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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Frontiers in Public Health

Transitional care gaps and caregiver burden after ICU discharge: a cross-sectional study of patient–caregiver dyads

Hongfei Wang, Ning Luo, Yin Li

Background Survivors of critical illness experience post-intensive care syndrome (PICS), and family caregivers bear a parallel burden, PICS-family, while gaps in transitional-care services persist. We aimed to determine the prevalence of a high transitional-care gap after intensive care unit (ICU) discharge (primary outcome) and to assess whether it was associated with caregiving burden and psychological strain; a secondary aim was to assess residence-related access barriers. Methods A single-center cross-sectional …

28.08.2026journal-article

Frontiers in Digital Health

Next viewer–development of a software for the spatial computing data glasses apple vision pro for patient-specific preoperative planning and navigation

Conrad Günther, Dirk Winkler, Svenja Jung, Martin Hoffmann, Katharina Scheidt, Fabian Kropla, Erdem Güresir, Ronny Grunert

Objective This study aims to evaluate the clinical utility of nextViewer , a novel spatial computing application for the Apple Vision Pro, to determine its efficacy in enhancing patient-specific neurosurgical preoperative planning, spatial comprehension, and multi-user team communication. Methods A complete translational workflow was established, encompassing the segmentation of high-resolution CT/MRI scans into patient-specific 3D models and their integration into the spatial computing environment. The software le …

28.08.2026journal-article

Frontiers in Digital Health

From technological closed-loop to human-machine trust: a systematic review of ethical and communication challenges of brain-computer interface in elderly care

Kun Fu, Peize Li, Xinxi Peng, Shuangcheng Li, Yifan Zhao, Xi Chen, Yi Ding, Chenxi Ye

As the global population ages, brain–computer interfaces (BCIs) have emerged as a promising technological pathway for restoring communication, motor function, and cognitive support in elderly care settings. However, the ethical and communication challenges accompanying BCI deployment in these contexts remain insufficiently understood. This systematic review identified 177 studies meeting the inclusion criteria from 12,423 records. Through comprehensive analysis, six core ethical themes were identified: privacy and …

28.08.2026journal-article

VNU Journal of Science: Medical and Pharmaceutical Sciences

Small Bowel Obstruction Caused by a Jackfruit Seed in a Patient With a History of Miles’ Operation for Rectal Cancer: The First Case Report in Vietnam

Tran Que Son, Trinh Ke Diep, Nong Ngoc Quang, Nguyen Chi Trung, Pham Anh Tuan, Vu Thi Thu, Tran Hoang Phuong Thao, Luong Thi Ngoc

Background: Small bowel obstruction secondary to fruit seed phytobezoars is a rare clinical entity, particularly in patients with a history of major abdominal surgery. Case Report: We report the case of an 83-year-old man who presented with abdominal pain, vomiting, and a non-functioning colostomy four days after accidentally ingesting a jackfruit seed. He had a history of Miles’ operation 15 years prior for rectal cancer. Abdominal computed tomography confirmed small bowel obstruction caused by a foreign body meas …

28.08.2026journal-article

BMJ Military Health

The recovery, readjustment and reintegration programme (R3P): a guide to implementation

Di Lamb, Joanna Jepson, Amos Simms

The Recovery, Readjustment and Reintegration Programme (R3P) is a structured, meaning-based psychological support tool that offers peers the opportunity to meet and discuss their shared experiences to enable better coping. Since its inception in 2020, the tool has been adopted nationally by the UK National Health Service and by international military partners. R3P is a leader-led, non-medical initiative, which navigates participants through group discussions focussing on five themes that are acknowledged to cause d …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Genetically engineered biological therapy in dermatology: modern technologies and development prospects. Part 1

V.V. Petunina, V.Yu. Vasenova, E.I. Tsygankova, E.V. Fedorova, B.N. Ramazonov

Modern dermatology is experiencing a revolutionary period due to the implementation of genetically engineered biological therapy (GEBT) and targeted methods for the treatment of chronic skin diseases. The article presents a comprehensive analysis of modern technologies of genetically engineered biological therapy (GEBT) in dermatology. The main methods of GEBT are considered, including the CRISPR/Cas9 system, adenoviral vectors and RNA interference, as well as various classes of biological drugs: inhibitors of tumo …

28.08.2026journal-article

Micromachines

Artificial Versus Magneto-Aerotactic Bacterial Robots for Cancer Therapy

Sylvain Martel

The use of magnetotactic bacteria (MTB), proposed by the author about 25 years ago, allowed the implementation of embedded capabilities allowing the execution of specific complex tasks such as the target delivery of therapeutics in tumoral hypoxic zones that could not be implemented in artificial micro/nanorobots due to technological limitations at such a small scale. Since then, technology has evolved but the question remains about how long such superior advantage of using only certain types of live microorganisms …

28.08.2026journal-article

Japanese Journal of Clinical Oncology

Clinical features and treatment outcomes of fibrous dysplasia: a report from the Bone and Soft Tissue Tumor Registry in Japan

Masayuki Morishita, Daisuke Kobayashi, Akira Ogose, Akira Kido, Akihiko Takeuchi, Kazu Matsumoto, Kota Watanabe, Yoji Furukawa, Michio Ozeki, Akira Kawai, Yoshihiro Nishida

Abstract Background Fibrous dysplasia (FD) is a benign bone disorder classified into monostotic (MFD) and polyostotic (PFD) forms. There is limited evidence available regarding the clinical management of FD, and no large-scale epidemiological or treatment reports have been published from Japan. Therefore, this study aimed to clarify FD epidemiology and management using data from the nationwide Bone and Soft Tissue Tumor (BSTT) Registry. Methods This study retrospectively analyzed patients with MFD and PFD registere …

28.08.2026journal-article

Life

Association of the Endothelial Activation and Stress Index (EASIX) with Clinical Outcomes in Patients with Pneumosepsis: A Retrospective Cohort Study

Derya Özyiğitoğlu, Ayşe Çapar, Emre Çapar, Şeyma Başlılar

Background: Endothelial dysfunction is a key component of sepsis pathophysiology. The Endothelial Activation and Stress Index (EASIX) is a practical biomarker derived from routine laboratory parameters and indirectly reflects endothelial injury. This study aimed to evaluate the prognostic association of EASIX with in-hospital mortality and organ-support requirements among patients with pneumosepsis admitted to the intensive care unit (ICU). Methods: This retrospective cohort study included 1787 adult patients with …

28.08.2026journal-article

Scientific Bulletin of the Dnipro State University of Internal Affairs

КЛАСИФІКАЦІЯ НОРМАТИВНО-ПРАВОВИХ АКТІВ У СФЕРІ ЗАБЕЗПЕЧЕННЯ БЕЗПЕКИ ГРОМАДИ АДМІНІСТРАТИВНОЮ ДІЯЛЬНІСТЮ НАЦІОНАЛЬНОЇ ПОЛІЦІЇ УКРАЇНИ

Максим АХРАМЄЄВ

У статті розглянуто погляди дослідників на класифікацію нормативно-правових актів, що регулюють питання адміністративної діяльності Національної поліції України, та на цій основні пропонуються підходи до класифікації нормативно-правових актів у сфері забезпечення безпеки громади адміністративною діяльністю Національної поліції України. Зазначається, що вся діяльність поліції, повноваження поліцейських та процедурні аспекти реалізації їхніх повноважень та виконання завдань, покладених на поліцію, відбувається виключ …

28.08.2026journal-article

Clinical and Experimental Dermatology

Superimposed Mosaicism in Tuberous Sclerosis Complex Presenting as Predominantly Right-Sided Facial Angiofibromas

Jane Hoban, Marion Leahy, Logeswaran Selvarajah, Muriel Sadlier, Laoise Griffin

A 9-year-old boy presented with flesh-coloured papules present since early childhood and were gradually increased in size and number. Clinical examination revealed multiple small, firm papules arranged in a linear configuration, more conspicuous on the right side compared with the left. Given the asymmetric distribution of the lesions, mosaic TSC was suspected. Molecular analysis of DNA extracted from affected skin identified two pathogenic somatic variants involving TSC1. Asymmetrical brain MRI findings supported …

28.08.2026journal-article

International Journal of Environmental Research and Public Health

Pre-, Peri-, and Postnatal Factors of Molar–Incisor Hypomineralization in Brazilian Schoolchildren: A Cross-Sectional Study

Karina Kendelhy Santos, Patrícia Gomes Fonseca, Túlio Silva Pereira, Jéssica Madeira Bittencourt, Maria Letícia Ramos-Jorge, Maria Eliza da Consolação Soares, Lívia Guimarães Zina, Izabella Barbosa Fernandes

To assess the prevalence of molar–incisor hypomineralization (MIH) and identify the associated factors in Brazilian schoolchildren, a representative cross-sectional study was conducted Diamantina, Brazil, with a random sample of 316 (80.8% response rate) children aged 7 to 10 from public and private schools. The presence of MIH was assessed according to the criteria of the European Academy of Pediatric Dentistry (EAPD). Sociodemographic data and data related to the prenatal, perinatal, and postnatal periods, as wel …

28.08.2026journal-article

Informatica

Generative Adversarial Networks for Primary Healthcare Planning: A Systematic Review of Synthetic Data Generation and Budget Forecasting

I Komang Sugiartha, Adang Suhendra, I Made Wiryana

Primary healthcare systems, particularly in low and middle income countries, are caused by insufficient data, constraints on resources, and shifts in the demand for services. The focus of this paper is on a sys- tematic literature review to understand the impact of Generative Adversarial Networks (GANs) in the area of budget and planning in primary healthcare systems. Peer-reviewed literature was used for the analysis, and 35 studies published in the period of 2017 to 2025 were selected and reviewed based on the in …

28.08.2026journal-article

Frontiers in Microbiology

Molecular epidemiology of Theileria parva in cattle, factors associated with the positivity in northern Malawi, and efficacy of traditional medicine

Gift Kingsley Kayira, Takahiro Ishizaki, Shingo Asakura, Ryota Matsuyama, Makoto Ukita, Kyoko Hayashida, Haruyuki Hirata, Kohei Makita

Introduction East Coast fever (ECF), caused by Theileria parva , remains endemic in Malawi. ECF vaccines and chemical treatments are regarded as expensive by small-holder farmers. The aims of this study were to clarify the epidemiology of ECF and to evaluate the efficacy of ethnoveterinary medicine, Synadenium cupulare on T. parva infection. Methods A cross-sectional study was conducted in three districts of northern Malawi (Chitipa, Karonga, and Mzimba). A structured questionnaire on feeding style, treatment of EC …

28.08.2026journal-article

Hippocrates Medical Journal

An Investigation of Awareness, Utilization, Satisfaction, and Barriers in Home Health Care Services

Mustafa Onmaz, Gunay Huseynova, Burak Altındağ, Ahmet Emre Hatır

Objective: This study aimed to determine awareness, knowledge, service utilization, satisfaction, general opinions, and perceived barriers regarding home health care services among adults attending a family medicine outpatient clinic.Materials and Methods: This cross-sectional study was conducted with 153 adults who applied to a Family Medicine Outpatient Clinic between February 15 and April 30, 2026. Data were collected through face-to-face interviews using a structured questionnaire developed by the researchers. …

28.08.2026journal-article

Movement Disorders Clinical Practice

Clinically Probable REM Sleep Behavior Disorder and Other Non‐Motor Symptoms in Progressive Supranuclear Palsy: Prevalence and Associated Clinical Features

Neeraj Balaini, Paras Borse, Manu Santhappan Girija, Reji Paul, Aimy Hynse, Asha Kishore

Abstract Background REM sleep behavior disorder (RBD) is now increasingly recognized in progressive supranuclear palsy (PSP), with unclear clinical relevance. Objectives To determine the frequency of pRBD and non‐motor symptoms in PSP and association between the two. Methods We enrolled 150 consecutive patients with PSP and 150 age‐ and sex‐matched controls. Probable RBD (pRBD) was identified using the REM Sleep Behavior Disorder Screening Questionnaire. Clinical, cognitive, and NMS scores were measured using valid …

28.08.2026journal-article

Structural Health Monitoring

Fault diagnosis of rotating machinery bearings under strong noise backgrounds using refined composite wavelet packet fuzzy diversity entropy

Xuenian Hu, Yongliang Song, Jin Xu, Yusong Pang, Gang Cheng, Chang Liu, Peiyao Cao, Wenqing Chen, Dongyang Liu

In recent years, multiscale fuzzy diversity entropy (MFDE) has been demonstrated as a highly promising feature extraction tool for intelligent fault diagnosis. Compared to existing entropy methods, MFDE offers the advantages of high consistency, strong robustness, and excellent computational efficiency. However, the coarse-graining process within MFDE exclusively accounts for fault information concealed in low-frequency bands, neglecting high-frequency components and thereby leading to incomplete feature extraction …

28.08.2026journal-article

Medicine

Long-term adverse effects following COVID-19 vaccination

Jehad A. Aldali, Sultan Ayoub Meo

During the COVID-19 pandemic, vaccinations were highly beneficial to public health, preventing disease and reducing mortality. This study aimed to investigate long-term adverse clinical symptoms following COVID-19 vaccination with the Oxford AstraZeneca (ChAdOx1 nCoV-19, Oxford), Pfizer-BioNTech (BNT162b2), and Moderna (mRNA-1273) vaccines. In this cross-sectional study, the total number of participants was 429; among them, 243 (56.6%) were male, and 186 (43.4%) were female. An online Google Form was prepared in bo …

28.08.2026journal-article

Medicine

Impact of renal function on the safety of biologic and synthetic DMARDs in rheumatoid arthritis

Dilara Bulut Gökten, Ömer Atakan Soğur, Zoljargal Sukhbaatar, Ridvan Mercan

This study aimed to evaluate treatment patterns, adverse events, and drug discontinuations associated with conventional synthetic (csDMARDs), biologic, and targeted synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis (RA) and chronic kidney disease (CKD). A retrospective cohort study was conducted on 264 RA patients with CKD, followed between 2015 and 2025. Renal function was assessed using estimated glomerular filtration rate (CKD-epidemiology collaboration) and categorized accord …

28.08.2026journal-article

Medicine

eGFR partially mediates the association between Dietary Inflammatory Index and all-cause mortality in older adults

Tingting Hu, Ying Zhang, Zhu Chen, Zhifen Zhang, Jun Su

This study examines the association between the Dietary Inflammatory Index (DII) and all-cause mortality in older adults and investigates the mediating role of estimated glomerular filtration rate (eGFR) using National Health and Nutrition Examination Survey data. We included 6300 participants aged ≥ 60 years from 9 National Health and Nutrition Examination Survey cycles (2001–2018). All-cause mortality (ascertained via linkage to the National Center for Health Statistics) was the primary endpoint. Cox proportional …

28.08.2026journal-article

Clinical Cancer Research

Multicenter Phase I Study of Triapine in Combination with [177Lu]Lutetium-Dotatate in Patients with Well-Differentiated Neuroendocrine Tumors (ETCTN 10388)

Aman Chauhan, Heidi L. Weiss, Charles Kunos, Rani Jayswal, Bhavana Konda, Heloisa P. Soares, Daneng Li, Thorvardur R. Halfdanarson, Mary F. Mulcahy, Heather A. Jacene, Aman Khurana, Rakhi Modak, Donglin Yan, Jan H. Beumer, Susan M. Christner, Peter I-Fan Wu, Biswajit Das, Larry V. Rubinstein, Steven D. Gore, S. Percy Ivy, Elise C. Kohn, William E. Carson, Lowell B. Anthony, Susanne M. Arnold

Abstract Purpose: The next generation of theranostics studies is looking at novel combinations with radiation sensitizers to enhance peptide receptor radionuclide therapy’s efficacy. In this study, we present safety and efficacy data from a multicenter phase I study of a [177Lu]lutetium-dotatate–triapine combination in patients with gastroenteropancreatic (GEP) neuroendocrine tumors (NET). Patients and Methods: The study consisted of 2 phases (part A: dose escalation; part B: dose expansion) administering the recom …

28.08.2026journal-article

Occupational Medicine

Nutrition and hydration habits of German anaesthesiology residents

J Reuter, P Meybohm, J Menger

Abstract Background Adequate nutrition and hydration during clinical workdays are essential for physicians’ wellbeing, health, cognitive function, and performance. Anaesthesiology residents work in high-pressure environments that may hinder adherence to recommended dietary and fluid intake guidelines and impair their healthy eating and drinking habits. Aims To assess the dietary and hydration habits of anaesthesiology residents in Germany, identify workplace-related barriers, and evaluate their readiness for behavi …

28.08.2026journal-article

Journal of Medical Internet Research

Application of Digital Health Technologies in Scoliosis Rehabilitation: Systematic Review Based on the Technology Classification Framework

Yujie Guan, Jiaben Xu, Zelin Liu, Qi Qin, Xian Wang, Chengyuan An, Gege Wang, Zhiyuan Zhang, Maomao Gong, Bin Zhao

Abstract Background Digital health technologies are increasingly being used in scoliosis rehabilitation, but current evidence remains fragmented, and the effectiveness of these technologies across different categories, and their implementation in the real world remains unclear. Objective We systematically evaluated the efficacy, implementation factors, and potential mechanisms of action of digital health technologies across various categories for scoliosis rehabilitation. Methods We searched PubMed, IEEE Xplore, Em …

28.08.2026journal-article

Borneo Nursing Journal (BNJ)

Kesiapan Menyusui pada Ibu Hamil Trimester III di Wilayah Kerja Puskesmas Pemurus Baru

Maya Safitri, Nurul Hidayah, Yuni Riska Nur Fariana, Dwi Sogi Sri Redjeki

Latar Belakang: Trimester Ketiga merupakan periode krusial bagi ibu hamil untuk mempersiapkan pemberian ASI eksklusif. Capaian ASI eksklusif di Kalimantan Selatan 66,01%, masih dibawah target nasional 80%. Rendahnya kesiapan terutama pada aspek psikologis berpotensi menghambat keberhasilan menyusui. Tujuan: Mengetahui kesiapan menyusui pada ibu hamil trimester III di wilayah kerja Puskesmas Pemurus Baru. Metode: Penelitian deskritif kuantitatif, dengan teknik sampling pengambilan sampel menggunakan total sampling. …