Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Alle Themen · Seite 14

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Health Education & Behavior

The Health Education Specialist Practice Analysis III 2025 (HESPA III 2025): Process and Outcomes

Antonio J. Gardner, Beth H. Chaney, Ian F. Hembry, James Henderson, Misozi Houston, William Datema, Cherylee Sherry, Shontelle Dixon, Melissa Opp

The Health Education Specialist Practice Analysis III 2025 was conducted to update and validate the hierarchical model associated with the contemporary framework for the practice of health education specialists across work settings at entry and advanced levels. The purpose of this manuscript was to report the processes and findings associated with the HESPA III 2025 study to assess the validity of the Areas of Responsibility, Competencies, Sub-competencies, and Knowledge Areas for entry- and advanced-level health e …

28.08.2026journal-article

Frontiers in Medicine

Evidence integration and bridging methodologies for high-risk and innovative medical devices and in vitro diagnostic medical devices: a scoping review

Nensi Bralić, Ružica Bandić, Miro Vuković, Danira Matijaca, Renata Valsami, Panagiotis Zoumpoulakis, Kalle Schnitzer, Mari Levula, Risto Roine, Antti Viitala, Antti Pihlava, Olivia McDermott, Ana Marušić

Background High-risk and innovative medical devices, as well as in vitro diagnostic medical devices, often pose challenges for conventional clinical evaluation because randomized clinical trials may be difficult to conduct. As a result, methodologies for integrating heterogeneous evidence and conducting bridging studies are becoming increasingly important in regulatory decision-making and health technology evaluation. Objective To map methodologies for evidence integration and bridging studies in high-risk and inno …

28.08.2026journal-article

Frontiers in Psychology

Communication across autism, ADHD, and non-clinical groups: examining autistic and ADHD traits from a dimensional perspective

Ramona Cardillo, Rachele Lievore, Enrico Toffalini, Giulia Crisci, Irene Cristina Mammarella

Introduction Communication difficulties are common among youth with Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD). However, traits associated with ASD and ADHD are continuously distributed in the general population, raising the question of how communication differences are better described when considering both diagnostic categories and dimensional trait variation. Methods This study included 493 Italian children and adolescents aged 7–16 years old ( M = 11.35; SD = 2.64): 147 ( …

28.08.2026journal-article

Frontiers in Cardiovascular Medicine

Association between gamma-glutamyl transferase and risk of major adverse cardiovascular events in patients with hypertrophic cardiomyopathy: a retrospective cohort study

Meng Yao, Xiaoyin Xing, Zhe Chen, Cunying Cui, Xinqiao Tian

Background Hypertrophic cardiomyopathy (HCM) is the most common hereditary heart disease, and the subsequent major adverse cardiovascular events (MACE) pose a serious threat to the health of patients. This investigation was intended to explore the association between gamma-glutamyl transferase (GGT) levels and MACE risk in patients with HCM. Methods Data from patients (≥ 18 years old) diagnosed with HCM at a hospital were enrolled in this retrospective cohort study. The association between GGT levels and the risk o …

28.08.2026journal-article

International Journal of Public Health and Medical Research

Research Advances and Future Directions of Biotechnology in the Treatment of Myasthenia Gravis

Jiaqi Lin

Myasthenia gravis (MG) is an autoimmune disease with a core pathological mechanism involving specific attacks by the immune system on proteins at the neuromuscular junction. This study reveals that our understanding of its pathogenesis has expanded beyond mere neuromuscular transmission dysfunction to encompass multiple aspects, including the dysregulation of immune regulatory networks, abnormal activation of the complement system, and damage mediated by specific autoantibodies. While conventional pharmacological t …

28.08.2026journal-article

Clinical Medicine and Pharmacology

A CLINICAL CASE OF ANKYLOSING SPONDYLITIS IN A PATIENT WITH DYSPLASTIC SCOLIOSIS

A. Hochenkova, Elena Belyaeva

Damage to the musculoskeletal system is one of the most common manifestations of rheumatic diseases. However, the reason for its involvement in the pathological process may be other diseases or their combinations. Ankylosing spondylitis (AS) is one of the most difficult to diagnose causes of specific pain in the lower back. The causes of difficulties in diagnosing the disease are untimely treatment of patients for medical help, a low-symptomatic course of AS, insufficient knowledge of the diagnostic criteria of the …

28.08.2026journal-article

Journal of Advanced Nursing

Balancing Standardisation and Individualisation in Psychosocial Interventions for Perinatal Bereavement: Bereaved Parents' Perspectives From a Qualitative Study

Jiaying Xie, Annmarie Grealish, Linda Biesty, Andrew Hunter

ABSTRACT Aim To explore bereaved parents' experiences of receiving psychosocial interventions (PSIs) in hospital‐based perinatal bereavement care in Ireland. Design Descriptive qualitative study. Methods Fifteen bereaved parents (13 mothers and 2 partners) whose loss occurred within the past three years were recruited via a national parent‐led charity. Semi‐structured online interviews were conducted between November 2024 and March 2025. Data were analysed using reflexive thematic analysis. Results Six themes captu …

28.08.2026journal-article

Annals of Global Health

Catching Up on Mortality, Falling Behind on Disability: A Dynamic Decomposition of the Health‑Adjusted Life Expectancy Gap between Higher‑Income and Lower‑Income Countries

Xue‑Qi Li, Wei Hu, Bo Yan, Jie Sun, Jun‑Yan Xi

Background: Global health inequalities are conventionally assessed through the mortality gap, yet the joint contribution of mortality and disability to health‑adjusted life expectancy (HALE) gap and their dynamic evolution remain poorly understood. We aim to decompose the HALE gap between higher‑income and lower‑income countries into mortality and disability drivers, separate long‑term trends from transient fluctuations, and reveal heterogeneity within the low‑income group. Methods: Using data from the Global Burde …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Rosacea epidemiology: a meta-analysis

G.R. Mustafina, R.R. Mankovskaia, E.S. Kamalov, S.S. Kurbatov

Background. Rosacea is a chronic, multifactorial dermatosis, the epidemiology of which is a pressing issue in modern dermatovenereology. Objective. To analyze the incidence of rosacea in the Republic of Bashkortostan for 2019—2023, as well as to review literature data on the prevalence of rosacea in the Russian Federation and other countries. We studied the structure of rosacea incidence depending on geographic and climatic factors, in particular on the Fitzpatrick skin type. We investugated the relationship betwee …

28.08.2026journal-article

Journal of Neuro-Oncology

CAR-T cell therapy: potential for paediatric brain tumours—an update

Alexandra Zehner, Benjamin Draper, Darren Hargrave, Laura K. Donovan, John Anderson

Abstract Central nervous system (CNS) tumours are the deadliest cancer for children and currently present limited treatment options. Chimeric antigen receptor (CAR)-T cell therapies have emerged as an innovative approach supported by encouraging clinical results. Current clinical trials using CAR-T cells in the treatment of paediatric CNS cancers differ in a number of variables, including the CAR-T cell route of delivery, presence of lymphodepletion, identified target antigen, and CAR engineering features. Consider …

28.08.2026journal-article

Microbiology Spectrum

Clinical application of BALF-mNGS in immunocompromised and immunocompetent patients with suspected invasive pulmonary aspergillosis: differentiating infection from colonization, microbiome features, and clinical impact

Junjie Zhao, Xinxin Chen, Xinyi Wang, Yidan Cui, Jiancheng Zhuge, Honglong Fang, Zhidan Hua

ABSTRACT Invasive pulmonary aspergillosis (IPA) not only causes high morbidity and mortality, especially in immunocompromised patients, but also occurs in immunocompetent individuals. Differentiating infection from colonization is challenging, and bronchoalveolar lavage fluid metagenomic next-generation sequencing (BALF-mNGS) may aid diagnosis, microbiome profiling, and clinical assessment. We retrospectively analyzed patients with suspected IPA who underwent BALF-mNGS between December 2021 and March 2025. Patients …

28.08.2026journal-article

Frontiers in Medicine

Case Report: Ultrasound-guided hydrodissection targeting the subsynovial connective tissue with dynamic ultrasound assessment in refractory carpal tunnel syndrome: a report of two cases

Daeook Lee, Taeseok Ahn, Myungjin Oh, Jongha Lee, Hyeonjun Woo, Hyunbum Kwon, Changyoung Park, Cheol-Hyun Kim, Jung-Yun Ahn, Jihyun Moon, Dong-Woo Lim

Carpal tunnel syndrome is established to be caused by compression of the median nerve. However, recent studies have highlighted fibrosis of the subsynovial connective tissue and consequent restriction of median nerve sliding as a key pathophysiological mechanism. In this case report, we present the results of dynamic ultrasound assessment conducted on two patients with persistent symptoms, with a mixture of polydeoxyribonucleotide (PDRN) 7 mg and 5% dextrose in water (5DW) applied to perform a more extensive ultras …

28.08.2026journal-article

Frontiers in Radiology

Systematic review of PET imaging features and clinical applications in pulmonary NUT carcinoma

Xue Liu, Li Bin, Yu Zhang, Huiting Liu, Cailiang Gao

Purpose Primary pulmonary nuclear protein in testis (NUT) carcinoma is a rare, aggressive malignancy driven by NUTM1 rearrangement. Although 18 F-FDG PET/CT is used in clinical management, its imaging features and value have not been systematically evaluated. Methods This PRISMA 2020 systematic review was registered with PROSPERO (CRD420261292692). PubMed, Embase, Web of Science, Cochrane Library, and grey literature were searched from inception to March 2026. Studies reporting 18 F-FDG PET/CT findings in pathologi …

28.08.2026journal-article

British Journal of Dermatology

Long-Term Health-Related Quality of Life Outcomes in Patients With Cellulitis Requiring Hospitalisation

Magda Vergouwe, Duncan R Cranendonk, Hessel Peters-Sengers, Emma Birnie, Stephanie Popping, Jan M Prins, W Joost Wiersinga, for the DANCE Consortium, Andy I M Hoepelman, Jan Jelrik Oosterheert, Michiel A van Agtmael, Judith Branger, Kees Brinkman, Fanny N Lauw, Annemarie H Pijlman, Sanjay U C Sankatsing, Robin Soetekouw, Jan Veenstra, Peter J de Vries

In 94 hospitalised patients with cellulitis, HRQoL was markedly impaired at admission and remained significantly below population norms at 90 days, particularly in patients with persistent pain and oedema. These findings highlight the need for post-discharge follow-up focused on symptom resolution.

28.08.2026journal-article

Journal of Comparative Social Work

Social Work’s Role in Promoting Participation for Children and Youth with Mental Health-Related Disabilities in the German Child and Youth Welfare System

Christopher Romanowski-Kirchner

This article offers a theory- and legally informed conceptual analysis of interprofessional collaboration between youth welfare and child and adolescent psychiatry, with a focus on the legal construct of seelische Behinderung (mental health-related disability) in German child and youth welfare services (section 35a of the Social Code Book VIII). The ‘integration assistance for children and adolescents with mental health-related disabilities’ is a specific social work service within the German child and youth welfar …

28.08.2026journal-article

Journal of Clinical Medicine

Etelcalcetide Versus Cinacalcet for Secondary Hyperparathyroidism in Hemodialysis Patients: A Multicentre Comparison with 24 Months of Follow-Up

Hakkı Öztürk, Çiğdem Ikhlef, Berrak Itır Aylı, Veysel Baran Tomar, Bartu Ediz, Ebru Gök Oğuz, Elif Arı Bakır, Galip Güz, Mehmet Deniz Aylı

Background/Objectives: Secondary hyperparathyroidism (SHPT) is a prevalent complication of end-stage kidney disease. Although etelcalcetide has demonstrated short-term superiority over cinacalcet in randomized trials, real-world comparative data beyond 12 months remain scarce. This study compared the long-term effectiveness of etelcalcetide versus cinacalcet in hemodialysis patients over 24 months using propensity score matching. Methods: This multicenter retrospective study screened 457 hemodialysis patients acros …

28.08.2026journal-article

European Journal of Haematology

InflaMix Predicts Severe CRS , ICU Admission, and Progression‐Free Survival After CAR ‐T Therapy in LBCL

Eugenio Galli, Daniele Mannina, Alessandro Corrente, Chiara De Philippis, Ilaria Pansini, Marcello Viscovo, Stefan Hohaus, Patrizia Chiusolo, Federica Sorà, Stefania Bramanti, Simona Sica

ABSTRACT Objectives Baseline systemic inflammation has emerged as a determinant of outcome after CD19‐directed CAR‐T therapy. We evaluated the prognostic performance of the recently developed INFLAmmation MIXture Model (InflaMix) in an independent bicentric cohort of patients with large B‐cell lymphoma (LBCL) receiving commercial CAR‐T cells, focusing on treatment‐related toxicities. Methods We retrospectively analyzed 212 consecutive patients with relapsed/refractory LBCL treated with axi‐cel, tisa‐cel, or liso‐ce …

28.08.2026journal-article

Journal of Clinical Psychology in Medical Settings

Treating Multiple Chemical Sensitivity as a Specific Phobia Using Cognitive Behavioural Therapy: A Case Study in an Older Adult

Matthew Wilcock, Alice Loyal, David Hitt

Abstract Multiple Chemical Sensitivity (MCS) is a poorly understood condition characterised by physical symptoms triggered by minimal exposure to odorous or chemical agents, often without identifiable organic pathology. This case study describes cognitive behavioural therapy (CBT) for MCS in an older adult referred to a respiratory team after developing persistent, generalised reactions to odours following an acute toxic inhalation. Symptoms led to severe avoidance, functional impairment and suicidal ideation. Foll …

28.08.2026journal-article

Belitung Nursing Journal

Clinical and nursing correlates of severity among chronically ill adults with aspiration pneumonia in Saudi Arabia: A retrospective cross-sectional study

Eman M. Gaber Hassan, Myra Cusi Britiller, Mohammad Daud Ali, May Mohammed Alshowikat, Fatimah Hassan Ahmed Alduhaim, Sarah Mohammad AlOtaibi, Asmahan Shabbab Hamad Al-Mutairi, Hassna Maquta Ali Alharthi, Dalal Sanad Almutairi, Fatimah Saleh Al Awami, Shimaa Mohammed Said

Background: Aspiration pneumonia is a major cause of morbidity and mortality in hospitalized adults, yet limited evidence exists from the Eastern region of Saudi Arabia. Objective: To identify clinical correlates of disease severity in patients with confirmed aspiration pneumonia. Methods: A retrospective cross‑sectional study was conducted using medical records of adult patients diagnosed with aspiration pneumonia across two major hospitals in Eastern Saudi Arabia (January 2018 – December 2023). A total of 294 eli …

28.08.2026journal-article

Hacettepe University Faculty of Health Sciences Journal

Effects of Gluten-Free Diet on Nutritional Status and Some Inflammation Parameters in Adult Celiac Disease Patients

Öznur Aydın, Evrim Kahramanoğlu Aksoy, Zeynep Göktaş

Objectives: Celiac disease is a lifelong autoimmune disorder in which strict adherence to a gluten-free diet is the cornerstone of treatment. However, many patients follow the gluten-free diet incorrectly due to limited nutrition education, which may affect nutritional adequacy, inflammation, and quality of life. This study aims to examine the effect of a gluten-free diet on nutritional status, anthropometric measurements, and serum interferon-gamma and interleukin-15 levels in adult celiac patientsMaterials and Me …

28.08.2026journal-article

Journal of the Society for Clinical Data Management

Project Management for Clinical Data Managers

Sachi Amatya, Dawn Edgerton, Helen Fasshauer, Stacey King, Erica Sage

Project management skills are critical for clinical data managers (CDMs) because high-quality clinical data must be delivered in compliance with ICH E6(R3) and ICH E8(R1) while coordinating complex, decentralized, and technology-enabled clinical trial environments. These skills enable effective planning, risk management, stakeholder communication, and oversight of timelines, budget, and resources across clinical portfolios and programs. CDMs are accountable for data integrity and end-to-end clinical data strategy; …

28.08.2026journal-article

Obesity Surgery

Preoperative Factors Associated with Weight Loss and Recurrent Weight Gain after Bariatric Surgery: A Longitudinal Study in a UK Public Healthcare Setting

Luqman Naim Bin Aizan, Akheel A. Syed, Bilal Alkhaffaf

Abstract Objective Bariatric surgery is an effective treatment for obesity. This study aims to identify demographic factors of weight loss and recurrent weight gain over a 10-year follow-up period. Methods This retrospective observational study includes 2092 patients for overall trends, 1032 patients for predictors of weight loss, and 605 patients for predictors of recurrent weight gain. Percentage total weight loss (%TWL) trends were measured over 10 years. The rate of weight loss and recurrent weight gain was use …

28.08.2026journal-article

Frontiers in Medicine

Genomic risk profiling in advanced maternal age: a Tamil Nadu prenatal study

Sujithra Appavu, Aruni Wilson Santhosh Kumar, Mukinkumar Sonai, Vinoth Appavu

Background Advanced maternal age (AMA; > = 35 years) is associated with increased fetal chromosomal risk and is an important indication for invasive prenatal diagnosis. This study evaluates karyotyping and chromosomal microarray analysis (CMA) findings among AMA pregnancies in Tamil Nadu, India. Methods In this prospective observational study, 2,200 pregnant women aged ≥35 years who underwent amniocentesis between July 2020 and June 2021 were enrolled. Conventional karyotyping was performed in all cases. CMA was …

28.08.2026journal-article

Frontiers in Medicine

Improvement in liver function and gross motor function after umbilical cord-derived mesenchymal stromal cell transplantation in a child with autoimmune hepatitis and concurrent cerebral palsy: a case report

Liem Thanh Nguyen, Huong Thu Le, Doan Van Ngo, Thi Kieu Trang Phan

Autoimmune hepatitis (AIH) is a complex immune-mediated liver disease of unknown origin that can rapidly progress to liver cirrhosis and end-stage liver failure. Standard treatment regimens typically involve immunosuppressive therapies, with most patients requiring lifelong maintenance. Recently, cell therapy has emerged as a potential therapeutic option for AIH. In this study, we report the case of a 2-year-old boy with type 2 autoimmune hepatitis and postcardiac arrest cerebral palsy who experienced clinical and …