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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
08.08.2026journal-article

BMC Geriatrics

Oral anticoagulation therapy in nonagenarian patients with atrial fibrillation: usage patterns, predictors, and in-hospital outcomes from a single-center retrospective study

Zinan Zhao, Ying Dai, Wenxing Peng, Ning Sun, Cheng Wu, Pengfei Jin, Yatong Zhang, Yifan Na, Junpeng Liu

Abstract Background Atrial fibrillation (AF) is highly prevalent in nonagenarians (≥ 90 years). However, this group is often excluded from clinical trials, leaving limited real-world evidence on oral anticoagulant (OAC) use, safety, and efficacy. This study sought to investigate the usage patterns, predictors, and in-hospital outcomes of OAC therapy in nonagenarian patients with AF to provide real-world evidence to inform clinical decision-making. Methods A retrospective single-center analysis was conducted on 290 …

08.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

A case study reviewing the critical role of meaningful employment in brain injury rehabilitation: An occupational therapy perspective

Jessica Smith, Rosanne DiZazzo-Miller, Christine Kivlen

Background Meaningful employment is essential to recovery, self-esteem, and life satisfaction for individuals with traumatic brain injuries (TBIs), particularly those who are high-functioning. Engagement in purposeful work can foster emotional and functional gains during rehabilitation. Objective This single-case retrospective study explored how meaningful employment impacted one client with TBI and examined how transportation barriers limited access to work. Methods Data were collected from December 2022 through M …

08.08.2026journal-article

Physiotherapy Research International

Methodological Approaches for Ultrasound Assessment of Peripheral and Abdominal Muscle Thickness in Intensive Care: A Scoping Review and Proposed Reporting Framework

Pedro Vinicius Porfirio, Wagner Souza Leite, Layane Santana Pereira Costa, Pedro Henrique de Moura, Ana Célia Oliveira dos Santos, Emanuel Fernandes Ferreira da Silva Junior, Elaine Araújo de Souza, Marismar Fernandes do Nascimento, Helga Cecilia Muniz de Souza, Shirley Lima Campos

ABSTRACT Objective To map and synthesize methodological approaches used for ultrasound (US) assessment of peripheral (upper‐ and lower‐limb) and abdominal muscle thickness in critically ill patients, and to propose a preliminary Standard Operating Procedure (SOP) as a structured reporting framework. Methods A review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses Extension for Scoping Reviews checklist, using systematic searches on PubMed, BIREME (including MEDLINE, LI …

08.08.2026journal-article

Glossa

Évaluation de l’endophasie dans l’aphasie avec anomie secondaire à une lésion neurologique acquise

Florine Cognet, Julie Maillard, Clémence Pitel, Hélène Lœvenbruck

Background. Aphasia is a language disorder caused by brain damage, affecting the ability to speak, understand, read, or write. Anomia, defined as a difficulty in lexical access, is one of its most frequent manifestations. Several studies have investigated inner speech (or endophasia), defined as language production without articulation or vocalization, to determine whether difficulties observed in overt speech are also present in the internal modality. Many patients report being able to generate the correct phonolo …

08.08.2026journal-article

Indonesian Journal of Nursing and Health Care

The Effect of Group Activity Therapy on Reducing Hallucination Symptoms in Patients with Schizophrenia at Dadi Regional Special Hospital, Makassar

Fardi, Firmansyah, Muhammad Abu, Jenita Laurensia Saranga'

Background: Hallucinations are among the most common positive symptoms experienced by individuals with schizophrenia and may impair psychological and social functioning while increasing the risk of harmful behaviors. In addition to pharmacological treatment, Group Activity Therapy (GAT) is a psychiatric nursing intervention designed to improve patients' ability to recognize and control hallucinations.Objective: This study aimed to analyze the effect of Group Activity Therapy on reducing hallucination symptoms among …

08.08.2026journal-article

Vietnam Journal of Computer Science

Speech-GAN: A Black-Box Generative Adversarial Network Attack Against Automatic Speech Recognition Systems

Faraz Mohammad Mushtak Mogal, Ali Osman Topal, Enea Mancellari, Volker Müller, Elmir Avdusinovic, Franck Leprévost

Automatic speech recognition (ASR) systems rely on deep learning models to transform human speech into text and actionable commands. Despite their effectiveness, such systems are vulnerable to adversarial audio, which can cause incorrect transcriptions and lead to unintended system behavior. Understanding these vulnerabilities is therefore essential for the safe deployment of ASR in security-sensitive and safety-critical contexts. In this paper, we present Speech-GAN, a generative adversarial network designed to pe …

08.08.2026journal-article

Angewandte Chemie International Edition

Giant Compressed Mo Blue Wheel {Mo 118 }: A Molecular Photothermal Agent for High‐Effective NIR‐II Chemo‐Photothermal Therapy

Mingjun Hou, Jialin Tong, Yu Zhang, Guogang Shan, Chunyi Sun, Weichao Chen, Kuizhan Shao, Xinlong Wang, Chao Qin, Jianguo Wang, Zhongmin Su

ABSTRACT The rational construction of well‐defined polyoxometalate (POM)‐based second near‐infrared (NIR‐II) molecular photothermal agents (PTAs) and the elucidation of their structure‐activity relationships are crucial, but remain unresolved. Herein, we report a decameric molybdenum blue (MB) wheel {Mo 118 }, comprising a {Mo 112 } wheel capped by two {(SO 4 )Mo 3 } units, where compression of the giant ring arises from {Mo 1 *} units and distinct coordination modes of corner‐sharing {Mo 2 } units. As a rare struc …

08.08.2026journal-article

ACS Applied Bio Materials

Near-Infrared Fluorescence Imaging and Photothermal Therapy of Tumors Using a Targeted Helical Protein Scaffold

Nicole Carrillo-Malani, Gabrielle Ho, Qiushi Liang, Joann Miller, Theresa M. Busch, Ahmad Amirshaghaghi, Zhiliang Cheng, Andrew Tsourkas

Abstract Photothermal therapy (PTT) using near-infrared (NIR) photoactive agents offers a minimally invasive approach for tumor ablation; however, many existing platforms rely on polymeric or nanoparticle carriers that limit targeting precision and control over dye loading. Here, we report the design of a modular eight-helix protein scaffold containing 20 cysteine residues that enables covalent, site-specific conjugation of the NIR dye AQuora800-maleimide. The protein scaffold is expressed with different HER2-targe …

08.08.2026journal-article

International Journal of Drug Delivery Technology

Pediatric Nurses’ Role in Nutritional Rehabilitation and Symptom Management for Children with Helicobacter Pylori

Amna Mohammed Ali Mustafa

Background: Helicobacter pylori (H. pylori) infection in the pediatric population triggers gastrointestinal distress, mucosal inflammation, and micronutrient malabsorption, necessitating specialized clinical and educational nursing care. Aim: This empirical study evaluated the effectiveness of pediatric nurses’ nutritional rehabilitation and symptom management for children diagnosed with helicobacter . pylori. Methods: A quasi-experimental, pre-test/post-test design was utilized. The study was conducted in the Pedi …

08.08.2026journal-article

Stem Cell Research & Therapy

Nicotinamide riboside enhances chondrogenic differentiation of human adipose stem cells via inducing SIRT1-mediated deacetylation of SMAD7 and activation of TGF-β/SMAD2/3 pathway

Yichi Xu, Jun Shu, Youbai Chen, Haimiao Wang, Ruoxu Zhang, Muzi Chen, Ran Tao

Abstract Mesenchymal stem cells (MSCs) are widely regarded as a promising candidate for cartilage regeneration, and MSC-based therapies have demonstrated therapeutic potential in promoting cartilage repair. Nevertheless, the chondrogenic differentiation efficacy still requires further improvement. This study identified that Nicotinamide Riboside, a precursor of nicotinamide adenine dinucleotide (NAD⁺), significantly enhances chondrogenic differentiation efficiency of human adipose-derived stem cells (hADSCs), prima …

08.08.2026journal-article

Clinical Rehabilitation

Approaches to influencing leisure participation following stroke: A scoping review

Kathryn Jarvis, Matthew J Reeves, Joanna Harrison, Cath Harris, Zain Patel, Katie Cairns, Catherine E Lightbody, Caroline Watkins

Objective To review the extent of the available evidence, and to identify and describe the approaches that have been used to facilitate leisure participation following stroke. Data sources Embase, Medline, PsycINFO, CINAHL, AMED and Cochrane Library were searched between 1989 and June 2026 for studies (quantitative, qualitative and mixed methods) reporting an intervention that addressed leisure and measured the impact on post-stroke leisure participation. Review methods Established scoping review methods guided dat …

08.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Interpretable machine learning models for classifying lateral epicondylitis based on wrist range of motion and strength in assembly line workers

Jun-hee Kim

Background Lateral epicondylitis (LE) is a prevalent overuse injury among workers performing repetitive wrist movements. Altered wrist range of motion (ROM) and reduced muscle strength occur in individuals with LE; however, their combined utility for classifying LE remains unclear. Interpretable machine learning can help identify and explain biomechanical features associated with LE. Objective This study developed and interpreted machine learning models to classify LE among assembly line workers using wrist ROM and …

08.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Effects of sportsmetrics training on biomechanical and functional performance outcomes related to ACL injury risk: a systematic review and meta-analysis

Mostafa Jalili Bafrouei, Fatemeh Zahra Maleki Gohar, Seyed Hamed Mousavi, Mohamad Rostami, Florian Forelli

Abstract Background This meta-analysis aimed to evaluate the effects of SportsMetrics training (SMT) on ACL injury-related biomechanical deficits and functional performance outcomes in athletes. Methods Literature searches were conducted in four databases from inception to May 10, 2026. The RoB 2 and ROBINS-I tools were used to assess the risk of bias, while meta-analyses and sensitivity analyses were performed using CMA 4 software. The GRADE approach was applied to evaluate the quality of evidence. Primary outcome …

08.08.2026journal-article

Urology Herald

Therapy-induced neuroendocrine prostate cancer

M. P. Korchagin, K. A. Firsov, A. S. Krylov, V. B. Matveev

Treatment-induced neuroendocrine prostate cancer (t-NEPC) is a rare and aggressive form of the disease, driven by the tumor's adaptive response to standard androgen deprivation therapy (ADT). Although its primary detection rate is low, t-NEPC accounts for up to 30% of cases of progressive prostate cancer (PCa), according to large-scale international studies. However, despite a significant increase in publications in recent years, many aspects of t-NEPC diagnosis and treatment remain controversial and require valida …

08.08.2026journal-article

Iranian Journal of Psychiatry and Clinical Psychology

Impact of Spiritual Therapy on Rumination and Resilience of Mothers of Children With Cerebral Palsy

Samaneh Fallah-Karimi, Leila MohammadiFard, Zahra Khalilzadeh-Farsangi, Nasrin Mahmoudi

Objectives Mothers of children with cerebral palsy are prone to psychological disorders such as stress and depression, which can lead to the activation of emotional schemas such as rumination. These negative beliefs can reduce resilience. This study aimed to assess the impact of spiritual therapy on rumination and resilience of mothers of children with cerebral palsy in Zahedan, south of Iran. Methods This is a quasi-experimental study with a pre-test/post-test design conducted on 60 mothers of children with cerebr …

08.08.2026journal-article

Cardiology in Review

Left Atrial Myopathy as a Phenotypic Axis in HFpEF: Implications for Pulmonary Hypertension, Exercise Intolerance, and Targeted Therapy

Mahwish Jabeen, Saeeda Younas, Ayesha Majid, Haram Fatima, Muhammad Bilal Akram, Muhammad Moin UD Din Arshad, Arooj Ihsan Ullah

Heart failure with preserved ejection fraction (HFpEF) is a highly heterogeneous syndrome characterized by impaired ventricular relaxation, systemic inflammation, and multisystem cardiovascular dysfunction. Despite growing recognition of HFpEF as a major global health burden, effective targeted therapies remain limited due to an incomplete understanding of its phenotypic diversity. Increasing evidence suggests that left atrial (LA) myopathy represents a central mechanistic and phenotypic axis in HFpEF rather than m …

08.08.2026journal-article

Global Journal of Medical, Pharmaceutical, and Biomedical Update

Effectiveness of Different Frequencies of Interferential Therapy on Pain and Disability in Individuals with Low Back Pain: A Randomized Controlled Trial Study

M. Vishwa, T. Rajashree, K. Soundararajan, P. Antony Leo Aseer, K. Subbiah, Hepzibah Rubella Devadoss

Objectives: The objective of the study is to compare the effectiveness of quadripolar with bipolar amplitude-modulated frequency (AMF) Interferential therapy (IFT) in reducing pain level and improving functional status in patients with lower back pain (LBP). Material and Methods: This randomized control trial was conducted over 10 months at the physiotherapy outpatient department, Sri Ramachandra Hospital, Chennai. A total of 120 adults with mechanical LBP were randomized into two groups receiving either quadripola …

08.08.2026journal-article

Life

Toward Personalized NSAID Therapy in Osteoarthritis: The Right Patient, the Right Treatment, at the Right Time

Valerica Creanga Zarnescu, Liliana Mititelu-Tartau, Ilie Onu, Daniel Andrei Iordan, Liliana-Lăcrămioara Pavel

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) remain the cornerstone of pharmacological treatment for osteoarthritis (OA) and are recommended by international guidelines for the management of symptomatic pain. Despite their well-established efficacy, substantial interindividual variability exists in treatment response, with some patients experiencing meaningful pain relief while others derive little clinical benefit despite appropriate drug selection and dosing. This variability reflects, at least in p …

08.08.2026journal-article

Macromolecular Rapid Communications

Peptide Self‐Assembly for Enhanced Cancer Therapy via Immunogenic Programmed Cell Death: Ferroptosis, Pyroptosis, Necroptosis, and Cuproptosis

Shasha Ning, Xinruo Xing, Yun‐Kai Chang, Mengmeng Mao, Hai‐Dong Xu, Yu Ma, Guowei Liang, Xianbao Sun, Gaolin Liang

ABSTRACT While immunotherapy has revolutionized cancer treatment, its clinical efficacy is still constrained by tumor heterogeneity, acquired drug resistance, and the immunosuppressive tumor microenvironment. Traditional apoptosis‐driven cancer therapeutic strategies are often inefficient and immunologically silent. In contrast, non‐apoptotic programmed cell death (PCD) pathways (ferroptosis, pyroptosis, necroptosis, and cuproptosis) offer high immunogenicity and the ability to bypass resistance mechanisms, yet the …

08.08.2026journal-article

International Journal of Engineering Trends and Technology

iRead: A Reading Enhancement Platform with Integrated Small-Vocabulary Speech Recognition for English, Filipino, and Hiligaynon

Jan Carlo T. Arroyo, Bon Eric A. Besonia, Allemar Jhone P. Delima, Felipe P. Vista IV, Mark Ronar G. Galagala, Marieth Flor M. Bernardez, Shiela Mae H. Espora, April Rose A. Zaragosa, Rizzamila R. Superio

Reading proficiency is considered a critical educational challenge in a highly multilingual nation such as the Philippines. Digital literacy tools available on the market and those that are found in the literature are mostly English-centric and often lack interactive mechanisms. This study shows the design, technical validation, and implementation of the iRead mobile application software. It is a multilingual mobile reading platform with offline speech recognition function available for three languages, specificall …

08.08.2026journal-article

ACS Nano

An Energy-Sustainable and Oxidative-Tolerant Nanofactory of Therapeutic Proteins for Long-Acting Therapy of Inflammatory Bowel Disease

Qian Chen, Lenan Xu, Ke Duan, Fengling Song, Honglei Zhang, Ziyan Huang, Ziying Zheng, Yi Qiu, Shuhan Shi, Jixiang Zhang, Yuting Xie, Guohuan Zeng, Yawen Zhang, Lina Yin, Daishun Ling, Guang Liang, Haibin Wu

Abstract The ability to continuously generate bioactive therapeutics at the diseased site is an appealing and crucial advantage for the treatment of chronic relapsing diseases such as inflammatory bowel disease (IBD). Current in situ therapeutic factory strategies mainly rely on plasmid drugs, which are usually associated with poor stability and susceptibility to oxidative degradation in the inflammatory microenvironment. Furthermore, the transcription of plasmid-based drugs to produce therapeutic proteins is an en …

08.08.2026journal-article

JHN: Journal of Health and Nursing

Changes in Platelet and CD4 Lymphocyte Counts After Antiretroviral Therapy in HIV-Infected Children

M. Alfarisyi Z, Rita Evalina, Olga Rasiyanti Siregar

Human immunodeficiency virus (HIV) infection in children causes immunological and hematological disturbances, most notably CD4+ T-lymphocyte depletion and thrombocytopenia. Antiretroviral therapy (ART) suppresses viral replication and may restore both, but pediatric data comparing these parameters remain limited. Objective. To compare platelet and CD4 lymphocyte counts before and after six months of ART in children with HIV. Methods. An observational analytic study with a retrospective cohort approach used medical …

08.08.2026journal-article

ACM Transactions on Computer-Human Interaction

The Acting Argument Paradigm: An Innovative Approach to Speech Therapy Using the Moovy TUI

Eleonora Aida Beccaluva, Mathyas Giudici, Eleonora Pasqua, Fabrizio Arosio, Franca Garzotto

Developmental Language Disorder (DLD) is characterized by persistent and significant language impairments. Children with DLD may experience difficulties in grammar, phonology, vocabulary, and specific morphosyntactic structures, such as clitic pronouns and passive constructions. To address these challenges, we propose an innovative treatment approach termed the Acting Argument Paradigm (AAP). Grounded in psycholinguistic theories, the core idea of this approach is to translate the abstract linguistic concept of arg …