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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Journal of Clinical Oncology

Long-Term Survival Outcomes of Modified-FOLFOXIRI Plus Cetuximab Versus Bevacizumab in RAS / BRAF Wild-Type Metastatic Colorectal Cancer: Final Analysis of the DEEPER Trial

Yu Sunakawa, Manabu Shiozawa, Takanori Watanabe, Hirofumi Ota, Hisateru Yasui, Taichi Yabuno, Mitsuyoshi Tei, Mitsugu Kochi, Dai Manaka, Hisatsugu Ohori, Tatsuro Yamaguchi, Tamotsu Sagawa, Masahito Kotaka, Yutaro Kubota, Takashi Sekikawa, Masato Nakamura, Masahiro Takeuchi, Wataru Ichikawa, Masashi Fujii, Akihito Tsuji

The randomized phase II DEEPER trial (jRCTs061180022) previously reported superior depth of response with modified 5-fluorouracil, leucovorin, oxaliplatin and irinotecan (m-FOLFOXIRI) plus cetuximab versus bevacizumab in patients with RAS wild-type metastatic colorectal cancer (mCRC). Here, we report updated final survival outcomes and exploratory subgroup analyses focusing on RAS / BRAF wild-type and left-sided tumors. Final overall survival (OS) and progression-free survival (PFS) were analyzed in the per-protoco …

27.08.2026journal-article

Cancer Medicine

Adjusted Risk Stratification of Indeterminate Thyroid Nodules Using the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI‐RADS)

Jessica Zhao, Rita Abi‐Raad, Sara I. Pai, Jonathan Langdon, Minhua Wang, Guoping Cai, John Sinard, Adebowale J. Adeniran, Sanhong Yu

ABSTRACT Background The TI‐RADS guides the initial management of thyroid nodules, but the malignancy risk across different categories of cytologically indeterminate thyroid nodules (CITNs), particularly AUS and FN, remains unclear. Methods We reviewed thyroid FNA specimens diagnosed as AUS or FN with TI‐RADS scores of 3, 4, or 5 from 2017 to 2025. Clinical data, molecular results, and surgical outcomes were analyzed. Results A total of 919 CITNs were identified: 304 with TI‐RADS 3, 454 with TI‐RADS 4, and 161 with …

27.08.2026journal-article

Neuro-Oncology

58 Disrupting metabolic plasticity in glioblastoma stem-like cells via FABP7 inhibition and DHA supplementation

Cécilia Bernier, Seth Peyton, Cyrene Jonah Catenza, Won-Shik Choi, Abigail Hill, Liang Li, Hélène Lemieux, Roseline Godbout

Abstract Introduction Glioblastoma (GBM) is a brain cancer with high recurrence and poor remission rates despite intensive therapies. Treatment resistance is attributed to GBM stem-like cells (GSCs), which display high metabolic plasticity to adapt to environmental and therapeutic stress. GSCs express high levels of fatty acid-binding protein 7 (FABP7), which facilitates intracellular lipid transport. FABP7 binds docosahexaenoic acid (DHA), a polyunsaturated fatty acid with anti-tumorigenic properties in GSCs. Howe …

27.08.2026journal-article

Neuro-Oncology

14 Writing To Patients With Vestibular Schwannoma Transitioning from complexity to clarity leveraging Learning language model

Hina Kapadia, Andrew Kay, Luke Galloway

Abstract Introduction Effective written communication is central to patient-centred and safe care. NHS guidance recommends that outpatient clinic letters be written directly to patients at a readability level equivalent to Flesch Reading Ease (FRE) ≥60. However, neurosurgical correspondence often remains highly technical. Vestibular schwannoma (VS) management, involving complex decisions regarding surgery, radiotherapy, or surveillance, provides a suitable model to examine readability and evaluate whether large lan …

27.08.2026journal-article

Neuro-Oncology

18 TTFields with maintenance temozolomide/pembrolizumab versus TTFields with maintenance temozolomide/placebo for newly diagnosed glioblastoma: the phase 3 EF-41/KEYNOTE D58 trial

Gerben Borst, David D Tran, Ashley P Ghiaseddin, Michael Lim, Michael Weller, Motoo Nagane, Jacob C Easaw, Elizabeth Cohen-Jonathan Moyal

Abstract Introduction With the current standard-of-care for glioblastoma (maximal safe resection followed by radiotherapy with concurrent TMZ, then maintenance temozolomide/TTFields), median overall survival (OS) is approximately 21 months. Immune checkpoint inhibitors have not demonstrated meaningful clinical benefit in glioblastoma, partly because the tumor microenvironment is immunosuppressive. Preclinically, TTFields can induce immunogenic cell death and activate type 1 interferon signaling, with downstream inc …

27.08.2026journal-article

Particle & Particle Systems Characterization

A Sustainable Approach for Effective Antimicrobial and Antiproliferative Activity Against Cervical Cancer Cells Using Caesulia axillaris ‐Mediated Pt@Co 3 O 4 /rGO NCs

Pavan R. Bhilkar, Amit B. Nimje, Swapnil C. Kamble, Ankita R. Daddemal‐Chaudhary, Rupali R. Chaudhary, Shubham S. Tripathy, Konstantin Volcho, Subhash R. Somkuwar, Ratiram G. Chaudhary

ABSTRACT Herein, we report the biogenic synthesis of platinum‐doped cobalt oxide–reduced graphene oxide nanocomposites (Pt@Co 3 O 4 /rGO NCs) via green approach using Caesulia axillaris leaf extract as both reducing and capping agents for multiple biological applications. As‐biosynthesized NCs was characterized by various analytical techniques. The XRD study demonstrated the crystalline nature of materials with an average crystallite size of 2.1 nm, while TEM revealed particle sizes around 8–14 nm. The Raman study …

27.08.2026journal-article

Current Oncology

Tolerance and Efficacy of Targeted Therapies After Immunotherapy for Advanced Non-Small Cell Lung Cancers Harboring Oncogenic Alterations: The GFPC-TOXIMAD Study

Thomas Pierret, Jean-Bernard Auliac, Charles Ricordel, Catherine Daniel, Jessica Nguyen, Florian Guisier, Aurélie Swalduz, Hubert Curcio, Anne Laure Desage, Laurence Bigay-Game, Eric Huchot, Lionel Falchero, Hélène Doubre, Olivier Bylicki, Christos Chouaïd, Laurent Greillier

Background: The sequential use of anti-programmed cell death (ligand)-1 [PD-(L)1] immune-checkpoint inhibitors (ICIs) followed by targeted tyrosine-kinase inhibitors (TKIs) for advanced non-small cell lung cancer (NSCLC) with oncogenic alterations raises questions about tolerance and efficacy. Recent study results suggested an increased risk of adverse events (AEs) with this sequence. Methods: Multicenter retrospective study on advanced NSCLC patients treated with ICIs followed by targeted therapies between 2015 an …

27.08.2026journal-article

European Journal of Pain

Preventive Treatment With Ceftriaxone Attenuates Neuropathic Pain and Anxiety‐Like Behaviour in a Mouse Model of Partial Sciatic Nerve Ligation

Pauline Braconnier, Mathilde Charlier, Alessia Romanin, Nicolas Gilbert, Nathalie Desmet, Emmanuel Hermans

ABSTRACT Background Neuropathic pain is associated with anxiety‐like disorders, suggesting shared neurobiological mechanisms. Glutamatergic dysregulation and impaired astrocytic glutamate uptake, particularly via the astrocytic transporter GLT‐1, have been implicated in central sensitization and associated affective disorders. Ceftriaxone, a β‐lactam antibiotic known to enhance GLT‐1 expression, may represent a potential strategy to alleviate pain‐related anxiety. Methods Neuropathic pain was induced in mice using …

27.08.2026journal-article

Cells

Endothelial Cells Offer a Better Option than Smooth Muscle Cells for the Treatment of Ischemic Limb Disease

Akazha Green, Hanyu Zhang, Bing Bo, Bijay Guragain, Yalin Wu, Yuhua Wei, Jianyi Zhang, Lei Ye

Peripheral arterial disease (PAD) is estimated to affect at least 10 million people in the United States and over 200 million individuals worldwide. The clinical manifestations of PAD range from impaired mobility and pain with activity to chronic limb-threatening ischemia with risk of eventual tissue loss. Despite the significant global prevalence and debilitating consequences of the disease, non-option patients remain largely undertreated. Recognizing that ECs are well-known for their therapeutic role in enhancing …

27.08.2026journal-article

Haematologica

Treatment for relapsed pediatric acute myeloid leukemia: variability and comparative effectiveness of current approaches to re-induction

Caitlin W. Elgarten, Lei Wang, Yimei Li, Alix E. Seif, Regina M. Myers, Daniel J. Zheng, Kira Bona, Emi H. Caywood, Taumoha Ghosh, M. Monica Gramatges, Meret Henry, Tamara P. Miller, Arunkumar Modi, Rajen Mody, Caroline Smith, Jamie Stokke, Naomi Winick, Jennifer J. Wilkes, Victor Wong, Brian T. Fisher, Kelly D. Getz, Richard Aplenc

Post-relapse survival of pediatric acute myeloid leukemia (AML) remains poor and there is a paucity of data to inform relapse regimen selection. We sought to describe the treatment landscape for first AML relapse and compare effectiveness of prevalent salvage regimens. To do this, we conducted a retrospective cohort study using the REAL-AML dataset including pediatric patients with first relapse of AML treated at 13 US pediatric institutions from 2011–2023. Primary analyses compared overall survival (OS) by regimen …

27.08.2026journal-article

Cells

The Chronic Wound Microbiome: Dynamics and Treatment Response

Ilaria Cavallo, Francesca Sivori, Massimo Francalancia, Alessandro Greco, Mauro Truglio, Fulvia Pimpinelli, Enea Gino Di Domenico

Chronic ulcers require prolonged care and carry an increased risk of infection and limb loss. Sequencing studies of diabetic foot ulcers, venous leg ulcers, and pressure ulcers have revealed dynamic, patient-specific microbial communities whose composition varies with local tissue conditions and treatment exposure. This review examines changes in microbial burden and community structure during wound-bed and antimicrobial interventions and their relationships with healing. Observed shifts may contribute to therapeut …

27.08.2026journal-article

Frontiers in Medicine

RBPMS::NTRK3-rearranged sacral malignant spindle cell tumor in neurofibromatosis diagnosed by RNA sequencing: a case report and literature review

Chaopeng Chen, Bin Qi, Yuanyuan Miao, Zhujiang Zhuang, Chaowen Wang, Weiping Dai

Malignant spindle cell tumors arising in patients with neurofibromatosis are diagnostically challenging because malignant peripheral nerve sheath tumor (MPNST) and emerging NTRK-rearranged mesenchymal neoplasms may show overlapping clinical, histological, and immunophenotypic features. We report a 31-year-old man with a more than 20-year history of neurofibromatosis who presented with progressive lumbosacral pain and left lower-limb numbness. Imaging revealed a large cystic-solid sacral mass involving the S1–S2 reg …

27.08.2026journal-article

Advanced Science

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng

ABSTRACT Immunotherapy has shed light on clinical oncology for several decades. However, it still suffers from heterogeneous therapeutic outcomes and potential immune‐related adverse events (irAEs). Inspired by a natural phenomenon that microalgae can absorb and accumulate selenium (Se), a well‐known healthcare element, we engineered a Se‐enriched cyanobacterium Synechococcus Sp (Se‐ Ssp ) for advanced immunotherapy. Simply by culturing in the presence of Na 2 SeO 3 , Se nanoparticles could be bio‐fabricated within …

27.08.2026journal-article

Annals of Gastroenterological Surgery

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

Atsushi Hamabe, Masaaki Ito, Shigeo Toda, Yusuke Suwa, Suguru Hasegawa, Masanori Kotake, Masafumi Inomata, Kazuki Ueda, Atsushi Ogura, Kiichi Sugimoto, Kei Kimura, Koki Otsuka, Tatsuki Noguchi, Koya Hida, Yasumitsu Hirano, Kazushige Kawai, Shigeru Yamagishi, Takeshi Naitoh, Ichiro Takemasa, Japan Society of Laparoscopic Colorectal Surgery

ABSTRACT Aim Circumferential resection margin (CRM) status is a well‐established prognostic factor in rectal cancer surgery; however, its long‐term oncological relevance has not been prospectively validated in Japan, where upfront surgery has long been widely used. This study assessed the prognostic impact of CRM in patients with locally advanced rectal cancer treated with minimally invasive surgery. Methods The PRODUCT trial was a multicenter, prospective, observational study conducted at 18 institutions in Japan. …

27.08.2026journal-article

Neuro-Oncology

45 Predicting sites of tumour progression in the invasive margin of glioblastomas (PRaM-GBM Study): a multicentre imaging study

Stephen Price, Roxanne Mayrand, Julia Cook, Alimu Dayimu, Anil Varma, Michael Jenkinson, Keyoumars Ashkan, Ryan Mathew, Stuart Smith, Raj Jena, Tomasz Matys, Alexis Joannides, Nikolaos Demiris

Abstract Introduction Despite advances in surgery and radiotherapy, glioblastoma patients often experience progression within a year, adjacent to the resection cavity. Conventional imaging techniques are not sensitive enough to detect invasive tumour, leaving occult tumour undetected. We have developed a diffusion tissue signature technique using diffusion tensor MRI (DTI) that can locate occult tumour and predict their pattern of progression. This multicentre study aims to qualify DTI as a biomarker for tumour pro …

27.08.2026journal-article

Neuro-Oncology

117 Transcript-resolved mapping of the m6A RNA modification landscape in glioma using nanopore direct RNA sequencing

Simon Deacon, Lauryn Walker, Masar Radhi, Jonathan Rowlinson, Robert Goldspring, Simon Paine, Matthew Loose, Stuart Smith

Abstract Introduction Glioblastoma (GBM) remains uniformly fatal despite multimodal therapy. While DNA methylation profiling has transformed brain tumour classification, post-transcriptional RNA modifications remain comparatively underexplored. N6-methyladenosine (m6A) is the most abundant internal RNA modification and regulates splicing, nuclear export, translation and RNA stability. As a dynamic and reversible mark, m6A may enable glioma cells to rapidly remodel transcriptional networks in response to microenviro …

27.08.2026journal-article

Neuro-Oncology

55 Radiotherapy Peer Review in Neuro-Oncology: National Survey of Practice, Barriers and AI Integration

Sarah Kingdon, Nicola Blackler, Amy Davies, Jennifer Golten, Chloë May, James Powell, Charlotte Smith, Aoife Williamson, Andrew Wright, Karan Patel

Abstract Introduction In neuro-oncology, radiotherapy peer review is central to quality assurance, due to anatomical complexity and proximity to critical structures. However, current UK practice is not well described. Method An online survey was designed by the Tessa Jowell Academy Peer Review Working Group and distributed nationally (October–December 2025). Survey questions covered peer review structure, scope, multidisciplinary involvement, artificial intelligence (AI) use, and perceived impact. Data were analyse …

27.08.2026journal-article

Neuro-Oncology

44 UK radiotherapy practice in volume delineation–data from the APPROACH trial (ISRCTN:1339049) radiotherapy quality assurance (RTQA) programme benchmark outlining case

Jennifer Golten, Emiliano Spezi, Anna Bruce, Daniel Egleston, Elizabeth Miles, James Powell, Louise Murray

Abstract Introduction Interobserver variation in radiotherapy contouring can affect protocol compliance and the robustness of clinical trial outcomes. The APPROACH (Analysis of Proton vs Photon Radiotherapy in Oligodendroglioma and Assessments of Cognitive Health) trial protocol mandates delineation of target volumes and organs-at-risk (OARs), including the hippocampi and hypothalamus, to enable correlation of delivered dose with late toxicity. Here we assess centres’ previous experience in contouring OARs and perf …

27.08.2026journal-article

Healthcare

Perceptions and Acceptability of Artemisia annua Herbal Tea for Malaria Treatment: A Qualitative Study in Kalima Health Zone, Maniema, Democratic Republic of the Congo

Jerome Munyangi wa Nkola, Pierre Akilimali Zalagile, Hendrick Lukuke Mbutshu, Spartacus Kabala Munyemo, Imani Ramazani Bin Eradi, Alioune Camara

Background: Malaria is a significant public health challenge in the Democratic Republic of the Congo. In conflict-affected areas, access to quality-assured ACTs is restricted by chronic stockouts and circulation of substandard and falsified antimalarials. This study investigates perceptions and social acceptability of Artemisia annua herbal tea in the Kalima Health Zone. Methods: Distinct from the prior provider-arm cross-sectional survey of the same program in the Kalima Health Zone which sampled only biomedical h …

27.08.2026journal-article

Psycho-Oncologie

Financial toxicity and its psychological sequelae in modern cancer care

Mohammad-Salar Hosseini

Financial toxicity has emerged as one of the key challenges in modern cancer care. Although traditionally regarded as an economic consequence of cancer diagnosis and treatment, growing evidence indicates that financial distress is also a major determinant of psychological well-being among people with cancer. Financial toxicity extends beyond objective aspects, and includes subjective financial distress, anxiety, uncertainty, employment disruption, debt, isolation, and care-compromising behaviors. Despite well-estab …

27.08.2026journal-article

Medicina

Association of Pathological Complete Response with Long-Term Oncological Outcomes After Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Retrospective Analysis of 327 Patients

Berk Sertoz, Kamil Erozkan, Recep Temel, Murat Sezak, Basak Doganavsargil, Osman Bozbiyik, Cemil Caliskan, Erhan Akgun

Background and Objectives: While total neoadjuvant therapy (TNT) is increasingly adopted, conventionally fractionated neoadjuvant chemoradiotherapy (CRT) followed by surgery remains the standard approach for many patients with locally advanced rectal cancer (LARC). Tumor regression following neoadjuvant therapy varies, potentially influencing oncologic outcomes. This study aimed to evaluate the association between pathological complete response (pCR) and long-term overall survival (OS) and disease-free survival (DF …

27.08.2026journal-article

Frontiers in Molecular Neuroscience

The potential of microbiome modulators to improve quality of life in cancer survivors through gut microbiome-immune interactions

Brandi C. Miller, Julia H. Hoover, Hariom Yadav, Shalini Jain

Advancements in oncology research have led to the development of highly effective and safe cancer treatments, resulting in increased survival rates from cancer. However, treatments including chemotherapy, radiation, immunotherapy, and combination regimens suppress or modulate the immune system, contributing to the development of multi-organ dysfunctions in cancer survivors. Cognitive impairment (CI) and bowel dysfunctions are adverse outcomes commonly reported in cancer survivors and collectively hamper quality of …

27.08.2026journal-article

Neuro-Oncology

89 Referral Patterns, Interventions and Outcomes: A 12 month Retrospective Review of Allied Health Professional Referrals from a Late Effects Clinic.

Grainne Kenny, Rebecca Clark, Agnieszka Kowalska, Philippa MacDonnell, Paula Shukla

Abstract Introduction Access to specialist neurological rehabilitation is recommended at diagnosis of a brain tumour and throughout follow-up to optimise function, treatment tolerance and quality of life. At Guy’s Cancer Centre, Physiotherapy, Occupational Therapy (OT) and Speech and Language Therapy (SLT) are embedded within the neuro-oncology multidisciplinary team. Additionally, a Clinical Nurse Specialist (CNS) led late effects clinic was established to manage long term effects of diagnosis and treatment. This …

27.08.2026journal-article

Neuro-Oncology

12 Anatomy as prognosis: are frontal lobe glioblastomas associated with worse outcomes? A single-centre retrospective population-based review

Nia Mihaylova, Leon Gerard D’Cruz, Eleni Simpson

Abstract Introduction Glioblastoma multiforme (GBM) is an aggressive brain malignancy with universally poor outcomes, and multiple covariant prognostic factors. While clinicians have long suspected that GBM’s lobe-location influences surgical and functional outcomes, its independent effect on survival has not been previously established. We aimed to determine whether frontal lobe involvement is associated with reduced overall survival in patients with GBM. Methods A retrospective cohort review of 58 patients diagno …