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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Public Health

Cost-effectiveness of tremelimumab plus durvalumab versus sorafenib for unresectable hepatocellular carcinoma in China: an economic evaluation based on five-year overall survival data from the HIMALAYA trial

Rui Feng, Ping Liang, Yajing Wang, Dong Li, Huixian Jia, Ying Zheng, Liman Huo, Qi Lv

Objective To assess the cost-effectiveness of tremelimumab plus durvalumab [the Single Tremelimumab Regular Interval Durvalumab (STRIDE) regimen] versus sorafenib as first-line treatment for unresectable hepatocellular carcinoma in China using 5-year follow-up data from the HIMALAYA trial. Methods A three-state partitioned survival model comprising progression-free survival, progressed disease, and death was developed from the perspective of the Chinese healthcare system. Individual patient data were reconstructed …

27.08.2026journal-article

Frontiers in Immunology

Datopotamab deruxtecan in breast cancer treatment: a systematic review of clinical efficacy and safety

Julia Piekarz, Natalia Picheta, Jakub Pobideł, Natalia Gierulska, Krzysztof Kułak, Rafał Tarkowski

Background Breast cancer (BC) remains the most common malignant tumor in women worldwide and a leading cause of cancer-related deaths. Despite therapeutic advances, patients with advanced BC, particularly triple-negative breast cancer (TNBC), still face limited effective treatment options. Antibody-drug conjugates (ADCs) represent a compelling strategy that combines precise tumor targeting with cytotoxic payloads, effectively bridging targeted delivery with microenvironmental disruption. Datopotamab deruxtecan (Dat …

27.08.2026journal-article

F1000Research

How to measure the perimeter from digital images

David Legland

Image analysis aims at extracting quantitative information from digital images. As for any measurement method, the measures obtained from image analysis present some measurement errors that should be better considered during interpretation of results. This work investigates the quality of measures obtained from image analysis based on measurements on synthetic shapes with various geometries, sizes, positions and orientations, by focusing on the methods available in common image analysis software. The perimeter is u …

27.08.2026journal-article

Clinical Psychology & Psychotherapy

Are Metacognitive Beliefs and Cognitive Flexibility Associated With Cannabis Use Disorder In Adolescents? A Case–Control Study

Neval Kızıl, Masum Öztürk, Fatma Subaşı Turgut, Yağmur Soysal, Ayfer Gözü Pirinççioğlu

ABSTRACT Objective Cannabis is among the most commonly used substances by adolescents and is frequently associated with the development of addiction. Various individual, environmental and psychological factors are associated with the onset and maintenance of cannabis use disorder (CUD). Our study aimed to compare levels of depression, anxiety, stress, perceived cognitive flexibility and metacognitive beliefs in adolescents diagnosed with CUD with those in a healthy control (HC) group. Another objective was to inves …

27.08.2026journal-article

Frontiers in Psychology

Artificial intelligence-assisted speaking in Spanish as a foreign language: effects on foreign language emotions and willingness to communicate

Yifan Miao, Pingping Hu

Introduction Although AI-powered conversational tools are increasingly used in foreign language education, little is known about their longitudinal effects on learners’ emotional experiences and willingness to communicate (WTC), particularly among beginner learners of languages other than English. Grounded in Positive Psychology, Control-Value Theory, and the WTC framework, this study examined the effects of AI-assisted speaking practice using TalkPal AI on foreign language enjoyment (FLE), foreign language anxiety …

27.08.2026journal-article

JURPIKAT

Akselerasi Validasi Spasial melalui Plotting Data Digital PTSL di Loket Yuridis Kantor Pertanahan

Toton Fanshurna, Nadia Ludyanti Esya Putri, Calista Putri Fitriana, Rensi Haiziah

Pendaftaran Tanah Sistematis Lengkap (PTSL) tak sekadar menghasilkan dokumen, melainkan membentuk basis data pertanahan yang menuntut ketepatan serta keterhubungan informasi yuridis dan spasial. Masalah timbul saat data digital dalam jumlah besar memerlukan penataan ulang akibat ketidaksesuaian informasi.Kegiatan pengabdian ini bertujuan mendukung percepatan validasi spasial melalui plotting data digital PTSL di Loket Yuridis Kantor Pertanahan Kabupaten Jember. Metode dilakukan secara partisipatif, meliputi identif …

27.08.2026journal-article

Karya Journal of Health Science

THE EFFECT OF EDUCATION GIVEN TO HEMODIALYSIS PATIENTS ON SELF-CARE AGENCY AND FLUID CONTROL: A RANDOMIZED CONTROLLED TRIAL

Zeynep Yılmaz, Mağfiret Kara Kaşıkçı, Fatmanur İrgin

Objective: This study investigated the effects of education on hemodialysis management provided to patients receiving hemodialysis treatment on self-care agency and fluid control.Method: The study was conducted using a randomized controlled experimental design. Participants receiving hemodialysis treatment were divided into two groups: the intervention group (n=26) and the control group (n=28). Data were collected using the Descriptive Information Form, Self-Care Agency Scale, and Fluid Control in Hemodialysis Pati …

27.08.2026journal-article

Journal of Medical and Dental Investigations

Can digital impression methods eliminate the current problems of conventional impression techniques?

Yakup Kantaci

Conventional impression materials remain a cornerstone of routine dental practice, yet they carry well-documented drawbacks, including a pronounced gag reflex, limited patient comfort, potential soft-tissue trauma, dimensional changes with temperature and elapsed time, the need for disinfection, cross-infection risk, and susceptibility to distortion during transport, storage, and laboratory handling. Digital impression systems have been introduced to overcome these limitations, and their use in dentistry—particular …

27.08.2026journal-article

Clinical Case Reports

Severe Multiorgan Failure Triggered by Infection in an Adult With Decades of Untreated Sickle Cell Disease: A Case Report

Sara Shahidi, Gisha Mohan

ABSTRACT A 67‐year‐old man with decades of untreated sickle cell disease developed septic shock with multiorgan failure, splenic infarction, and marrow fibrosis; his genotype could not be confirmed. He recovered with intensive supportive care, with hydroxyurea initiated for long‐term disease modification, illustrating catastrophic infection‐triggered decompensation despite prolonged clinical quiescence.

27.08.2026journal-article

International Journal of Research in Economics and Finance

Strategic Management of Higher Education Reforms in the Digital Era: Driving Human Capital Value through Ethical Digital Leadership

Yassamine El Jai, Latifa Belfakir

The rapid evolution of the global digital economy requires a profound structural transformation within Higher Education Institutions (HEIs) in order to develop resilient and highly competitive Human Capital (HC). This paper examines the intersection of Digital Transformation (DT), institutional leadership, and HC optimization within modern educational reforms. Digital tools such as Artificial Intelligence (AI) or Virtual Learning Environments (VLEs) usually offer unprecedented opportunities to scale up HC value glo …

27.08.2026journal-article

Engineering, Construction and Architectural Management

Information technology integration capability, digital marketing capability and construction enterprise performance: a moderated mediation analysis

Xiaolin Li, Ziyu Wang, Ruirui Zhang, Linpu Guo, Qiaoyan Yuan, Songbo Zhu

Purpose This study intends to explore whether information technology integration capability (ITIC), digital marketing capability and cross-channel integration capability (CIC) can improve construction enterprise performance (CEP) in China's construction industry amid global informatization, as well as the moderating role of digital platform capability between ITIC/digital marketing capability and CIC. Design/methodology/approach A theoretical model based on the research hypotheses proposed in this study was develop …

27.08.2026journal-article

Journal of Applied Research in Higher Education

Preparing sustainability-ready graduates: how identity and digital media literacy shape pro-environmental engagement in higher education

Edy Sabara, Jamaluddin Jamaluddin, Nurul Mukhlisah Abdal, Muhammad Asriadi, Wirawan Setialaksana

Purpose This study extends the theory of planned behaviour (TPB) by integrating ecomedia literacy and ecocultural identity to explain pro-environmental behaviour (PEB) among university students in Indonesia. It examines how cognitive, affective and socio-digital factors jointly shape sustainability engagement in higher education. Design/methodology/approach A quantitative, non-experimental cross-sectional design used an online survey distributed from 17 to 30 November, 2025 to 514 students across Indonesian univers …

27.08.2026journal-article

Philosophical Transactions of the Royal Society B: Biological Sciences

Functions of the EGFR in health and disease

Thomas Bauer, Martin Holcmann, Maria Sibilia

Abstract The epidermal growth factor receptor (EGFR) is a critical mediator of cellular physiology, and its deregulation is implicated in a broad spectrum of pathological conditions, ranging from skin disorders to epithelial malignancies and brain tumours. Although lack of EGFR signalling primarily affects skin and brain development and tissue homeostasis, aberrant EGFR activation through overexpression or mutation converts the receptor into a potent oncogenic driver. This occurs particularly in human cancers such …

27.08.2026journal-article

Wellcome Open Research

The chromosomal genome sequence of a staghorn coral, Acropora cf. manni (Scleractinia: Acroporidae)

David J Combosch, Andrew H Baird, David R Burdick, Hector Torrado, Dareon Rios, Sebastian Metz, Michael Sweet, Graeme Oatley, Elizabeth Sinclair, Eerik Aunin, Noah Gettle, Camilla Santos, Michael Paulini, Haoyu Niu, Victoria McKenna, Rebecca O’Brien, Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team, Wellcome Sanger Institute Scientific Operations: Sequencing Operations, Wellcome Sanger Institute Tree of Life Core Informatics team, EBI Aquatic Symbiosis Genomics Data Portal Team, Aquatic Symbiosis Genomics Project Leadership

We present a genome assembly from a colony sample of Acropora cf. manni (staghorn coral; Cnidaria; Anthozoa; Scleractinia; Acroporidae). The assembly contains two haplotypes with total lengths of 459.26 megabases and 489.30 megabases. Most of haplotype 1 (94.39%) is scaffolded into 14 chromosomal pseudomolecules. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 18.48 kilobases. Metagenome binning recovered one bacterial bin from the phylum Chlamydiota.

27.08.2026journal-article

Basic & Clinical Pharmacology & Toxicology

Plant‐Derived Heterocyclic Compounds: A Promising Review on Natural Remedies for Rheumatoid Arthritis Management and Their Mechanistic Insights in Inflammation and Joint Protection

Jindong Dai, Xue Xia, Xincheng Hu, Thangamani Kanagaraj, Kanagaraj Rajalakshmi, Mangirish Deshpande, Natarajan Kiruthiga, Dongwei Zhu, Yisun Fan

ABSTRACT Rheumatoid arthritis (RA) represents a persistent autoimmune disease that causes continuous joint inflammation and results in synovial tissue overgrowth and worsening cartilage breakdown together with degeneration of bones. The existing pharmaceutical treatments provide symptom management although they create important adverse effects and raise ongoing security concerns. Plant‐derived heterocyclic compounds present themselves as promising pharmaceutical substitution options because they demonstrate a wide …

27.08.2026journal-article

Frontiers in Medicine

Treatment and clinical outcomes among stage II–IVA nasopharyngeal carcinoma patients with undetectable pretreatment Epstein-Barr viral DNA

Ci-ming Sun, Zhen Xu, Cheng-hao Li, Jun-xiang Chen, Xin-yi Su, Jing-xia Song, Shuang-hong Song, Qing-qing Xu, Yan-Ling Wu

Background This study analyzed the efficacy of multiple combined chemotherapy modalities on the long-term survival outcomes in stage II–IVA nasopharyngeal carcinoma (NPC) patients with undetectable pretreatment Epstein-Barr viral DNA (pre-DNA). Patients and methods We retrospectively analyzed 2,440 patients with stage II–IVA NPC with undetectable pre-DNA. Patients received any of the following treatment modalities: intensity-modulated radiotherapy (IMRT) alone; concurrent chemoradiotherapy (CCRT); induction chemoth …

27.08.2026journal-article

Clinical Journal of Health Sciences

The Mediating Role of Rumination in the Relationship Between University Students' Attachment Dimensions and Future Anxiety

İlayda Üçer, Manolya Çalışır

The purpose of this study is to examine the mediating role of ruminative thought processes in the relationship between attachment dimensions and future anxiety among college students. To this end, 420 participants were included in the study. Participants completed the Sociodemographic Information Form, the Experiences in Close Relationships Inventory II, the Rumination Response Scale, and the Future Anxiety Scale for College Students online. According to the study results, there are positive correlations between th …

27.08.2026journal-article

Veterinary Medicine and Science

Clinical Case and Follow‐Up of Babesia banethi Infection in a Red Fox

Mariaelisa Carbonara, Michela Prioletti, Antonio Camarda, Stefano Castellana, Giuseppe Menga, Giovanna Girardi, Gad Baneth, Domenico Otranto

ABSTRACT Background Red foxes play an important role in the circulation of ticks and tick‐borne pathogens, including Babesia spp. While for Babesia vulpes many studies are available on its epidemiology in fox populations as well as pathogenicity in dogs, no data are reported for the recently described Babesia banethi infecting red foxes. Objective Here we describe the clinical and parasitological follow‐up of a naturally occurring B. banethi infection in a red fox from southern Italy. Case presentation An adult mal …

27.08.2026journal-article

International Journal of Humanity and Social Sciences

Examining the Role of Employee Mental Well-Being in Enhancing Work Engagement and Task Performance among Health Employees in the Public Sector: The Case of Chibombo District

Lungowe Chindele, Chilayi Mayondi, Victor Chikampa, Jacqueline Siwale, Angelo Salasini, Chimuka Mwaanga

Purpose: The study examined the role of employee mental well-being in enhancing work engagement and task performance among public sector healthcare workers in Zambia. Drawing on the Job Demands–Resources (JD-R) Theory, the study proposed that employee mental well-being promotes work engagement, which subsequently enhances task performance. It further assessed whether mental well-being and work engagement significantly predict employee task performance. Methodology: A quantitative cross-sectional survey design was e …

27.08.2026journal-article

Journal of Clinical Medicine

Initial Clinical Experience with Percutaneous Endocardial Septal Pulsed Field Ablation in Hypertrophic Obstructive Cardiomyopathy: A First-in-Human Case Series

Haoruo Zhang, Yanfeng Tian, Songqing Yang, Rui Cao, Haoran Jing, Chunlin Gong, Jiaoyue Zhong, Yuran Chen, Siting Hong, Zhaojun Wang

Background: Pulsed field ablation is a nonthermal ablation modality with a potentially favorable tissue selectivity profile. However, its application in septal reduction therapy for hypertrophic obstructive cardiomyopathy remains unexplored clinically. We investigated the feasibility and short-term outcomes of percutaneous endocardial septal pulsed field ablation in patients with symptomatic hypertrophic obstructive cardiomyopathy. Methods: Five patients with symptomatic hypertrophic obstructive cardiomyopathy and …

27.08.2026journal-article

Clinical Journal of Health Sciences

The Role of Anima-Animus Balance in Relationships and Its Psychopathological Reflections: A Review within the Framework of Analytical and Clinical Psychology

Gamze Küçükaslan, Reşat Güven, Buse Odabaşı, Deniz Ergün

This study is a systematic review examining the role of anima and animus archetypes in the spiritual integration processes of individuals, their effects on interpersonal relationships, and their psychopathological manifestations within the framework of Carl Gustav Jung’s analytical psychology theory. Anima and animus are defined as opposite-sex archetypes located in the unconscious of the individual and play a decisive role in the individuation process. In this context, the effects of anima and animus on the indivi …

27.08.2026journal-article

Wellcome Open Research

Sleep CHAMPzzz: Sleep and Circadian Health in Adolescents - a Mental-health Participation Study (protocol)

Gosia Lipinska, Laura C. Roden, Jonathan Davy, Karine Scheuermaier, F. Xavier Gómez-Olivé, Raphaella Lewis, Swantje Wells, Ksenija Maravic da Silva, Yvonne M. Milton, Erika Abric, Fiona Belford, Anita E.M. Lee, Ben A. Carew, Niela van der Poll, Teagan L.Y. Niemand, Noel Reddy, Kirstin Davies, Morgan Naidoo, Tilly Weston, Dale E. Rae

Background Adolescence is characterised by changes in brain development, sleep and circadian biology. Sleep and circadian processes are important modulators of depression and anxiety, which can increase mental health difficulties, and often progress to chronic disorders in adulthood. This study aims to identify sleep and circadian-related mechanisms through which adolescents may either develop or demonstrate resilience to depression and anxiety. Methods SleepCHAMPzzz (Sleep and Circadian Health in Adolescents - a M …

27.08.2026journal-article

Information

Education Informatics as a Discipline for Equitable, Evidence-Informed and Sovereign Digital Education Systems: A Critical Conceptual Review

Hannes Tegelbeckers, Frank Bünning

Education systems are increasingly shaped by decisions about infrastructure, interoperability, data governance, procurement, and artificial intelligence, yet no established field treats these decisions as a single object of professional responsibility. This article asks whether Education Informatics can be specified as a distinct interface discipline, analogous to Business Informatics and Engineering Informatics. It is a critical conceptual review addressing four review questions; its search is documented using the …

27.08.2026journal-article

Frontiers in Oral Health

Comparative effectiveness of therapeutic ultrasound and pharmacotherapy in the management of muscular temporomandibular disorders: a randomized clinical trial

M. Subhikshaa, Prathima Shetty, K. M. Veena, Prashanth Shenoy, Rachana Prabhu, Laxmikanth Chatra

Introduction Temporomandibular disorders (TMDs) of muscular origin are a common cause of chronic orofacial pain and functional limitation. Conservative management includes pharmacotherapy and physiotherapeutic modalities such as therapeutic ultrasound. However, evidence directly comparing their effectiveness remains limited. This randomized clinical trial compared therapeutic ultrasound and pharmacotherapy in reducing pain intensity and improving mandibular function in patients with muscular TMDs. Materials and met …