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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
10.08.2026journal-article

Pharmaceutical Statistics

Quantitative Dose Optimization for Gene Therapy Trials: Implications for Project Optimus and Early‐Phase Design

Kevin Roberts, Jeffrey Palmer, Jessica Volpe, Wei Zhong, Avery McIntosh

ABSTRACT Quantitative dose optimization in early phase clinical trials for investigational new drugs has been expanding across drug modalities and disease indications in response to the limitations of non‐quantitative or algorithmic methods of dose progression. In the context of the FDA's Project Optimus Initiative, which emphasizes dose optimization rather than reliance on the maximum tolerated dose, these challenges motivate the development of alternative quantitative frameworks tailored to gene therapies. In thi …

10.08.2026journal-article

Healthcare

Preliminary Validity and Reliability Evidence for a Derived 12-Item Greek Short-Form Model of the Quality Indicators for Physiotherapy Management of Hip and Knee Osteoarthritis (QUIPA)

Christina Gkaripi, Maria Moutzouri, Eirini Grammatopoulou, Petros Tatsios, Stefanos Karanasios, Georgios Krekoukias

Background/Objectives: Osteoarthritis of the hip and/or knee is a major contributor to pain, disability, and reduced quality of life. The aim of this study was to provide preliminary validity and reliability evidence for a Greek adaptation of the Quality Indicators for Physiotherapy Management of Hip and Knee Osteoarthritis (QUIPA) questionnaire. Methods: This cross-sectional methodological study involved cross-cultural adaptation and psychometric evaluation of the Greek QUIPA in 90 adults aged 45–65 years with hip …

10.08.2026journal-article

PLOS One

From cultural awareness to safety in Canadian speech‑language pathology practice: A scoping review protocol

Mariam Komeili, Jessi Robinson, Hannah Akrigg

Despite growing attention to cultural safety and cultural responsiveness in health professions, no scoping review has focused exclusively on Canadian Speech‑Language Pathology (S-LP) practice across Indigenous peoples and other equity‑deserving groups. Existing reviews often combine S-LP with other rehabilitation professions, focus on either pediatric or adult populations but not both, or limit analysis to a single service‑delivery context. This scoping review protocol outlines an approach to mapping Canadian liter …

10.08.2026journal-article

Frontiers in Pain Research

Effects of cold therapy on ecchymosis and pain after subcutaneous heparin injection: a meta-analysis and systematic review

Xiao Min Cao, Xi Xi Feng, Yin Qi Tan, Dan Dan Chen, Xue Sen Zhang

Objective This systematic review and meta-analysis aimed to compare the efficacy of three local physical cooling techniques (ice pack compression, vapor cooling spray, and pre-cooled needles) on pain and ecchymosis after subcutaneous anticoagulant injection, re-examine prior controversies with the latest evidence, and provide evidence-based references for clinical nursing. Methods Five electronic databases (PubMed, Embase, Cochrane Library, Web of Science, CINAHL) were systematically searched for randomized control …

10.08.2026journal-article

Frontiers in Public Health

Factors associated with nurses’ adherence to standard precautions: implications for healthcare-associated infection prevention and occupational safety in Taiwan

Aih-Fung Chiu, Chun-Fung Chiu, Chun-Man Hsieh

Background Healthcare-associated infections (HAIs) remain a major threat to patient safety and healthcare workforce protection, particularly after the COVID-19 pandemic. Standard precautions (SPs) are the most fundamental infection prevention measures used to reduce pathogen transmission and occupational exposure in clinical settings. Although awareness of SPs has increased, adherence among nurses continues to vary across practice domains. Factors such as familiarity with SP-related knowledge, years of nursing expe …

10.08.2026journal-article

British Journal of Clinical Pharmacology

Systemic menopausal hormone therapy treatment patterns in Danish women—A nationwide drug utilization study

Hannah K. Wood‐Kurland, Kathrine Kold Sørensen, Amalie Lykkemark Møller, Lina Steinrud Mørch, Mikkel Porsborg Andersen, Thomas Alexander Gerds, Amani Meaidi, Christian Torp‐Pedersen

Abstract Objectives This paper aims to describe the treatment patterns of contemporary systemic menopausal hormone therapy (MHT) in Denmark. Study design This study is a nationwide drug utilization study including an open cohort of all Danish women aged >40 years between 2000–2024. Main outcome measures This study analysed the use of systemic MHT, identified by prescription redemption and categorized by route of administration. Results During the study period, n = 2 350 335 women reached the age of >40 years and n …

10.08.2026journal-article

Problems of Balneology, Physiotherapy and Exercise Therapy

Механизмы государственно-частного партнерства в модернизации санаторно-курортной инфраструктуры Кавказских Минеральных Вод

Н. А. Завалько, К. В. Харченко, С. А. Зуденкова, О. А. Сагина, А. Ж. Зубец

Introduction: The spa and resort complex of the Caucasian Mineral Waters (CMW) provides up to 20% of the total volume of sanatorium services In Russia; however, the depreciation of medical equipment in the North Caucasus Federal District reaches 51.1%, with critical asset wear at certain health resorts exceeding 70%. Amid growing consumer demand (from 3.9 to 7.3 million guests during 2020–2024) and the adoption of the CMW agglomeration master plan with an investment volume of 700 billion rubles, the development of …

10.08.2026journal-article

Problems of Balneology, Physiotherapy and Exercise Therapy

Экономическая оценка конкурентоспособности санаториев Калининградской области на рынке трансграничного медицинского туризма Балтийского региона

И. А. Квасов, Н. К. Попадюк, И. А. Пекова, Ж. А. Франкевич, Е. Е. Кабанова

Introduction: The Kaliningrad region, as an exclave territory of the Russian Federation on the Baltic Sea coast, possesses significant sanatorium and resort potential; however, its positioning in the cross-border medical tourism market remains insufficiently studied from an economic competitiveness perspective. The region's exclave status and proximity to Poland and Lithuania, which constitute the competitive field of Baltic spa services, necessitate a quantitative assessment of price, infrastructure, and instituti …

10.08.2026journal-article

Indian Journal of Physiology and Pharmacology

Utility of novel biomarkers of ‘cancer therapy-related cardiac dysfunction’ among breast cancer patients

V. Devanatha Desikan, Bobby Zachariah, Biswajit Dubashi, Santhosh Satheesh

Objectives: Cancer therapy-related cardiac dysfunction (CTRCD), defined based on changes in left ventricular ejection fraction (LVEF) and cardiac biomarker levels, is a significant complication of chemotherapy, often subclinical in early stages. While conventional markers (high sensitivity cardio troponin I [hscTnI], N-terminal pro-brain natriuretic peptide) are routinely used, the role of novel biomarkers (glycogen phosphorylase BB [GPBB]), myeloperoxidase (MPO), chemokine ligand-23 (CCL23) and macrophage migratio …

10.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Two Decades of Declining International Medical Graduate Representation in Physical Medicine and Rehabilitation Residency Programs

Antonio Madrazo-Ibarra, Daniel de la Huerta-Meza, José M. Gutiérrez Naranjo

Objective: To evaluate trends of international medical graduates (IMGs) matching into U.S. physical medicine and rehabilitation (PM&R) residency programs. Design: This retrospective cohort study analyzed National Resident Matching Program data from 2005 to 2025. The primary outcome was the annual proportion of PM&R positions filled by IMGs. Secondary outcomes included temporal trends in match rates among IMGs, U.S. medical doctors (U.S. MDs), and doctors of osteopathic medicine (DOs), identifying trend breakpoints, …

10.08.2026journal-article

International Journal of Social Rehabilitation

Content Analysis of #Tobacco Cessation on Facebook, Instagram, and YouTube Social Media Platforms

Srilakshmi H, Arunkumar S, Canty Sandra S, Nanda Balan Iyenkani, Zoha Abdullah, Rajkumar C

<p>Social media platforms have emerged as influential tools for disseminating health-related information and behaviour change interventions. Tobacco cessation campaigns increasingly use digital media platforms to reach wider audiences, raise awareness, and encourage quitting. However, the effectiveness of different social media platforms in promoting tobacco cessation varies depending on their content style, engagement mechanisms, and audience interaction.</p> <p><bold> Aim</bold></p> <p>The present study aimed to …

10.08.2026journal-article

Journal of Clinical Oncology

Phase I/II Study of Sonrotoclax (BGB-11417) Monotherapy in Patients With Mantle Cell Lymphoma Previously Treated With Anti-CD20 Therapy and a Bruton Tyrosine Kinase Inhibitor

Toby A. Eyre, Yuqin Song, Olivier Hermine, Yuerong Shuang, Wojciech Jurczak, João Samuel Farias, Carolina Mahuad, Muhit Özcan, Ron D. Jachimowicz, Tianlei Chen, Elena Ivanova, Xiaotong Li, Gabriel Man, Priscille Bourquelot, Remus Vezan, Michael Wang

PURPOSE Mantle cell lymphoma (MCL) is a rare and typically aggressive B-cell non-Hodgkin lymphoma characterized by recurrent relapse after short remissions. Sonrotoclax (BGB-11417) is a next-generation B-cell lymphoma 2 inhibitor with greater selectivity and potency than venetoclax, a shorter half-life, and no drug accumulation. Sonrotoclax monotherapy was evaluated in Bruton tyrosine kinase inhibitor–pretreated patients with relapsed/refractory (R/R) MCL. METHODS BGB-11417-201 (ClinicalTrials.gov identifier: NCT05 …

10.08.2026journal-article

Journal of Maine Medical Center

Enhanced Rehabilitation Program in Acute Care: New Program Development and Results in Response to Delayed Hospital Discharges

David L Smith, Morgan Hall, Mary E McNulty, Elizabeth Pontius, Cathy Peabody, Beth Burke, Julie Fox

Problem: The objective of this project was to evaluate and describe the flow of patients who have delayed discharge after they have participated in an enhanced therapy program. Approach: In the current practice, which started in 2021, the care coordination team identifies patients medically ready for discharge but with barriers. Working with the rehabilitation team, the care coordination team determines if the patient is suitable for the enhanced therapy program. These patients go on to receive 1 hour of physical t …

10.08.2026journal-article

Orthopedic Reviews

Extracorporeal Shockwave Therapy in Pain Management – an In-Depth Narrative Review

Wisdom Ufondu, Oludotun Ogunsola, Ava Williams, Kayla Valenti, Gabriella Herbert, Ezinne Ezenekwe, Justin Bufano, Toyyib Suleiman, Fredrick Esiso, David Jevotovsky, Jamal Hasoon, Vwaire Orhurhu

Purpose of Review The purpose of this narrative review is to explain the cellular mechanisms behind chronic pain, the mechanisms behind extracorporeal shockwave therapy, and its efficacy for the treatment of various chronic pain conditions including tendinopathies, greater trochanteric pain, de quervain tenosynovitis, myofascial pain, plantar fasciitis, fibromyalgia, osteoarthritis, fractures, osteonecrosis, bone edema, coccydynia, low back pain, chronic pelvic pain syndrome/chronic prostatitis, ulcers, and carpal …

10.08.2026journal-article

Journal of Occupational and Organizational Psychology

Self‐monitoring and job performance: Substance or style? A meta‐analysis

Klaus Moser, Katharina Ebner, Dragoș Iliescu, Alexandru‐Andrei Sîrbu

Abstract Self‐monitoring aims at adjusting one's behaviour in social interactions. While scholars have been convinced that self‐monitoring predicts job performance, the strength and nature of the relationship between self‐monitoring and job performance remain unclear. Specifically, it may not be explained by a competency perspective but rather a biased‐perceiver perspective, where self‐monitors may primarily succeed in influencing raters' perceptions of their performance. Therefore, a meta‐analysis was conducted, i …

10.08.2026journal-article

Jurnal SOLMA

Pendampingan Literasi Keuangan Syariah Melalui Metode Finansial Behavior Therapy Bagi Penyandang Disabilitas Tunanetra di Ponorogo

Nugraheni Fitroh R. Syakarna, Fatkhur Rohman Albanjari, Septin Maisharah Karyono

Background: Penyandang disabilitas merupakan kelompok masyarakat yang memiliki keterbatasan dalam mengakses informasi dan layanan publik, termasuk layanan pendidikan dan ekonomi. Program pengabdian masyarakat ini bertujuan untuk meningkatkan literasi keuangan syariah bagi penyandang disabilitas tunanetra di Ponorogo melalui pendekatan Financial Behavior Therapy (FBT). Metode: Kegiatan dilaksanakan sebanyak delapan kali pertemuan meliputi tahap pre-test, pelatihan, pendampingan, hingga post-test. Materi disampaikan …

10.08.2026journal-article

Journal of Clinical Nursing

Factors Associated With Non‐First‐Attempt Success in Peripheral Intravenous Cannulation by an Intravenous Therapy Team: A Prospective Observational Study

Mei‐Jung Wu, Ming‐Chin Lin, Chi‐Ming Yang, Yi‐Chun Lin, Made Satya Nugraha Gautama, Tsai‐Wei Huang

ABSTRACT Background Difficult peripheral intravenous cannulation affects a substantial proportion of hospitalized patients, yet factors associated with cannulation failure among cases assisted by a dedicated intravenous therapy team on general wards remain poorly characterized. Aim To identify patient‐related, operator‐related, and procedural factors independently associated with non‐first‐attempt success in peripheral intravenous cannulation performed by an intravenous therapy team on general medical and surgical …

10.08.2026journal-article

Child: Care, Health and Development

Optimizing Teacher–Occupational Therapist Collaboration: A Multimethod Knowledge Translation Initiative

Lina Ianni, Chantal Camden, Wenonah Campbell, Heather Colquhoun, Dana Anaby

ABSTRACT Introduction Supporting students with special needs in inclusive schools requires collaboration between teachers and occupational therapists (OTs). While service models promoting health, in‐class support and shared knowledge are recommended, relational and organizational barriers persist. This multimethod study evaluates the impact of a tailored knowledge translation (KT) intervention on collaborative attitudes and behaviours of OT–teacher teams. Methods A 12‐week KT intervention, including six sessions wi …

10.08.2026journal-article

JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY

Hematopoietic progenitor cell mobilization, collection, transportation, and infusion of fresh products

Karen Lima Prata, Andrea Tiemi Kondo, Karine Sampaio Nunes Barroso, Aline Miranda de Souza, Andreza Alice Feitosa Ribeiro

Introduction: The quality of the graft is a critical determinant of transplant success. Methods: Literature review and expert discussion. Results: In this review, we highlight the essential aspects of hematopoietic progenitor cell mobilization and collection, including apheresis and bone marrow harvest. We also discuss optimal cell dose and concentration, as well as key considerations for product labeling, transportation, and infusion of fresh cell therapy products. Conclusion: This document contains recommendation …

10.08.2026journal-article

Biomedical Optics Express

Photoacoustic imaging to optimize tumor delivery of human hemoglobin-derived oxygen carriers and subsequent photodynamic therapy

Yong Li, Pengwei Han, Jiayue Wang, Zhanxiu Cai, Jiaxin Liu, Feng Gao, Jiao Li

Photodynamic therapy shows promise as a minimally invasive, tumor-selective treatment, but it requires the presence of oxygen, often scarce within tumors. Such therapy can be potentiated by delivering hemoglobin-based oxygen carriers into tumors, but the appropriate carrier concentration and interval between their delivery and photodynamic therapy must be selected for a given treatment setting. Here we exploited the ability of photoacoustic imaging to non-invasively measure intratumoral oxygenation in order to opti …

10.08.2026journal-article

Frontiers in Immunology

Serum IL-6 and functional outcome after endovascular therapy: the mediating role of infarct volume growth in acute ischemic stroke

Shuo Li, Shiyao Zhang, Lifan Ji, Yanfang Qu, Zhihui Huang, Jie Gao, Yiting Zhang, Zhenzhen Li, Huiling Sun, Lin Zhu, Teng Jiang, Yadong Yu, Qiwen Deng

Background and purpose Inflammatory factors are pivotal in systemic and central nervous system inflammation post-stroke. This study examined if peripheral inflammatory factors were associated with outcomes after endovascular therapy for acute large vessel occlusion stroke by mediating infarct growth. Methods We conducted a retrospective analysis of the EVTRNA (Circulating Non-coding RNA in Acute Ischemic Stroke with Endovascular Treatment) trial. Patients who underwent pre-endovascular therapy multimodal MRI, posto …

10.08.2026journal-article

Artefactum - revista de estudos interdisciplinares

REDUCED WORK HOURS AND SUSTAINABLE DEVELOPMENT: INTERNATIONAL EVIDENCE ON PRODUCTIVITY, OCCUPATIONAL HEALTH, AND QUALITY OF LIFE

Charlisson Mendes Gonçalves

The reduction of working hours has been proposed as a policy capable of combining productivity gains, improvements in occupational health, and the promotion of more sustainable development. This article conducts a integrative literature review of the international literature with the aim of analyzing the scientific evidence on the impacts of working time reduction on these three axes. Based on a corpus of 30 references – including peer-reviewed articles, systematic reviews, reports from international organizations, …

10.08.2026journal-article

African Journal of Empirical Research

Hemiplegic stroke in rural western Kenya: Clinical profile, risk factors, rehabilitation strategies and functional outcomes between 2025 and 2026

Pascal Okoth Nyambok, Purity Akoth Juma, Catherine Mwikali Muia, Nahor Kipruto, Whitney Omwenga, Trevor Isigi Aluta, Theophylus Kiprotich Kirui, Barasa Augustine Wekesa, Maleya Ryan Odari, Maliso Mohammad

Stroke is a leading cause of disability globally, with a disproportionate burden in low- and middle-income countries. Hemiplegia is among the most disabling consequences of stroke, yet there is limited evidence from rural Kenya regarding functional outcomes and rehabilitation needs. To examine the clinical profile, risk factors, rehabilitation strategies, and functional outcomes among stroke survivors in rural Western Kenya. Objective: To describe rehabilitation interventions and functional outcomes among stroke su …

10.08.2026journal-article

Journal of Rehabilitation Medicine

Prehabilitation for patients undergoing metabolic/bariatric surgery: a retrospective cohort study using propensity score matching

Yiling Yan, Shengdi Lu, Heming Wang, Jiayuan Peng, Lihua Huang, Yun Shen, Feng Liu

Importance: Multimodal prehabilitation improves outcomes in colorectal surgery, but its effectiveness and cost-effectiveness before metabolic and bariatric surgery are unknown. Objective: To evaluate the effectiveness and cost-effectiveness of a 6-week multimodal prehabilitation programme compared with standard preintervention education in patients undergoing bariatric surgery. Design, setting, and participants: Propensity score matched cohort observational study at Shanghai Tenth People’s Hospital, China, January …