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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Advanced Science

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye

ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance. PHB2 was consistently upregulated in resistant tumors and associated with poor clinical outcomes. Mechanistically, PHB2 binds the lipid‐metabolic enzyme ACSL3 through a defined AMP‐bi …

21.08.2026journal-article

Clinical Pharmacology & Therapeutics

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Jyun‐Heng Lai, Anton L V Avanceña, Juan P Cata, Jamie C. Barner, Sharon H. Giordano, Chanhyun Park, Hui Zhao, Kirk E. Evoy, John K. Lin, Jennifer C. Spencer, Mariana Chavez‐MacGregor, Kelly K. Hunt, Kerollos Nashat Wanis

Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear. This target trial emulation, analyzing US commercial claims (2013–2023), evaluated these safety outcomes under gabapentin–opioids initiation vs. opioids only during the first postoperative month following breast cancer surgery, with su …

21.08.2026journal-article

International Journal of Health Management Review

GUIDELINES FOR THE TREATMENT AND EPIDEMIOLOGICAL CONTROL OF LEISHMANIASIS

Aíssa Rodrigues Ramos, Caren Andrigheti Grazziotin, Lucas Andre Gauer, Helena Duani, Claudia Aparecida Fernandes Cordeiro, Elisa Fioreze Dal Bó, Debora Denyse Rodrigues Pereira Cruz, Rafael Martins da Silva Figueiredo, Camilla Bastos Motta de Lacerda, Eduardo de Lacerda Aguiar, Alexandra Borja Mancheno, Lívia Ugikawa Fujiwara, Letícia Prado Ribeiro, Sandra Regina Silva de Moura, Emilly Guimarães dos Santos, Allana Moura de Araújo

Leishmaniasis is an endemic parasitic disease with significant global impact; World Health Organization (WHO) estimates indicate that over 12 million people are infected, predominantly in underdeveloped and developing tropical countries. The disease is caused by protozoa of the genus *Leishmania*, transmitted by female phlebotomine sandflies. Clinically, it manifests in three main forms: cutaneous (the most prevalent), mucocutaneous, and visceral (associated with high fatality rates). Conventional therapies face cr …

21.08.2026journal-article

Medicine

The landscape mapping of single-cell sequencing in the research progression and hotspots of liver cancer based on systematical analysis

Wenbiao Chen, Feng Xiong, Haitao Li

Background: Single-cell sequencing technology is a new research method which is greatly applied to the pathogenesis and clinical research of liver cancer. The aim of the study is to map the research levels, research hotspots, and progressive trends in the field of single-cell sequencing on liver cancer. Methods: The articles related to liver cancer and single-cell sequencing were collected from Web of Science Core Collection database, and then bibliometric methods including CiteSpace, VOSviewer, and the R package B …

21.08.2026journal-article

PLOS Global Public Health

Awareness, knowledge, and cervical cancer screening behaviour in an urban informal settlement: Evidence from multinomial and interaction models

Winfred Kananu Kubai, Alfred Owino Odongo, Gilbert Koome Rithaa

Cervical cancer screening uptake in Kenya remains far below global targets, particularly in urban informal settlements where knowledge gaps persist despite widespread awareness campaigns. Understanding how knowledge shapes screening behavior is critical to explaining the persistent gap between willingness and action. The objective was to examine knowledge-related determinants of cervical cancer screening uptake among mothers aged 25–49 years in Kiandutu Informal Settlement, focusing on both main knowledge effects a …

21.08.2026journal-article

Health Education Research

Feasibility and cost of partnering with social media influencers to promote colorectal cancer screening

Heather Orom, Natasha C Allard, Tiffany Nguyen

Abstract There is considerable interest in collaborating with social media influencers to promote health messages, but little evidence demonstrating how this might be done in organizations with few resources or experience. We tested the feasibility and cost of partnering with social media nano- and micro-influencers to promote colorectal cancer (CRC) screening messages. We identified 16 US influencers through an online influencer marketing campaign platform. To test if influencers would create theory-consistent con …

21.08.2026journal-article

Frontiers in Immunology

YBX1 as an adaptive RNA hub in cancer: linking state-dependent RNA regulation to tumor immunity, metabolic reprogramming, and therapy resistance

Zhang XiaoTian, Wang YiTong, Feng Chongchong

Y-box binding protein 1 (YBX1) has been implicated across an unusually broad range of malignancies and processes: immune remodeling, epithelial plasticity, metabolic rewiring, epitranscriptomic reading, and resistance to chemotherapy, targeted agents, and checkpoint blockade. A linear one-gene/one-pathway oncogene model does not readily accommodate this breadth. We argue that the apparent diffuseness reflects a context-dependent regulatory node rather than experimental noise, and develop the hypothesis that YBX1 ac …

21.08.2026journal-article

Frontiers in Pharmacology

Hyaluronidase treatment is associated with increased cytokine levels and reduced peritoneal neutrophil accumulation during LPS-induced inflammation

Karla de Castro Figueiredo Bordon, Karina Furlani Zoccal, Sayuri Noemi Otuka, Mouzarllem Barros Reis, Cryslane Almeida de Lima, Ualter Guilherme Cipriano, Vania Luiza Deperon Bonato, Eliane Candiani Arantes

Background Hyaluronidases are classically described as spreading factors that facilitate venom dissemination through extracellular matrix degradation, but their immunomodulatory roles remain poorly defined. In particular, comparative data between native scorpion venom hyaluronidase and commercial bovine hyaluronidase remain limited. This study investigated whether hyaluronidase treatment was associated with condition-dependent changes in inflammatory parameters. Methods BALB/c mice were subjected to lipopolysacchar …

21.08.2026journal-article

Pediatric Research

Mutations of the DICER1 gene among children and adolescents with thyroid cancer: a systematic review

Aikaterini Dimaki, Eleni P. Kotanidou, Vasiliki Rengina Tsinopoulou, Ilias Konstantinos Dimakis, Athanasios Tragiannidis, Emmanouil Hatzipantelis, Assimina Galli-Tsinopoulou

Abstract Backgound The DICER1 gene located on chromosome 14q, essential for the maturation of miRNAs, is commonly associated with multinodular goiter and thyroid carcinomas. We aimed to systematically search the literature and identify mutations in the DICER1 gene associated with thyroid cancer in children and adolescents. Methods The study was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement through four databases (Pubmed, Web of Science/Scopus/Google …

21.08.2026journal-article

EMBO Molecular Medicine

Metastasis of triple negative breast cancer is regulated by a targetable miR-342-E2F network

Victoria K Arnet, Cameron N Johnstone, Richard P Redvers, Caroline A Chambers, Katherine A Pillman, John Toubia, Rachael Lumb, B Kate Dredge, Andrew G Bert, Emily Hackett-Jones, Pannapa Pinweha, Julie M Bracken, Shruti Deshpande, Zoe K Price, Michael Ortiz, Kaitlin G Scheer, Jasleen Rajpal, Ashleigh B Geiger, Suraya Roslan, Xiaochun Li, Sandra O’Toole, Traude H Beilharz, Cameron P Bracken, Yeesim Khew-Goodall, Gregory J Goodall, Robin L Anderson, Philip A Gregory

Abstract Triple-negative breast cancer (TNBC) has a high incidence of metastasis and limited therapeutic options. Here, we identify a multimodal and targetable miR-342-E2F network that regulates metastatic outgrowth in TNBC. Through integrating clinical and experimental datasets, we uncover miR-342 as a suppressor of TNBC metastasis. Temporal re-expression of miR-342 significantly inhibited metastatic progression in both immunocompetent and xenograft TNBC models by specifically limiting the outgrowth of disseminate …

21.08.2026journal-article

Neuro-Oncology Advances

Combination of EZH2 and MEK inhibitors as an Effective Therapy for Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors

Sogo Oki, Yukitomo Ishi, Shigeru Yamaguchi, Manabu Natsumeda, Christine A Pratilas, Michiyuki Hakozaki, Hideki Tanizawa, Zen-ichi Tanei, Miki Fujimura

Abstract Background Neurofibromatosis type 1 (NF1)–associated malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with poor outcomes and limited therapeutic options. Although mitogen-activated protein kinase kinase (MEK) inhibitors are active in benign plexiform neurofibromas, their efficacy in MPNST treatment is modest. Enhancer of zeste homolog 2 (EZH2) inhibitors are preclinically efficacious in MPNST treatment, but their mechanisms of action remain unclear. We evaluated the therapeutic pot …

21.08.2026journal-article

NeuroSci

Parkinson’s Disease: Pathophysiology, Treatment Strategies, Wellness Approaches, and Obstacles/Paths Forward

Frank C. Church, Jill C. Rau, Stefania Brotini

Parkinson’s disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons. Its symptoms affect both motor functions—such as bradykinesia, rigidity, resting tremor, and postural instability—and non-motor functions, including neuropsychiatric issues, sleep disorders, and constipation. Drawing on the literature, the following topics were developed and presented: Pathophysiology; Treatment; Neuropsychiatric and Cognitive Function; Sleep Challenges; Exercise and Movement; Striving for Wellness; …

21.08.2026journal-article

European Journal of Prosthodontics and Restorative Dentistry

Texture-Aware 3D Deep Learning in Segmenting Skull-Conjoined Brain Tumor

Pooja P P, Dr Aruna S K

Magnetic resonance imaging (MRI) cannot provide sufficient contrast, heterogeneity of the tumor texture, and vague tumor-bone interfaces that makes it difficult and challenging to carefully segment brain tumours that are located close to the cranial skull boundary of the brain. Traditional convolutional neural network (CNN) architecture tends to lose delicate structural aspects in these areas. The paper introduces a texture-sensitive hybrid deep learning architecture to skin skull-conjoined brain tumors segmentatio …

21.08.2026journal-article

Cancer Plus

The role of NRG1 and its receptor HER3 in gastrointestinal tumors

Yue Zhao, Yuting Yong, Yuanshuai Li, Wenling Zhan, Yuyang Song, Chong Li, Wenting Pan, Xinlong Yan

Neuregulin 1 (NRG1), as a key ligand of the epidermal growth factor receptor family, plays a crucial role in the initiation, progression, and metastasis of various solid tumors by binding to human epidermal growth factor receptor 3 (HER3) and activating downstream signaling pathways. In recent years, NRG1 gene fusions have been identified as rare oncogenic drivers in gastrointestinal tumors, with their abnormal expression in gastric and colorectal cancers closely associated with poor patient prognosis. This paper s …

21.08.2026journal-article

World Journal of Gastroenterology

Pancreatic cancer: Recent epidemiological trends and risk determinants

Amit Hudgi, Alexander Woodcock, Ali Mirza, Porsha Okiye, Brendan Kemple, Humberto Sifuentes, Subbaramia Sridhar

Pancreatic cancer is one of the common malignancies worldwide, characterized by late-stage diagnosis, aggressive progression, and persistently high mortality. Despite being the 12th most diagnosed cancer globally, it ranks as the sixth leading cause of cancer-related death, reflecting its poor prognosis and limited survival gains. Here we form a narrative review synthesizing current global epidemiological data on pancreatic cancer, drawing primarily from GLOBOCAN, Surveillance, Epidemiology, and End Results, and ot …

21.08.2026journal-article

Journal of Critical Care Research and Emergency Medicine

The Importance of a Multidisciplinary Approach and Treatment of Recurrent Supraventricular Tachycardia in the Geriatric Population – A Case Report

Jakov Jurić MD

Supraventricular tachycardia (SVT) is a cardiac rhythm disorder characterized by sudden episodes of rapid heart rate and may cause palpitations, chest discomfort, and dyspnea. This case report describes a 75-year-old patient with recurrent SVT, baseline respiratory difficulties, previous right upper lobectomy, and current left-lung adenocarcinoma. During an episode of palpitations and worsening dyspnea, non-pharmacological maneuvers were unsuccessful, while intravenous administration of 6 mg adenosine resulted in r …

21.08.2026journal-article

ARACÊ

MANEJO CLÍNICO E TRATAMENTO DA HIPERPLASIA GENGIVAL LEUCÊMICA

Maria Karla Indrina Morais, Giacomo Gobbo Trojan, Raquel Gonçalves Dos Santos, Geórgia Brandão Olyntho

Contexto: A leucemia é um distúrbio hematológico que pode se apresentar, preliminarmente, na cavidade oral por intermédio da hiperplasia gengival, sendo propensa a ter diagnósticos equivocados quando mal avaliada pelo profissional de saúde. Objetivo: Evidenciar a relevância do papel do cirurgião-dentista, por meio de uma discussão, em diagnosticar, de forma precoce e adequada, as doenças sistêmicas desde o surgimento das primeiras manifestações clínicas, bem como realizar as devidas abordagens necessárias para cada …

21.08.2026journal-article

RSV

Syphilis and Other Sexually Transmitted Infections: Challenges for Prevention, Timely Diagnosis, and Treatment

Divina Maria de Jesus, Fabiana Ferreira de Castro, Domilene Borges Costa, Dênis Carvalho Soares Cavalcante, Thaita Thaisi Zago, Priscila Rodrigues Oliveira, Sérgio Raimundo Ernesto Machado, Siglia Sousa de França

Sexually transmitted infections (STIs) remain a major public health challenge despite significant advances in prevention, diagnosis, and treatment strategies. Among these infections, syphilis has regained global importance due to persistent transmission, increasing incidence rates, and the continued occurrence of congenital cases associated with inadequate prenatal detection and treatment. Although syphilis is preventable and curable, failures in prevention, delayed diagnosis, limited access to healthcare services, …

21.08.2026journal-article

Innovation in Aging

Reducing oral frailty improves functional independence in older Brazilians: A causal inference study of disability-free survival using longitudinal modified treatment policies

John Rong Hao Tay, Huihua Li, Karen G Peres, Rahul Malhotra, Anna Quialheiro, Eleonora D'Orsi, Marco A Peres

Abstract Background and Objectives Poor oral health is associated with functional decline and mortality in older adults, yet causal evidence linking oral health improvement with functional independence remains limited. We simulated the effects of hypothetical reductions in oral frailty on the cumulative probability of being alive and independent in basic activities of daily living (ADLs) among older adults in Brazil. Research Design and Methods Data from the EpiFloripa Aging Cohort Study of community-dwelling adult …

21.08.2026journal-article

Big Data and Cognitive Computing

Predicting Recurring Treatment Events Within Multiple Future Time Windows

Michal Weisman Raymond, Yuval Shahar

Medical treatment decision making is a complex process that involves integrating multivariate time-oriented data from multiple sources and is often influenced by factors such as patient load. In this study, we propose the Recurring Target Prediction (RTP) Pipeline to support treatment decision making by predicting the next medical action most likely to be administered, based on the historical data from patients in similar contexts. The method transforms raw time-stamped data into symbolic time intervals, incorporat …

21.08.2026journal-article

Cancer Discovery

A Spatial Atlas of Muscle-Invasive Bladder Cancer Reveals Lineage-Specific Vulnerabilities and Immune Architecture

Kai Yu, Jianfeng Chen, Yu-Yi Chu, Sajith Nair, Emanuele Crupi, Elshad Hasanov, Ying Mei, Xueshuai Han, Yang Liu, Yunhe Liu, Guangsheng Pei, Fuduan Peng, Jianlong Liao, Enyu Dai, Tian Chu, Kyung Serk Cho, Jiahui Jiang, Xinmiao Yan, Yibo Dai, Jun Wang, Baifeng Zhang, Giannicola Genovese, Nagireddy Putluri, Livia Eberlin, Liuqing Yang, Chunru Lin, Lawrence N. Kwong, Diana Shamsutdinova, Khalida M. Wani, Bogdan A. Czerniak, Wendong Yu, Jianping Zhao, Charles C. Guo, Donna Hansel, Curtis Pettaway, Louis Pisters, Kelly Bree, Neema Navai, Byron H. Lee, Ashish M. Kamat

Abstract Muscle-invasive bladder cancer (MIBC) is clinically heterogeneous, and current molecular subtyping does not capture the spatial organization of tumor states and microenvironmental context. In this study, we construct a spatial atlas of MIBC by integrating spatial transcriptomics from 22 tumors with matched bulk RNA and whole-exome sequencing data. We identify a continuous, spatially organized luminal-to-basal axis within individual tumors that is associated with greater chromosomal instability and transcri …

1 Zitationen
21.08.2026journal-article

British Journal of Radiology

Comparison of response criteria in palliative radiotherapy for bleeding gastric cancer: A secondary analysis of the JROSG 17-3 multicenter prospective observational study

Yutaro Koide, Tetsuo Saito, Takashi Kosugi, Naoki Nakamura, Takeo Takahashi, Terufumi Kawamoto, Nobuko Utsumi, Shuhei Sekii, Hitoshi Wada, Ayako Tonari, Hirofumi Ogawa, Norio Mitsuhashi, Kazunari Yamada, Kei Ito, Norio Araki, Miwako Nozaki, Joichi Heianna, Kenta Murotani, Yasuhiro Hirano, Atai Satoh, Tsuyoshi Onoe, Naoto Shikama

Abstract Purpose In radiotherapy for bleeding gastric cancer, no standard response definition exists; studies have used transfusion-only or transfusion-plus-hemoglobin criteria. After inter-facility transfer or during home care—sometimes following palliative radiotherapy—laboratory results from other facilities are often unavailable, leaving patients inevaluable. We therefore tested whether omitting hemoglobin compromises the precision of response assessment. Methods and Materials In criteria A, referring to our or …

21.08.2026journal-article

Advanced Science

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao

ABSTRACT Poly(A)‐binding proteins (PABPs) are frequently dysregulated in cancers, yet their functional roles remain largely elusive. Here, we identify that PABPC4, a member of PABPs, is upregulated during colorectal cancer (CRC) progression and associated with poor prognosis. Single‐cell transcriptomics reveals that PABPC4 is predominantly expressed in the macrophages of the tumor microenvironment (TME). Conditional knockout of Pabpc4 in macrophages (C4cKO) profoundly inhibited the progression of multiple cancers, …