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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Journal of International Research in Medical and Pharmaceutical Sciences

Chemical Migration from Plastic Bottled-water Containers under Environmental Stress: A Critical Review of Toxicological Mechanisms, Ecological Effects and Clinical Health Implications

S. Shoba, M. Hemashri, K. Jalakandeswari, K. Jeeva, I. Rukshana, D. Uvasri

Plastic bottled water is a complex exposure system in which the bottle body, closure, processing history, water chemistry and post-production environment can all influence the transfer of chemicals and particles into the contained water. This critical narrative review evaluates evidence on migration from polyethylene terephthalate (PET) bottles and relevant closure or reusable-bottle polymers under thermal, photochemical, temporal and mechanical stress, and integrates that evidence with toxicological, ecological an …

28.08.2026journal-article

Frontiers in Cellular and Infection Microbiology

Clinical characteristics, microbiological landscape, and severity-stratified management of pyogenic spondylitis: a retrospective cohort study

Zongqiang Yang, Qiang Liu, Junxiao Liu, Hanhua Guo, Zhangui Gu, Long Ma, Ningkui Niu, Jiandang Shi

Objective To characterize the clinical, radiological, and microbiological features of pyogenic spondylitis (PS) and to describe outcomes observed within a severity-stratified real-world management pathway integrating antimicrobial therapy, stabilization, debridement, and fusion according to structural instability and neurological risk. Methods We conducted a retrospective observational cohort study of 149 patients with PS treated at Ningxia Medical University General Hospital between January 2015 and December 2023. …

28.08.2026journal-article

Advances in Research

Broad-spectrum Antibacterial Activity of Callistemon salignus Essential Oil against Foodborne, Waterborne, Environmental and Clinical Opportunistic Bacterial Pathogens

Omobolanle E. Oladapo, Mona M. E. Eleiwa, Sideeqot T. Abdullahi, Kehinde O. Amisu, Oladipupo A. Lawal, Emmanuel E. Aduak, Kanyinsola O. Akinkunmi, Victoria C. Dada, Olaide R. Tijani, Andy R. Opoku, Solayide A. Adesida

Aims: Microbial contamination of food and water constitutes a significant public-health risk worldwide, particularly because of the increasing prevalence of multidrug-resistant (MDR) opportunistic bacterial pathogens. The growing threat of antimicrobial resistance compromises the effectiveness of conventional antibiotics and highlights the need to explore alternative or complementary antimicrobial agents from natural sources, particularly medicinal plants and their derivatives. Therefore, this study aimed to compre …

28.08.2026journal-article

New Zealand Medical Journal

Aotearoa New Zealand public strongly support investment in cancer treatment and care services: findings from a national survey

Virginia Signal, Ella Iosua, Kate Gregory, Rachael Neumann, Jeannine Stairmand, Jerram Bateman, Andrew Gray, Rana Peniamina, Louise Signal, Bronwen McNoe

aim: Cancer remains a leading cause of morbidity and mortality in Aotearoa New Zealand, with rising incidence, persistent inequities and pressure on diagnosis, treatment and workforce capacity. This study examined public views on government funding, access and delivery of cancer diagnosis, treatment and supportive care services, perceptions of health workforce support and willingness to pay additional tax for healthcare funding. methods: We analysed data from a nationally representative cross-sectional online surve …

28.08.2026journal-article

Israel Journal of Health Policy Research

Pitfalls encountered while projecting the future Israeli anesthesiologist workforce: lessons from the Israel anesthesiologist workforce study

Ariel Wimpfheimer, Yehuda Ginosar, Daniela Quesada, Shai Fein, Charles Weissman, The Israel Anesthesiology Workforce Study Group, Haled Abd-Al-Halim, Hakeem Abu-Rais, Chaim Berkenstadt, Ilya Chernoy, Maruan Armaly, Yaakov Duvdivani, Leonid Eidelman, Brian Fredman, Yulia Gadulov, Zeev Goldik, Yaakov Gozal, Zoya Haituv, Alex Izakson, Yaakov Katz, Idit Matot, Noam Mubada, Reuven Pizov, Aeyal Raz, Gefen Revaz Assuta, Igor Reznikof, Nogzar Rigzny, Michael Rudin, Vladimir Rukinglass, Albert Sabatnitzki, Eran Segal, Eric Siton, Mustafa Somri, Riad Tome, Jacob Turban, Nathan Weksler, Dafna Wilner, Yossi Witchelevsky, Alex Zlotnik

Abstract Background The smooth and efficient operation of a country’s healthcare system is highly dependent on the size and specialty composition of its physician workforce. Therefore, it is incumbent upon a country’s healthcare leadership to continually examine the workforce situation in each medical specialty, especially critical specialties like anesthesiology, so as to detect issues that could lead to shortfalls and surpluses and then apply effective corrective actions. The aim was to assess the accuracy of the …

28.08.2026journal-article

Clinical Medicine and Pharmacology

CHEMORADIATION AND ANTI-PD-1 THERAPY FOR RECTAL CANCER IN A PATIENT WITH MULTIPLE PRIMARY TUMORS: A RARE CLINICAL CASE

M. Bobkov

The article presents a rare clinical case of a 69-year-old patient with three multi-ple primary malignant tumors: cutaneous melanoma (pT4aN2bM0, stage IIIb), synchronous left renal cell carcinoma (cT2N0M0, stage II), and low-ampullary rectal cancer (cT2N0M0, stage I, pMMR/MSS). Treatment with the PD-1 inhibi-tor prolgolimab resulted in complete regression of metastatic melanoma lesions and stabilization of renal cancer. Upon development of rectal cancer, neoadjuvant chemoradiotherapy with capecitabine was initiated …

28.08.2026journal-article

Journal of Translational Medicine

Comprehensive review of myalgic encephalomyelitis/chronic fatigue syndrome

Madhan Jeyaraman, Naveen Jeyaraman, Swaminathan Ramasubramanian, Luise Schäfer, Filippo Migliorini, Sangeetha Balaji

Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, debilitating disease that is unexplained and is characterised by persistent unexplained fatigue, Post Exertional Malaise (PEM), cognitive impairment, unrefreshing sleep and multisystem impairment. Despite the high burden of symptoms and the worldwide prevalence, ME/CFS has been poorly understood, underdiagnosed and underfunded. This large-scale review summarises the available evidence regarding the epidemiology, diagnostic progress, …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Spectrum of variants in the filaggrin gene in the Russian population and in patients with ichthyosis vulgaris

I.V. Zavarina, A.A. Kechin, O.V. Dolya, R.E. Mikheeva, N.A. Oskina, E.E. Baranova

Background. The filaggrin protein, encoded by the FLG gene, is key to maintaining a healthy skin barrier and normal immune system function. Filaggrin loss-of-function mutations are the primary cause of ichthyosis vulgaris, a common dermatological disorder. At the same time, high variability in individual variant frequencies between the studied populations and a large number of repeats in the third exon significantly complicate gene analysis using standard PCR methods. Objective. To examine the spectrum of genetic v …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Clinical and Immunological Phenotypes of Alopecia Areata in Children with Concomitant Atopic Dermatitis: Results of a Cluster Analysis

N.N. Potekayev, G.P. Tereshchenko, A.G. Gadzhigoroeva, A.L. Savastenko, M. Kurdi, O.V. Zhukova

Background. Alopecia areata (AA) and atopic dermatitis (AD) are chronic immune-mediated diseases that frequently coexist in children. Despite established epidemiological links, the internal structure of this comorbidity, including how objective disease severity and polyatopy correlate, remains poorly characterized. Aim. To identify and characterize clinical-immunological phenotypes of AA in children with concomitant AD using cluster analysis. Methods. A single-center, cross-sectional study included 68 children aged …

28.08.2026journal-article

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218

<b>TECNOLOGIAS EM SAÚDE APLICADAS AO CONTROLE DO TABAGISMO: REVISÃO INTEGRATIVA SOBRE IMPACTOS NA ORGANIZAÇÃO DO PROCESSO DE TRABALHO E NA QUALIDADE DA ASSISTÊNCIA</b><b></b>

Maria Josane Pereira, Andrea Caprara

Objetivo: Analisar as evidências científicas acerca da utilização de tecnologias em saúde aplicadas ao controle do tabagismo e seus impactos na organização do processo de trabalho e na qualidade da assistência. Método: Revisão integrativa da literatura realizada nas bases PubMed/MEDLINE, Scopus, Web of Science, CINAHL, LILACS, SciELO e BVS. Foram incluídos estudos publicados entre 2021 e 2026, nos idiomas português, inglês e espanhol. A seleção seguiu as recomendações do PRISMA 2020, resultando em 10 estudos incluí …

28.08.2026journal-article

Clinical Cancer Research

Neoadjuvant Olaparib and Pembrolizumab Combination Therapy in the Treatment of Patients with HRD-Positive Advanced Ovarian Cancer: A Pilot Study

Kenichi Harano, Takehiro Nakao, Shin Nishio, Takahiro Katsuda, Kazuto Tasaki, Kazuhiro Takehara, Takanori Yokoyama, Hideki Furuya, Kyoko Hongo, Masatoshi Asano, Takashi Ikeno, Masashi Wakabayashi, Akihiro Sato, Hitoshi Saito, Chiaki Mashima, Ryo Kamata, Akihiro Ohashi, Suguru Odajima, Hiroshi Tanabe, Tetsuro Taki, Yasuto Fujimoto, Hirohiko Miyake, Reiko Watanabe, Genichiro Ishii, Toru Mukohara

Abstract Purpose: Preclinical studies suggest that poly (ADP-ribose) polymerase inhibition enhances tumor immunogenicity through stimulation of IFN genes pathway activation, providing rationale for combination with immune checkpoint inhibitors. However, clinical evidence supporting this synergy remains limited. We conducted a neoadjuvant pilot study evaluating olaparib with or without pembrolizumab in homologous recombination deficiency (HRD)–positive advanced ovarian cancer. Patients and Methods: Patients with new …

28.08.2026journal-article

Focus Localis

Yhteensovittavan johtamisen käsite sosiaali- ja terveydenhuollon kontekstissa

Ulla Kekäläinen, Sanna Tchaplinski, Johanna Lammintakanen, Sanna Laulainen

The need for Integrative leadership is currently emphasized, especially in health and social care where health and social services are being integrated into client-oriented entities. The article describes and analyses the concept of integrative leadership by applying the three-phase hybrid conceptual analysis model proposed by Schwartz-Barcott and Kim (2000). In the theoretical phase of the study, the characteristics of integrative leadership were identified through an integrative literature review (N=14). In the e …

28.08.2026journal-article

The Journal of Medicine, Law & Public Health

The Impossibility of 100% Specificity in Rapid Diagnostic Test Reporting

José A. Martínez

Background: In commercial materials for rapid diagnostic tests, it is still common to find claims of “100% specificity”. From a statistical and epistemological point of view, this kind of statement is deeply problematic. Aims: This paper examines how justified those claims really are and what they mean in concrete clinical and public health settings. Methods: We analyze the statistical foundations of specificity estimation, apply the Mayo-Spanos severity framework, and review three commercial rapid antigen test lis …

28.08.2026journal-article

Nutrients

Pectin and Kaolin as Adjunctive Metabolic Therapy for Maintaining Remission in Ulcerative Colitis: Biological Rationale, Current Evidence and Future Clinical Perspectives

John K. Triantafillidis, Andreas Panayiotou, Apostolos E. Papalois

Background: Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease in which long-term maintenance of remission remains a major therapeutic challenge. Increasing evidence indicates that disruption of host–microbiome metabolic interactions, impaired production of short-chain fatty acids (SCFAs), defective epithelial energy metabolism, and intestinal barrier dysfunction contribute to disease relapse. These observations have generated interest in adjunctive metabolic strategies aimed at restoring lum …

28.08.2026journal-article

Frontiers in Public Health

Age-moderating effects and training characteristics of neuromuscular training for preventing knee injuries: a systematic review and meta-analysis

Youwei Yao, Ming Pan, Xuesong Niu

Objective Sports-related knee injuries are common and may cause pain, joint damage, reduced sport participation, and long-term physical activity limitations. Although neuromuscular training (NMT) is widely used for injury prevention, whether its effectiveness is moderated by age or intervention characteristics remains unclear. This systematic review and meta-analysis evaluated the effectiveness of NMT for preventing sports-related knee injuries and examined the influence of age and training characteristics. Methods …

28.08.2026journal-article

Healthcare

Organizational Support and Job Satisfaction of Nurses in Contemporary Clinical Practice: Indirect Associations Through Distributive Justice and Emotional Exhaustion

Marin Mamić, Nikolina Farčić, Slavka Galić, Vesna Ćosić, Ivana Mamić, Ivana Barać, Zvjezdana Gvozdanović, Goranka Rafaj, Silvija Marić, Ivan Vukoja, Robert Lovrić

Background/Objectives: Nurses’ job satisfaction is influenced by organizational conditions and psychological responses to demanding work. Although perceived organizational support, organizational justice, and burnout are established correlates of nurses’ work outcomes, less is known about how distributive justice and emotional exhaustion may operate simultaneously within the association between organizational support and job satisfaction. This study examined these two theoretically distinct indirect pathways. Metho …

28.08.2026journal-article

Processes

The Maieutic-H Model: Integrating Machine Learning-Based Prioritisation, Interaction Analysis, and Motivational Strategies for Scalable Healthcare Waste Management

Maria Assunta Cappelli, Eva Cappelli, Francesco Cappelli, Giovanni Marmora, Gianluigi Giorgetti, Giovanni De Feo

Healthcare waste mismanagement persists because the organisational and communicative dynamics driving erroneous practices remain largely unaddressed, particularly in high-turnover clinical units that concentrate the highest volumes of hazardous waste and operational pressure. Existing training interventions typically address motivational, analytical, or operational dimensions in isolation, lacking a systemic and adaptive framework. This study designs and theoretically validates Maieutic-H, a multilevel training eco …

28.08.2026journal-article

Cancer Medicine

Preoperative RDW –Albumin Ratio as a Prognostic Biomarker in Gastric Cancer Surgery

Xinhang Cao, Weiwei Shang, Dandan Xiao, Wei Wang, Ziyu Wang, Yangbai Sun, Yan Zhang, Mingzhe Ma

ABSTRACT Background The ratio of red blood cell distribution width (RDW) to serum albumin (RAR) combines hematologic and nutritional information from routine blood tests and has shown potential value for prognostication in several diseases. This study aimed to evaluate the prognostic significance of preoperative RAR in patients with gastric cancer undergoing curative gastrectomy and to explore whether RAR could provide additional prognostic information beyond conventional indicators such as TNM stage. Aims This stu …

28.08.2026journal-article

American Journal of Occupational Therapy

Longitudinal Associations of Driving Status and Occupational Dysfunction With Health Outcomes After Acquired Brain Injury

Shuto Takehara, Tasuku Sotokawa, Yuta Tauchi, Rie Sakamoto, Yoshihiro Kanata, Kazuhisa Domen

Importance Driving facilitates community involvement after acquired brain injury (ABI). While driving cessation can lower quality of life, the long-term health impacts of driving resumption, and how baseline occupational dysfunction (OD) affects them remain unclear. Objective To investigate the longitudinal associations between driving status (resumption vs. cessation) and health outcomes following ABI and determine whether baseline OD influences these associations. Design Retrospective longitudinal cohort study us …

28.08.2026journal-article

JAMA Network Open

Prediction of Treatment Benefit With Internet-Based Cognitive Behavioral Therapy for Depression

Cora Schefft, Heiner Stuke, Selin Demir, Maximilian Preiß, Lukas Pezawas, Jakob Kaminski, Björn Meyer, Steffen Moritz, Thomas Berger, Johanne Schröder, Jan Philipp Klein, Stephan Köhler

Importance Treatment benefit prediction models may help identify which patients will benefit most from internet-based cognitive behavioral therapy (iCBT) for depression; it is unclear whether such models can support useful treatment allocation across programs. Objective To develop a model predicting individual treatment benefit from iCBT for depression across programs and to externally validate it in independent samples. Design, Setting, and Participants This prognostic study used individual participant data from 5 …

1 Zitationen
28.08.2026journal-article

Medicine

Early real-world utilization of ADA-adaz (Hyrimoz) in the United States

Anna Chen, Rebecca Bungay, Patrick Gagnon-Sanschagrin, Jerome Bedard, Nathan Gobeil, Annie Guerin, Edward Li

Adalimumab (ADA)-adaz (Hyrimoz®; Sandoz, Inc.) became available in the United States (US) in July 2023. This study assessed real-world ADA-adaz adoption experience by describing characteristics and treatment history of patients initiating ADA-adaz in the months following its US availability and preliminarily assessing persistence and adherence to ADA-adaz. A retrospective cohort study using open and closed claims from Komodo Research Data (01/2016-05/2024) was conducted. The index date was the first ADA-adaz prescr …

28.08.2026journal-article

Medicine

Risk factor for knee cartilage damage in patients with anterior cruciate ligament rupture

Xinwei Xiong, Dacheng Li, Yang Li, Qiangli Zhang

Anterior cruciate ligament (ACL) rupture is frequently accompanied by additional intra-articular lesions, among which articular cartilage-damage is clinically relevant because it may contribute to persistent symptoms and subsequent post-traumatic osteoarthritis. This retrospective observational study consecutively enrolled adults with primary unilateral ACL rupture treated between June 2020 and June 2025. Knee cartilage status was assessed using magnetic resonance imaging (MRI) and/or arthroscopic evaluation and gr …

28.08.2026journal-article

Medicine

An Aspergillus luchuensis isolated from a patient with hemoptysis insights from a comprehensive genome-based analysis

Kai Chang, Huajie Xie, Yanyan Wang, Xin Zhao, Wanlin Na, Ningwei Xian, Yuan Liu, Zhongyong Jiang, Chenxia Liu

Rationale: Asp luchuensis , a member of the A niger group, is widely used in food fermentation and rarely causes invasive pulmonary aspergillosis (IPA) in humans. Clinical cases of IPA induced by this strain are extremely scarce, and its genomic characteristics, virulence profiles, and pathogenic mechanisms remain poorly understood, resulting in insufficient clinical recognition of its invasive infection potential. Patient concerns: A 57-year-old immunocompetent non-neutropenic male patient with a long-term smoking …

28.08.2026journal-article

Proceedings of the Institution of Civil Engineers - Urban Design and Planning

Phygital approaches in the co-production of climate-resilient public open space: scoping review

Dina M. Saadallah, Sara M. Ibrahim, Hany M. Ayad

Public open spaces1 (POS) are fundamental to urban resilience, providing multifunctional, adaptable environments capable of addressing intensifying climatic challenges. As climate change accelerates, designing climate-resilient public open spaces2 (CRPOS) through active community involvement has become a planning imperative. Recent innovations have introduced ‘phygital’ methodologies integrating physical spatial interventions with digital technologies, including participatory geographic information system, digital …