating early treatment intensification in patients with high-risk mantle cell lymphoma using CAR-T-cell treatment after an abbreviated induction therapy with rituximab and ibrutinib and 6 months ibrutinib maintenance as compared to standard of care induction and maintenance

Marie-Kristin Tilch, Christian Schmidt, Marek Trneny, Eva Giné, Olivier Hermine, Anke Ohler, Stephanie Herold, Eva Hoster, Linmiao Jiang, Christiane Pott, Martin Dreyling, Georg Hess

Abstract Background Brexucabtagene-autoleucel (brexu-cel) is an anti-CD19 chimeric antigen receptor T-cell (CAR-T) product approved for relapsed/refractory Mantle Cell Lymphoma (MCL) after two prior treatment lines, including Bruton tyrosine kinase inhibitors (BTKi). Patients with high-risk (hr) disease—defined by high-intermediate or high-risk MIPI-c, p53 overexpression, or TP53 alterations—have a poor prognosis, underscoring the need for improved first-line strategies. The European Mantle Cell Lymphoma Network th …

11.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Validity of the Cepstral Spectral Index of Dysphonia in the Persian Language in Sustained Vowel, Sentence, and All-Voiced Sentence Contexts

Saeed Saeedi, Shaheen N. Awan, Samira Aghadoost, Christopher R. Watts, Mahshid Aghajanzadeh, Ben Barsties v. Latoszek

Purpose: Cepstral Spectral Index of Dysphonia (CSID) characterizes and objectively quantifies characteristics of voice quality. The findings of CSID's impact in determining dysphonia characteristics in different languages, however, are unclear but important if this tool is to be used cross-linguistically. Therefore, the purpose of the study was to determine the validity of CSID in Persian speakers. Method: Persian-speaking participants were assigned to two groups: patients with voice disorders ( n = 102) and vocall …

11.08.2026journal-article

Engineering, Technology & Applied Science Research

STOI-Optimized Fixed-Point Speech Enhancement Architecture with Verilog Verification for Hearing Aid ASICs

Vinodakumar M. Sonar, Srinivasarao Udara

This paper presents a fixed-point speech enhancement architecture optimized for intelligibility and designed for low-power hearing aid deployment. The system integrates a perceptual post-filtering pipeline guided by the Short-Time Objective Intelligibility (STOI) metric, enabling dynamic gain control across frequency bands. The algorithmic model, developed in MATLAB using Q-format arithmetic, is mapped precisely to synthesizable Verilog Register-Transfer Level (RTL), ensuring bit-accurate correspondence and reprodu …

11.08.2026journal-article

Journal of Occupational & Environmental Medicine

Factors Associated with Burnout and Stress Symptoms in Brazilian Workers: Evidence from a Prospective Longitudinal Study from 2020 to 2023

Gabriel Eduardo Domingues, Maria Isabel Triches, Tatiana de Oliveira Sato

Objectives: This prospective study aims to identify factors associated with burnout and stress symptoms. Methods: 1,211 Brazilian workers were included at baseline and 467 at follow-up. A sociodemographic and occupational questionnaire, Copenhagen Psychosocial Questionnaire II-Br (COPSOQ II-Br), and Work Ability Index (WAI) were used to collect data. Multivariate logistic regression was applied. Results: Age was a protective factor for stress (OR=0.97, 95%CI=0.95-0.99) and burnout (OR=0.96, 95%CI=0.93-0.98); as wel …

11.08.2026journal-article

International Journal of Physiotherapy and Research

Correlation Between Q Angle and Hip Abductor Strength in Patellofemoral Pain Syndrome

Priya S, Harish S Krishna, Denson Alphonse

Background: Young active females are frequently exposed to dynamic lower limb loading during physical activity, rendering them susceptible to patellofemoral pain syndrome (PFPS). The quadriceps angle (Q angle) and hip abductor strength are critical biomechanical parameters influencing patellar tracking and patellofemoral joint stress. Alterations in these factors may contribute to or result from patellofemoral dysfunction. Context and Purpose of Study: To evaluate the correlation between Q angle and hip abductor st …

11.08.2026journal-article

Lumina : Indonesian Journal of Neurology

Multiple Sclerosis with Limited Treatment Options: A Case Report on Azathioprine as an Alternative Therapy

Nicholas Ciarico, Kennytha Yoesdyanto, Iglesias Owen

Introduction: Multiple sclerosis (MS) is a chronic immune-mediated disease affecting the central nervous system, characterized by demyelination and progressive disability. Estimated prevalence in Indonesia is approximately 0.01 per 100,000 population. Treatment includes managing acute relapses with corticosteroids and DMT to prevent relapses and further disability. Immunosuppressants such as azathioprine are often used in Indonesia as a more accessible and affordable alternative to standard DMTs. Case Presentation: …

11.08.2026journal-article

International Journal of Innovative Science and Research Technology

A Comparative Study on the Effectiveness of Incremental Vestibulo-Ocular Reflex Adaptation Training and Conventional Physiotherapy on Dizziness and Balance in Patients with Benign Paroxysmal Positional Vertigo

Shalini V., Franklin Shaju M. K., Cathrine S., Divya J. Pawani

Objective: To evaluate the efficacy of traditional vestibular rehabilitation and incremental vestibulo-ocular reflex adaption training in treating dizziness and balance in patients with benign paroxysmal positional vertigo (BPPV).  Methodology: The research was conducted at RVS College of Physiotherapy. The study was authorized by the RVS College of Physiotherapy review board, and the subjects gave their informed consent before the study began.  Results: Patients in group A who received incremental vestibulo-ocul …

11.08.2026journal-article

International Journal of Asian Studies

Counter-protesters against hate speech in Japan: negative framing by police, media, and activists

Ayaka Löschke

Abstract In 2013, counter-protests emerged in Japan in response to escalating far-right demonstrations featuring hate speech. Counter-protesters formed a movement described as “Liberal Antifa.” Many used Antifa symbols, yet the movement remained non-violent and distinct from the more militant Antifa in other Western countries. They verbally confronted far-right activists and used electronic noise, helping reduce far-right demonstrations. From the summer of 2025, their visibility once again increased through protest …

11.08.2026journal-article

Oral

Short-Term Clinical Outcomes of Initial Scaling and Root Planing with or Without Surgical Periodontal Therapy in Patients with Advanced Periodontitis: A Retrospective Comparative Study

Cristian Cojocaru, Florinel Cosmin Bida, Dana Gabriela Budala, Ionut Taraboanta, Andrei Georgescu, Zinovia Surlari, Irina-Georgeta Sufaru, Florin Razvan Curca, Oana-Maria Butnaru, Gabriel Rotundu, Ionut Luchian

Background/Objectives: Surgical periodontal therapy is frequently performed when residual periodontal pockets persist after scaling and root planing (SRP). This study compared the clinical outcomes of SRP alone and SRP followed by surgical periodontal therapy in patients with stage III/IV periodontitis. Methods: A retrospective comparative study was conducted in 180 adults with stage III/IV periodontitis. Ninety patients received SRP alone, while ninety underwent SRP followed by surgical periodontal therapy when cl …

11.08.2026journal-article

Frontiers in Immunology

Photodynamic priming enhances anti-PD1 therapy responses in patient-derived pancreatic cancer organoid immune cocultures

Pushpamali De Silva, Demi Wekking, Joanna Joeun Choe, Madeline D. Kidd, Josie L. Pearce, Dario Missael Rocha Castellanos, Piotr Zelga, Russell Jenkins, Kenneth K. Wang, Vinay Chandrasekhara, Edward V. Maytin, Andrew Scott Liss, Tayyaba Hasan

Photodynamic priming (PDP), a fallout of photodynamic therapy, transiently modulates the tumor microenvironment (TME), enhances therapeutic susceptibility, and promotes immunogenic cell death through the release of damage-associated molecular patterns (DAMPs). Pancreatic ductal adenocarcinoma (PDAC) remains non-responsive to current therapies with a desmoplastic and immunosuppressive TME that limits drug delivery and blunts responses to immune checkpoint blockade. We investigated whether PDP could enhance anti-PD1 …

11.08.2026journal-article

PLOS One

Influence of psychosocial adaptation on existential distress among young breast cancer survivors in the rehabilitation period: An analysis of the chain mediating effects of social support and psychological resilience

Lin Tao, Mitao Li, Jieying Lv, Qiuzhou Wang, Lan Fu, Junying Li

This study investigated the influence of psychosocial adaptation on existential distress among young breast cancer survivors during the rehabilitation period, with a focus on the chain-mediating roles of social support and psychological resilience. A cross-sectional survey was conducted with 390 young Chinese breast cancer survivors (aged 18−49 years, within 5 years post-treatment) recruited from tertiary hospitals. Participants completed standardized measures assessing psychosocial adaptation (PAIS-SR), social sup …

11.08.2026journal-article

Russian Journal of Occupational Health and Industrial Ecology

The main components of the effectiveness of scientific researches on the preservation of public health and labor longevity (on the occasion of the 50<sup>th</sup> anniversary of the Research Institute for Complex Problems of Hygiene and Occupational Diseases)

Sergej N. Filimonov, Nadezhda N. Mikhailova, Tatyana G. Korsakova

The article provides an overview of the main results of the activities of the Scientific Research Institute for Complex Problems of Hygiene and Occupational Diseases on the preservation of public health and longevity, the study of the influence of environmental factors, the analysis of medical and social problems; the prospects for further development of the institute are presented.Contributions:Filimonov S.N. — editing the article;Mikhailova N.N. — concept and design of research, collection and analysis of materia …

11.08.2026journal-article

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Astrocyte-neuron interactions as modulators of neural plasticity in stroke recovery: implications for rehabilitation strategies

Nicholas Aderinto, Israel Charles Abraham, Evelyn Faith Ogungbemi, Timilehin Mayowa, Promise Ayooluwa Ajala, Eugene Omoike, Aizenosa Olohita Oyakhire, Aliu O. Yakubu, Akpan-Brown Idongesit, Ifeanyichukwu Muogbo, Temitomi Jane Oyedele, Gbolahan Olatunji, Emmanuel Kokori

Abstract Stroke remains a leading cause of global mortality and disability, necessitating innovative rehabilitation strategies to enhance recovery. Interactions between astrocytes and neurons modulate neural plasticity. This review synthesizes current evidence on the role of astrocytes in stroke recovery, focusing on their contributions to neural plasticity through neurotransmitter homeostasis, gliotransmission, neurotrophic factor release, metabolic support, modulation of inflammation, and extracellular matrix rem …

11.08.2026journal-article

Journal of Occupational & Environmental Medicine

Subjective Fatigue Across Multiple Sectors in Super Short-haul High-Frequency Operations: An Observational Study of Japanese Regional Airline Pilots

Naoya Sawamoto, Yoshihito Shigihara, Rie Yokota

Objective: To examine the effect of sector count on subjective fatigue in super short-haul high-frequency (SSH-HF) operations (≥five sectors, block-time <1 h) among Japanese regional airline pilots. Methods: We surveyed 147 line pilots at three Japanese regional carriers, assessing severe fatigue (Samn-Perelli Scale ≥6) after the second, fourth, and sixth sectors of six-sector duties. Multivariable mixed-effects models, stratified by workload tertile, were used. Results: Adjusted predicted probability of severe fat …

11.08.2026journal-article

Asian Journal of Neurosurgery

Safety of Antiplatelet Therapy Continuation During Single-Level Anterior Cervical Decompression and Fusion: A Retrospective Observational Study

Eitaro Okumura, Ryo Hashimoto, Yosuke Nakayama, Hiroki Eguchi, Motoo Kubota

Abstract This study aimed to investigate whether continuation of antiplatelet therapy during single-level anterior cervical decompression and fusion (ACDF) is associated with increased intraoperative blood loss or perioperative complications. We retrospectively reviewed 43 patients who underwent single-level ACDF at our institution between January 2023 and August 2025. Patients were stratified into two groups: those who continued antiplatelet medication perioperatively (AP+ group; n = 3) and those who were not taki …

11.08.2026journal-article

Journal of modern medicine

INDIVIDUALIZED SELECTION OF ORAL AND INTRAVENOUS IRON THERAPY IN WOMEN OF REPRODUCTIVE AGE WITH IRON DEFICIENCY ANEMIA

G.M. Ruzimatova

<p>Iron deficiency anemia (IDA) is highly prevalent among women of reproductive age because menstrual blood loss, pregnancy, childbirth, dietary insufficiency, and gastrointestinal disorders may coexist. The objective of this re­view was to synthesize current evidence on the individualized selection of oral and intravenous iron preparations, with emphasis on efficacy, tolerability, speed of hematologic response, and safety. A structured narrative review of peer-reviewed randomized trials, systematic reviews, and in …

11.08.2026journal-article

Russian Journal of Occupational Health and Industrial Ecology

Neurophysiological and neuropsychological features of patients with vibration sickness in combination with sensorineural hearing loss

Oxana I. Shevchenko, Oleg L. Lakhman, Natalya V. Slivnitsyna, Dina V. Rusanova

Introduction. The study of pathophysiological changes in the central nervous system in the dynamics of the progression of vibration disease (VD) caused by exposure to local vibration, combined with occupational sensorineural hearing loss (OSHL), includes research into the causes of these disorders, the mechanisms of their development, and emphasizes the importance of an integrated approach to diagnosing changes in the functional activity of the brain.The study aims to evaluate and compare changes in neurophysiologi …

11.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Concentric hip work is the most robust lower-limb kinetic correlate of depth-jump height in male collegiate volleyball players

Di Lu, Cheng Chen, Yueming Li, Wenfeng Zhang, Jian Sun, Duanying Li

Abstract Background Depth-jump height is commonly used to assess lower-limb explosive performance, but it remains unclear which phase-specific hip, knee, and ankle joint kinetic variables are most consistently associated with performance in volleyball players. Methods In this cross-sectional movement-analysis study, thirty male collegiate volleyball players completed height-oriented depth-jump tests from a standardized 30-cm box. Three-dimensional motion capture and two force platforms were used to quantify jump he …

11.08.2026journal-article

History of Psychiatry: Madness, Science, Culture

Demanding characteristics: Psychiatry, psychology and the social sciences in Martin T. Orne’s therapy of Anne Sexton

James Bradley, Susan Bradley Smith

This article uses Anne Sexton’s therapy by Martin T. Orne as a frame for investigating and contextualising the unusual therapeutic rationale that lay behind her treatment. The rationale had three sources: the results of Orne’s experimental psychological research, particularly the ‘demand characteristics of social psychology experiments’; the functional sociology of Robert Merton and Talcott Parsons; and the influence of Jerome D. Frank’s concept of ‘effective hope’. Unpacking this story builds on the work of a numb …

11.08.2026journal-article

ASCE MAGAZINE

Terapia con Células CAR-T Anti-CD19 en Lupus Eritematoso Sistémico Refractario: Hacia una Evaluación Integral Mediante Biomarcadores de Función Vascular y Renal

Ginger Julexi Sacon Medranda, Ruddy Romina Egas Vizueta, María José Bravo Espinoza, Diego Marcelo Guagchinga Guanoluisa, Diana Lizeth Cárdenas Hernández

El Lupus Eritematoso Sistémico (LES) refractario representa un desafío terapéutico significativo. Las células CAR-T anti-CD19 emergen como una estrategia prometedora para lograr una remisión profunda mediante el "reseteo" inmunológico. Revisar críticamente la evidencia actual sobre la eficacia y seguridad de la terapia CAR-T en LES refractario, con énfasis en biomarcadores objetivos de microcirculación cutánea y reserva funcional renal. Se realizó una revisión narrativa de la literatura publicada hasta 2024, incluy …

11.08.2026journal-article

Cardiovascular Therapy and Prevention

Mentoring in residency: the perspectives of trainees

V. I. Chumakov, E. V. Shishkina, A. I. Artyukhina, R. V. Myakonkiy, V. V. Velikanov

Aim. This article analyzes clinical residents' assessments of the mentoring system. Material and methods. The use of theoretical analysis and evaluation of information obtained through a literature review, a questionnaire survey, focus groups, comparison, data pooling, and generalization made it possible to substantiate the psychological and pedagogical foundations of a mentoring system for residents. The study involved 519 respondents (residents). Results. The presented educational path system, based on the acmeol …

11.08.2026journal-article

Revista Ocupación Humana

De Bangkok a Colombia

Pamela Talero Cabrejo, Aida Navas, Karen Aguia Rojas

Entre el 5 y el 12 de febrero de 2026, Bangkok acogió la Asamblea General y el XIX Congreso Mundial de la Federación Mundial de Terapeutas Ocupacionales. Este editorial propone un análisis reflexivo y crítico, desde la perspectiva de la delegación colombiana ante esta organización, sobre tres tensiones globales que atravesaron las discusiones en ese escenario y que son relevantes en el contexto colombiano y latinoamericano actual: los conflictos sociales, políticos y armados; la agudización de los cambios ambiental …

11.08.2026journal-article

International Journal For Multidisciplinary Research

Occupational Stress of Primary School Teachers in Tinsukia District, Assam

Monikangkana Gohain, Ishmirekha Handique Konwar

The present study investigated the occupational stress of primary school teachers in Tinsukia District, Assam. The study employed descriptive survey method. The sample consists of 120 primary school teachers (60 male and 60 female) by using stratified random sampling technique. The Occupational Stress Index (OSI) by Srivastava and Singh was used for collection of data. The data were analysed using descriptive statistics, including Mean, Median, Standard Deviation along with the t-test to compare the variables. The …

11.08.2026journal-article

DEN Open

Risk of Delayed Post‐polypectomy Bleeding in Patients With Antithrombotic Therapy

Rumiko Tsuboi, Satohiro Matsumoto, Makiko Mieno, Shizukiyo Ishikawa, Yurika Imai, Mina Morino, Keita Matsumoto, Yudai Koito, Hitomi Kashima, Takaya Miura, Yuko Takahashi, Takehiro Ishii, Shuhei Yoshikawa, Haruka Otake, Masanari Sekine, Takeshi Uehara, Takeharu Asano, Hiroyuki Miyatani, Hirosato Mashima

ABSTRACT Objectives Recent changes in the perioperative management of antithrombotic therapy (ATT), including the discontinuation of routine heparin bridging and the increased use of cold snare polypectomy, may reduce delayed post‐polypectomy bleeding (DPPB) rates. However, few recent studies have evaluated these changes. We compared DPPB rates between patients with and without ATT and explored factors associated with bleeding. Methods We conducted a retrospective cohort study of adult patients who underwent endosc …