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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Physics in Medicine & Biology

Laser-driven particle accelerators for cancer therapy: a review of state-of-the-art techniques, challenges and opportunities

Roumani Alabd, Daniel R Franklin

Abstract Charged particle radiation therapy (such as electron, proton and heavy ion therapies) is presently delivered via large linear or circular electromagnetic particle accelerators. There is growing interest in laser plasma accelerators as an alternative source for therapeutic charged particle radiation, including protons, carbon ions, and very high energy electrons. Laser plasma accelerators offer the potential for extremely high dose rates in a very compact physical footprint. While these radiation sources ad …

26.08.2026journal-article

Seminars in Speech and Language

Group Education for Future Healthcare Professionals on Aphasia and Communication Partner Strategies

Corri Newman, Erin L. O'Bryan, Imran Musaji, Douglas F. Parham, Jamie Harrington

Abstract Many healthcare professionals receive little to no training in communicating with individuals with aphasia, which can negatively affect patient participation and quality of care. Communication partner training (CPT), including Supported Conversation for Adults with Aphasia (SCA), has demonstrated benefits, but many established training models rely on multi-component or resource-intensive formats. This study examined whether future healthcare professionals could acquire knowledge of aphasia and supported co …

26.08.2026journal-article

Journal of Oral Rehabilitation

Association Between Oral Function and Obstructive Sleep Apnea in Elderly Patients: A Cross‐Sectional Study Using Home Sleep Apnea Testing

Yuki Sakamoto, Shunsuke Sawada, Yuka Kojima

ABSTRACT Objective Obstructive sleep apnea (OSA) is common among elderly individuals and is associated with various systemic diseases. While obesity and craniofacial morphology are established risk factors, age‐related decline in oral and pharyngeal muscle function may also contribute to OSA development in older adults. However, the relationship between OSA and oral function in elderly patients remains insufficiently investigated. Methods This cross‐sectional study enrolled 40 patients aged ≥ 65 years who visited t …

26.08.2026journal-article

Current Oncology

DNA Damage Response Alterations Stratify Response to ICI-Based Therapy in Advanced NSCLC with High PD-L1 Expression

Fang Hao, Linlin Zhang, Diansheng Zhong

Background: Although high PD-L1 expression correlates with improved outcomes to immune checkpoint inhibitor (ICI), it remains an imperfect predictive biomarker. DNA damage response (DDR) pathway alterations are closely associated with antitumor immunity, shaping tumor immunogenicity and the immune microenvironment. This study evaluates the distribution and clinical impact of DDR alterations in advanced Non-small cell lung cancer (NSCLC) with Programmed death-ligand 1 (PD-L1) ≥ 50%, providing insights for personaliz …

26.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Artificial intelligence responses to toilet training questions: A reliability and readability analysis of ChatGPT and gemini applications

Ayşegül Sarıkaya, Ayşe Alptekin

Background Toilet training is a critical developmental milestone that may have long-term implications for children's psychosocial development if improperly guided. With the increasing use of artificial intelligence (AI) chatbot applications for health-related information, evaluating the reliability and readability of AI-generated guidance on sensitive developmental topics has become essential. Objective This study aimed to evaluate the reliability and readability of responses provided by AI chatbot applications reg …

26.08.2026journal-article

Canadian Diabetes & Endocrinology Today

Cardiovascular Risk with Gender‑Affirming Hormone Therapy

Irena Druce

Gender incongruence refers to a persistent mismatch between an individual’s experienced gender and the sex assigned at birth. While modern terminology is recent, descriptions of gender variance date back to antiquity, including writings attributed to Hippocrates. By the 7th century, Paul of Aegina, in his Medical Compendium, described surgical procedures aimed at modifying sex characteristics. While these early interventions were not grounded in a modern understanding of gender identity, they reflect attempts to ad …

26.08.2026journal-article

Russian Bulletin of Obstetrician-Gynecologist

The influence of socio-psychological factors, adverse effects of hormone therapy on the refusal of patients from its implementation or interruption of therapy after surgical treatment of ovarian endometriosis

E.Yu. Zhilnio, I.A. Salov, V.M. Kuleshov, Yu.V. Naumova

Objective. To analyze the role of socio-psychological factors and undesirable effects of hormone therapy on the patient’s refusal to undergo it or discontinue therapy after surgical treatment for ovarian endometriosis. Materials and methods. A prospective study is presented in which the frequency of refusals of patients and the frequency of interruption of anti-relapse hormone therapy after surgical treatment for ovarian endometriosis in the gynecological department of Saratov City Clinical Hospital No. 8 during th …

26.08.2026journal-article

Eurasian Journal of Medicine and Oncology

Сirculating DNA markers for assessing antitumor therapy efficacy and monitoring metastatic colorectal cancer

Anastasia Ponomaryova, Dmitry Kostromitsky, Anna Tarasova, Elena Rykova, Alexey Dobrodeev, Ulyana Zhilenkova, Sergey Afanasiev, Nadezhda Cherdyntseva

Introduction: Colorectal cancer remains one of the leading causes of oncological morbidity and mortality. Aberrant methylation patterns of tumor-suppressor genes and oncogenes have been detected in circulating DNA isolated from the blood of cancer patients, suggesting their potential utility as diagnostic and prognostic markers. Objective: To evaluate changes in the methylation levels of VIM, SEPTIN9, and DCC genes in cell-surface-bound cell-free DNA (csb-cfDNA) from the blood of metas …

26.08.2026journal-article

Journal of Advances in Medical and Pharmaceutical Sciences

Osteogenesis Imperfecta from Historical Nosology to Gene-directed Therapy: A Critical Narrative Review of Mechanism, Evidence and Translational Uncertainty

Stefan Bittmann, Elisabeth Luchter, Elena Moschüring-Alieva

Osteogenesis imperfecta is the prototypical heritable disorder of bone fragility, and the last three decades have transformed it from a clinically defined syndrome into a molecularly stratified group of conditions involving more than twenty genes. That transformation has not been matched by comparable progress in classification, outcome measurement or therapeutic evidence, and the resulting mismatch is the central concern of this review. The purpose of the article is to evaluate critically how historical nosology, …

26.08.2026journal-article

Biologics

Longitudinal FIB-4 and APRI Monitoring in Psoriatic Arthritis: Associations with Cumulative Methotrexate Exposure and Biologic Therapy Class

Mehmet Serkan Kılıçoğlu, Safa El Mardi Alaoui, Ozan Volkan Yurdakul, Ayşegül Yabacı Tak, Teoman Aydın

Background: Psoriatic arthritis (PsA) is associated with hepatic risk, but longitudinal data during methotrexate (MTX) and biologic therapy are limited. We evaluated two-year changes in age-fixed FIB-4 and APRI and their associations with cumulative MTX exposure and biologic class. Methods: This retrospective cohort included 74 patients receiving continuous biologic therapy for 24 months. Baseline age was used to calculate FIB-4 at both time points. Logistic regression assessed factors associated with FIB-4 ≥ 1.3 a …

26.08.2026journal-article

Pedagogy. Theory & Practice

Historical and pedagogical analysis of value and goal orientations in speech therapist training in the context of the development of Russian special education

Elena Valeryevna Koryakova, Elena Valentinovna Kondratenko

The purpose of the study is to identify, through an analysis of historical trends, the value and goal orientations in the development of the Russian system of professional training for speech therapists aimed at providing psychological and pedagogical support to students with disabilities. The article presents a historical periodization of the genesis of value and goal orientations in speech therapist training in Russia (10th century – early 21st century): 1) the religious and charitable stage (10th-17th centuries) …

26.08.2026journal-article

Cognitive Therapy and Research

Investigating the Relationship Between Insight and Metacognition in Anxiety Treatment: Results from an Online Imagery Rescripting Intervention

Asala Halaj, Hila Sorka-Ella, Jonathan D. Huppert, Anthony S. David

Abstract Background Imagery Rescripting (IR) has shown promise in reducing anxiety symptoms and improving coping skills, but who benefits most may depend on individual factors. Insight refers to recognizing symptoms as abnormal and in need of treatment, while metacognitive beliefs are beliefs that people hold about their own thoughts, such as beliefs about their uncontrollability or danger. Both may shape treatment outcomes. Objective This study examined pre-post changes in insight and anxiety symptoms following an …

26.08.2026journal-article

JMIR Mental Health

Large Language Models as a New Tool for Therapists in Internet-Based Cognitive Behavioral Therapy: Blinded Clinician Rating Pilot Experiment

Thomas Tandrup Lamm, Arthur Bran Herbener, Oliver Rønn Christensen, Malene Flensborg Damholdt, Kaare Bro Wellnitz, Heidi Frølund Pedersen, Lisbeth Frostholm

Background Internet-based cognitive behavioral therapy (iCBT) is an effective and scalable alternative to face-to-face psychotherapy, but its reach is constrained by the time therapists spend reviewing patient input and manually drafting written responses. Studies suggest that large language models (LLMs) may be capable of generating high-quality therapeutic text, with the potential to support therapists in delivering treatment. Their suitability as therapist-support tools in structured iCBT, however, remains insuf …

26.08.2026journal-article

Frontiers in Cardiovascular Medicine

Design and rationale for MICROFIT (Microvascular Coronary Rehabilitation For Improving Treatment)—a feasibility randomized trial of intensive lifestyle rehabilitation for symptomatic coronary microvascular dysfunction

Joanna Abramik, David Murphy, John Graby, Anna Lacey, Theresa Smith, Christopher Lawton, Faith Martin, Fiona Gillison, Matthias G. Friedrich, Amedeo Chiribiri, Mark Mariathas, Kevin Carson, Jonathan Carl Luis Rodrigues, Dylan Thompson, Ali Khavandi

Background Coronary microvascular dysfunction (CMD), a common endotype of angina with non-obstructed coronary arteries (ANOCA), is linked to poor cardiovascular outcomes, and can significantly impact quality of life, mental health, and functional capacity. CMD management strategies focus on symptom control with antianginal therapies, with limited effect and prognostic benefit. While lifestyle changes and risk factor modification are advocated by international guidelines, evidence supporting cardiac rehabilitation f …

26.08.2026journal-article

Advanced Functional Materials

Halogen‐Engineered Covalent Organic Framework Hydrogel for Efficient Photocatalytic Hydrogen Release in Atopic Dermatitis Therapy

Jieyue Liao, Shengjie Xue, Shuai He, Longlong Mu, Yingnan Luo, Shiyu Ni, Yunlei Zhou

ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease with intractable pruritus and barrier disruption. Current therapies offer limited efficacy and are associated with adverse effects, highlighting the urgent need for safer alternatives. Hydrogen (H 2 ) shows anti‐inflammatory and antioxidant potential, but effective topical delivery remains challenging. Herein, we report a halogen‐modulated covalent organic framework (COF) hydrogel that integrates a “halogen‐engineered internal electric field” st …

26.08.2026journal-article

Bulletin of Faculty of Physical Therapy

Current state of entry-level geriatric physiotherapy curriculum in Kenya

Karen M. Blood, Justin T. Mierzwicki, Barbara Billek-Sawhney

Abstract Background Kenya is experiencing a shift in the demographic profile towards a higher percentage of older adults. Physiotherapists must possess a strong knowledge base to meet the unique needs of older adults to ensure quality outcomes. The purposes of this study were to evaluate the level of preparation of Kenyan physiotherapists related to the examination and treatment of older adults and identify the format with which geriatric physiotherapy education is delivered in entry-level physiotherapy programs. M …

26.08.2026journal-article

The American Journal of Interdisciplinary Innovations and Research

Beyond Behavior: A New Perspective on Autism through Existential Therapy

Merouane Elmaazouzi

Autism Spectrum Disorder (ASD) presents unique challenges in social interaction and communication, often addressed through traditional behaviorist approaches that focus on modifying observable behaviors. However, such methods may overlook the existential needs of individuals with ASD, potentially leading to dehumanizing effects. This article advocates for the integration of existential therapy as a more holistic and human-centered psychotherapeutic intervention, emphasizing principles such as freedom, authenticity, …

26.08.2026journal-article

Biomedicines

Physical Recovery After CAR-T Cell Therapy vs. Autologous Stem Cell Transplantation Assessed Through Quantitative Rehabilitation Measures

Flavio Feri, Yuliya Hutsava, Rita Monico, Francesco Morena, Vincenzo Maria Perriello

Introduction: Chimeric Antigen Receptor T (CAR-T) cell therapy and autologous stem cell transplantation (ASCT) are both associated with significant physical and psychological challenges during post-transfusion recovery. To date, most assessments of physical recovery rely on subjective measures, which are prone to individual perception and bias. Direct comparative data on objective physical function between these therapies remain lacking. Objective: The study aims to compare physical recovery trajectories following …

26.08.2026journal-article

Russian Bulletin of Obstetrician-Gynecologist

Evaluation of the effectiveness of local hormone therapy in older patients with pelvic descension

N.V. Yudina, A.E. Brylyaeva, S.N. Buyanova

Objective. To evaluate the results of pelvic descension correction in patients of the older age group on the background of combined treatment, including surgical intervention in combination with the use of local hormone therapy at the stages of preoperative preparation and postoperative rehabilitation. Materials and methods. The prospective study was conducted from 2024 to 2025 on the basis of the Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky. The study in …

26.08.2026journal-article

Journal of Cancer Research and Therapeutics

Advances and future perspectives in the treatment of small cell lung cancer: From chemotherapy and radiotherapy to the era of targeted therapy and immunotherapy

Xiangwei Cheng, Weibin Lv, Linfeng Wu, Yifan Wang, Yiping Zhu

ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignant tumor that mainly originates from pulmonary neuroendocrine cells and is characterized by rapid proliferation, high metastatic potential, and acquired therapeutic resistance. The therapeutic landscape for SCLC is largely confined to traditional modalities, such as surgery and chemoradiotherapy. However, 80–85% of patients are diagnosed with extensive-stage SCLC at initial presentation; surgical intervention and radiotherapy are often not applicable fo …

26.08.2026journal-article

ACTA MEDICA IRANICA

Reducing Pain in the First Stage of Labour Using Counter-Pressure Therapy in the Indonesian Hospital

Sri Rejeki, Satriya Pranata, . Machmudah, Arief Yanto, Lalu Muhammad Irham, Tri Hartiti, Aric Vranada

Inadequately managed labor pain can negatively impact the birthing process. Potential adverse effects of labor pain include stress, fatigue, impaired breathing patterns, inhibited oxytocin production, psychological distress, and an increased risk of medical interventions. Counter-pressure is a safe nursing intervention used to alleviate labor pain. This study aimed to determine the effect of counter-pressure on intrapartum maternal pain. A pre-experimental, one-group pretest-posttest design was utilized, focusing o …

26.08.2026journal-article

Buildings

Artificial Intelligence for Structural Condition Assessment and Rehabilitation: Recent Advances and Future Directions

Shima Zare, Mohammad Najafi

The growing need to ensure the safety, resilience, and sustainability of existing building structures has accelerated the adoption of artificial intelligence (AI) for structural condition assessment and rehabilitation. This critical narrative review synthesizes 82 retained sources, including 33 application-oriented sources, through a transparent, structured literature search and study-selection process; it is not a formal systematic review or meta-analysis. To organize this fragmented evidence base, the review intr …

26.08.2026journal-article

Respirology

Comparison of Efficacy Between Non‐Invasive Ventilation and High‐Flow Nasal Cannula Oxygen Therapy in Treating Acute Pulmonary Edema

Qiaoyun Huang, Jianyi Niu, Shanshan Zha, Zhenfeng He, Xueying Fan, Luqian Zhou, Rongchang Chen, Lili Guan

ABSTRACT Background and Objective Non‐invasive ventilation (NIV) is the first‐line treatment for acute pulmonary edema (APE). However, with the development of high‐flow nasal cannula oxygen therapy (HFNC), recent small‐sample prospective studies have suggested comparable efficacy between HFNC and NIV in treating acute cardiogenic pulmonary edema. To further evaluate the efficacy of these two respiratory support modalities, we directly compared their outcomes using data from two public databases, aiming to provide h …