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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Pain Medicine

Central Sensitization and Cognitive Vulnerability: A Neurobiological Framework for CNS Resilience and Brain Aging

Kevin V Hackshaw

Abstract Objective Preservation of central nervous system (CNS) resilience during midlife is increasingly recognized as an important determinant of healthy cognitive aging, as biological processes contributing to Alzheimer's disease and related dementias (ADRD) may begin decades before clinically apparent impairment. Identifying measurable physiological states associated with diminished CNS resilience during this period is therefore an important objective of brain-aging research. Central sensitization is a neurophy …

25.08.2026journal-article

International Journal of Molecular Sciences

Safety and Efficacy of Mesenchymal Stem Cell Therapy in Aging Frailty: A Systematic Review

Eleni Poutouri, Maria Sotiropoulou, Michael Potoupnis, Georgios Koliakos, Evanthia Kassi, Symeon Tournis, Panagiotis Anagnostis

Aging frailty is a multifactorial geriatric syndrome characterized by reduced physiological reserve across multiple interrelated systems, leading to increased vulnerability to adverse health outcomes. Mesenchymal stem cells (MSCs) have emerged as a potential therapeutic intervention due to their immunomodulatory and regenerative properties. This systematic review aimed to evaluate the available clinical evidence regarding the safety and efficacy of MSC administration in individuals with aging frailty. A systematic …

25.08.2026journal-article

International Migration

‘People Recognise Us as the Bravest of the Brave’: Retired Gurkha Soldiers Negotiating Employment, Racialisation and Identity in Britain

Shovita Dhakal Adhikari, Louise Ryan

ABSTRACT This article aims to contribute new insights into ageing migrants and masculinity by drawing upon life story interviews with retired Nepali Gurkha soldiers settled in South‐East England. Less is known about middle‐aged and older migrants who migrate not to retire per se but to pursue a second or third career in later life. Our research adds new insights into how these men mobilise capitals to navigate new and unfamiliar job markets, post‐retirement, in their middle and older age. Drawing upon the concept o …

25.08.2026journal-article

Healthcare

Loss of Independence Among Racially and Ethnically Diverse Older Adults: An ICF-Based Analysis of NHATS

Young-Shin Lee, Seon-Hi Shin, Alison Moore, Leticia Camacho, Juan A. Cruz, Hee-Jin Jun

Background: Preventing mobility-related loss of independence (LoI) is a critical public health priority. While the drivers of LoI are complex, this study examines how personal, social, and environmental factors influence these outcomes to identify actionable preventive targets. We applied the International Classification of Functioning, Disability, and Health (ICF) framework to examine these pathways across racial and ethnic groups. Methods: Using 2023 National Health and Aging Trends Study (NHATS) data (N = 7106), …

25.08.2026journal-article

SLEEP

Dementia Risk in Patients with Comorbid Insomnia and Obstructive Sleep Apnea: A Propensity Score–Matched Cohort Study

Ping-Hao Chiang, Yao Te Tsai, Yang-Chi Lin, Hsueh-Yu Li, Chieh-Hsuan Tsai, Chia-Yu Hsu

Abstract Study Objectives Obstructive sleep apnea (OSA) and insomnia frequently co-occur as comorbid insomnia and sleep apnea (COMISA). While it has increasingly been recognized as a distinct clinical presentation, its cognitive consequences remain unclear. We evaluated the 5-year incident dementia risk associated with COMISA compared with OSA alone. Materials and Methods This retrospective propensity score–matched cohort study using electronic health records from the TriNetX US Collaborative Network. Adults with a …

25.08.2026journal-article

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

Napping Characteristics and Incident Dementia: Results From The National Health and Aging Trends Study

Kening Jiang, Alden L Gross, Catriona Tingsea Wu, Junxin Li, Halima Amjad, Emerson M Wickwire, Jennifer S Albrecht, Atul Malhotra, Chien-Yu (Irene) Tseng, Marc Kaizi-Lutu, Chunyu Liu, Christopher N Kaufmann, Adam P Spira

Abstract Background Whether daytime napping may be a risk factor for dementia, in addition to nighttime sleep disturbances, remains unclear. This study investigated longitudinal associations of napping characteristics with incident dementia among U.S. older adults. Methods Data came from the National Health and Aging Trends Study (NHATS). Napping characteristics were self-reported in a sleep module at round 3 (2013), including (1) frequency (non-napper, infrequent, frequent); (2) intention (non-napper, intentional, …

25.08.2026journal-article

Frontiers in Medicine

Changing epidemiology of non-occupational acute carbon monoxide poisoning and the increasing share of older adults during the clean heating transition: a 10-year emergency department study in rural Tianjin, China

Wei Kang, Yanqiu Du, Miao Zhao, Jisheng Yang, Jian Liang, Xin Wang, Xianjia Ning, Guohua Zhao

Background and Objective Non-occupational Acute Carbon Monoxide Poisoning (ACOP) remains a preventable emergency condition in northern rural China, where winter heating and indoor combustion have historically been important exposure sources. In rural Tianjin, the clean heating transition period was accompanied by a substantial decline in the overall incidence of non-occupational ACOP, while the residual burden shifted toward older adults and lifestyle-related exposure sources. However, whether this transition has c …

25.08.2026journal-article

Biopsychosocial Science and Medicine

“Be Good to Others and Treat People as you Would Like to be Treated Yourself.” A Mixed Methods Investigation of Positive Social Relationships and Cardiovascular Health in the MIDUS Study

Jennifer Morozink Boylan, Dakota W. Cintron, Julia K. Boehm

Objective: We analyzed qualitative data about social relationships and examined their quantitative associations with concurrent and prospective cardiovascular health (CVH). Methods: Cross-sectional analyses involved the Midlife in the United States (MIDUS) Study wave 2 (M2) and Refresher (MR) biomarker samples (N=2036). Longitudinal analyses involved participants with both M2 and MIDUS wave 3 (M3) biological data (N=650). Participants wrote responses to the question “What do you do to make your life go well?” Judge …

25.08.2026journal-article

Frontiers in Psychology

Toddlers’ symbolic play in dyadic mother–child and triadic mother–child-older-sibling interactions

Sharon Sherman, Naomi Havron

Symbolic play supports crucial aspects of early childhood development, including language and social-cognitive skills. Parent-child dyadic play has been shown to facilitate symbolic play development, but less is known about the addition of siblings (triadic interactions), which may present both opportunities and challenges. We examined toddlers' symbolic play across dyadic (mother-child) and triadic (mother-child-sibling) free-play interactions recorded through videoconferencing. Twenty toddlers (aged 1.5–2.5 years …

25.08.2026journal-article

The Open Psychology Journal

Intergenerational Co-Residence and Life Satisfaction: The Moderating Role of Productive Engagement among Older Adults

Mutia Aulia Dewi, Sri Redatin Retno Pudjiati

Introduction Living with adult children may provide emotional and instrumental support, thereby enhancing older adults' life satisfaction. However, it may also increase intergenerational conflict, potentially reducing life satisfaction. These mixed findings suggest that other factors, such as productive engagement, may influence the relationship between intergenerational co-residence and life satisfaction. Methods This study examined the moderating role of productive engagement on the relationship between intergene …

25.08.2026journal-article

Journal of Racial and Ethnic Health Disparities

Changes in Racial Disparities in Viral Suppression Among People with HIV from 2013–2020: A Statewide Cohort Study

Cuihong Huang, Xueying Yang, Chen Zhang, Fanghui Shi, Jiajia Zhang, Bankole Olatosi, Sharon Weissman, Xiaoming Li

Abstract Objective Limited studies have sought to qualify the extent and trends of racial disparities in viral suppression (VS) among people with HIV(PWH) across the Southern US. This study aims to examine the spatiotemporal trend and structural social determinants of racial disparities of VS. Methods A population-based retrospective cohort study across all counties in South Carolina (SC) from 2013 to 2020. Linear trend test was employed to explore the temporal trend of the disparity indices (Black to White Ratio [ …

25.08.2026journal-article

European Geriatric Medicine

Preoperative antithrombotic use is associated with delayed mobilization and plural blood transfusions following hip fracture surgery: a case–control study

Henrik Nupponen, Hanna Pajulammi, Anssi Korppi, Esa Jämsen

Abstract Purpose Early surgical treatment is important to allow a prompt start for rehabilitation after hip fracture. In patients using antithrombotic drugs, the surgery is often delayed, but it is unclear how this affects early post-operative recovery. Methods The course of treatment and early post-operative outcomes of hip fracture patients, aged ≥ 70 years, using either warfarin, direct oral anticoagulants (DOACs), or adenosine diphosphate. (ADP) inhibitors were compared to age- and sex-matched controls not usin …

25.08.2026journal-article

Geriatrics & Gerontology International

Weekend Warrior Physical Activity, Sedentary Behavior, and Incident Disability in Middle‐Aged and Older Adults: A UK Biobank Accelerometer Study

Xuan Zhu, Heyan Xia, Tao Sun, Xiaojun Wang

ABSTRACT Aim Regular moderate‐to‐vigorous physical activity (MVPA) is associated with lower risks of functional decline and disability. Whether concentrating MVPA into 1 or 2 days per week—the “weekend warrior” pattern—is associated with disability risk similarly to regularly distributed activity remains unclear, particularly among individuals with high sedentary behavior. Methods We analyzed wrist‐worn accelerometer data from 41 225 UK Biobank participants without identifiable baseline disability based on availabl …

25.08.2026journal-article

Scientific Journal of Economics and Management Research

The Impact of Commercial Health Insurance on Household Consumption in the Context of Population Aging

Jinxia Liu, Shuang Zhu

Against the strategic backdrop of expanding domestic demand and addressing population aging, this study examines the impact of commercial health insurance on household consumption using provincial panel data from China for 2014–2024. The results show that commercial health insurance significantly promotes household consumption expenditure, crowds out basic consumption, and positively affects developmental and enjoyment-oriented consumption. This positive effect is persistent, with lagged health insurance developmen …

25.08.2026journal-article

Frontiers in Immunology

Mitochondrial homeostasis and aging: the mtDNA-cGAS-STING axis

Ling Wang, Zhengwei Zhang, Binbin Xia, Jun Li, Hongmei You

Aging and its associated diseases have become an increasingly severe global health challenge, not only significantly exacerbating the global disease burden but also posing a continuous threat to public health systems worldwide. During the aging process, the aberrant release of endogenous mitochondrial DNA (mtDNA) is a key trigger for the activation of the cGAS–STING innate immune pathway. Existing research has confirmed that the overactivation of the cGAS–STING pathway is the core molecular mechanism driving the se …

25.08.2026journal-article

Mindfulness

Efficacy of Mindfulness-Based Stress Reduction Versus Lifestyle Education for Fluid and Driving-Related Cognition in Older Adults: Results from the Healthy Agers Randomized Controlled Trial

Madhura Phansikar, Megan E. Fisher, Elizabeth Jean Duraney, Anita Shankar, Nathan McPherson, Rosie Canter, Stephanie Aghamoosa, Rebecca Andridge, Ruchika S. Prakash

Abstract Objectives The current study examined the efficacy of mindfulness-based stress reduction (MBSR), compared with an active control lifestyle education program (LifeEd), in improving fluid and driving-related cognition in older adults. Dose–response associations between mindfulness practice and treatment gains were also examined. Method One hundred fifty participants were randomized to one of two groups. Outcomes were assessed at pre-intervention, post-intervention, and 6- and 12-month follow-ups. Results The …

25.08.2026journal-article

World Journal of Surgery

High Undertriage in Geriatric Trauma in a Developing Trauma System: Implications for Trauma Team Activation Criteria

Muhamad Izwan Ismail, Japsimranjit Kaur, Rizasohaini Baseri, Norfarizan Azmi

ABSTRACT Introduction Older adults are at increased risk of adverse outcomes after trauma but are frequently undertriaged because age‐related physiological changes may mask injury severity. We evaluated the performance of our institutional trauma team activation (TTA) criteria in patients aged ≥ 65 years within a developing trauma system. Methods We conducted a retrospective observational study using a trauma registry at a tertiary referral hospital in Malaysia between July 2024 and December 2025. Consecutive traum …

25.08.2026journal-article

Artefactum - revista de estudos interdisciplinares

PHYSICAL EXERCISE AND COGNITIVE HEALTH IN AGING: AN INTEGRATIVE LITERATURE REVIEW

Gabriel Vinícius Reis de Queiroz, Ricardo Sérgio Chucre Rocha Junior, Soly Guedes Barbosa, Pedro Henrique Avelino Oliveira, Jânio de Jesus Gonçalves Júnior, Felipe Farias Campos, Jefferson Luiz de Souza e Silva, Lisandro Contente Gomes, Marcos José Castro dos Santos, Tatiane Bahia do Vale Silva

Objective: To analyze the available scientific evidence on the effects of physical exercise on cognitive health in older adults. Methods: An integrative literature review was conducted in MEDLINE/PubMed, LILACS/BVS, SciELO, Scopus, Web of Science, and Embase, covering publications from 2020 to 2026. Original studies involving individuals aged 60 years or older, or samples with a mean age of 60 years or older, that investigated the relationship between physical exercise and cognitive outcomes were included. The sele …

25.08.2026journal-article

Frontiers in Nutrition

Effects of resistance training combined with creatine supplementation on muscle strength, physical function, and muscle mass in older adults: a systematic review and three-level meta-analysis

Lingzi Yao, Doudou Yang, Jiajia Gao

Objective To systematically evaluate the additional effects of creatine supplementation combined with resistance training, compared with resistance training alone, on muscle strength, muscle mass and physical function in older adults. Methods PubMed, Embase, the Cochrane Library and Web of Science were searched from inception to 20 May 2026. Randomized controlled trials enrolling older adults aged 60 years and older and comparing creatine supplementation plus resistance training with resistance training alone or pl …

25.08.2026journal-article

BMC Geriatrics

Multidisciplinary prognostic accuracy in severe frailty: assessing short-term survival predictions in hospitalized older adults

Elena Pinardi, Simona Umidi, Beatrice Tonus, Jacopo Usai, Alice Margherita Ornago, Maria Cristina Ferrara, Alberto Finazzi, Chukwuma Okoye, Paolo Mazzola, Gianlorenzo Scaccabarozzi, Giuseppe Bellelli

Abstract Background The increasing number of hospitalized older adults with severe frailty and limited life expectancy highlights the need for accurate short-term prognosis to inform care planning, effective communication, and resource allocation. However, survival prediction in this population is underexplored. This study aimed to assess (i) agreement among healthcare professionals on short-term prognosis, (ii) predictive accuracy of multiprofessional survival estimates, and (iii) factors affecting prognostic accu …

25.08.2026journal-article

Frontiers in Medicine

Older adult patients with out-of-hospital pressure injuries: a single-center retrospective study in a tertiary hospital in China

Hongling Sun, Caiyun Xu, Yan Sun, Hui Wang, Shuyan Li, Jinping Xia

Background To investigate the prevalence and clinical characteristics of pressure injuries (PIs) present at hospital admission among older adult patients, and to identify factors influencing healing outcomes through a single-center retrospective analysis. The goal is to inform nursing strategies for PI management in older adults. Methods Data were retrieved from a self-developed pressure injury prevention and management platform at a tertiary hospital in Zhejiang Province. Patients aged ≥60 years admitted between J …

25.08.2026journal-article

Geriatrics

Novel Hypothesis on Phase Angle as a Candidate Marker Associated with Physiological Reserve in Geriatric Patients in Long-Term Care

Alejandro Padilla Isassi, Rosalba Maya Hernández, María Elisa Otero Cerdeira, Ingrid Alejandra Abarca Salinas

Background: Physiological reserve reflects the capacity of the organism to maintain homeostasis under biological stress. We suggest the hypothesis that phase angle derived from bioelectrical impedance analysis could be a potential objective marker of Physiological reserve. Methods: An analytical cross-sectional study was conducted in 45 older adults residing in long-term care units at Hospital Español de México (2025). Frailty was assessed with the FRAIL index, sarcopenia using EWGSOP2 criteria, functionality with …

25.08.2026journal-article

Advanced Science

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang

ABSTRACT Repairing peripheral nerve injury remains a clinical challenge due to its limited regenerative capacity and the situation is further compounded with age. In this study, we identified the dysregulated repair program of Schwann cells (SCs) as a key feature of the aging‐dependent impairment of nerve regeneration, mediated by dual influence of ferroptosis. The ferroptosis‐stressor‐rich microenvironment inhibits SC function in regenerating nerves. Moreover, the persistent intracellular ferroptosis stressor accu …