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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

International Journal of Psychological and Brain Sciences

Trust and Misinformation in Youth Digital Mental Health Information-Seeking in Kenya: Implications for Diagnosis Accuracy and Treatment-Seeking Behavior

Rosemary Odhiambo

Digital platforms have become primary environments through which Kenyan youth seek mental health information, interpret psychological distress, and decide whether to pursue professional care. While digital mental health information-seeking can enhance awareness, reduce stigma, and provide immediate psychosocial support, the credibility of online content remains uneven, exposing youth to misinformation, unregulated pseudo-therapy, and algorithm-reinforced diagnostic narratives. This study examines how trust and misi …

27.08.2026journal-article

Frontiers in Immunology

Remodeling the tumor immune microenvironment: mechanisms of crosstalk between regulated cell death macrophages

Xiaotang Duan, Peiling Ma, Xinyue Ao, Xinyu Li, Jiaxin Huang, Linjiang Song

Although advances have been made in tumor immunotherapy, the immunosuppressive tumor microenvironment and treatment resistance still limit durable clinical benefit. Rather than functioning exclusively as terminal cytotoxic phenomena, regulated cell death (RCD) pathways generate surface cues, soluble mediators and cellular cargo that reshape immune responses. Here, we review the reciprocal interactions linking tumor-associated macrophages (TAMs) with apoptosis, necroptosis, pyroptosis, autophagy-related regulation, …

27.08.2026journal-article

Supportive Care in Cancer

"This is the first time I felt they're mine": the significance of tattoos in coping and identity reconstruction following mastectomy

Tsipi Hanalis-Miller, Avital Genkin, Avital Gershfeld-Litvin

Abstract Background Breast cancer and subsequent mastectomy result in significant physical and emotional changes, including damaged body image, compromised sense of femininity, diminished self-esteem, and profound experiences of grief and loss. While reconstruction procedures are routinely offered, some women choose artistic mastectomy tattoos as an alternative means of reclaiming their bodies and reconstructing identity. Objective Grounded in the Dual Process Model of Coping with Bereavement, this study explored h …

27.08.2026journal-article

Annals of Pharmacotherapy

Relacorilant in Combination With Nab-Paclitaxel for the Treatment of Adults With Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Emilie J. Lynch, Lauren T. Carpenter, Kelli N. Corona, Adebola O. Fatimilehin, Nathan D. Seligson

Objective: To review the pharmacology, efficacy, and safety of relacorilant (Lifyorli) in combination with nab-paclitaxel (NP) for the treatment of adults with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer who have received 1 to 3 prior lines of systemic therapy, including at least one bevacizumab-containing regimen. Data Sources: A literature search was conducted using Embase and PubMed/MEDLINE, applicable published abstracts, and ongoing studies from ClinicalTrials.gov betwee …

27.08.2026journal-article

Cancer Medicine

Demographic, Clinicopathological Characteristics, and Prognosis of 81 Chinese Elderly Patients With Acral Melanoma

Kaidi Yang, Xin Cai, Jin Wu, Kui Jiang, Weizhen Zhang, Hongfeng Zhou, Fang Liu, Yan Wang, Jiwei Liu, Di Wu

ABSTRACT Purpose Acral melanoma (AM) is a rare melanoma subtype involving palms, soles, and nail beds. Clinical‐pathological features and survival of elderly AM patients remain insufficiently understood. This study aimed to investigate the characteristics and survival of elderly Chinese AM patients to support clinical management. Methods Consecutive AM patients aged ≥ 75 years treated at five Chinese melanoma centers between January 2012 and March 2025 were enrolled. Results A total of 81 elderly AM patients were i …

27.08.2026journal-article

JAMA Oncology

Cancer Biologics Utilization After Biosimilar Entry and Financial Implications For Payers and Patients

Xiaoyu Liu, Xiaoyi Xu, Z John Lu, Ya-Chen Tina Shih

Importance Biosimilars are highly similar to originator biologics and were introduced to increase market competition, lower the price of biologics, and expand patient access by improving affordability. By the end of 2024, three anticancer biologics have experienced biosimilar entry in the US (bevacizumab, rituximab, and trastuzumab), underscoring the need to evaluate their financial implications for payers and patients. Objective To assess market dynamics and examine financial implications associated with biosimila …

27.08.2026journal-article

Histochemistry and Cell Biology

Lamin subtype expression in Merkel-cell carcinoma: its relation to polyomavirus infection and tumor metastasis

Merel Stiekema, Monique Ummelen, Moritz Jesinghaus, Corinna U. Keber, Viktoria Wischmann, Ingrid Moll, Jack Cleutjens, Marc A. M. J. van Zandvoort, Jos L. V. Broers, Frans C. S. Ramaekers, Roland Moll

Abstract Merkel-cell carcinoma (MCC) is known for its high metastatic potential. Studies in several tumor types have proposed a role for up- or downregulation of nuclear A- and B-type lamins in facilitating the process of invasion and metastasis, but such studies are lacking for MCC. Therefore, lamin expression levels were examined in 38 tissue samples from 28 patients with MCC using immunohistochemistry. The series comprised primary tumors and different metastases and both Merkel cell polyomavirus (MCPyV) positive …

27.08.2026journal-article

Journal of Pancreatology

Postoperative blood glucose levels: A predictor of poor survival in resected pancreatic cancer

Yi Liu, Yina Liao, Zhiwen Xiao, Yiying Li, Nuoyan Zhang, Yang Shi, Yilin Song, Xinyue Wang, Quanxing Ni, Timothy M. Pawlik, Xianjun Yu, Guopei Luo

Abstract Background: Although pancreatic resection influences glucose metabolism, the clinical impact of postoperative fasting blood glucose (FBG) on survival outcomes in patients undergoing curative-intent resection for pancreatic cancer remains unreported. Methods: Data from patients who underwent curative-intent resection for pancreatic cancer and have diabetic status records were retrieved from a prospectively maintained database from November 2010 to May 2017. Postoperative FBG was measured at 2–4 months after …

27.08.2026journal-article

BMC Cancer

SPON2 promotes glioma invasion and pro-angiogenic activity with involvement of ITGA5-related integrin signaling and β-catenin/TCF transcriptional activity

Jingjing Pan, Gege Zhou, Tao Jiang, Heqin Zhan

Abstract Purpose Glioma is a highly aggressive primary brain tumor characterized by infiltrative growth, vascular abnormalities, and poor clinical outcome. However, extracellular matrix-associated regulators that contribute to glioma progression remain incompletely understood. This study aimed to determine the expression, biological function, and potential molecular mechanism of SPON2 in glioma. Methods Differential expression, survival, WHO grade, IDH status, and adjusted survival analyses were performed using pub …

27.08.2026journal-article

Frontiers in Medicine

From transcriptomic profiling to precision oncology: a bibliometric analysis of RNA sequencing in acute myeloid leukemia

Yuye Ren, Jiao Ma, Wenya Hu, Lan Zhang, Xiaomin Wang

Background RNA sequencing (RNA-seq) has become an important tool for investigating the molecular heterogeneity of acute myeloid leukemia (AML); however, the global development and thematic evolution of this field remain inadequately characterized. Objective To map the global landscape of AML RNA-seq research and identify major knowledge domains, emerging themes, and temporal changes in research priorities. Methods Publications indexed in the Web of Science Core Collection and Scopus between January 1, 2007, and Aug …

27.08.2026journal-article

Cancers

Prognostic Significance of Peri-Treatment Inflammatory Burden Index in Patients with Rectal Cancer Undergoing Preoperative Chemoradiotherapy

Takanobu Mori, Yoshinaga Okugawa, Tadanobu Shimura, Ma Ruiya, Naru Mizuno, Shinji Yamashita, Akira Yamamoto, Takahito Kitajima, Hiroki Imaoka, Mikio Kawamura, Yuhki Koike, Hiromi Yasuda, Yoshiki Okita, Shigeyuki Yoshiyama, Minako Kobayashi, Tomofumi Koide, Masaki Ohi, Yuji Toiyama

Background/Objectives: Systemic inflammatory responses influence treatment response and oncological outcomes in patients with cancer. Growing evidence indicates that the inflammatory burden index (IBI) serves as a reliable prognostic indicator across various malignancies. However, the clinical significance of the peri-treatment inflammatory status in patients with rectal cancer (RC) undergoing preoperative chemoradiotherapy (CRT) remains unclear. Methods: We assessed the pre- and post-treatment IBI in 97 patients w …

27.08.2026journal-article

Addiction Science Reviews

Cognitive Behavioral Therapy in the Treatment of Internet Gaming Addiction: A Systematic Review

Elif Naz Ciner, Meryem Karaaziz

The aim of this study is to systematically examine the effectiveness of Cognitive Behavioral Therapy (CBT) in individuals experiencing internet gaming addiction. A systematic review method was employed, and studies published in English between 2002 and 2025 were identified through searches in Google Scholar and PubMed using predetermined keywords. Within the scope of the inclusion and exclusion criteria, randomized controlled trials and experimental intervention studies were evaluated, and 10 studies were included …

27.08.2026journal-article

Neuro-Oncology

5 A multivariate plasma biomarker model enabling safe exclusion of glioblastoma

M Jonathan Decarpentrie, Clara David, Julien Favresse, M Julien Cabo, Fabienne George, Lionel D’Hondt, Matteo Riva, Jonathan Douxfils

Abstract Introduction Glioblastoma (GBM) is the most aggressive primary brain tumor and remains difficult to diagnose due to reliance on MRI and invasive biopsies, which are limited by accessibility, morbidity, and radiologic uncertainty. Blood-based biomarkers may provide a minimally-invasive strategy to support early diagnostic-triage. Methods In this retrospective case-control study, plasma samples from 72 patients with newly-diagnosed GBM and 102 age-matched healthy controls were analyzed. Seven circulating pro …

27.08.2026journal-article

The Oncologist

Paired genomic profiling of primary tumor and lymph-node metastases identifies candidate prognostic features in penile squamous cell carcinoma

Kexin Lou, linghui Liang, Hongzhou Cai, Ting Xu, Fufeng Wang, Di Wang, Qifan Jing, Jiani C Yin, Xiaoxiang Zhang, Zicheng Xu

Abstract Background Penile squamous cell carcinoma (PSCC) is a rare malignancy with limited genomic data in Asian populations. Lymph node metastasis heavily dictates prognosis, yet molecular determinants of progression remain poorly understood. We aimed to characterize the genomic landscape and explore candidate prognostic genomic features using paired primary and metastatic PSCC tumors. Patients and Methods Targeted next-generation sequencing (437 cancer-related genes) was performed on primary tumors and matched l …

27.08.2026journal-article

Biotechnology and Bioprocess Engineering

Enhancing TGF-β1 production in CHO cells via MS-275 treatment, Bax/Bak knockout, and PACEsol overexpression

Kyungsoo Kim, Kyoung Eun Baek, Gyun Min Lee

Abstract Efficient production of recombinant human transforming growth factor-β1 (rhTGF-β1) in Chinese hamster ovary (CHO) cells is limited by low yields and inefficient precursor processing. Here, we developed an integrated strategy combining chemical and genetic engineering. Screening of additives revealed that the histone deacetylase inhibitor MS-275 increased specific productivity ( q hTGF−β1 ) but inhibited growth, without affecting precursor processing. To counteract this, Bax and Bak double knockout cells we …

27.08.2026journal-article

Neuro-Oncology

Volumetric Changes in Hippocampal Subfields and Memory Performance After Fractionated Brain Radiation Therapy

Hieu Nguyen, Austin B Hopper, Jiwandeep S Kohli, Connor Puett, Anika Christofferson, Roshan Karunamuni, Kathryn R Tringale, Soumya Unnikrishnan, Alena Stasenko, Carrie R McDonald, Jona A Hattangadi-Gluth

Abstract Background The hippocampus comprises discrete anatomic subfields subserving different components of memory. We evaluated longitudinal, dose-dependent volumetric changes in hippocampal subfields after fractionated RT and determined their associations with verbal and visuospatial memory performance. Methods Eighty-nine adults with primary brain tumors received fractionated RT on a prospective clinical trial. High-resolution 3D volumetric MRI and memory tests were obtained at baseline and 3, 6, and 12-months …

27.08.2026journal-article

Journal of Eating Disorders

Mentalization-based treatment for eating disorders: a systematic review and narrative synthesis

Katie Gabrielle Salucci, Sela Scott, Amelia Austin

Abstract Background Mentalization-based treatment (MBT) targets difficulties in reflective functioning, emotion regulation and interpersonal relationships, which may contribute to the development and maintenance of eating disorders (EDs). This systematic review synthesised the available quantitative evidence on the outcomes of MBT or MBT-informed interventions for people with EDs. Methods A protocol was prospectively registered with PROSPERO (CRD42024421136) and the review was conducted in accordance with PRISMA gu …

27.08.2026journal-article

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

Evaluation of Endometriosis-Associated Pain Scores and Complications after Laparoscopic Surgery in Patients Unresponsive to Medical Treatment

Hale Ankara Aktaş, Murat Levent Dereli, Gülfem Başol, Fatih Şanlıkan, Yasmin Aboalhasan Yoldaş, Esra Keles, Gazi Yıldız, Emre Mat

Endometriosis is a chronic gynecologic disorder characterized by the presence of endometrial-like tissue outside the uterus, often associated with pelvic pain and infertility. Although several medical treatments exist, many patients experience persistent symptoms that require surgical management. Painful pelvic symptoms are the main reason why women with endometriosis who do not respond to medical options seek treatment. This study aimed to evaluate changes in pelvic pain symptoms before and after laparoscopic endo …

27.08.2026journal-article

Infection Control & Hospital Epidemiology

Impact of ethyl alcohol nasal treatment on hospital-onset Staphylococcus aureus bacteremia at a tertiary health system

Donna Nucci, Jennifer H. Sather, Michael Aniskiewicz, Scott C. Roberts

Abstract Introduction: Staphylococcus aureus is a common pathogen that can cause nosocomial infection. Ethyl alcohol has emerged as a potential alternative to mupirocin and povidone-iodine for nasal decolonization; however, data on real-world application are limited. Methods: A quasi-experiment study was performed. Twice daily 62% ethyl alcohol nasal swabs were offered to inpatients at risk for MRSA acquisition. Compliance was monitored and reasons for non-adherence were evaluated. Rates of hospital-onset S. aureus …

27.08.2026journal-article

Strategy Science

Unique Strategies and Average Treatment Effects

Jason Snyder, Robert Wuebker, Todd Zenger

What explains the increasing disconnect between empirical strategy research and real-world strategy? Although empirical methods have evolved, notably in the use of techniques that support causal identification, we argue that empirical strategy’s focus on estimating well-identified average treatment effects from a population-level model of performance is fundamentally misaligned with the strategist’s need for firm-specific insights about how to build firm-specific models that guide strategic decision making. This mi …

27.08.2026journal-article

Frontiers in Oncology

PD-1/PD-L1 inhibitor-related cystitis: clinical features, diagnostic exclusion, and outcomes in one definite and seven probable cases with an updated literature review

Wei Ding, Heqian Liu, Lin Li, Yingqing Liu, Jiawei Wang, Zhonglang Wang, Lingsong Tao, Xiansheng Zhang

Background PD-1/PD-L1 inhibitor-related cystitis (PD-(L)1-RC) is an uncommon urinary immune-related adverse event that may be mistaken for bacterial cystitis, tumor progression, radiation injury, stone disease, or chemotherapy-related hemorrhagic cystitis. This study describes the clinical phenotype, diagnostic exclusion process, treatment response, and updated literature context of PD-(L)1-RC. Methods We retrospectively reviewed eight patients who developed new lower urinary tract symptoms after PD-1/PD-L1 inhibit …

27.08.2026journal-article

Neuro-Oncology

28 Travel time and carbon footprint of patients accessing stereotactic radiosurgery for intracranial metastatic disease from South West Wales

Rebecca John, Jennifer Kahan, Prashanth Bhat, Douglas Etheridge, Genotan Reggian, Nicholas Gomez, Ali Hussnain, Sara Walters, Najmus Sahar Iqbal, Jillian MacLean, James Powell

Abstract Introduction At present, all oncology patients from South West Wales Cancer Centre (SWWCC) who require stereotactic radiosurgery (SRS) are treated approximately 74km away in Velindre Cancer Centre (VCC) in Cardiff. Research by The Tessa Jowell Academy SRS working group highlighted the wide variation in access to SRS for patients and risk of inequity. We analysed travel time and the potential environmental impact of the current SRS service. Method Data was retrospectively collected on all SWWCC patients who …

27.08.2026journal-article

Neuro-Oncology

80 The Multi-Modal Combination of Magnetic Resonance Spectroscopy and Apparent Diffusion Coefficient Features Improves Radiological Prognostic Stratification of Paediatric Medulloblastoma

Timothy Mulvany, Daniel Griffiths-King, Katherine Crombie, Sara Burling, Lara Worthington, Andrew Peet, John Apps, Jan Novak

Abstract Introduction Magnetic Resonance Spectroscopy (MRS) and Apparent Coefficient Maps (ADC) features have previously demonstrated prognostic value, identifying high-risk groups of paediatric medulloblastoma (MB) and predicting patient survival. Despite evidence in diagnostic applications that their multi-modal combination can provide further added value over either modality individually, the combination of ADC and MRS has not been evaluated for MB prognostics. Method This study utilises the MRS and ADC from 44 …

27.08.2026journal-article

Frontiers in Medicine

Rising burden of early-onset lung cancer among Chinese adolescents and young adults (1990–2023): a Bayesian age-period-cohort analysis with projections to 2038

Yi Dong, Yongjie Guan, Maosen Zhao, Shuang Feng, Xiaowei Wang, Mingming Wang, Maoyong Fu, Jiayu Shang, Ke Gao

Background Early-onset lung cancer (diagnosed at age 15–39 years) remains uncommon, yet incidence is rising in several world regions. China—the largest contributor to global lung cancer mortality—has not had its youth burden comprehensively characterized or projected. Methods Using the Global Burden of Disease Study 2023 (GBD 2023), we extracted annual incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) for Chinese adolescents and young adults (AYA) aged 15–39 years from 1990 to 2023. Joinp …