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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Bioengineering

Computational Oncology of Chemotaxis-Driven Tumour–Immune Spatial Patterning and Stability

Zonghao Liu, Jiguang Yu, Louis Shuo Wang, Lei Su, Ye Liang, Yang Du, Jingfeng Liu

We develop a reaction–diffusion–chemotaxis model for spatial tumour–immune–chemokine dynamics that couples logistic tumour growth, immune-mediated killing, chemokine-dependent immune recruitment, chemotactic migration, and signal production. For the non-dimensional system, we establish local classical solvability, nonnegativity, a uniform tumour-density bound, and global mass estimates for the immune and chemokine components. The tumour-free equilibrium is stable precisely when the baseline immune-control index sat …

2 Zitationen
21.08.2026journal-article

Anti-Cancer Agents in Medicinal Chemistry

Research Progress on the Antitumor Effects of Isorhamnetin (ISO) and Its Molecular Mechanisms

Yanan Hua, Xinxu Shen, Shuqi Niu, Jinlin Guo

Introduction: Cancer remains a leading contributor to global mortality, and current therapeutic interventions continue to grapple with significant limitations. The multi-target characteristics and low toxicity of natural products position them as promising sources of novel anti-tumor agents. Isorhamnetin (ISO), a naturally occurring O-methylated flavonol, exemplifies this potential, demonstrating diverse bioactivities such as cardiovascular protection, inflammation modulation, and cancer suppression. Method: This r …

21.08.2026journal-article

Farmaciâ Kazahstana

THE ROLE OF IVABRADINE IN THE EFFECTIVE TREATMENT OF POSTURAL ORTHOSTATIC TACHYCARDIA ARTER «COVID-19»

Arailym Seydanova, Khamida Abdikadirova, Aikerym Ikromova, Sevinch Abdinabieva, Sevinch Rezhametova, Akniet Adil

Introduction: COVID-19 is a novel type of coronavirus that has had a profound impact on global human health and economic systems. Since its emergence in 2019, it has escalated into a worldwide pandemic, resulting in significant mortality across populations. The COVID-19 pandemic not only led to a spike in acute-phase illnesses and deaths, but also, over time, contributed to the development of so-called “long COVID” or chronic post-COVID symptoms in many patients over time. One manifestation of post-COVID syndrome i …

21.08.2026journal-article

Leukemia

Health status impairments in tyrosine kinase inhibitor-treated chronic myeloid leukemia patients versus blood or marrow transplant survivors and non-cancer controls

Smita Bhatia, Qingrui Meng, Lindsey Hageman, Sarah B. Palmer, Eunice E. Choe, Nora Balas, Wendy Landier, Omer Jamy, Pankit Vachhani, Alysia Bosworth, F. Lennie Wong, Jorge Cortes, Stephen J. Forman, Daniel J. Weisdorf, Saro H. Armenian, Ravi Bhatia

Abstract Tyrosine kinase inhibitor (TKI) therapy has resulted in a significant reduction in chronic myeloid leukemia (CML)-related mortality. However, the impact of TKIs on the health status of long-term CML survivors remains unstudied. We examined the health status of 62 TKI-treated CML patients who did not receive blood or marrow transplantation (BMT) (CML_TKI; median follow-up: 12.5 y) compared with an unaffected population (303 non-CML controls), and CML patients treated with BMT but without TKI exposure (220 C …

21.08.2026journal-article

International Journal of Colorectal Disease

Endopelvic fascia in rectal cancer surgery: cadaveric anatomy and histological continuity between the obturator fascia and the rectum

Satoru Muro, Yuichiro Tsukada, Masaaki Ito, Akimoto Nimura, Keiichi Akita

Abstract Purpose In rectal cancer surgery, dissection on either side of the endopelvic fascia (EPF) determines whether this layer remains on the pelvic wall or is included with the specimen. However, its continuity with adjacent pelvic wall and rectal supporting tissues, and the anatomical meaning of these local dissection planes, remain unclear. This cadaveric study aimed to clarify the macroscopic and histological characteristics of the EPF in relation to the obturator fascia, rectal wall, and hiatal ligament. Me …

21.08.2026journal-article

Medicine

Prognostic factors and outcomes associated with postmastectomy radiation therapy following neoadjuvant chemotherapy and mastectomy for breast cancer

Hye Jin Kang, Myungsoo Kim, Yoo-Kang Kwak, So Jung Lee

The indications for postmastectomy radiation therapy (PMRT) after neoadjuvant chemotherapy (NAC) remain controversial. We aimed to identify prognostic factors and investigate subgroups in which PMRT could improve treatment outcomes. This study included 178 patients with clinical stage II–III breast cancer who underwent mastectomy after NAC between May 2006 and December 2022. PMRT was administered to 149 (83.7%) patients. The median follow-up period was 64 months. The response to NAC, molecular subtype, and patholog …

21.08.2026journal-article

Current Cancer Drug Targets

Pharmaceutical Potential of Antibody-Drug Conjugate Doublets for Targeted Treatment of Cancers Heterogeneously Expressing RON Receptor Tyrosine Kinase

Durga Puro, Sreedhar Reddy Suthe, Hang-Ping Yao, Ming-Hai Wang

Introduction/Background: Limited RON expression by cancer cells is detri-mental for the therapeutic efficacy of Antibody-Drug Conjugates (ADCs). The present study aimed to validate a pharmaceutical strategy of using ADCs in vitro to target cancer cells with RON expression below the therapeutic threshold. Materials and Methods: Anti-RON ADCs Zt/g4-MMAE and H5B14-DCM, with distinct epitope-binding properties and different payload-effect mechanisms, were formulated to form anti-RON ADC doublets. Hydrophobic interactio …

21.08.2026journal-article

Clinical and Experimental Reproductive Medicine

Lactoferrin treatment ameliorates endometriosis-associated subfertility in a rat model

Mona M. Abdel Baky, Maggie E. Amer, Marwa Abass, Mohammed A. Elmetwally, Heba A. El-Ghaweet

Objective: Endometriosis is a chronic inflammatory disorder that affects approximately 10% of reproductive-age women and is frequently associated with subfertility. This study evaluated the potential ameliorative effect of lactoferrin on endometriosis-associated subfertility in a rat model.Methods: Rats were allocated into four groups: Sham, Sham+Lacto, Endo, and Endo+Lacto. In these group labels, “Endo” denotes endometriosis and “Lacto” denotes lactoferrin. Endometriosis was surgically induced in the Endo and Endo …

21.08.2026journal-article

Neuro-Oncology Pediatrics

A Phase I Trial of the ADAM-10 inhibitor, INCB007839, in Children with Recurrent/Progressive High-Grade Gliomas: A Report from the Pediatric Brain Tumor Consortium (PBTC-056)

Alicia Lenzen, Sonia Partap, Catherine Billups, Tina Young Poussaint, Sameer Farouk Sait, Nathan Robison, Sheila McThenia, James Felker, Clinton F Stewart, Jason Fangusaro, Arzu Onar-Thomas, Ira J Dunkel, Katherine E Warren, Michelle Monje

Abstract Background Pediatric high-grade gliomas (pHGGs), including diffuse midline glioma (DMG) and diffuse intrinsic pontine glioma (DIPG), are the leading cause of central nervous system tumor-related morbidity and mortality in children. Neuronal activity promotes pHGG growth; one key mechanism is neuronal activity-regulated shedding of neuroligin-3 into the glioma microenvironment, mediated by protease ADAM (A Disintegrin and Metalloprotease) 10. INCB007839, an ADAM 10 inhibitor, was used in this trial to block …

21.08.2026journal-article

Obstetric Anesthesia Digest

Comparative Effectiveness of Diverse Strategies for the Prevention or Treatment of Epidural-Related Maternal Fever: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

R Yu, X Deng, N Hu, DX Chen

( Am J Obstet Gynecol . 2025 Dec;233(6):581–590.e30. doi: 10.1016/j.ajog.2025.07.029) The gold standard treatment for labor pain is epidural analgesia, and there is a large body of evidence that establishes its safety for both mothers and babies. Protocols vary based on institution, and can include differences in concentration, drug composition, and timing. Despite this variation, a common concern is epidural-related maternal fever (ERMF). ERMF is estimated to occur in 15% to 25% of patients who receive epidural an …

21.08.2026journal-article

Frontiers in Oncology

Primary splenic angiosarcoma presenting with multiple bone destruction as the initial manifestation: a case report and narrative review

Weijun Wang, Xia Liu

Background Primary splenic angiosarcoma (PSA) is an extremely rare and highly aggressive malignant vascular tumor. Its clinical presentation is often nonspecific, and the diagnosis is frequently delayed. Osseous metastasis as the initial clinical manifestation is particularly uncommon, posing significant diagnostic challenges. A critical yet underappreciated phenomenon is the discordance between histological differentiation and biological behavior in angiosarcoma: well-differentiated tumors can exhibit highly aggre …

21.08.2026journal-article

Frontiers in Oncology

Development of a nomogram for predicting axillary pathologic complete response after neoadjuvant therapy in clinically node-positive breast cancer

Bin Li, An Yi, Tenghua Yu, Yongqiang Bao, Lihong He, Zhuoyu He, Jin Liu, Yan Liu, Chunling Jiang

Background Reliable and accessible tools for estimating axillary pathologic complete response (ax-pCR) after neoadjuvant therapy (NAT) remain limited. This study evaluated whether routinely available biomarkers measured before and after NAT provide complementary information for ax-pCR prediction. Methods We conducted a retrospective study of patients with clinically node-positive, non-metastatic breast cancer who underwent NAT followed by surgery. Clinicopathological characteristics, treatment information, serum al …

21.08.2026journal-article

BMC Urology

Association of metformin use with metabolic trajectories and disease progression in prostate cancer patients receiving androgen deprivation therapy: a target trial emulation study

Yongkai He, Liang Tang, Kun Yuan, HuiYing Liu, ZhiWei Huang, Zhen Liu, Yu Liu, Quan Yang, Bo Chen

Abstract Background Androgen deprivation therapy (ADT) is associated with substantial metabolic deterioration in patients with prostate cancer. Metformin may attenuate ADT-related metabolic complications, although its association with longitudinal metabolic trajectories and prostate cancer outcomes remains uncertain. Methods We conducted a retrospective cohort study emulating a target trial using a 90-day landmark design. Patients with prostate adenocarcinoma initiating ADT between 2015 and 2020 were classified acc …

21.08.2026journal-article

Jurnal Polimesin

Comparative evaluation of post-weld heat treatment (PWHT) temperature effects on GMAW-welded SS400 and AISI 1045 Steels

Rafsanzani Pane, Sudirman Lubis, Benny Oktrialdi, Sawirman Sawirman, Irfan Nofri

Post-weld heat treatment (PWHT) can modify the microstructure and mechanical properties of welded steels through recovery, recrystallization, and grain growth. This study investigated the effect of PWHT temperature on the mechanical properties and microstructure of SS400 and AISI 1045 steels welded using the gas metal arc welding (GMAW) process. The welded joints were prepared using a single-V groove configuration with a constant welding current of 130 A, ER70S-6 filler metal, and CO₂ shielding gas. After welding, …

21.08.2026journal-article

Revista ft

Exame citológico versus teste de DNA-HPV: revisão de literatura sobre métodos de rastreamento do câncer do colo do útero nas perspectivas atuais

Soelley Duarte Alves da Silva, Carlos Murilo Lopes, Divonete Ursulino da Silva, Marilene Duarte de Araújo, Conceição Adriane Nóbrega de Mendonça, Severina Ramos Nóbrega de Mendonça, Jane Pereira da Silva, Osani Barbosa Machado, Ednalva Gomes Oliveira da Silva, Claudiomar Angelo Gomes Sampaio, Yara Cecy Araujo Veloso, Eduardo Paulo Queiroz

INTRODUCTION: Cervical cancer is a prevalent malignancy in Brazil, primarily caused by persistent infection with high-risk Human Papillomavirus (HPV). OBJECTIVE: This review synthesized evidence regarding the diagnostic accuracy of conventional cytology compared to HPV-DNA testing, supporting the transition to molecular screening in Brazilian guidelines. MATERIALS AND METHODS: A systematic search was conducted in MEDLINE, LILACS, and SCOPUS for studies published between 2015 and 2025, analyzing 17 selected investig …

21.08.2026journal-article

Pharmaceutical Statistics

Seamless Phase I– II Cancer Clinical Trials Using Kernel‐Based Covariate Similarity

Kana Makino, Natsumi Makigusa, Masahiro Kojima

ABSTRACT In response to the U.S. Food and Drug Administration's (FDA) Project Optimus, a paradigm shift is underway in the design of early‐phase oncology trials. To accelerate drug development, seamless Phase I/II designs have gained increasing attention, along with growing interest in the efficient reuse of Phase I data. We propose a nonparametric information‐borrowing method that adaptively discounts Phase I observations according to the similarity of covariate distributions between Phase I and Phase II. Similari …

21.08.2026journal-article

Anti-Cancer Agents in Medicinal Chemistry

Targeting Metabolic Dysfunctions in Cancer through Nanoparticles: Advances in Therapeutic Delivery

Pankaj Popli, Mehak Awasthi, Manish Kumar Jeengar, Indu Singh, Thakur Gurjeet Singh, Rajan Swami

Introduction: Cancer progression is characterized by metabolic reprogramming, including the enhanced Warburg effect, hypoxia-driven adaptations, ferroptosis regulation, and altered lipid metabolism. These metabolic changes promote tumor growth, survival, metastasis, and therapeutic resistance. This review aims to analyze the recent advances in nanoparticle-based strategies designed to target metabolic vulnerabilities in cancer and ameliorate therapeutic outcomes. Methods: A comprehensive analysis of recent studies …

21.08.2026journal-article

Frontiers in Oncology

Case Report: Safety and efficacy of tarlatamab for SCLC in a liver transplant recipient

Jonas Leonhardt, Johann Pratschke, Jürgen Behr, Jeremias Götschke, Philipp Jurmeister, Diego Kauffmann-Guerrero, Frederick Klauschen, Laura Lambrecht, Paula Mras, Christian Schneider, Blerina Resuli, Amanda Tufman

Tarlatamab is a bispecific T-cell engager used for the treatment of small cell lung cancer (SCLC). Patients with a history of solid organ transplantation carry an elevated risk of malignancy yet are excluded from most clinical trials. We report the first case of Tarlatamab use in a liver transplant recipient with SCLC, resulting in marked tumor response and a favorable safety profile without evidence of graft rejection.

21.08.2026journal-article

Obstetric Anesthesia Digest

Treatment of Traumatic Birth Experience With Postpartum Early Eye Movement Desensitization and Reprocessing Therapy: A Randomized Clinical Trial

YMGA Hendrix, MG van Pampus, A Hofman, J Henrichs, HE van der Horst, A de Jongh

( Am J Obstet Gynecol 2025;233:654.e1–25. doi: 10.1016/j.ajog.2025.07.051) Studies show that around 10% to 20% of women view childbirth as a traumatic experience. This can happen in both medically complicated and uncomplicated deliveries and can have vast negative effects for both mother and infant. These potential effects include post-traumatic stress disorder (PTSD), troubles with mother-infant bonding, postpartum depression, childbirth fears, or lower quality of life.

21.08.2026journal-article

Frontiers in Urology

Paratesticular myofibroblastic lesion in a prepubertal child: a case report of a rare spindle cell tumor with testis-sparing management

Jeremy Sheiber, Jordan Nguyen, Michelle Smith, Manish Bajaj, Abhishek Seth, Pamela Ellsworth, Peter Y. Cai

Paratesticular tumors are uncommon in the pediatric population and can represent a wide range of benign and malignant pathologies. We report the case of an otherwise healthy 2-year-old boy who presented with an asymptomatic right scrotal mass. Serial scrotal ultrasounds demonstrated a stable, well-circumscribed extratesticular lesion adjacent to the epididymal head with internal vascularity and normal bilateral testicular architecture. Serum tumor markers, including alpha-fetoprotein, beta-human chorionic gonadotro …

21.08.2026journal-article

Frontiers in Cell and Developmental Biology

Development and internal validation of a task-conditioned multimodal radiology–pathology model for breast cancer staging and biomarker profiling: a retrospective cohort study

Yang Liu, Yunfei Dong, Guiyun Zhang, Yue Wu, Shanshan Zhang, Yufo Chen, Ruirui Cao, Rui Wang, Chengliang Yin, Yumei Li

Objectives To retrospectively develop and evaluate a task-conditioned multimodal artificial intelligence framework, in which a learned task embedding and modality-availability mask generate endpoint-specific weights over predefined radiology-only, pathology-only, and fusion experts, for breast cancer staging and biomarker profiling. Methods We retrospectively assembled a cohort of 923 patients with paired radiology and pathology data. Nine tasks included TNM components [tumor extent (T), nodal involvement (N), and …

21.08.2026journal-article

Frontiers in Pharmacology

A multicenter, randomized, double-blind, double-simulated, positive drug parallel-controlled clinical trial to evaluate the efficacy and safety of Xiao’er Fengreqing oral liquid in the treatment of acute pharyngitis/tonsillitis in children

Lei Shi, Kai Liu, Yike Song, Chunsun Mu, Chunxiang Wang, Yongchao Jiang, Robb Russell, Yaqian Wen, Rihe Liu, Jianping Liu, Huilan Liu, Zhaolan Liu

Background Acute pharyngitis and tonsillitis are common in children. Xiao’er Fengreqing Oral Liquid (XFQOL) shows potential benefits in previous studies of pediatric acute upper respiratory tract infections and influenza, but high-quality clinical evidence for pediatric acute pharyngitis/tonsillitis remains limited. Methods This multicenter, block-randomized, double-blind, double-dummy, active-controlled trial enrolled 120 children from three tertiary hospitals. Participants were randomly assigned in a 1:1 ratio to …

21.08.2026journal-article

Endocrine-Related Cancer

Molecular clusters and precision medicine in pheochromocytomas and paragangliomas

Madson Q. Almeida, Patricia L. M. Dahia, Mercedes Robledo

Abstract Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from chromaffin cells of the adrenal medulla and extra-adrenal paraganglia. Over the past two decades, the genomic characterization of PPGLs has profoundly transformed their diagnosis, classification, risk stratification, and therapeutic management. Up to 40% of PPGLs harbor germline pathogenic variants, the highest proportion among human neoplasms, and somatic driver events are identified in a substantial fraction of the r …

21.08.2026journal-article

ARACÊ

ABORDAGEM CLÍNICA E TRATAMENTO DA OSTEONECROSE DOS MAXILARES ASSOCIADA A MEDICAMENTOS (MRONJ) EM SÍTIOS IMPLANTARES

Giacomo Gobbo Trojan, Maximiano Guilherme Tenorio Albuquerque, Antonio Jose Freitas Castro, Lucas Eustáquio Brito De Oliveira, Pablo Ruan Nogueira Dantas, Ana Beatriz Hey Vagas, Geórgia Brandão Olyntho

A osteonecrose dos maxilares associada a medicamentos (MRONJ) configura uma complicação grave em pacientes sob terapias antirreabsortivas. Embora as exodontias sejam classicamente apontadas como o principal fator desencadeante, a instalação e a carga funcional de implantes dentários têm emergido como elementos críticos na gênese da necrose peri-implantar (PI-MRONJ). Esta revisão narrativa analisou a literatura recente para avaliar fatores de risco, estratégias de prevenção e modalidades terapêuticas. As evidências …