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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Cancer Medicine

Preoperative RDW –Albumin Ratio as a Prognostic Biomarker in Gastric Cancer Surgery

Xinhang Cao, Weiwei Shang, Dandan Xiao, Wei Wang, Ziyu Wang, Yangbai Sun, Yan Zhang, Mingzhe Ma

ABSTRACT Background The ratio of red blood cell distribution width (RDW) to serum albumin (RAR) combines hematologic and nutritional information from routine blood tests and has shown potential value for prognostication in several diseases. This study aimed to evaluate the prognostic significance of preoperative RAR in patients with gastric cancer undergoing curative gastrectomy and to explore whether RAR could provide additional prognostic information beyond conventional indicators such as TNM stage. Aims This stu …

28.08.2026journal-article

American Journal of Occupational Therapy

Longitudinal Associations of Driving Status and Occupational Dysfunction With Health Outcomes After Acquired Brain Injury

Shuto Takehara, Tasuku Sotokawa, Yuta Tauchi, Rie Sakamoto, Yoshihiro Kanata, Kazuhisa Domen

Importance Driving facilitates community involvement after acquired brain injury (ABI). While driving cessation can lower quality of life, the long-term health impacts of driving resumption, and how baseline occupational dysfunction (OD) affects them remain unclear. Objective To investigate the longitudinal associations between driving status (resumption vs. cessation) and health outcomes following ABI and determine whether baseline OD influences these associations. Design Retrospective longitudinal cohort study us …

28.08.2026journal-article

JAMA Network Open

Prediction of Treatment Benefit With Internet-Based Cognitive Behavioral Therapy for Depression

Cora Schefft, Heiner Stuke, Selin Demir, Maximilian Preiß, Lukas Pezawas, Jakob Kaminski, Björn Meyer, Steffen Moritz, Thomas Berger, Johanne Schröder, Jan Philipp Klein, Stephan Köhler

Importance Treatment benefit prediction models may help identify which patients will benefit most from internet-based cognitive behavioral therapy (iCBT) for depression; it is unclear whether such models can support useful treatment allocation across programs. Objective To develop a model predicting individual treatment benefit from iCBT for depression across programs and to externally validate it in independent samples. Design, Setting, and Participants This prognostic study used individual participant data from 5 …

1 Zitationen
28.08.2026journal-article

Medicine

Early real-world utilization of ADA-adaz (Hyrimoz) in the United States

Anna Chen, Rebecca Bungay, Patrick Gagnon-Sanschagrin, Jerome Bedard, Nathan Gobeil, Annie Guerin, Edward Li

Adalimumab (ADA)-adaz (Hyrimoz®; Sandoz, Inc.) became available in the United States (US) in July 2023. This study assessed real-world ADA-adaz adoption experience by describing characteristics and treatment history of patients initiating ADA-adaz in the months following its US availability and preliminarily assessing persistence and adherence to ADA-adaz. A retrospective cohort study using open and closed claims from Komodo Research Data (01/2016-05/2024) was conducted. The index date was the first ADA-adaz prescr …

28.08.2026journal-article

Medicine

Risk factor for knee cartilage damage in patients with anterior cruciate ligament rupture

Xinwei Xiong, Dacheng Li, Yang Li, Qiangli Zhang

Anterior cruciate ligament (ACL) rupture is frequently accompanied by additional intra-articular lesions, among which articular cartilage-damage is clinically relevant because it may contribute to persistent symptoms and subsequent post-traumatic osteoarthritis. This retrospective observational study consecutively enrolled adults with primary unilateral ACL rupture treated between June 2020 and June 2025. Knee cartilage status was assessed using magnetic resonance imaging (MRI) and/or arthroscopic evaluation and gr …

28.08.2026journal-article

Medicine

An Aspergillus luchuensis isolated from a patient with hemoptysis insights from a comprehensive genome-based analysis

Kai Chang, Huajie Xie, Yanyan Wang, Xin Zhao, Wanlin Na, Ningwei Xian, Yuan Liu, Zhongyong Jiang, Chenxia Liu

Rationale: Asp luchuensis , a member of the A niger group, is widely used in food fermentation and rarely causes invasive pulmonary aspergillosis (IPA) in humans. Clinical cases of IPA induced by this strain are extremely scarce, and its genomic characteristics, virulence profiles, and pathogenic mechanisms remain poorly understood, resulting in insufficient clinical recognition of its invasive infection potential. Patient concerns: A 57-year-old immunocompetent non-neutropenic male patient with a long-term smoking …

28.08.2026journal-article

Proceedings of the Institution of Civil Engineers - Urban Design and Planning

Phygital approaches in the co-production of climate-resilient public open space: scoping review

Dina M. Saadallah, Sara M. Ibrahim, Hany M. Ayad

Public open spaces1 (POS) are fundamental to urban resilience, providing multifunctional, adaptable environments capable of addressing intensifying climatic challenges. As climate change accelerates, designing climate-resilient public open spaces2 (CRPOS) through active community involvement has become a planning imperative. Recent innovations have introduced ‘phygital’ methodologies integrating physical spatial interventions with digital technologies, including participatory geographic information system, digital …

28.08.2026journal-article

Malignant tumours

Resolution on the results of the expert council on the topic “Diagnosis and treatment of advanced non-small cell lung cancer with BRAF mutation: from the search for molecular targets to therapeutic strategies in real-world clinical practice”

K. K. Laktionov, V. V. Breder, I. A. Demidova, V. V. Karaseva, F. V. Moiseenko, S. V. Orlov, E. V. Reutova, D. L. Stroyakovsky

On January 27, 2026, an Advisory Board was held to discuss issues of molecular genetic diagnosis of the BRAF V600E mutation in patients with advanced non-small cell lung cancer (NSCLC), as well as current treatment options for NSCLC patients with the BRAF V600E mutation. Next generation sequencing (NGS) is the most sensitive and specific method for molecular genetic testing. Its implementation in routine clinical practice will improve the detection rate of BRAF positive NSCLC patients. The accepted standard of care …

28.08.2026journal-article

Statistics in Medicine

A Guide for Exploring Pleiotropic Associations in Genome‐Wide Association Studies Using Summary Statistics

Christina Y. Feng, Pierre‐Emmanuel Sugier, Nan Zou, Benoit Liquet

ABSTRACT Genome‐wide association studies (GWAS) have shown that pleiotropy, whereby a single genetic variant or gene influences multiple traits, is common in complex human diseases. Detecting cross‐phenotype associations from GWAS summary statistics remains challenging because of small effect sizes, extensive multiple testing, heterogeneous effects, and possible differences in effect direction across traits. Methods that jointly analyze multiple traits can improve the ability to detect pleiotropic signals while ret …

28.08.2026journal-article

Journal of Neurological Surgery Part A: Central European Neurosurgery

Mini-Invasive Neurosurgical Treatment of Subdural Empyema: A Two-Patient Case Series

Ejona Rifat Isakaj Lilamani, Aurora Arben Muça, Arben Jonuz Rroji, Artid Agron Lame, Arba Firdus Cecia, Mithat Ismail Demneri, Arsen Haki Seferi, Ridvan Hamid Alimehmeti

Abstract Subdural empyema is a neurosurgical emergency traditionally managed with craniotomy and prolonged intravenous antibiotic therapy. Minimally invasive approaches may represent an alternative in selected cases, particularly when combined with timely diagnosis and targeted antimicrobial treatment. We report two cases of subdural empyema treated with minimally invasive burr-hole evacuation. A 22-year-old man with developmental anomalies and postischemic stroke history presented with intermittent high fever for …

28.08.2026journal-article

INTERNATIONAL JOURNAL OF PUBLIC HEALTH RESEARCH AND DEVELOPMENT

COMPARATIVE ASSESSMENT OF PUBLIC HEALTH EMERGENCY SUPPLY CHAIN AND PHARMACEUTICAL PREPAREDNESS IN PLATEAU AND NASARAWA STATES, NIGERIA, BENCHMARKED AGAINST FEDERAL STANDARDS

James Soujah Abu, Abah Michael Idoko, Adamu Ishaku Akyala, Vincent-Vera Okwosa, Olasunkanmi Samson Coker, Onojah Matthew

Subnational health systems in Nigeria are central to public health emergency response, yet comparative, indicator-based evidence on state-level supply chain and pharmaceutical preparedness remains limited. This study compared emergency supply chain and pharmaceutical preparedness in Plateau and Nasarawa States, Nigeria, and benchmarked Nasarawa State against federal preparedness standards. A comparative, indicator-based assessment was conducted using administrative records, logistics management information system ( …

28.08.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

Prognostic value of Amyloid PET in Real-World Amnestic MCI: Influence of reader experience and interpretation method

Beatriz Echeveste, Edgar Fernando Guillén, Elena Prieto, Katharina C. E. Hirschmüller, Mario Riverol, Javier Arbizu

Abstract Purpose This study assessed the prognostic value and inter-/intra-observer reliability of three amyloid PET interpretation methods—conventional visual reading, assisted visual interpretation and standardized uptake value ratio (SUVR)-based quantification—for predicting conversion to Alzheimer’s disease (AD). Methods This retrospective longitudinal study included 145 patients with amnestic mild cognitive impairment who underwent amyloid PET and were followed for up to 8 years at a single memory clinic. Two …

28.08.2026journal-article

New Zealand Medical Journal

How can we value what is not measured: the need for better data on women’s health and primary care

Fiona Imlach, Natalia Boven, Vanessa Selak

Decisions about healthcare funding and delivery in Aotearoa New Zealand, as well as the monitoring of health service performance and outcomes, are driven by readily available data, in particular from administrative health datasets. Most of these national health data collections are generated through the delivery of secondary health services. Further, apart from hospitalisation and mortality collections, these lack diagnostic coding, rendering the burden and cost of chronic health conditions predominantly managed in …

28.08.2026journal-article

Records Management Journal

Productive rigidity: why electronic document and records management systems still matter in Estonia’s public sector

Sidra Azmat Butt, Ingrid Pappel, Dirk Draheim, Riina Palu

Purpose This study aims to examine why electronic document and records management systems (EDRMS) continue to play a central role in digitally advanced public-sector environments, despite the rise of cloud collaboration and artificial intelligence (AI) tools, using Estonia as a case. The paper introduces productive rigidity to explain how compliance structures stabilise recordkeeping while still allowing gradual change. Design/methodology/approach A qualitative case study approach: five semi-structured interviews w …

28.08.2026journal-article

International Journal of Public Health and Nursing

Mitigating the Respiratory Health Impacts of Air Pollution on Urban Youth: An Analysis of Policy, Community and Individual Protective Responses

Hai Binh Nguyen, Minh Chinh Pham

Air pollution is an increasingly consequential environmental health risk for young people in rapidly urbanizing areas. Yet respiratory risk is shaped not only by pollutant exposure but also by policy effectiveness, community support and individual protective behaviour. This study develops and tests a multilevel framework integrating air-pollution exposure, policy management and control, community action, youth protective awareness and respiratory health symptoms. The original dataset contained 438 questionnaire rec …

28.08.2026journal-article

Hypertension Research

Antihypertensive therapy tailored to the circadian blood pressure profile as precision medicine

Francesca Coccina, Chiara Cuccurullo, Rosa Scurti, Sante D. Pierdomenico

Abstract Circadian blood pressure (BP) values may be different from clinic BP values. Thus, antihypertensive therapy guided solely by clinic BP might not prove appropriate. Moreover, ambulatory BP parameters are superior to clinic BP in predicting outcomes, indicating they should receive more attention as therapeutic targets. Among all relevant 24-h BP parameters, in both untreated and treated patients, two clinically unpredictable windows with proven prognostic relevance deserve attention: the period after awakeni …

28.08.2026journal-article

International Journal of Public Health and Medical Research

Reproductive Endocrine Mechanisms Regulating Ovarian Reserve in Polyendocrine Metabolic Ovarian Syndrome

Yixin Feng

This paper investigates the reproductive endocrine mechanisms of the ovarian reserve in polyendocrinopathy, autoimmune polyglandular syndrome type 1 (APCOS), which is a new term for polycystic ovary syndrome (PCOS). Rather than viewing ovarian reserve as a single number, the paper believes that the concept of reserve in PMOs should be understood through the interplay of follicle number, follicular arrest, granulosa-cell signalling, gonadotropin imbalance, androgen excess and metabolic disturbances. Based on the maj …

28.08.2026journal-article

Nutrition Bulletin

Plant‐Based Diet and Sleep Quality in Adults: Exploring the Role of Lifestyle and Health Mediators

Márcia de Oliveira Lima, Júlia Souza de Melo, Larissa de Lima Soares, Risia Cristina Egito de Menezes, Renan Serenini, Giovana Longo‐Silva

ABSTRACT This study investigated the association between plant‐based dietary indices (PDI) and sleep quality and examined the mediating roles of lifestyle and health‐related factors. A total of 5260 participants (18–65 years) were included. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). PDI—including overall (oPDI), healthy (hPDI), unhealthy (uPDI), and pro‐vegetarian diet index (PVDI)—was derived from a food frequency questionnaire covering 15 food groups. Associations between each PDI …

28.08.2026journal-article

Journal of Immigrant and Minority Health

Healthcare Services Use and Satisfaction Among Iraqi and Syrian Refugees in San Diego: A Qualitative Study

Nissma Bencheikh, Omar Barakat, Ariana Khayamian, Lana Bridi, Nour Makarem, Tala Al-Rousan

Abstract Arabic-speaking refugees in the United States face an elevated burden of chronic disease yet encounter significant barriers to care, and little research has examined their experiences in the U.S. primary care system. This study characterizes the patient experiences of Syrian and Iraqi refugees in San Diego to identify factors that enhance or hinder healthcare integration and satisfaction. Semi-structured interviews lasting 30 to 90 min were conducted in Arabic with 109 Syrian and Iraqi refugees residing in …

28.08.2026journal-article

Salud Medicina e Innovación Journal

Responsabilidad profesional del odontólogo frente a la sospecha de maltrato infantil: revisión sistemática de la evidencia clínica, ética y jurídica

Brayan Santiago1 Escobar-Hernández, Pablo Sacaquirín-Zhunio, Ramón Esteban Peñafiel-Maldonado, María Eugenia Mogrovejo Avila, Viviana León-Rodríguez, Miriam Fernanda Ortega López

Introduction: Child maltreatment often causes injuries to the head, neck, and oral cavity, placing dentists in a position to detect possible cases during clinical care. Evidence on their legal responsibilities remains dispersed across bioethics, forensic dentistry, and oral healthcare. Objective: To synthesize the available scientific evidence on dentists’ legal responsibilities in suspected cases of child maltreatment, with emphasis on professional duties and the legal consequences of acting or failing to act. Met …

28.08.2026journal-article

Journal of Mechanics in Medicine and Biology

OPTIMIZING LOCKING COMPRESSION PLATE DESIGN VIA SEGMENTAL STEPPED THICKNESS: A BIOMECHANICAL SIMULATION APPROACH

GOURAV SINGH, AJAY PANDEY

Locking compression plates (LCPs) are widely utilized in orthopaedic fracture fixation due to their superior mechanical stability and reliability. However, conventional LCPs fabricated from nonbiodegradable metals often cause stress shielding, long-term biocompatibility concerns, and necessitate secondary removal surgeries. Biodegradable alternatives such as magnesium (Mg) alloys have emerged as promising substitutes owing to their biocompatibility and controlled resorption, yet they frequently exhibit insufficient …

28.08.2026journal-article

Academia Drug Development and Pharmacotherapy

Micelles in cancer nanomedicine: targeted delivery, imaging, and therapy

Amirhossein Rashnoodi, Zaynab Seraj, Niyoosha Zamani, Bahareh Khalili Najafabad

Despite advancements in oncology, conventional cancer therapies remain limited by poor specificity, systemic toxicity, and suboptimal therapeutic indices. Micellar nanostructures have emerged as a transformative platform to overcome these hurdles, leveraging their amphiphilic nature to encapsulate hydrophobic agents within aqueous biological environments. This review evaluates the current landscape of micelle-based technologies in cancer management, focusing on their integration into medical physics through diagnos …

28.08.2026journal-article

REST Journal on Data Analytics and Artificial Intelligence

Comparative Analysis of Public Economic Domains: A Weighted Product Method Approach

Manjula Selvam

This study employs the Weighted Product Method (WPM) to comprehensively evaluate and compare five critical domains of public economics: Development Economics, Political Economy, Environmental Economics, Health Economics, and Labour Economics. Health Economics, and Labour Economics. The fields are assessed using four key criteria: relevance, effectiveness in addressing market failures, criticism and limitations, and influence on inequality. The results indicate notable differences among the economic domains, with La …

28.08.2026journal-article

Annals of Public and Cooperative Economics

The market presence of cooperative banks and stability in European banking: New evidence

Hans Groeneveld

Abstract Most studies examining differences between cooperative banks (CBs) and other banking institutions rely on bank‐level data, thereby overlooking effects of the market presence of CBs on banking market structures. To address this gap, we test whether CB's domestic market share predicts national banking stability ( Z ‐scores) using a unique panel dataset for 15 European countries spanning 1991–2024 and a two‐way fixed‐effects framework. Our empirical findings confirm that CBs contribute to overall banking stab …