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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Journal of Psychiatry and Neuroscience

Fronto-Cingulate Gamma Synchrony Predicts Deep Brain Stimulation Response in Treatment-Resistant Depression: Preliminary Evidence

Fatemeh Gholamali Nezhad, Ishaan Tailor, Sina Chegini, Ilya Demchenko, Alice Rueda, Sridhar Krishnan, Mohammad A Kamaleddin, Wendy Lou, Milad Lankarany, Robert Chen, Andres M Lozano, Venkat Bhat

Background: Gamma-band activity has been linked to cognitive-affective processing in depression. However, its role in deep brain stimulation (DBS) response in treatment-resistant depression (TRD) remains unclear. This exploratory study investigated whether ventral capsule/ventral striatum DBS (VCVS-DBS) modulates gamma activity during cognitive-affective processing and whether DBS-related gamma changes are associated with improvement in depressive symptoms. Methods: Seven participants with TRD completed an affectiv …

21.08.2026journal-article

Medicine

Durable response to olaparib plus continued PD-1 blockade in germline PALB2-mutated triple-negative breast cancer with leptomeningeal metastasis

Yulei Wang, Jiali Lin, Yi Zhang, Bo Liang, Xin Lin, Xiangqing Chen, Lijuan Guo, Yifang Zhang, Yuxia Chen, Guochun Zhang

Rationale: Triple-negative breast cancer (TNBC) with germline PALB2 (gPALB2 ) mutations represents a rare but actionable subset sensitive to poly(ADP-ribose) polymerase (PARP) inhibition. However, clinical evidence supporting PARP inhibition combined with programmed cell death protein 1 (PD-1) blockade after progression on prior immunotherapy remains limited, particularly in central nervous system-involved disease. Patient concerns: A 61-year-old woman initially diagnosed with stage I TNBC developed chest wall recu …

21.08.2026journal-article

Revista Mexicana de Urología

Time to serum creatinine recovery after percutaneous nephrostomy in advanced cervical cancer

Andrea Paola González-Rodríguez, Jorge Guerrero-Ixtláhuac, Santiago Ramírez-Guerrero, Simmons David Gough-Coto

Objective: to estimate the mean time to serum creatinine normalization after percutaneous nephrostomy in patients with advanced cervical cancer and obstructive uropathy. Methods: a retrospective observational study conducted over a two-year period at a tertiary cancer center. Women undergoing percutaneous nephrostomy between July 2023 and June 2025 were included. The primary outcome was the time to achieve serum creatinine < 1.3 mg/dL. Results: a total of 408 nephrostomies were recorded, of which 298 (73.0%) were p …

21.08.2026journal-article

International Journal of Health Management Review

THERAPEUTIC MANAGEMENT OF CUTANEOUS MELANOMA IN FELINES: CURRENT TREATMENT APPROACHES

Maisa Leão Peixoto, Letícia de Oliveira Del Tedesco, Luís Gustavo Siqueira Matias Ramos, Sindy Knak, Igor Diogo Gaspar, Gabriel dos Reis Vilhena, Geisla de Oliveira, Vitória Karine Brustolin, Lucas Eduardo Silva Favaro, Júlia Barbosa Rodrigues, Raquel Dacas, Ludmila Venuto Santos, Suyane Costa Ribeiro, Karine Viana Teixeira, Sarah Bernardes Simoes, Juliana Caetano de Jesus

Unlike in dogs, melanocytic neoplasms in cats are predominantly malignant, exhibiting high potential for infiltration and metastasis. Although it is a rare type of cancer, cutaneous melanoma carries a poor prognosis due to delayed diagnosis and the lack of standardized therapeutic protocols. This literature review synthesizes current scientific evidence regarding the therapeutic management of feline melanoma, based on PubMed searches covering the last five years. For local control, wide surgical resection remains t …

21.08.2026journal-article

Cancer Biotherapy and Radiopharmaceuticals

Pharmacokinetic Evaluation of Fibroblast Activation Protein-Targeted Radiopharmaceutical Uptake in Low-Stage Rectal Cancer Tumor Microenvironment

XuDong Zhang, Ke Duan, YuHan Long, Tong Zhou

Purpose: Radionuclide therapy targeting fibroblast activation protein (FAP) offers an effective treatment for tumors with high FAP expression, such as those imaged with 68 Ga-fibroblast activation protein inhibitor (FAPI) and treated with 177 Lu-FAPI. Personalized therapy planning, based on imaging-derived standardized uptake values, pharmacokinetic parameters, and dosimetric modeling, is essential to optimize therapeutic outcomes while minimizing toxicity to healthy tissues. Methods and Results: The study develops …

21.08.2026journal-article

Frontiers in Cell and Developmental Biology

Spatiotemporal control of mitoribosome-mediated metabolic reprogramming in cancer: implications for heterogeneity and therapeutic targeting

Xiaojie Chen, Weidong Wang, Fangxin Shen, Zhiwei Zhao

Mitochondrial ribosomes (mitoribosomes), particularly mitochondrial ribosomal subunit proteins (MRPS), are emerging as contributors to cancer metabolic reprogramming. Rather than static components of mitochondrial translation, MRPS exhibit pronounced spatiotemporal heterogeneity that shapes tumor metabolic plasticity and therapeutic response. This review systematically summarizes evidence that MRPS functions are dynamically regulated across tumor progression and spatial microenvironments. Temporally, MRPS mediate m …

21.08.2026journal-article

Frontiers in Cell and Developmental Biology

The role of molecular profiling for castration-resistant prostate cancer treatment and therapy development

Timothy J. Mann, Therese M. Becker, Tara L. Roberts, Paul de Souza, John G. Lock

Early-stage prostate cancer (PCa) is overwhelmingly driven by aberrant androgen receptor (AR) signalling. Accordingly, standard-of-care treatments include androgen deprivation therapy (ADT) and AR pathway inhibitors (ARPIs), with disease detection and therapy-response monitoring relying on blood-borne PSA, a product of AR transcriptional programs. Crucially, resistance to these therapies is inevitable but heterogeneous in nature; potentially driven by a diverse array of alternate signalling pathways and differentia …

21.08.2026journal-article

Cancer Discovery

Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis

Zhihang Chen, Xiaoxue Ren, Yifan Zhang, Youmei Kang, Ye Yang, Yihang Xu, Qian Zhou, Changyi Liao, Qianwen Zeng, Xin Liu, Renxuan Lin, Yu Yang, Feng Luo, Shunli Shen, Sui Peng, Xiaoxing Li, Jianting Long, Lixia Xu, Ming Kuang

Abstract Neutrophils are major players in innate immunity. However, their landscape and functions in colorectal cancer liver metastasis (CRLM) remain poorly understood. In this study, using single-cell RNA sequencing and spatial-enhanced-resolution-omics sequencing, we provide a comprehensive transcriptional landscape of tumor-associated neutrophils (TAN) in CRLM. Our analysis reveals that a terminally differentiated protumor neutrophil subset (TAN1), characterized by a glycolysis signature and a senescent phenotyp …

21.08.2026journal-article

Frontiers in Oncology

Toward functional precision oncology: organotypic brain slices in glioblastoma

Aleksandra Bondar, Susanne Raulefs, Jette Wrana, Markus Ballmann, Gerhard Rammes, Stephanie E. Combs, Thomas Ernst Schmid

Glioblastoma remains the most aggressive primary brain tumor in adults and is characterized by extensive invasiveness, high recurrence rates, and pronounced inter- and intratumoral heterogeneity. These features continue to limit the effectiveness of current therapies and highlight the need for experimental models that more faithfully capture the complexity of the disease. Conventional two-dimensional in vitro systems, while highly accessible and experimentally tractable, fail to reproduce the three-dimensional arch …

21.08.2026journal-article

Frontiers in Pharmacology

Continuous multidimensional physiological monitoring redefines early warning and preemptive treatment for neutropenic sepsis following cisplatin chemotherapy in non-small cell lung cancer

Zhe Wang, Kunpeng Yang, Lei Wang, Hui Zhao, Peiyun Lv, Chenglun Cai, Wenjuan Sun, Bao Wang

Background Despite the advent of targeted therapies, cisplatin remains a cornerstone in the management of non-small cell lung cancer Its systemic toxicity, however, often triggers neutropenic sepsis, a rapidly fatal oncological emergency. Traditional intermittent monitoring is inadequate here. Chemotherapy-induced “inflammatory silence” frequently masks the classical febrile response, leaving patients unprotected during outpatient windows. Methods In this Perspective, we mined global real-world pharmacovigilance da …

21.08.2026journal-article

Nature Communications

Molecular heterogeneity and clonal origin of CCR8+ effector regulatory T cells in human cancer

Julian Swatler, Simone Puccio, Emanuele Voulaz, Giuseppe Marulli, Matthew Wheeler, Sharmila Sambanthamoorthy, Eloise Scamardella, Simona Feno, Sabina Testa, Chiara Camisaschi, Valentina Errico, Matteo Simonelli, Agnese Losurdo, Emilia Maria Cristina Mazza, Enrico Lugli

Abstract CD4 + CD25 + FOXP3 + regulatory T cells (Treg) are highly activated in tumors and promote disease progression. Specific, universal targeting of these effector Treg cells is limited by the lack of a conserved signature across human cancers and information on their origin. Here we combine analysis of single-cell RNA-sequencing datasets with spectral flow cytometry and identify a core signature of 88 genes consistently upregulated in intratumoral Treg cells among 9 epithelial cancers. We describe 4 Treg cell …

21.08.2026journal-article

Cancers

Transcriptomic Profiling Identifies a Subset of Renal Tumors with Overlapping Features of Clear Cell Papillary Renal Cell Tumor and Renal Cell Carcinoma with Fibromyomatous Stroma

Rasmus Jakobsson, Martin Lindström, Yvonne Arvidsson, Iva Johansson, Jonas A. Nilsson, Niels Marcussen, Joakim Karlsson, Martin E. Johansson

Background: Renal cell carcinomas (RCCs) represent neoplasms with variable biological behaviour, some of which remain difficult to classify within the current diagnostic framework. Clear cell papillary renal cell tumor (CCPRCT) is now recognised as an indolent entity, whereas RCC with fibromyomatous stroma (RCCFMS) remains a provisional subtype with partially overlapping morphological features. Methods: We analysed a multifocal RCC with clear cell morphology and prominent fibromyomatous stroma via whole-genome and …

21.08.2026journal-article

Proceedings of the National Academy of Sciences

Loss of Sox10 prevents tumor initiation in vivo and induces luminal-to-basal reprogramming in Neu+ tumor cells

Brennan Garland, Samuel Delisle, John Abou-Hamad, Christiano de Souza, Riana Zuccarini, David P. Cook, Rebecca C. Auer, Luc A. Sabourin

The SRY-HMG-Box transcription factor SOX10 plays a critical role in neural crest development, but its function in epithelial tumorigenesis remains unclear. Here, we identify SOX10 as a key regulator of tumor-initiating activity in Neu-driven mammary cancers. Genetic ablation of Sox10 in the luminal compartment of MMTV-Neu (NIC) mice resulted in delayed but normal mammary gland development. Sox10 deletion resulted in a reduction in mammary progenitors and a complete loss of tumor initiation in Sox10-deficient lumina …

21.08.2026journal-article

JMIR Pediatrics and Parenting

Examining the Characteristics of Adolescents Recruited to a Novel Digital Treatment for Eating Disorders: Baseline Assessment in an Open Feasibility Trial

Guri Holgersen, Emilie Sektnan Nordby, Irene Bircow Elgen, Ester Marie Stornes Espeset, Tine Nordgreen

Abstract Background Digital interventions for eating disorders have the potential to increase access to care and broaden the range of treatment options for adolescents. However, little is known about the characteristics of those who seek these interventions. Identifying such characteristics will help ensure that these interventions meet the needs of the target population, highlight potentially underrepresented groups, and support clinicians in assessing clinical suitability for individual patients. Objective This s …

21.08.2026journal-article

Brain Sciences

Tinnitus Phenotypes and Their Response to the Enriched Acoustic Environment (EAE) Treatment

Charles Bouzou, Marta Fernández-Ledesma, María Cuesta, Pedro Cobo

Background/Objectives: The aim of this study was to apply data-driven clustering techniques for the subtyping of tinnitus severity to a retrospective cross-sectional cohort of 564 subjects. Additionally, the response of the resulting phenotypes to an enriched acoustic environment (EAE) treatment was investigated. Methods: A hierarchical decision cascade was applied to classify the measured audiograms of participants into six hearing loss (HL) patterns. K-clustering techniques were applied to demographic (gender), h …

21.08.2026journal-article

Journal of Psycholinguistic Research

Enhancing Pragmatic Communication in Healthy Aging: A Preliminary Investigation of the Long-Term Effects of the Advanced Cognitive Pragmatic Treatment

Ilaria Gabbatore, Giorgia Vegna, Dize Hilviu, Ariele Merlini, Francesca M. Bosco

Abstract The aging process is associated with changes in cognitive and communicative skills, including pragmatic one, the ability to appropriately use language and other expressive means in social contexts. Despite its importance for quality of life and autonomy, the decline of pragmatic ability has received little attention in aging research and intervention. This preliminary study aims to investigate the efficacy and specificity of the Advanced Cognitive Pragmatic Treatment (Advanced-CPT), a novel training progra …

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21.08.2026journal-article

Clinical Cancer Research

Utilizing Machine Learning to Identify Multimodal Signatures for Patients Who Would Benefit from the Addition of Tremelimumab to Durvalumab and Chemotherapy (TRIDENT)

Ferdinandos Skoulidis, Salma K. Jabbour, Edward B. Garon, Puneeth Iyengar, Giorgio Scagliotti, Loïc Ferrer, Guillaume Etchepare, Olivier Gallinato, Jérôme Faure, Paul Bernard, Thierry Colin, Philippe Menu, Yian Lin, Ling Cai, Ammar Ahmed Chaudhry, Amanda Remorino, Ross Stewart, Luisa Luciani-Silverman, Katy Miller, David Dellamonica, Jolyon Faria, Yiduo Zhang

Abstract Purpose: POSEIDON (NCT03164616) was a randomized, open-label, multicenter phase III trial comparing first-line durvalumab with or without tremelimumab in combination with chemotherapy versus chemotherapy alone in patients with metastatic non–small cell lung cancer (NSCLC). Overall survival (OS) and progression-free survival were significantly increased in the tremelimumab plus durvalumab and chemotherapy arm. We conducted a post hoc analysis (TRIDENT) to identify patients who may receive greater OS benefit …

21.08.2026journal-article

International Journal of Health Management Review

THERAPEUTIC STRATEGIES AND SURGICAL MANAGEMENT IN THE TREATMENT OF EQUINE OSTEOARTHRITIS

Vitória Ferreira Gonçalves, Maria Luiza Vieira Martinez, Cryscia Rodrigues de Andrade, Luiza Junqueira Nunes, Fernanda Tonato Costa, Luis Aparecido Bortolotto Alves, Amanda Monteiro dos Santos, Pedro Augusto Andrade Sousa Orzia, Vanusa Vieira Dias, Stephany Rocha Cavalcanti, Filipe Costa Ferreira da Silva

Osteoarthritis (OA) is one of the most prevalent musculoskeletal disorders in horses, representing the leading cause of lameness and loss of athletic performance (Estrada McDermott et al., 2021). Although historically classified as a purely degenerative pathology resulting from chronic mechanical wear, the pathogenesis of OA is now recognized as a multifactorial, low-grade inflammatory process in which the innate immune system—particularly synovial macrophages—plays a central role in perpetuating articular cartilag …

21.08.2026journal-article

Journal of Neuro-Oncology

Five-year changes in health-related quality of life after proton therapy in a primarily meningioma cohort: a prospective study

Per Fessé, Linda Åkeflo, Karin Ahlberg, Emelie Blomqvist, Per Fransson, Ingrid Kristensen, Kristin Kunni, Ulrica Langegård, Emma Ohlsson-Nevo, Katarina Sjövall

Abstract Purpose Long-term patient-reported outcomes after Proton beam therapy (PBT) remain insufficiently described for patients with benign intracranial and seller-region tumors. The aim of this study was to evaluate health-related quality of life (HRQoL) and brain tumor–specific symptoms over five years after PBT in a primarily meningioma cohort. Methods In this prospective cohort study, adults treated with PBT completed the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and QLQ-BN20 …

21.08.2026journal-article

Baghdad Science Journal

Optical and Structural Characterization of Sn@Zn and Sn Core-Shell Nanoparticles Synthesized by PLAL: Evaluation of Prostate Cancer

Aya K. Mahmoed, Sabah N. Mazhir

In this study, Sn nanoparticles and Sn/Zn core-shell nanoparticles were synthesized using (PLA) techniques. Pulsed laser ablation with a (1064 nm) wavelength, (6 Hz) frequency, (300 mJ) energy, and (250 pulses) number of shots was used to subject colloidal dispersions of Sn and Zn, and bimetallic Sn@Zn core/shell nanoparticles were generated by the metal target in 15 mL of distilled water (DW). The investigation of nanoparticles was done by X-ray diffraction (XRD), atomic force microscopy (AFM), UV-VIS spectroscopy …

21.08.2026journal-article

ACS Nano

Living Microbe-Driven Bioorthogonal Catalysts Enables Cytotoxin Generation, Cuproptosis and Lactate Depletion for Synergistic Tumor Therapy

Lili Xia, Xiangxuan Chao, Zitong Zhao, Xiaozhen Zhou, Chenyao Wu, Xinran Song, Wenli Zhou, Yuyao Li, Wei Feng, Yu Chen

Abstract Bioorthogonal chemistry provides a compelling strategy for in situ cytotoxin generation. However, the clinical translation of conventional bioorthogonal catalysts is impeded by poor tumor accumulation, insufficient targeting specificity, limited in vivo catalytic efficiency, and inadequate spatiotemporal control. Meanwhile, excessive lactate accumulation in the tumor microenvironment (TME) drives metabolic reprogramming, malignant progression, and therapeutic resistance. Here, we develop a living bacterial …

21.08.2026journal-article

International Journal of Health Management Review

DIAGNOSTIC CHALLENGES AND TREATMENT OPTIONS FOR ATHEROSCLEROSIS IN DOGS

Letícia de Oliveira Del Tedesco, Maria Eduarda Andrade de Carvalho, Isadora Pinto Sobreira, Larissa Marques Luque, Lucas Eduardo Silva Favaro, Camile Carvalho de Castro, Leticia Lais Zambiasi, Júlia Maso Rissardi, Cleidiane Maria Aguiar da Silva, Tassili Queiroz de Oliveira Costa, Mirella Rangel Teixeira, Mykaela Kessya da Silva Ferreira, Karoline Wencionek Nunes

Atherosclerosis in dogs is a chronic inflammatory vascular disease that occurs infrequently but is clinically significant due to its association with ischemic events and severe systemic complications. This narrative review analyzed the pathophysiology, metabolism, diagnostic methods, and therapeutic management of the disease. Results indicate that lipid metabolism disorders, endocrinopathies (such as hypothyroidism and hyperadrenocorticism), endothelial dysfunction, and pro-thrombotic states are the primary factors …

21.08.2026journal-article

Cancers

SMAD7-Associated Glycolytic Regulation Promotes Lactate-Dependent Macrophage Phenotype Modulation in Colorectal Cancer

Marco Colella, Andrea Iannucci, Rachele Frascatani, Claudia Maresca, Viviana Casagrande, Vincenzo Formica, Edoardo Troncone, Andrea Divizia, Massimo Federici, Giovanni Monteleone

Colorectal cancer (CRC) progression is shaped by dynamic interactions between tumor-intrinsic metabolic adaptations and immune remodeling within the tumor microenvironment. In CRC, the expression of SMAD7, a classical inhibitor of TGF-β1 signaling, is increased and has been associated with tumor-associated inflammatory responses and malignant progression. In this study, we investigated the potential role of SMAD7 in regulating glycolytic metabolism and macrophage phenotype in CRC. Knockdown of SMAD7 in CRC cell lin …

21.08.2026journal-article

Advanced Science

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang

ABSTRACT The efficacy of chemotherapy in colorectal cancer (CRC) is closely linked to its ability to remodel the tumor immune microenvironment (TIME), though the underlying molecular determinants remain incompletely defined. Here, we identified tumor‐cell intrinsic autophagy as a pivotal orchestrator of an immunologically active TIME, essential for chemotherapy response. We demonstrated that 5‐FU/Oxaliplatin treatment triggers autophagy‐dependent TIMP‐2 production, which restrains MMP‐2/9 activity and promotes intr …