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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Journal of Advanced Nursing

Balancing Standardisation and Individualisation in Psychosocial Interventions for Perinatal Bereavement: Bereaved Parents' Perspectives From a Qualitative Study

Jiaying Xie, Annmarie Grealish, Linda Biesty, Andrew Hunter

ABSTRACT Aim To explore bereaved parents' experiences of receiving psychosocial interventions (PSIs) in hospital‐based perinatal bereavement care in Ireland. Design Descriptive qualitative study. Methods Fifteen bereaved parents (13 mothers and 2 partners) whose loss occurred within the past three years were recruited via a national parent‐led charity. Semi‐structured online interviews were conducted between November 2024 and March 2025. Data were analysed using reflexive thematic analysis. Results Six themes captu …

28.08.2026journal-article

Clinical Medicine and Pharmacology

A CLINICAL CASE OF ANKYLOSING SPONDYLITIS IN A PATIENT WITH DYSPLASTIC SCOLIOSIS

A. Hochenkova, Elena Belyaeva

Damage to the musculoskeletal system is one of the most common manifestations of rheumatic diseases. However, the reason for its involvement in the pathological process may be other diseases or their combinations. Ankylosing spondylitis (AS) is one of the most difficult to diagnose causes of specific pain in the lower back. The causes of difficulties in diagnosing the disease are untimely treatment of patients for medical help, a low-symptomatic course of AS, insufficient knowledge of the diagnostic criteria of the …

28.08.2026journal-article

Frontiers in Medicine

Case Report: Ultrasound-guided hydrodissection targeting the subsynovial connective tissue with dynamic ultrasound assessment in refractory carpal tunnel syndrome: a report of two cases

Daeook Lee, Taeseok Ahn, Myungjin Oh, Jongha Lee, Hyeonjun Woo, Hyunbum Kwon, Changyoung Park, Cheol-Hyun Kim, Jung-Yun Ahn, Jihyun Moon, Dong-Woo Lim

Carpal tunnel syndrome is established to be caused by compression of the median nerve. However, recent studies have highlighted fibrosis of the subsynovial connective tissue and consequent restriction of median nerve sliding as a key pathophysiological mechanism. In this case report, we present the results of dynamic ultrasound assessment conducted on two patients with persistent symptoms, with a mixture of polydeoxyribonucleotide (PDRN) 7 mg and 5% dextrose in water (5DW) applied to perform a more extensive ultras …

28.08.2026journal-article

Frontiers in Radiology

Systematic review of PET imaging features and clinical applications in pulmonary NUT carcinoma

Xue Liu, Li Bin, Yu Zhang, Huiting Liu, Cailiang Gao

Purpose Primary pulmonary nuclear protein in testis (NUT) carcinoma is a rare, aggressive malignancy driven by NUTM1 rearrangement. Although 18 F-FDG PET/CT is used in clinical management, its imaging features and value have not been systematically evaluated. Methods This PRISMA 2020 systematic review was registered with PROSPERO (CRD420261292692). PubMed, Embase, Web of Science, Cochrane Library, and grey literature were searched from inception to March 2026. Studies reporting 18 F-FDG PET/CT findings in pathologi …

28.08.2026journal-article

Microbiology Spectrum

Clinical application of BALF-mNGS in immunocompromised and immunocompetent patients with suspected invasive pulmonary aspergillosis: differentiating infection from colonization, microbiome features, and clinical impact

Junjie Zhao, Xinxin Chen, Xinyi Wang, Yidan Cui, Jiancheng Zhuge, Honglong Fang, Zhidan Hua

ABSTRACT Invasive pulmonary aspergillosis (IPA) not only causes high morbidity and mortality, especially in immunocompromised patients, but also occurs in immunocompetent individuals. Differentiating infection from colonization is challenging, and bronchoalveolar lavage fluid metagenomic next-generation sequencing (BALF-mNGS) may aid diagnosis, microbiome profiling, and clinical assessment. We retrospectively analyzed patients with suspected IPA who underwent BALF-mNGS between December 2021 and March 2025. Patients …

28.08.2026journal-article

Journal of Clinical Medicine

Etelcalcetide Versus Cinacalcet for Secondary Hyperparathyroidism in Hemodialysis Patients: A Multicentre Comparison with 24 Months of Follow-Up

Hakkı Öztürk, Çiğdem Ikhlef, Berrak Itır Aylı, Veysel Baran Tomar, Bartu Ediz, Ebru Gök Oğuz, Elif Arı Bakır, Galip Güz, Mehmet Deniz Aylı

Background/Objectives: Secondary hyperparathyroidism (SHPT) is a prevalent complication of end-stage kidney disease. Although etelcalcetide has demonstrated short-term superiority over cinacalcet in randomized trials, real-world comparative data beyond 12 months remain scarce. This study compared the long-term effectiveness of etelcalcetide versus cinacalcet in hemodialysis patients over 24 months using propensity score matching. Methods: This multicenter retrospective study screened 457 hemodialysis patients acros …

28.08.2026journal-article

Journal of Clinical Psychology in Medical Settings

Treating Multiple Chemical Sensitivity as a Specific Phobia Using Cognitive Behavioural Therapy: A Case Study in an Older Adult

Matthew Wilcock, Alice Loyal, David Hitt

Abstract Multiple Chemical Sensitivity (MCS) is a poorly understood condition characterised by physical symptoms triggered by minimal exposure to odorous or chemical agents, often without identifiable organic pathology. This case study describes cognitive behavioural therapy (CBT) for MCS in an older adult referred to a respiratory team after developing persistent, generalised reactions to odours following an acute toxic inhalation. Symptoms led to severe avoidance, functional impairment and suicidal ideation. Foll …

28.08.2026journal-article

Belitung Nursing Journal

Clinical and nursing correlates of severity among chronically ill adults with aspiration pneumonia in Saudi Arabia: A retrospective cross-sectional study

Eman M. Gaber Hassan, Myra Cusi Britiller, Mohammad Daud Ali, May Mohammed Alshowikat, Fatimah Hassan Ahmed Alduhaim, Sarah Mohammad AlOtaibi, Asmahan Shabbab Hamad Al-Mutairi, Hassna Maquta Ali Alharthi, Dalal Sanad Almutairi, Fatimah Saleh Al Awami, Shimaa Mohammed Said

Background: Aspiration pneumonia is a major cause of morbidity and mortality in hospitalized adults, yet limited evidence exists from the Eastern region of Saudi Arabia. Objective: To identify clinical correlates of disease severity in patients with confirmed aspiration pneumonia. Methods: A retrospective cross‑sectional study was conducted using medical records of adult patients diagnosed with aspiration pneumonia across two major hospitals in Eastern Saudi Arabia (January 2018 – December 2023). A total of 294 eli …

28.08.2026journal-article

Journal of Comparative Social Work

Social Work’s Role in Promoting Participation for Children and Youth with Mental Health-Related Disabilities in the German Child and Youth Welfare System

Christopher Romanowski-Kirchner

This article offers a theory- and legally informed conceptual analysis of interprofessional collaboration between youth welfare and child and adolescent psychiatry, with a focus on the legal construct of seelische Behinderung (mental health-related disability) in German child and youth welfare services (section 35a of the Social Code Book VIII). The ‘integration assistance for children and adolescents with mental health-related disabilities’ is a specific social work service within the German child and youth welfar …

28.08.2026journal-article

British Journal of Dermatology

Long-Term Health-Related Quality of Life Outcomes in Patients With Cellulitis Requiring Hospitalisation

Magda Vergouwe, Duncan R Cranendonk, Hessel Peters-Sengers, Emma Birnie, Stephanie Popping, Jan M Prins, W Joost Wiersinga, for the DANCE Consortium, Andy I M Hoepelman, Jan Jelrik Oosterheert, Michiel A van Agtmael, Judith Branger, Kees Brinkman, Fanny N Lauw, Annemarie H Pijlman, Sanjay U C Sankatsing, Robin Soetekouw, Jan Veenstra, Peter J de Vries

In 94 hospitalised patients with cellulitis, HRQoL was markedly impaired at admission and remained significantly below population norms at 90 days, particularly in patients with persistent pain and oedema. These findings highlight the need for post-discharge follow-up focused on symptom resolution.

28.08.2026journal-article

European Journal of Haematology

InflaMix Predicts Severe CRS , ICU Admission, and Progression‐Free Survival After CAR ‐T Therapy in LBCL

Eugenio Galli, Daniele Mannina, Alessandro Corrente, Chiara De Philippis, Ilaria Pansini, Marcello Viscovo, Stefan Hohaus, Patrizia Chiusolo, Federica Sorà, Stefania Bramanti, Simona Sica

ABSTRACT Objectives Baseline systemic inflammation has emerged as a determinant of outcome after CD19‐directed CAR‐T therapy. We evaluated the prognostic performance of the recently developed INFLAmmation MIXture Model (InflaMix) in an independent bicentric cohort of patients with large B‐cell lymphoma (LBCL) receiving commercial CAR‐T cells, focusing on treatment‐related toxicities. Methods We retrospectively analyzed 212 consecutive patients with relapsed/refractory LBCL treated with axi‐cel, tisa‐cel, or liso‐ce …

28.08.2026journal-article

Journal of Neuro-Oncology

CAR-T cell therapy: potential for paediatric brain tumours—an update

Alexandra Zehner, Benjamin Draper, Darren Hargrave, Laura K. Donovan, John Anderson

Abstract Central nervous system (CNS) tumours are the deadliest cancer for children and currently present limited treatment options. Chimeric antigen receptor (CAR)-T cell therapies have emerged as an innovative approach supported by encouraging clinical results. Current clinical trials using CAR-T cells in the treatment of paediatric CNS cancers differ in a number of variables, including the CAR-T cell route of delivery, presence of lymphodepletion, identified target antigen, and CAR engineering features. Consider …

28.08.2026journal-article

Annals of Global Health

Catching Up on Mortality, Falling Behind on Disability: A Dynamic Decomposition of the Health‑Adjusted Life Expectancy Gap between Higher‑Income and Lower‑Income Countries

Xue‑Qi Li, Wei Hu, Bo Yan, Jie Sun, Jun‑Yan Xi

Background: Global health inequalities are conventionally assessed through the mortality gap, yet the joint contribution of mortality and disability to health‑adjusted life expectancy (HALE) gap and their dynamic evolution remain poorly understood. We aim to decompose the HALE gap between higher‑income and lower‑income countries into mortality and disability drivers, separate long‑term trends from transient fluctuations, and reveal heterogeneity within the low‑income group. Methods: Using data from the Global Burde …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Rosacea epidemiology: a meta-analysis

G.R. Mustafina, R.R. Mankovskaia, E.S. Kamalov, S.S. Kurbatov

Background. Rosacea is a chronic, multifactorial dermatosis, the epidemiology of which is a pressing issue in modern dermatovenereology. Objective. To analyze the incidence of rosacea in the Republic of Bashkortostan for 2019—2023, as well as to review literature data on the prevalence of rosacea in the Russian Federation and other countries. We studied the structure of rosacea incidence depending on geographic and climatic factors, in particular on the Fitzpatrick skin type. We investugated the relationship betwee …

28.08.2026journal-article

Journal of the Society for Clinical Data Management

Project Management for Clinical Data Managers

Sachi Amatya, Dawn Edgerton, Helen Fasshauer, Stacey King, Erica Sage

Project management skills are critical for clinical data managers (CDMs) because high-quality clinical data must be delivered in compliance with ICH E6(R3) and ICH E8(R1) while coordinating complex, decentralized, and technology-enabled clinical trial environments. These skills enable effective planning, risk management, stakeholder communication, and oversight of timelines, budget, and resources across clinical portfolios and programs. CDMs are accountable for data integrity and end-to-end clinical data strategy; …

28.08.2026journal-article

Hacettepe University Faculty of Health Sciences Journal

Effects of Gluten-Free Diet on Nutritional Status and Some Inflammation Parameters in Adult Celiac Disease Patients

Öznur Aydın, Evrim Kahramanoğlu Aksoy, Zeynep Göktaş

Objectives: Celiac disease is a lifelong autoimmune disorder in which strict adherence to a gluten-free diet is the cornerstone of treatment. However, many patients follow the gluten-free diet incorrectly due to limited nutrition education, which may affect nutritional adequacy, inflammation, and quality of life. This study aims to examine the effect of a gluten-free diet on nutritional status, anthropometric measurements, and serum interferon-gamma and interleukin-15 levels in adult celiac patientsMaterials and Me …

28.08.2026journal-article

Obesity Surgery

Preoperative Factors Associated with Weight Loss and Recurrent Weight Gain after Bariatric Surgery: A Longitudinal Study in a UK Public Healthcare Setting

Luqman Naim Bin Aizan, Akheel A. Syed, Bilal Alkhaffaf

Abstract Objective Bariatric surgery is an effective treatment for obesity. This study aims to identify demographic factors of weight loss and recurrent weight gain over a 10-year follow-up period. Methods This retrospective observational study includes 2092 patients for overall trends, 1032 patients for predictors of weight loss, and 605 patients for predictors of recurrent weight gain. Percentage total weight loss (%TWL) trends were measured over 10 years. The rate of weight loss and recurrent weight gain was use …

28.08.2026journal-article

Frontiers in Medicine

Genomic risk profiling in advanced maternal age: a Tamil Nadu prenatal study

Sujithra Appavu, Aruni Wilson Santhosh Kumar, Mukinkumar Sonai, Vinoth Appavu

Background Advanced maternal age (AMA; > = 35 years) is associated with increased fetal chromosomal risk and is an important indication for invasive prenatal diagnosis. This study evaluates karyotyping and chromosomal microarray analysis (CMA) findings among AMA pregnancies in Tamil Nadu, India. Methods In this prospective observational study, 2,200 pregnant women aged ≥35 years who underwent amniocentesis between July 2020 and June 2021 were enrolled. Conventional karyotyping was performed in all cases. CMA was …

28.08.2026journal-article

Frontiers in Medicine

Improvement in liver function and gross motor function after umbilical cord-derived mesenchymal stromal cell transplantation in a child with autoimmune hepatitis and concurrent cerebral palsy: a case report

Liem Thanh Nguyen, Huong Thu Le, Doan Van Ngo, Thi Kieu Trang Phan

Autoimmune hepatitis (AIH) is a complex immune-mediated liver disease of unknown origin that can rapidly progress to liver cirrhosis and end-stage liver failure. Standard treatment regimens typically involve immunosuppressive therapies, with most patients requiring lifelong maintenance. Recently, cell therapy has emerged as a potential therapeutic option for AIH. In this study, we report the case of a 2-year-old boy with type 2 autoimmune hepatitis and postcardiac arrest cerebral palsy who experienced clinical and …

28.08.2026journal-article

Journal of Experimental & Clinical Cancer Research

Overcoming immune checkpoint inhibitor-mediated T-cell exhaustion with a TCR β chain-directed selective dual T-cell activator

Shantel Angstadt, Lucas A. Horn, Kristen Fousek, Nika Rajabian, Haiyan Qin, Miriam M. Medina-Enriquez, Marcus D. Kelly, Nicole Hsiao-Sanchez, Thomas J. Meyer, Jacques Moisan, Madan Katragadda, Andrew Bayliffe, Zhen Su, Jeffrey Schlom, Claudia Palena

Abstract Background Resistance to immune checkpoint inhibition (ICI) using antibodies against the PD-1/PD-L1 axis remains a significant clinical challenge. Here, we report that combination of anti-PD-1 with a bifunctional fusion molecule, anti-TCRβ-IL-2, comprised of a monovalent Fab that binds and activates the T-cell receptor (TCR) through distinct variable beta (Vβ) chain residues and an IL-2 molecule, mediates robust anti-tumor control in the context of ICI resistance. Methods Syngeneic murine models with varyi …

28.08.2026journal-article

BMC Medical Ethics

On the blind spot: ethical conflicts of health care professionals in addressing opioid diversion - a template study protocol for multinational qualitative research

Annette Binder, Sonja Mathes

Abstract Background Opioid diversion—the unauthorized redirection of prescription opioids—is a growing global concern with significant public health implications. While diversion can occur at many points in the supply chain, instances involving healthcare professionals (HCPs) are particularly complex, as they often occur within clinical settings and most often involve self-medication, substance use disorders among healthcare professionals, or peer dynamics. These cases raise not only legal and professional concerns …

28.08.2026journal-article

BMC Pulmonary Medicine

Impact of CPAP and ventilator system resistance on respiratory effort in healthy volunteers

Simon Lindner, Lena Doerflinger, Luisa S. Drotleff, Burcu Link, Benjamin Neetz, Julia D. Michels-Zetsche, Felix J. F. Herth, Daniel Duerschmied, Simone Britsch

Abstract Introduction Continuous positive airway pressure (CPAP) is widely used for the treatment of acute and chronic respiratory failure and inspiratory support pressure (ΔP insp ) can be added to achieve non-invasive ventilation (NIV). We performed a physiological study to determine the effect of CPAP and inspiratory support pressure on respiratory effort measured by esophageal tidal swings in healthy volunteers. Methods Esophageal tidal swings were measured in spontaneously breathing, healthy volunteers undergo …

28.08.2026journal-article

BMC Public Health

Epidemiological characteristics of hospitalized injury patients in a tertiary hospital of Guangxi Zhuang Autonomous Region, China: a retrospective single-center observational study

Chunxiu Yang, Jun Liang, Qingjiao Nong

Abstract Background Injury is a substantial public health issue that ranks among the primary causes of mortality and disability globally. This study aimed to analyze the epidemiological characteristics and types of injury among hospitalized patients through a single-center hospital-based retrospective study conducted in Guangxi Zhuang Autonomous Region in China. Methods A total of 15,869 hospitalized injury patient records were retrieved from the Hospital Information System (HIS) of the People’s Hospital of Guangxi …

28.08.2026journal-article

Frontiers in Pediatrics

Case Report: Pediatric immune-mediated necrotizing myopathies mimicking inherited muscle disorders: clinical, paraclinical, and genetic insights from two cases

Gianmarco Severa, Maria Camila Cortes-Rojas, Marta Gomez-Garcia de la Banda, Thibaut Belmondo, Audrey Benezit, France Leturcq, Camille Verebi, Baptiste Periou, Eduard Gallardo, Denise Cassandrini, Thierry Gendre, Sophie Hue, Cyril Gitiaux, Nadia Toubal, Sonia Nouioua, Nadira Boucher, Brigitte Bader-Meunier, François Jérôme Authier, Robert-Yves Carlier, Susana Quijano-Roy, Edoardo Malfatti

Objectives Immune-mediated necrotizing myopathies (IMNMs) are a group of rare acquired myopathies. We describe two pediatric cases presenting with early-onset proximal and axial muscle weakness, rhabdomyolysis, and progressive evolution mimicking limb-girdle muscular dystrophy. Methods This retrospective case series is based on a review of the medical records of two pediatric IMNM patients with symptom onset at 2 (P1) and 16 (P2) years of age and diagnoses at 5 and 17 years, respectively. Both patients underwent cl …