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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Lymphatics

Draining the Brain: A Novel Noninvasive Lymphatic Therapy for Parkinson’s Disease

Yazan Mahafza, Winnie Pao, Angela Bialorucki, Heidi Simon, Wei F. Chen

The discovery of the glymphatic system and meningeal lymphatic vessels established that the brain possesses an organized lymphatic clearance network that drains to the deep cervical lymphatics. Disruption of this system has been suggested to contribute to the accumulation of pathogenic proteins implicated in neurodegeneration. Cervical lymphatic reconstruction has been associated with some neurological benefit in Alzheimer’s and Parkinson’s disease, and preclinical work has demonstrated that noninvasive manipulatio …

27.08.2026journal-article

Cellular Oncology

Epigenetic memory of epithelial–mesenchymal transition: linking transient plasticity to metastasis, therapy resistance, and immune evasion

Dominika Denisz, Magdalena Fabian, Jan Olszewski, Karolina Bajdak-Rusinek

Abstract Epithelial–mesenchymal transition (EMT) is increasingly recognized as a dynamic, plastic process that equips tumor cells with invasive capacity, stress tolerance, stem-like features, and adaptability, contributing to metastasis, therapeutic failure, and immune escape. Accumulating evidence indicates that these effects can outlast the inducing signal: tumor cells may retain molecular and functional traces of prior EMT exposure, biasing future cell-state behavior. This Review terms this phenomenon EMT memory …

27.08.2026journal-article

Addiction Science Reviews

A Systematic Review on the Effectiveness of Cognitive Behavioral Therapy in Substance Use Disorders

Erva Ceren Gülsatar, Fahriye Balkır

Substance Use Disorder (SUD) is a multidimensional clinical condition characterized by impaired control over substance use and significant deterioration in psychological, physical, and social functioning. The aim of this systematic review was to evaluate the effectiveness of Cognitive Behavioral Therapy (CBT) in the treatment of substance use disorders based on current evidence. The review was conducted in accordance with the PRISMA 2020 guidelines. Studies published between January 2010 and June 2026 were identifi …

27.08.2026journal-article

International Journal of Molecular Sciences

Repurposing Disulfiram for Cancer Therapy: Mechanistic Insights and Translational Challenges

Anna Bilska-Wilkosz, Magdalena Górny, Małgorzata Iciek

Disulfiram (DSF), long used as an aversive agent in alcohol dependence therapy, has recently regained attention as a promising candidate for oncological drug repurposing. After administration, DSF is rapidly reduced to diethyldithiocarbamate (DDC), which, in the presence of Cu2+, forms the complex Cu(DDC)2. This compound acts as a strong inducer of oxidative stress, an inhibitor of the ubiquitin–proteasome system, and a suppressor of endogenous hydrogen sulfide (H2S) synthesis. DSF also modifies protein and non-pro …

27.08.2026journal-article

Journal of Occupational & Environmental Medicine

The Effectiveness of Ergonomic Training and Chiropractic Treatment in Industrial Workers with Nonspecific Chronic Neck Pain: A Randomized Controlled Trial

Deniz Balikçi, Beyzanur Dikmen Hoşbaş, Ömer Şevgin

OBJECTIVE: To evaluate whether adding chiropractic treatment to ergonomic training improves pain, function, and sleep in industrial workers with chronic nonspecific neck pain. METHODS: Forty-five male industrial workers were randomized (15 per group) to ergonomic training plus chiropractic treatment (CTG), plus sham manipulation (SMTG), or alone (CG) for four weeks. Pain (VAS), biopsychosocial impact (BNQ), disability (NDI), and sleep quality (PSQI) were assessed before and after. The group × time interaction was t …

27.08.2026journal-article

Arthroscopy, Sports Medicine, and Rehabilitation

Availability and Pricing of Orthobiologic Knee Injections Vary by Practice Type but Not by Community Socioeconomic Vulnerability in Suburban New York

Tracy M. Tauro, Benjamin Hershfeld, Katharine Chen, Ran Lampert, Adam D. Bitterman, Randy M. Cohn, Nicholas A. Sgaglione

Purpose To assess the availability, price transparency, and pricing of platelet‐rich plasma (PRP), bone marrow aspirate concentration, and stem cell injections for knee osteoarthritis (OA) among orthopaedic sports medicine (OSM) practices and alternative clinics in suburban New York and to evaluate the impact of the economic status of a population on the availability and pricing of biologic injections. Methods Between July and September 2025, OSM practices and alternative clinics offering PRP, bone marrow aspirate …

27.08.2026journal-article

Cellulose

Bioactive silver(I) complex delivered via bacterial cellulose and Zeolitic imidazolate framework-8 composites for skin cancer therapy

Silmara C. Lazarini Frajácomo, Augusto Henrique Piva, Hernane da Silva Barud, Eliane Trovatti, Tamires de Souza Nossa, Bernardo Castro-Dominguez, Regina Celia Galvão Frem, Bruna C. Lustri, Douglas H. Nakahata, Pedro P. Corbi, Wilton R. Lustri

Abstract Topical antimicrobial strategies that combine targeted drug delivery with selective cytotoxicity are critically needed for treating infected skin lesions, especially those complicated by multidrug-resistant bacteria. Here, we report the synthesis, characterization, and evaluation of a silver(I) complex with the sulfonamide probenecid (Ag–PROB) and its integration into a bacterial cellulose (BC) based composite with zeolitic imidazolate framework-8 (ZIF-8) for controlled release applications. We developed t …

27.08.2026journal-article

Perspectives of the ASHA Special Interest Groups

Breathing Retraining and Laryngeal Control in Exercise-Induced Laryngeal Obstruction and Breathing Pattern Dysfunction: A Practical Therapy Model for Clinicians

Amrita Bonthu, Claudio F. Milstein

Objective: Exercise-induced laryngeal obstruction (EILO) and breathing pattern dysfunction (BPD) are common, yet frequently misdiagnosed, contributors to exertional dyspnea, especially in adolescent and young adult athletes. Despite increasing recognition of behavioral interventions as first-line therapy, there is a lack of simple, accessible, and reproducible protocols in clinical settings. This clinical focus article describes a practical, clinician-friendly therapy model that integrates laryngeal control, respir …

27.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Effects of psychological interventions on competitive anxiety and athletic performance in golfers: a systematic review and meta-analysis

Longhui Li, Zilong Zhao, Xuewen Li, Yang Yi

Abstract Background Competitive anxiety is common in golf and can negatively affect athletic performance. Psychological interventions are widely used to manage competitive anxiety and enhance performance; however, evidence specific to golfers has not yet been systematically synthesized. This study aims to evaluate the effects of psychological interventions on competitive anxiety and athletic performance in golfers. In addition, subgroup analyses were conducted to explore potential sources of variation in interventi …

27.08.2026journal-article

Frontiers in Public Health

Lung cancer screening in occupational settings: a scoping review

Edelqueen Ijeoma Okoro, Helena Keller, Felix Greiner, Jan Heidrich, Volker Harth

Background Lung cancer is the leading cause of cancer-related mortality worldwide. It is often asymptomatic until advanced stages, resulting in delayed diagnosis and poor survival. Screening enables early detection and reduces mortality. Multiple occupational and environmental exposures have been linked to lung cancer, and some guidelines recommend their inclusion in risk assessment. This review aims to map the existing evidence on lung cancer screening (LCS) in occupational settings. Methods This review followed J …

27.08.2026journal-article

Frontiers in Nuclear Medicine

Artificial intelligence across oncologic theranostics: evidence for patient stratification, dosimetry, and adaptive radiopharmaceutical therapy

Mallareddy Banala, Shabbir Ezuddin, Mark Foley, Russ Kuker

Artificial intelligence (AI) has been studied across radiopharmaceutical therapy (RPT); however, evidence for treatment-changing use remains limited. We conducted a structured narrative review with descriptive mapping of learned models for patient stratification, segmentation, tumor-burden quantification, quantitative preprocessing, dosimetry, toxicity prediction, response assessment, and radiation-safety/logistics support. The mapped set contained 73 direct full journal reports and eight direct conference abstract …

27.08.2026journal-article

Neuro-Oncology

15 Promoting the need for a dedicated Neuro‑Oncology Occupational Therapy Service at QEHB: A Quality Improvement Project

Megan Jones

Abstract Introduction This project highlights the role of Occupational Therapists (OTs) in supporting the neuro‑oncology patient population at the Queen Elizabeth Hospital Birmingham (QEHB). Although the OT service is well established, there is currently no structured pathway to ensure that patients with brain cancer receive optimal pre‑ and post‑operative management. This patient group is also at risk of inadequate follow‑up after discharge, re-affirming the need for service development and targeted investment. Me …

27.08.2026journal-article

Applied Sciences

Voice-Controlled Intralogistics on an Open Cyber–Physical Middleware: Deep Learning-Based Speech Processing and Validation in an Industrial Noisy Environment

Predrag Pecev, Marinko Maslarić, Vladimir Todorović, Saša Sudar, Svetlana Nikoličić

The rapid development of Industry 4.0 brings significant benefits to intralogistics through increased flexibility, interoperability, and real-time responsiveness. However, the growing complexity of industrial environments creates challenges for logistics process adaptation and the integration of emerging technologies such as voice-driven control of heterogeneous robotic and IoT systems. Open-source solutions offer a promising approach by enabling vendor independence and cost-effective deployment. This paper investi …

27.08.2026journal-article

Micromachines

From Signal Stacking to Dynamic Coupling: A Critical Review of Wearable EEG–EMG Fusion Brain–Computer Interfaces for Stroke Rehabilitation

Mengna Dai, Mingke Jiao, Yuheng Wang

This structured critical review examines wearable brain–computer interface (BCI) systems that integrate electroencephalographic (EEG) and electromyographic (EMG) signals for post-stroke motor rehabilitation. The central engineering problem is the spatio-temporal heterogeneity between cortical and muscular signals, which limits the reliability and generalizability of conventional EEG–EMG fusion. We review acquisition and synchronization methods, data-, feature-, and decision-level fusion, deep-learning architectures …

27.08.2026journal-article

Cancer Immunology Research

CD4+ T Cells Play Distinct Roles during the Priming versus Effector Phases of Immune Checkpoint Therapy–Dependent Tumor Elimination by CD8+ T Cells

Samuel Ameh, Derek J. Theisen, Mahima Thapa, Jackson S. Turner, Abhinav Rangarajan, Christopher A. Nelson, Aaron J. Schmitz, Yuang Song, Ruan F. Vieira Medrano, Cora D. Arthur, J. Michael White, Kathleen C.F. Sheehan, Daved H. Fremont, Ali H. Ellebedy, Hussein Sultan, Robert D. Schreiber

Abstract It is well established that CD4+ T cells play a critical role in facilitating immune checkpoint therapy (ICT). Although CD4+ T-cell function in lymph nodes during CD8+ T-cell priming has been well investigated, their requirement at the effector phase in the tumor is only now beginning to be appreciated. Herein, we used our major histocompatibility complex class II–negative (MHC-II−) sarcoma models to confirm that CD4+ T cells are essential not only during T-cell priming but also to maintain T-cell effector …

27.08.2026journal-article

PLOS Digital Health

Extracting adverse event nature, severity, timelines and resulting interventions from clinical notes of patients receiving CAR-T cell therapy using large language models

Jordan Guillot, Brenda Miao, Arvind Suresh, Madhumita Sushil, Christopher Y. K. Williams, Rohit Vashisht, Tomiko T. Oskotsky, Marina Sirota, Atul J. Butte

Chimeric Antigen Receptor T-cell (CAR‑T) therapy, genetically engineered patient T cells targeting tumor antigens, has transformed care for hematologic malignancies but requires careful tracking of adverse events (AEs) often documented only in unstructured electronic health record (EHR) notes. We evaluated a Large Language Model (LLM)–based approach in UCSF’s secure environment to extract AEs, dates, grades, and interventions within 30 days post‑infusion for six commercial CAR‑T products (2012–2023), benchmarking a …

27.08.2026journal-article

International Journal of Health and Pharmaceutical (IJHP)

Hypoglycemia Incidence Among Patients With Type 2 Diabetes Mellitus Receiving Antidiabetic Therapy: A Retrospective Hospital-Based Study in South Kalimantan, Indonesia

Nadiyah Wafa, Tyas Setia Nugraha, Herda Ariyani

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease with an increasing prevalence. Antidiabetic drugs (OAD) are necessary for glycemic control, but they carry the risk of causing hypoglycemia. Objective: This study aimed to assess patient characteristics, OAD usage patterns including drug type, dosage, and regimen, hypoglycemic complaints, and side effect categories using the Naranjo Algorithm. Method: A descriptive, observational quantitative study with a retrospective, non-experimental design was condu …

27.08.2026journal-article

Alzheimer's Research & Therapy

Association of self-reported hearing loss and tinnitus with brain structure and cognitive function: a population-based cross-sectional analysis from the Study of Health in Pomerania (SHIP)

Claudia Schwarz, Stefan Frenzel, Till Ittermann, Ulrike Grittner, Silke M Wortha, Tina Brzoska, Hans J Grabe, Agnes Flöel, Friedrich Ihler

Abstract Background Hearing loss has been reported as a major, potentially modifiable risk factor for dementia and often co-occurs with tinnitus. Both conditions are prevalent and have been linked to brain health and cognitive decline. However, evidence from studies containing the whole age span of adults remains limited. Therefore, this study investigated associations of hearing loss and tinnitus with brain structure and cognitive performance in a large population-based cohort from northeastern Germany. Methods Da …

27.08.2026journal-article

HRB Open Research

Pilot of a person-centred, interdisciplinary approach to goal setting in Ireland’s National Rehabilitation Hospital: a study protocol

Lauren Christophers, Zsofia Torok, Catherine Cornall, Aine Carroll

Background Research has emphasised the value of a person-centred, interdisciplinary team (IDT) approach to structured goal setting in rehabilitation; yet these approaches are not consistently implemented in clinical practice, limiting the effect that goal setting can have on rehabilitation. The introduction of a new IDT, person-centred goal-setting process to Ireland’s National Rehabilitation Hospital (NRH) offers an opportunity to gain insight into barriers to implementing and normalising IDT goal setting in compl …

27.08.2026journal-article

Biomedicines

From Delivery to Design: Site-Specific Genome Engineering for Next-Generation CAR T-Cell Therapy

Hala Aldahshan, Abeer Al-Hubaysh, Dimah K. Alrabiah, Meshael Alturki, Reem R. Alkharji, Salwa Lin, Mohammed S. Aldughaim, Raef Albugami

Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of haematological malignancies, but conventional viral transduction results in semi-random genomic integration, contributing to heterogeneous CAR expression and potential insertional effects. Site-specific genome engineering offers an alternative by directing CAR insertion to defined genomic loci, allowing greater control over transgene expression and cellular function. This narrative review evaluates advances in site-specific CAR T-cell e …

27.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Early Organization of Simultaneous Multimodal Behaviors: Perception- and Production-Based Contingencies as a Scaffold for Language Development

Bonnie Levin-Asher, Liat Kishon-Rabin

Aim: This study investigated how infants' simultaneous multimodal behaviors (SMBs)—the concurrent coordination of vocal, gaze, facial, and manual signals—are organized during natural caregiver–infant interactions at 3 and 6 months. Within a contingency-based framework, we examined how perception-based and production-based SMBs reflect early multisensory and sensorimotor coordination and how these patterns relate to later language development with the aim of characterizing SMBs as functional units of early communica …

27.08.2026journal-article

International Journal of Humanities and Social Science

The Geography of Everyday Exclusion: Third Spaces and Occupational Inequality in Delhi NCR

Siya Jain

Third spaces that sit between home (first space) and work (second space) are often described as neutral ground that is open and accessible to everyone. This study questions that assumption in the context of Delhi NCR (Delhi, Noida, Gurgaon, Ghaziabad), asking whether formal and informal (precarious) workers experience and access these spaces on equal terms. A structured questionnaire including largely quantitative questions was designed and administered to 116 workers, comprising 50 formal and 66 informal workers ( …

27.08.2026journal-article

Philosophical Transactions of the Royal Society B: Biological Sciences

Piecing together the structure of epidermal growth factor receptor complexes: a journey from crystals to cells and its impact on cancer therapy

Selene Roberts, Dave Clarke, Ioannis Galdadas, Marisa Martin-Fernandez

Abstract The epidermal growth factor receptor (EGFR) was cloned and identified as an oncogene 40 years ago, and since then has become the poster child for receptor tyrosine kinases in physiological and pathophysiological settings. Cell surface EGFRs bind growth factors secreted by adjacent cells and undergo conformational changes that transduce normal or dysregulated growth and division signals across the plasma membrane. It took more than two decades for atomic resolution of partial structures to become available, …

27.08.2026journal-article

Clinical Psychology & Psychotherapy

Imagery Interventions and Cognitive‐Behavioural Therapy for Psychological Complaints Related to Bullying: A Systematic Review and Meta‐Analysis

Meng Liang, Gerly Tamm, Olivia De Laere, Yannick Vander Zwalmen, Ernst H. W. Koster

ABSTRACT Bullying is associated with internalizing symptoms and impaired everyday functioning. Cognitive‐behavioural therapy (CBT) and imagery interventions have been studied as treatments to improve mental health after such experiences. This meta‐analysis aimed to evaluate the effects of individual CBT and imagery interventions in targeting internalizing symptoms (negative affect, depression, anxiety and post‐traumatic stress symptoms) and improving self‐perception and coping in bullying victims. Systematic search …