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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
10.08.2026journal-article

International Journal of Current Science Research and Review

Biological Characteristics, Innovative Isolation Methods, and Clinical Role of Exosomes in Cancer Therapy: Review

Abdul Rauf Samim, Mohammad Naser Sabawoon, Mohammad Aziz Khan Amirzai

Exosomes are a subset of nano-sized (30–150 nm) extracellular vehicles (EVs) released by cells through the endosomal route, you know like they get made inside and then pushed out. Objective: The primary objective of this scientific review is to give a broad and current appraisal of the intricate biological layout of exosomes, plus modern isolation technologies (for instance microfluidics and spectroscopy), and finally their clinical meaning for cancer detection and treatment. Methods: This article is arranged follo …

10.08.2026journal-article

The Family Journal

Where Is the Medical Family Therapist in Grey's Anatomy and The Pitt ? A Cinema Therapy Perspective

Afarin Rajaei, Danna Abraham, Katherine M. Hertlein

Medical television dramas significantly influence the public's understandings of healthcare systems, professional identities, emotional care, and relational dynamics in medical settings. Despite the deeply relational nature of these storylines, Medical Family Therapists (MedFTs) remain largely absent from these representations of healthcare. Drawing from systemic theory, narrative medicine, and Medical Family Therapy literature, in this article, we analyze themes including physician burnout, moral injury, family co …

10.08.2026journal-article

Problems of Balneology, Physiotherapy and Exercise Therapy

Оценка результативности муниципальных программ поддержки санаторно-курортного комплекса города Сочи в постолимпийский период (2014–2024)

Н. Л. Красюкова, О. В. Панина, С. Г. Еремин, А. О. Кузьмина, Н. Г. Преснякова

Introduction: The sanatorium-resort complex of Sochi, which accounts for 75% of the municipal gross product, underwent a fundamental transformation following the 2014 Olympic Games. Cumulative tourist flow over the post-Olympic decade totaled 72.2 million visitors, while the municipal budget potential increased from 10.6 to 64.0 billion rubles. Despite massive public investment, a comprehensive assessment of the effectiveness of municipal support programs remains fragmented. Objective: To evaluate the effectiveness …

10.08.2026journal-article

Small

Injectable Optoelectronic Probe With In Situ Photoactivation and ROS Monitoring for Oxygen‐Dependent Metronomic Photodynamic Cancer Therapy

Jagyeong Goo, Gyan Raj Koirala, Taeyeon Lee, Hanhee Cho, Seong Ik Jeon, Wan Su Yun, Jeongrae Kim, Lili Guo, Suyoun Oh, Won‐Gun Koh, Jongho Lee, Tae‐il Kim, Kwangmeyung Kim

ABSTRACT Photodynamic therapy (PDT) offers an effective and minimally invasive approach to cancer treatment; however, its efficacy is intrinsically constrained by limited light penetration, which fails to target deep tumor tissues, and treatment‐induced hypoxia arising from the reduction in intratumoral oxygen levels. Here, we report an injectable optoelectronic probe integrating microscale light‐emitting diodes (microLEDs) to enable low‐frequency metronomic PDT (mPDT), together with a microLED–photodetector system …

10.08.2026journal-article

Frontiers in Pharmacology

Cost-effectiveness analysis of triplet therapy of encorafenib, binimetinib, and cetuximab for treatment of metastatic BRAF V600E-mutated colorectal cancer in China

Mengmeng Liu, Tong Liu

Background This study evaluates the cost-effectiveness of triplet therapy of encorafenib, binimetinib, and cetuximab in contrast to doublet therapy of encorafenib and cetuximab or a control group of cetuximab plus FOLFIRI as second-line or subsequent treatment for advanced or metastatic colorectal cancer (mCRC) patients with BRAF V600 E mutation-positive status in China. Methods An economic evaluation using a 3-state partitioned survival model assessed the cost-effectiveness of triplet therapy versus doublet therap …

10.08.2026journal-article

Jurnal Pendidikan Teknik Mesin

BIOMECHANICAL SENSITIVITY OF A THREE-IMPLANT MANDIBULAR REHABILITATION MODEL UNDER ORTHOTROPIC BONE PROPERTY VARIATIONS: A 3D FINITE ELEMENT STUDY

Alifian Bagas Saputra, Kriswanto, Septian Eko Cahyono, Jamari, Athanasius Priharyoto Bayuseno, Dhiaulhaque, Hastaka Juan Pratama Putra

Achieving clinical effectiveness depends on an awareness of the mechanical features of implanted supported mandibular prosthesis. This study used three-dimensional finite element analysis to assess how sensitive a three-implant mandibular arrangement is to changes in the properties of cortical and cancellous bone. Using Ti-6Al-4V material, implants were shown; the bone was defined with orthotropic linear-elastic properties. Young's modulus and shear modulus were systematically changed by 5–15%. Under a 100 N axial …

10.08.2026journal-article

Cancers

The Influence of the Central Metal (Zn) in the Porphyrin Skeleton on the Mechanism Induced by Photodynamic Therapy

Rostyslav Marunych, Dorota Bartusik-Aebisher, Barbara Smolak, Klaudia Dynarowicz, David Aebisher

This review analyzes how Zinc(II) coordination alters the electronic configuration of porphyrin-based photosensitizers to optimize reactive oxygen species (ROS) generation and subcellular targeting in photodynamic therapy (PDT). By focusing on the structural design principles that govern excited-state behavior, the work moves beyond clinical descriptions to provide a mechanistic understanding of how engineered metalloporphyrins can achieve precise tumor destruction. When these engineered metal porphyrins are expose …

10.08.2026journal-article

Journal of College of Education

<b>تعرض المراهقين لمواقع التواصل الاجتماعي والاخبار الزائفة في مواقع التواصل الاجتماعي</b> <b>وتأثيرها على انتشار خطاب الكراهية والتطرف لدي المراهقين</b>

م.م. بسام كريم زيدان

هدفت هذه الدراسة إلى تحليل تأثير الأخبار الزائفة المنتشرة عبر مواقع التواصل الاجتماعي على انتشار خطاب الكراهية والتطرف لدى المراهقين. وتسعى إلى تحديد العوامل التي تسهم في انتشار الأخبار الزائفة بين هذه الفئة العمرية. وأعتمدت الدراسة على المنهج الوصفي التحليلي، حيث تم جمع البيانات باستخدام استبيان وُزّع على عينة عشوائية مكونة من 250 مراهقًا تتراوح أعمارهم بين 13 و18 سنة، ممن يعتمدون على مواقع التواصل الاجتماعي كمصدر رئيسي للمعلومات. واشتمل الاستبيان على أربعة محاور رئيسية: المعلومات الديموغرافية، مقياس التعرض للأخبا …

10.08.2026journal-article

Problems of Balneology, Physiotherapy and Exercise Therapy

Финансовые последствия ухудшения качества рекреационных вод Черноморского побережья для санаториев климатобальнеологического профиля Большого Сочи

А. А. Бакулина, И. Ю. Ильина, Л. В. Адамская, В. Э. Комов, И. А. Бартошевич

Introduction: The Black Sea coast of Greater Sochi is the largest climate-balneological cluster in the Russian Federation, generating over 26 billion rubles in annual revenue from health resort organizations. The accident involving the tankers Volgoneft-212 and Volgoneft-239 in the Kerch Strait in December 2024, resulting in a spill of approximately 4,000 tonnes of fuel oil, highlighted the financial vulnerability of health resorts operating under conditions of systematically declining recreational water quality. M …

10.08.2026journal-article

Frontiers in Pharmacology

Cost-effectiveness of targeted therapy versus chemotherapy for patients with advanced or metastatic gastric cancer in China

Kehui Meng, Meiyu Wu, Andong Li, Zixuan Zhang, Yangke Yi, Chaohao Shi, Xiaomin Wan, Chongqing Tan, Hao He

Background Multi-biomarker testing increasingly guides first-line therapy for advanced or metastatic gastric cancer in China, but its economic value is uncertain. Methods We conducted a Chinese healthcare payer–perspective cost-effectiveness analysis comparing a testing-guided pathway with No-testing, using a hybrid decision tree plus three-state Markov model for a 1,000-patient cohort over 10 years. Results Testing-guided care increased costs by $64,242.13 and quality-adjusted life years (QALYs) by 0.63, yielding …

10.08.2026journal-article

Frontiers in Oncology

Rezvilutamide combined with ADT in an HIV-positive patient with high-volume mHSPC on efavirenz-based antiretroviral therapy: a case report

Heng Zhang, Tailin He, Zhiyuan Li, Yujie Gao, Yan Li, Yundie Zhou, Haifeng Wang

This case report describes a patient with metastatic hormone-sensitive prostate cancer (mHSPC), high tumor burden, and concurrent HIV infection receiving continuous efavirenz (a potent CYP3A4 inducer), who was treated with an intensified regimen based on androgen deprivation therapy (ADT) combined with the novel androgen receptor inhibitor rezvilutamide. Under rigorous multidisciplinary monitoring, this regimen achieved a rapid and profound response, characterized by a decline in prostate-specific antigen (PSA) lev …

10.08.2026journal-article

Gestión en Salud y Seguridad Social

Medicina laboral: una ciencia en el contexto actual

Laura Isabel Mata Jiménez

De acuerdo con la Organización Mundial de la Salud (OMS), el hospital forma parte de una organización médica y social, cuya misión consiste en proporcionar a la población asistencia sanitaria completa, tanto curativa como preventiva, con proyección hacia el ámbito familiar, además de contribuir con la formación del personal sanitario y la investigación biosocial.

10.08.2026journal-article

BMC Cardiovascular Disorders

Causal beliefs and behavioural self-evaluation in cardiac rehabilitation: a cross-national study in the United States and Japan

Tamami Shirai

Abstract Background Patients with established cardiovascular disease (CVD) continue to face substantial residual risk of recurrent events despite optimal medical management. Beliefs about disease causation, particularly attribution to genetic versus lifestyle factors, may influence health behaviour; however, their relationship with behavioural self-evaluation remains poorly understood. This study examined (1) cross-national differences in causal beliefs between patients in the United States (US) and Japan, and (2) …

10.08.2026journal-article

Critical Care Medicine

Heterogeneous Treatment Effects of Renal Replacement Therapy in Critically Ill Patients: A Multicenter Observational Study Using a Japanese ICU Registry

Sae Nakamura, Kosuke Inoue, Kazunari Takahashi, Shun Maeda, Tomoko Fujii

Objective: Randomized trials evaluating the timing of renal replacement therapy (RRT) have informed current practice toward more conservative initiation strategies because of the lack of mortality benefit from early initiation. However, the optimal indications for RRT to offer lifesaving benefits remain uncertain. We aimed to estimate heterogeneous treatment effect of RRT and to identify patient groups associated with benefit or harm. Design: Multicenter observational study. SETTING: A nationwide intensive care reg …

10.08.2026journal-article

Life

Generative AI and Large Language Models in Rehabilitation: A Scoping Review

Su-Min Cha

Generative artificial intelligence (AI) and large language models (LLMs) are increasingly evaluated in rehabilitation, yet their clinical validity, reproducibility, and safety remain uncertain. This scoping review mapped peer-reviewed studies of generative AI/LLMs across rehabilitation assessment, clinical reasoning, decision support, planning, education, and functional classification. Following JBI methodology and PRISMA-ScR, five databases were searched for English-language studies published from 1 January 2015 t …

10.08.2026journal-article

Advanced Materials

Ultrasound‐Driven Interfacial Electron Modulation Reprograms Mitochondrial Metabolism for Glioblastoma Therapy

Wen Zhang, Boyu Wang, Shunran Peng, Long Zhang, Ruijie Huang, Fan Gao, Weiqiang Huang, Weiyong Liu, Xuan Nie, Yezi You, Fei Wang

ABSTRACT Glioblastoma (GBM) remains difficult to treat because the restrictive blood–brain barrier (BBB), the hypoxic tumor microenvironments, and mitochondrial electron transport chain (ETC)‐driven metabolic adaptability jointly limit therapeutic delivery and efficacy. Selective disruption of mitochondrial metabolism in GBM is challenging because ETC function is also essential for normal brain cells, and many therapeutic agents show limited BBB penetration or reduced activity under oxygen‐limited conditions. Here, …

10.08.2026journal-article

Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science

Personalized knee rehabilitation using a crank-adjustable four-bar mechanism with optimized ICR trajectories

Gurpreet Singh, Naresh K. Raghuwanshi, Ramanpreet Singh

Aging often leads to mobility issues from conditions like arthritis and stroke, causing knee pain and limiting daily activities. Effective rehabilitation is vital for restoring function and enhancing quality of life. However, most knee rehabilitation devices lack adaptability to individual knee joint kinematics, particularly the variable instantaneous center of rotation (ICR) during gait. This study proposes a crank-length adjustable four-bar mechanism device for knee rehabilitation in subjects of three different s …

10.08.2026journal-article

Problems of Balneology, Physiotherapy and Exercise Therapy

Экономическое обоснование санаторного этапа реабилитации как инструмента снижения затрат системы обязательного медицинского страхования

Н. А. Барменкова, В. С. Новиков, Х. Х. Рамалданов, Ю. Ю. Орлов, В. В. Суряднов

Introduction: As Federal Mandatory Health Insurance Fund (FOMIF) expenditures reached 3.89 trillion rubles in 2024 with a deficit of 19.02 billion rubles, finding cost-optimization mechanisms while maintaining healthcare quality becomes critical. Sanatorium-stage rehabilitation is considered a potentially cost-effective tool for reducing readmission rates and direct medical costs, yet its quantitative impact on the mandatory insurance system under Russian conditions remains fragmented. Objective: To develop and val …

10.08.2026journal-article

Advanced Science

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang

ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy is largely ineffective in most solid tumors, partially because of inadequate intratumoral trafficking. Bridging therapy, administered between leukapheresis and CAR‐T cell infusion, offers a distinct opportunity to control the disease and precondition the tumor microenvironment without directly exposing CAR‐T cells to concomitant drugs. Here, a poly (ADP‐ribose) polymerase (PARP) inhibitor combined with anlotinib is evaluated as bridging therapy for ovarian can …

10.08.2026journal-article

International Journal of Bioprinting

3D-printed scaffolds for periodontitis therapy: Spatial programming and microenvironmental regulation

Ziyi Xu, Huina He, Yue Wang, Yuxuan Sun, Haoyang Wu, Jingchen Xu

Periodontitis is a chronic inflammatory disease characterized by plaque biofilm dysbiosis, immune dysregulation, oxidative stress, alveolar bone resorption, and impaired wound healing. Although conventional periodontal therapies can reduce microbial burden and slow disease progression, predictable regeneration of the cementum-periodontal ligament (PDL)-alveolar bone complex remains difficult in irregular, infected, and inflammation-compromised defects. Three-dimensional (3D) printing offers a programmable strategy …

10.08.2026journal-article

Behavioral Sciences

The Effects of Expressive Arts Therapy on Emotion Regulation and Aggression in Violent Offenders: A Randomized Controlled Trial

Zhijie Xu, Xixi Ou, Jialin Fan

Violent crime is a widely recognized public health concern. According to emotion regulation theory, aggressive behavior in violent offenders is linked to maladaptive emotion regulation strategies. However, few studies have explored interventions targeting emotional factors to reduce aggression in this population. Expressive arts therapy (EAT), which facilitates emotional expression and release, has shown therapeutic potential, but its effectiveness for violent offenders remains understudied. This randomized control …

10.08.2026journal-article

Applied Artificial Intelligence Research

Research on the Coupling Mechanism of AI-Empowered Inter-library Mutual Assistance and Reading Therapy in Digital Intelligent Libraries from the Perspective of Educational Equity

Nan Liu

Educational equity is a cornerstone of social equity in modern society. As a new type of knowledge service infrastructure, digital intelligent libraries bear an important mission in promoting educational equity. At present, interlibrary mutual assistance has achieved notable results in resource co-construction and sharing, but deep collaboration at the service level still needs to be strengthened. Bibliotherapy has gradually developed in library service practices, yet it mostly remains at the stage of independent e …

10.08.2026journal-article

Psychotherapy & Politics International

Unspoken difference

Dr Ishba Rehman

Amid a deeply divided political and social landscape, racially minoritised therapists face unique challenges in inter-racial therapy. As communities grow more diverse but also more divided, helping professions, including counselling and psychotherapy, must critically reflect on their positionality when engaging with difference. Understanding how ‘difference’ is experienced by both therapist and client is vital. This study draws on critical race theory (CRT) to explore the complexities of difference, power, and iden …

10.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

EFICÁCIA DA OZONIOTERAPIA NO TRATAMENTO DE ÚLCERAS DIABÉTICAS: UMA REVISÃO INTEGRATIVA DA LITERATURA

Nicole Alencar Teixeira, Larissa Lima de Abrantes, Mirele Neris Araujo, Sarah Oliveira Viana, Isabel Verlangeiro Vieira, Renata Aparecida Elias Dantas

Esse artigo buscou analisar a eficácia da ozonioterapia em tratamentos com úlceras diabéticas, em comparação aos tratamentos convencionais, através de uma revisão integrativa da literatura. A metodologia consistiu na busca de estudos nas bases de dados bibliográficos PubMed/MEDLINE, Biblioteca Virtual (BVS), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Web of Science (Coleção Principal da Clarivate), nas quais foram utilizados descritores em ciências da saúde (DeCS), “Ozone Therapy” AND “ …