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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Neuro-Oncology

16 Computational dissection of invasive glioblastoma reveals druggable and regulatory targets

Maria Shah, Stuart Smith, Emyr Bakker, Ruman Rahman

Abstract Introduction Glioblastoma (GBM) recurrence is driven by residual disease that infiltrates beyond the resection margin, a region poorly characterised at the molecular level. Fluorescence-guided surgery using 5-aminolevulinic acid (5ALA) identifies metabolically active invasive tumour populations and provides an opportunity to interrogate the biology underpinning local invasion and recurrence. Methods Spatially resolved bulk RNA-seq data derived from 5ALA-defined GBM regions were analysed to identify genes e …

27.08.2026journal-article

Academia Global and Public Health

Preventive health practices and colorectal cancer screening in women veterans

Emma Schnittka, Promila Banerjee, Hepsi Kalapala

Introduction: Colorectal cancer (CRC) is the fourth-leading cause of cancer-related mortality among U.S. women and the second-leading cause among women younger than 50 years. Although screening reduces CRC incidence and mortality, adherence remains below national targets. This study evaluated associations between CRC screening compliance and other preventive health practices among women veterans. Materials and methods: A retrospective cross-sectional analysis was conducted at the Edward Hines Jr. Veterans Affairs ( …

27.08.2026journal-article

Diagnostics

Simultaneous Preoperative Prediction of Locally Advanced Breast Cancer, DCIS Component, and Multifocality Using Structured Mammographic Features and Gradient-Boosting Machine Learning

Sorour Raeiskarimi, Mahdi Saeedi-Moghadam, Fariba Zarei, Banafsheh Zeinali-Rafsanjani

Background/Objectives: Accurate preoperative detection of locally advanced breast cancer is essential for neoadjuvant therapy planning. We developed and validated gradient-boosting models using structured BI-RADS mammographic features to simultaneously predict locally advanced breast cancer (LABC), DCIS component, and multifocality in a multi-center cohort. Methods: This retrospective study enrolled 2295 patients from three university-affiliated hospitals; features were coded according to BI-RADS. CatBoost and logi …

27.08.2026journal-article

Angewandte Chemie

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu

ABSTRACT Photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) have emerged as promising anticancer modalities due to their noninvasive nature, spatiotemporal precision, and high tumor suppression efficacy. Integrating platinum with these phototherapies addresses key limitations of conventional platinum chemotherapy, specifically systemic toxicity and pervasive drug resistance. Since cancer cell membrane proteins, including receptors and transporters, and subcellular organelles play a pivotal role as th …

27.08.2026journal-article

Frontiers in Public Health

Association of meteorological exposures with major cancer mortality in Minhang District, Shanghai: a time series study based on distributed lag non-linear models

Jiaqi Guo, Junhui Huang, Chao Xu, Shuili Xuan, Jingyi Ni, Wei Liu, Linli Chen, Yibin Zhou

Objective This study examined the associations between meteorological exposures and major cancer mortality, with a focus on exposure-lag relationships. Methods We collected daily cancer death records and weather data from Minhang District, Shanghai, 2014 to 2023. Joinpoint regression estimated annual percent changes in age-standardized cancer mortality rates. Spearman's rank correlation was employed to explore how meteorological factors related to cancer death. Finally, a distributed lag non-linear model (DLNM) eva …

27.08.2026journal-article

International Journal of Molecular Sciences

Anti-Tumor Potential of Selective L-Type Amino Acid Transporter (LAT1) Inhibitor, JPH203, in Patient-Derived Canine Bladder Cancer Organoids

Ting-Wei Yu, Minami Kawahashi, Fumiya Goda, Ami Kanaya, Mohamed Elbadawy, Hitoshi Endou, Shoichiro Ide, Hideyuki Yamawaki, Masahiro Kaneda, Amira Abugomaa, Tsuyoshi Uchide, Tatsuya Usui, Kazuaki Sasaki

L-type amino acid transporter 1 (LAT1), which controls the neutral amino acid uptake across the cell membranes, has been frequently overexpressed in various human cancers. Overexpression of LAT1 is associated with higher proliferation and shorter patient survival in tumors. Here, upregulated LAT1 expression was observed in patient-derived canine bladder cancers (BCs), and a small-molecule LAT1 inhibitor (JPH203) successfully reduced BC tumor growth both in vitro and in vivo. Patient-derived cancer cells were collec …

27.08.2026journal-article

Environmental Toxicology

Integrated Alpha–Gamma Radiation Exposure From Natural Radionuclides in Cement and Gypsum Production: Implications for Occupational Lung Cancer Risk

Adil M. Hussien, Kardo O. Mamand, Hiwa M. Qadir, Berun N. Ghafoor, Goran H. Mohammad

ABSTRACT Natural radionuclides in cement and gypsum production materials pose significant risks of occupational radiation exposure that are not well documented in Iraqi Kurdistan. This study quantifies alpha and gamma radiation levels from naturally occurring radioactive materials, specifically 222 Rn, 238 U, 232 Th, and 40 K, in cement and gypsum samples from regional production facilities. Radionuclide activity concentrations were measured using alpha counting techniques and gamma spectrometry. The air concentrat …

27.08.2026journal-article

Philosophical Transactions of the Royal Society B: Biological Sciences

Impact of lineage-specific epidermal growth factor receptor mutations in cancer

Amy Rios, Kimberly A. Jorge, Gizelle G. Ramirez, Chester A. Thompson, Tikvah K. Hayes

Abstract The epidermal growth factor receptor, or EGFR, is one of the most frequently altered oncogenes in human cancer and is a critical therapeutic target. EGFR alterations span a broad spectrum, including gene amplification, point mutations, truncations, in-frame insertions or deletions, and fusions, yet their mutational distribution is cancer type-specific. This distribution impacts the effectiveness of EGFR-targeted therapies across EGFR-mutant cancers. This review will cover what is currently known about the …

27.08.2026journal-article

Cancer Research

KRAS Mutations Reprogram RNA m6A Modifications to Drive CD73-Dependent Immune Evasion in Colorectal Cancer

Seungjae Shin, Seung-Pyo Hong, Seoho Lee, Yeonseo Jang, Jisoo Yang, Jaeik Oh, Dongjun Jang, Soo-Jin Lee, Jiwon Kim, Sang Eun Lee, Yoojin Yang, Dohee Kim, Eunjeong Yang, Seohyeon Park, Sabeen Hwang, Ae Jin Choi, Hae Rim Jung, Yumi Oh, Chang-Han Lee, Joo-Youn Cho, Kyungho Choi, Jeong Mo Bae, Jong-Il Kim, Sung-Yup Cho

Abstract KRAS mutations, present in about 40% of colorectal cancers, are strongly associated with an immunosuppressive tumor microenvironment characterized by restricted immune infiltration and poor responses to immunotherapy. In this study, we found that KRAS mutations remodel the N6-methyladenosine (m6A) epitranscriptome to promote immune evasion. Methylated RNA immunoprecipitation sequencing revealed that KRAS-mutant cells exhibit increased m6A deposition on CD73 mRNA, enhancing its stability through IGF2BP3. TE …

27.08.2026journal-article

BMC Oral Health

Parental knowledge, attitude, and practice on oral complications of leukemia treatment: a cross-sectional study

Nosrat Nourbakhsh, Ailar Adib Haji Bagheri, Maryam Torkian, Sheida Bagheri, Sahar Talebi

Abstract Background Leukemia is among the most common childhood cancers, and treatments such as chemotherapy and radiotherapy often lead to oral and dental complications. With rising survival rates, attention to oral health and its impact on quality of life has become increasingly important. Parental knowledge and practice play a vital role in preventing and managing these complications. Therefore, this study assessed the knowledge, attitude, and practice (KAP) of parents of children with leukemia regarding oral sy …

27.08.2026journal-article

International Journal of Molecular Sciences

Exploratory Toxicogenomic Profiling Identifies Candidate DINCH-Responsive Genes Relevant to Prostate Cancer

Chi-Fen Chang, Wen-Hsin Lin, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Te-Ling Lu, Shu-Pin Huang, Bo-Ying Bao

Diisononyl cyclohexane-1,2-dicarboxylate (DINCH), a non-phthalate plasticizer adopted as a safer alternative for food-contact and medical-grade materials, is ubiquitously detected in human biomonitoring studies. Despite widespread exposure, its transcriptional effects in prostate cells and the potential prostate cancer relevance of DINCH-responsive genes remain unclear. We integrated transcriptomic profiling of DINCH-exposed human prostate epithelial cells with exploratory genetic association analyses in 630 patien …

27.08.2026journal-article

Frontiers in Immunology

Datopotamab deruxtecan in breast cancer treatment: a systematic review of clinical efficacy and safety

Julia Piekarz, Natalia Picheta, Jakub Pobideł, Natalia Gierulska, Krzysztof Kułak, Rafał Tarkowski

Background Breast cancer (BC) remains the most common malignant tumor in women worldwide and a leading cause of cancer-related deaths. Despite therapeutic advances, patients with advanced BC, particularly triple-negative breast cancer (TNBC), still face limited effective treatment options. Antibody-drug conjugates (ADCs) represent a compelling strategy that combines precise tumor targeting with cytotoxic payloads, effectively bridging targeted delivery with microenvironmental disruption. Datopotamab deruxtecan (Dat …

27.08.2026journal-article

Neuro-Oncology

102 Real-world Use of Vorasidenib in Adult IDH1/2-Mutant Low-Grade Glioma Across UK NHS Trusts

Abraham Sondhi, Susan Short

Abstract Introduction Vorasidenib is a novel therapy for patients aged ≥12 years with residual or recurrent grade 2 IDH1/2-mutant diffuse glioma. Clinical trials demonstrate reduced tumour growth and improved seizure control without additional neurocognitive toxicity. NICE currently does not recommend routine NHS use due to cost-effectiveness concerns. This study evaluates the practical application, accessibility, and challenges of Vorasidenib across NHS trusts. Method A questionnaire was distributed in February 20 …

27.08.2026journal-article

Neuro-Oncology

50 Comparative evaluation of long- and short-read methylation-aware sequencing for CNS tumour diagnostics

Simon Deacon, Inswasti Cahyani, Nadine Holmes, Graeme Fox, Rory Munro, Satrio Wibowo, Thomas Murray, Mark Housley, Robert Goldspring, Sebastian Brandner, Felix Sahm, Stuart Smith, Simon Paine, Matthew Loose

Abstract Introduction DNA methylation–based classification has transformed the diagnosis of central nervous system (CNS) tumours. However, methylation profiling alone is insufficient for definitive diagnosis and must be integrated with genomic alterations such as single nucleotide variants, structural variants, and gene fusions. Molecular diagnostics are therefore moving towards unified sequencing approaches capable of simultaneously capturing epigenomic and genomic information within a single assay. Rapid nanopore …

27.08.2026journal-article

Cancers

Mitoxyperilysis Drives Immunosuppressive Tumor Microenvironment Remodeling and Hepatocellular Carcinoma Progression via ANXA1-Mediated Macrophage M2 Polarization

Meng Qin, Wenzhi He, Gang Wu

Background: Mitoxyperilysis is a recently described form of regulated cell death, but its clinical and immunological relevance in hepatocellular carcinoma (HCC) remains unclear. This study investigated the prognostic significance of mitoxyperilysis-related transcriptional activity and its role in remodeling the tumor immune microenvironment. Methods: A Mitoxyperilysis Score was generated by single-sample gene set enrichment analysis. Prognostic associations were evaluated using Kaplan–Meier analysis, multivariable …

27.08.2026journal-article

Thoracic Cancer

Apigenin Alleviates Pyroptosis in Lung Adenocarcinoma Cells by Modulating TNF ‐α/ NF ‐ κB Signaling and AIM2 Inflammasome Activation

Kairui Zhu, Yulong Mu, Zhenguo Su, Zhen Yue, Dongyang Wu, Guiwu Qu, Chenyang Jiang, Qing Li, Youjie Li, Ning Xie

ABSTRACT Background Pyroptosis‐related signaling contributes to lung adenocarcinoma (LUAD) progression and prognosis. Apigenin (AP) has anti‐inflammatory and cytoprotective properties, but its effects on pyroptosis‐associated signaling in injured LUAD cells remain unclear. Methods A549 cells were treated with carbonyl cyanide m ‐chlorophenyl hydrazone (CCCP) and ferrous sulfate (FeSO 4 ) to establish a cellular injury model. Cell morphology, Cell Counting Kit‐8 signals, and pyroptosis‐associated proteins were asses …

27.08.2026journal-article

Journal of Pediatric Hematology/Oncology

Catatonia in a 13-Year-Old With T-Cell Lymphoblastic Lymphoma Following Intrathecal Methotrexate

Raquel Lazarowitz, Jennifer Picado, Jitka Stankova

Background: Methotrexate neurotoxicity is a recognized complication in pediatric lymphoid malignancies, presenting with seizures, stroke-like episodes, or leukoencephalopathy. Catatonia is a rare and underrecognized manifestation. Observation: A 13-year-old girl with T-cell lymphoblastic lymphoma developed agitation, confusion, and catatonia 5 days after intrathecal methotrexate. Investigations excluded structural, infectious, metabolic, and malignant causes. Psychiatry confirmed catatonia (Bush-Francis Catatonia R …

27.08.2026journal-article

Journal of the National Comprehensive Cancer Network

Fostering Improvements in Equitable Care Delivery: Insights From the Health Equity Report Card (HERC) Pilot in Academic Cancer Centers

Ashley Orr, Taneal D. Carter, Mallory Stubblebine, Heather McKee Hurwitz, Tiffany Go, Leticia Mercado, Darryl Outlaw, Elizabeth Bouchard, Levent Dumenci, Crystal S. Denlinger, Alyssa A. Schatz

Background: The Health Equity Report Card (HERC) was developed to support institutions in measuring equitable care practices and implementing improvement efforts. An objective of this study was to determine whether academic cancer centers can use their baseline HERC scores to identify institution-specific strategies to improve equitable care delivery. Methods: This quality improvement study collected quantitative and qualitative data from 5 NCCN Member Institutions about their quality improvement efforts in respons …

27.08.2026journal-article

Clinical Cancer Research

Focused Ultrasound-Enhanced Drug Delivery to Brain Tumors: Quantitative and Translational Insights from CNS Physiologically Based Pharmacokinetic Modeling

Andrew Wu, Charuka Wickramasinghe, Yuanyuan Jiang, Xun Bao, Jing Li

Abstract Purpose: Successful clinical translation of focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening strategy to brain cancer therapy has been hindered by limited quantitative understanding of CNS pharmacokinetics. Using a physiologically based pharmacokinetic (PBPK) modeling framework, this study aimed to quantitatively characterize FUS-modulated CNS pharmacokinetics and identify key determinants of potential clinical benefits. Experimental Design: A previously validated 9-compartment CNS PBPK m …

27.08.2026journal-article

PLOS One

HDAC2 restrains IGF2BP1-associated m6A dysregulation in cervical cancer immunotherapy resistance

Qiuhong Deng, Zhi Wang, Jine Zhao, Ning Li, Linghua Zhang, Wanxia He, Yongmei Zhang

Background Cervical cancer (CC) immunotherapy resistance remains a critical clinical challenge. Although immune checkpoint blockade shows efficacy in subsets of patients, the epigenetic and post-transcriptional mechanisms driving resistance are poorly understood. Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), an m6A “reader,” is implicated in tumor progression, but its role in CC immunotherapy resistance is undefined. The aim of this study was to elucidate the function of epigenetic regulator IGF2BP …

27.08.2026journal-article

Frontiers in Medicine

Treatment and clinical outcomes among stage II–IVA nasopharyngeal carcinoma patients with undetectable pretreatment Epstein-Barr viral DNA

Ci-ming Sun, Zhen Xu, Cheng-hao Li, Jun-xiang Chen, Xin-yi Su, Jing-xia Song, Shuang-hong Song, Qing-qing Xu, Yan-Ling Wu

Background This study analyzed the efficacy of multiple combined chemotherapy modalities on the long-term survival outcomes in stage II–IVA nasopharyngeal carcinoma (NPC) patients with undetectable pretreatment Epstein-Barr viral DNA (pre-DNA). Patients and methods We retrospectively analyzed 2,440 patients with stage II–IVA NPC with undetectable pre-DNA. Patients received any of the following treatment modalities: intensity-modulated radiotherapy (IMRT) alone; concurrent chemoradiotherapy (CCRT); induction chemoth …

27.08.2026journal-article

Advances in Research

Evaluation of Quality of Life among Breast Cancer Patients in Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria

B. O. Adegoke, J. A. Omotayo, J. G. Olaogun, G. O. Popoola, A. S. Ajiboye, S. B. Ohunakin

Background: The burden of breast cancer is gradually assuming epidemic proportions in Nigeria and globally. Increases in its incidence and mortality in Nigeria over the past three decades have been reported as 296 per cent and 223 per cent, respectively. The high morbidity and mortality rates associated with breast cancer necessitate efforts to improve the quality of life of patients with breast cancer. The World Health Organisation (WHO) defines quality of life (QoL) as an individual’s perception of their position …

27.08.2026journal-article

Frontiers in Oncology

Case Report: Synchronous SCLC and minimally invasive adenocarcinoma in the same lobe: NGS-confirmed cross-histological molecular heterogeneity in an ultra-rare case

Haoyuan Yin

A 73-year-old male was diagnosed with synchronous multiple primary lung cancer (sMPLC) involving small cell lung cancer (SCLC) and minimally invasive adenocarcinoma in the right upper lobe—an ultra-rare entity accounting for only 2.0% of all lung cancers, with cross-histological (SCLC + adenocarcinoma) same-lobe presentation reported in fewer than 10 cases globally to date. Notably, the SCLC component exhibited striking aggressiveness and diagnostic mimicry: it initially presented as a 0.3cm tiny nodule with benign …

27.08.2026journal-article

International Journal of Molecular Sciences

Targeting PKM2 Enhances the Anti-Tumor Function of CD8+ T Cells Through Metabolic Reprogramming

Junxiu Zhang, Shuyi Wu, Qin Yin, Yanglin Liu, Shuguo Zheng, Peiwei Yang

The efficacy of adoptive cell transfer (ACT) therapy in solid tumors is often limited by the functional exhaustion and insufficient persistence of infused CD8+ T cells within the tumor microenvironment. Through the integrated analysis of single-cell transcriptomic data, this study identified enolase 1 (ENO1), a key rate-limiting enzyme in glycolysis, as a core gene highly correlated with the superior anti-tumor phenotype of tumor-infiltrating lymphocytes (TILs). However, in vitro functional validation demonstrated …