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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

Evaluation of Endometriosis-Associated Pain Scores and Complications after Laparoscopic Surgery in Patients Unresponsive to Medical Treatment

Hale Ankara Aktaş, Murat Levent Dereli, Gülfem Başol, Fatih Şanlıkan, Yasmin Aboalhasan Yoldaş, Esra Keles, Gazi Yıldız, Emre Mat

Endometriosis is a chronic gynecologic disorder characterized by the presence of endometrial-like tissue outside the uterus, often associated with pelvic pain and infertility. Although several medical treatments exist, many patients experience persistent symptoms that require surgical management. Painful pelvic symptoms are the main reason why women with endometriosis who do not respond to medical options seek treatment. This study aimed to evaluate changes in pelvic pain symptoms before and after laparoscopic endo …

27.08.2026journal-article

Neuro-Oncology

Volumetric Changes in Hippocampal Subfields and Memory Performance After Fractionated Brain Radiation Therapy

Hieu Nguyen, Austin B Hopper, Jiwandeep S Kohli, Connor Puett, Anika Christofferson, Roshan Karunamuni, Kathryn R Tringale, Soumya Unnikrishnan, Alena Stasenko, Carrie R McDonald, Jona A Hattangadi-Gluth

Abstract Background The hippocampus comprises discrete anatomic subfields subserving different components of memory. We evaluated longitudinal, dose-dependent volumetric changes in hippocampal subfields after fractionated RT and determined their associations with verbal and visuospatial memory performance. Methods Eighty-nine adults with primary brain tumors received fractionated RT on a prospective clinical trial. High-resolution 3D volumetric MRI and memory tests were obtained at baseline and 3, 6, and 12-months …

27.08.2026journal-article

Strategy Science

Unique Strategies and Average Treatment Effects

Jason Snyder, Robert Wuebker, Todd Zenger

What explains the increasing disconnect between empirical strategy research and real-world strategy? Although empirical methods have evolved, notably in the use of techniques that support causal identification, we argue that empirical strategy’s focus on estimating well-identified average treatment effects from a population-level model of performance is fundamentally misaligned with the strategist’s need for firm-specific insights about how to build firm-specific models that guide strategic decision making. This mi …

27.08.2026journal-article

International Journal of Cancer

Toward Objective Anal Cancer Screening: From Swab‐Based Genome‐Wide Methylation Marker Discovery to Novel Test Development

Kirsten Rozemeijer, Jürgen Claesen, Fernando Dias Gonçalves Lima, Albertus T. Hesselink, Phoebe Klingers, Timo ter Braak, Yara van den Burgt, Chris J. L. M. Meijer, Jan M. Prins, Henry J. C. de Vries, Mark A. van de Wiel, Renske D. M. Steenbergen

ABSTRACT Anal high‐grade squamous intraepithelial lesions (HSIL:AIN2/3) are precursors to anal cancer, and early detection and treatment through screening is crucial for effective cancer prevention. Current guidelines recommend anal swab‐based screening and highlight the need for objective biomarkers to improve risk stratification. While DNA methylation markers have shown strong potential in anal biopsies, their performance in anal swabs is reduced, likely due to sample‐type dependency. This study aimed to identify …

27.08.2026journal-article

Cancer

Cancer statistics for Asian American, Native Hawaiian, and Pacific Islander people, 2026

Nikita Sandeep Wagle, Angela N. Giaquinto, Mandi Yu, Hyuna Sung, Tyler B. Kratzer, Kekoa Taparra, Jessica Star, Ahmedin Jemal, Rebecca L. Siegel

ABSTRACT Background Cancer statistics for Asian American and Native Hawaiian and Pacific Islander (NHPI) people are usually aggregated, masking substantial variation within this heterogeneous population. Herein, the American Cancer Society reports cancer incidence and survival for 8 Asian American and 3 NHPI ethnic groups. Methods The authors used population‐based cancer registry data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results program, for Asian American and NHPI ethnic groups …

27.08.2026journal-article

Inquiry@Queen's Undergraduate Research Conference Proceedings

Trends in Eligibility Criteria in Solid Tumor Systemic Therapy Trials Over Time

Jenny Han

Background: Cancer clinical trials have used restrictive eligibility criteria, limiting patient access and the generalizability of findings. In response, FRIENDS and ASCO issued recommendations to modernize eligibility criteria in 2017 and 2021. We evaluated whether these recommendations led to measurable changes in eligibility criteria in systemic therapy trials for solid tumours by comparing trial protocols at two points across a 10-year period. Methods: We reviewed randomized clinical trial protocols evaluating …

27.08.2026journal-article

Inquiry@Queen's Undergraduate Research Conference Proceedings

End-of-life Cancer Care Among Adults with Intellectual and Developmental Disabilities

Sophia Shi

Introduction: Intellectual or developmental disabilities (IDD) refer to conditions that affect intellectual, adaptive, and social skills that arise during the developmental period. Previous research indicates that adults with IDD are more likely to be diagnosed with advanced cancer and have lower rates of survival compared to non-disabled people. However, there is limited research examining end-of-life (EOL) cancer care among this patient population, and even less research documenting the lived experience of adults …

27.08.2026journal-article

Neuro-Oncology

28 Travel time and carbon footprint of patients accessing stereotactic radiosurgery for intracranial metastatic disease from South West Wales

Rebecca John, Jennifer Kahan, Prashanth Bhat, Douglas Etheridge, Genotan Reggian, Nicholas Gomez, Ali Hussnain, Sara Walters, Najmus Sahar Iqbal, Jillian MacLean, James Powell

Abstract Introduction At present, all oncology patients from South West Wales Cancer Centre (SWWCC) who require stereotactic radiosurgery (SRS) are treated approximately 74km away in Velindre Cancer Centre (VCC) in Cardiff. Research by The Tessa Jowell Academy SRS working group highlighted the wide variation in access to SRS for patients and risk of inequity. We analysed travel time and the potential environmental impact of the current SRS service. Method Data was retrospectively collected on all SWWCC patients who …

27.08.2026journal-article

Neuro-Oncology

80 The Multi-Modal Combination of Magnetic Resonance Spectroscopy and Apparent Diffusion Coefficient Features Improves Radiological Prognostic Stratification of Paediatric Medulloblastoma

Timothy Mulvany, Daniel Griffiths-King, Katherine Crombie, Sara Burling, Lara Worthington, Andrew Peet, John Apps, Jan Novak

Abstract Introduction Magnetic Resonance Spectroscopy (MRS) and Apparent Coefficient Maps (ADC) features have previously demonstrated prognostic value, identifying high-risk groups of paediatric medulloblastoma (MB) and predicting patient survival. Despite evidence in diagnostic applications that their multi-modal combination can provide further added value over either modality individually, the combination of ADC and MRS has not been evaluated for MB prognostics. Method This study utilises the MRS and ADC from 44 …

27.08.2026journal-article

Journal of King Saud University – Science

Eugenol extraction and characterization from clove as a potential anticancer therapeutic agent against breast cancer: Combining an in vitro and in silico molecular docking and dynamics studies

Nazifa Patel, Adil Ali, Tarun Kumar Upadhyay, Roli Mishra, Vipin Kumar Mishra, Pranav Kumar Prabhakar, Ahmed Mulfi Alharbi, Safia Obaidur Rab, Mamdouh Alshammari, Mohd Saeed

Breast cancer (BC) is leading cause of cancer-related mortality among women worldwide, with approximately 2.3 million new cases and 670,000 deaths reported in 2022. Despite advances in therapy, challenges such as drug resistance and adverse side effects necessitate the exploration of alternative treatments, particularly from natural sources. Eugenol (EUG), a bioactive compound derived from clove ( Syzygium aromaticum ), has gained attention for its antioxidant and anticancer properties. In this study, EUG was extra …

27.08.2026journal-article

Frontiers in Oncology

PD-1/PD-L1 inhibitor-related cystitis: clinical features, diagnostic exclusion, and outcomes in one definite and seven probable cases with an updated literature review

Wei Ding, Heqian Liu, Lin Li, Yingqing Liu, Jiawei Wang, Zhonglang Wang, Lingsong Tao, Xiansheng Zhang

Background PD-1/PD-L1 inhibitor-related cystitis (PD-(L)1-RC) is an uncommon urinary immune-related adverse event that may be mistaken for bacterial cystitis, tumor progression, radiation injury, stone disease, or chemotherapy-related hemorrhagic cystitis. This study describes the clinical phenotype, diagnostic exclusion process, treatment response, and updated literature context of PD-(L)1-RC. Methods We retrospectively reviewed eight patients who developed new lower urinary tract symptoms after PD-1/PD-L1 inhibit …

27.08.2026journal-article

Frontiers in Medicine

Rising burden of early-onset lung cancer among Chinese adolescents and young adults (1990–2023): a Bayesian age-period-cohort analysis with projections to 2038

Yi Dong, Yongjie Guan, Maosen Zhao, Shuang Feng, Xiaowei Wang, Mingming Wang, Maoyong Fu, Jiayu Shang, Ke Gao

Background Early-onset lung cancer (diagnosed at age 15–39 years) remains uncommon, yet incidence is rising in several world regions. China—the largest contributor to global lung cancer mortality—has not had its youth burden comprehensively characterized or projected. Methods Using the Global Burden of Disease Study 2023 (GBD 2023), we extracted annual incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) for Chinese adolescents and young adults (AYA) aged 15–39 years from 1990 to 2023. Joinp …

27.08.2026journal-article

European Respiratory Journal

The Role of Inflammation in the Pathogenesis of Pulmonary Fibrosis: Mechanisms and Treatment Implications

Nazanin Nazemi, Bruno Crestani, Doumet Georges Helou, Oliver Distler, Janine Gote-Schniering, Anna-Maria Hoffmann Vold, Carlos Machahua, Martin Kolb, Manuela Funke-Chambour

Fibrotic interstitial lung diseases (fILDs) encompass a heterogeneous group of interstitial lung diseases (ILDs) and may arise from persistent inflammation caused by systemic disease or environmental exposures. Idiopathic pulmonary fibrosis (IPF), the prototypical fILD, is characterized by progressive fibrosis, limited inflammation, and a high mortality rate. In contrast, other fILDs display variable contributions of fibrosis and inflammation that are only partially determined by the underlying diagnosis. Within mo …

27.08.2026journal-article

Pediatric Blood & Cancer

Long‐Term Restoration of Anticoagulant Function After Liver Transplantation for Severe Congenital Protein C Deficiency: A Single‐Center Experience Involving Three Pediatric Patients

Kotaro Sakaya, Akira Ishiguro, Atsushi Sakamoto, Shouichi Ohga, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara

ABSTRACT Severe congenital protein C (PC) deficiency is a rare inherited coagulation disorder that can be difficult to control with conventional medical treatment alone. We report a single‐center case series of three pediatric patients with severe congenital PC deficiency who underwent liver transplantation (LT). In all patients, plasma PC activity levels exceeded 64% after LT and remained stable without anticoagulation treatment or PC supplementation. Two patients were followed for more than 10 years, representing …

27.08.2026journal-article

Frontiers in Immunology

Mechanical properties of the tumor microenvironment: drivers of immunotherapy resistance in solid tumors

Zhen Zhang, Tianhao Deng, Wanshuang Zhou, Xiaoning Tan

The limited efficacy of immunotherapy in solid tumors is increasingly recognized to reflect not only molecular and cellular immune suppression, but also profound mechanical abnormalities within the tumor microenvironment (TME). Emerging evidence indicates that extracellular matrix (ECM) stiffening and architectural remodeling, altered cellular stiffness, elevated solid stress, abnormal fluid shear stress, and increased interstitial fluid pressure (IFP) critically shape antitumor immunity and contribute to immunothe …

27.08.2026journal-article

Advanced Science

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan

ABSTRACT Butyrate (BA) is essential for intestinal health, but its intestinal therapeutic applications are hindered by its malodorous nature, premature gastric absorption, and rapid intestinal metabolism. To address these challenges, an inodorous macromolecule β‐glucan‐BA (GLU‐BA) is synthesized via one‐step esterification, allowing for BA production in the intestine with burst yet gradual dynamics. After oral administration, GLU‐BA self‐assembles into nanomicelles, preventing premature gastric absorption. Upon rea …

27.08.2026journal-article

Pediatric Blood & Cancer

A Call to Action to Improve Rates of Lymph Node Sampling During Wilms Tumor Resection

Matthew M. Byrne, Korry T. Wirth, David Darcy, Marjorie J. Arca, Abdelhafeez Abdelhafeez

ABSTRACT Failure to perform lymphadenectomies for patients with Wilms tumor (WT) was recognized as a practice gap by the American Pediatric Surgical Association in 2018. An educational campaign was conducted to promote lymphadenectomy. We sought to evaluate the national patterns of lymph node sampling, examine provider‐level differences, and assess whether sampling rates changed following this initiative. This is a retrospective analysis of the ACS NSQIP‐Pediatric Participant Use Files from 2012 to 2022. Patients a …

27.08.2026journal-article

International Journal of Cancer

Comparison of Healthcare Utilization Before Diagnosis Between Non‐Advanced and Advanced Lung Cancer Patients: A Study Among 72,851 Cases in Germany

Josephine Küsel‐Kanbach, Oliver Riedel, Ulrike Haug

ABSTRACT There is no study from Germany on the association between stage of lung cancer (LC) and patient characteristics. We aimed to compare advanced versus non‐advanced LC cases regarding indicators of healthcare utilization. Using claims data covering 20% of the German population, we included LC patients diagnosed between 2013 and 2019. Stratified by stage (advanced vs. non‐advanced), we assessed comorbidities, hospitalizations, outpatient physician contacts and utilization of preventive measures before LC diagn …

27.08.2026journal-article

Frontiers in Oral Health

Periodontal management in patients with diabetes: the impact of periodontal treatment on cardiometabolic biomarkers

Alicia Morales, Gustavo Sáenz-Ravello, Loreto Matamala, Mauricio Baeza, Patricia Hernández-Ríos

Introduction Type II Diabetes Mellitus (T2DM) and periodontitis present an independent bidirectional relationship. While T2DM is associated with a higher prevalence, incidence, and severity of periodontitis, periodontitis might worsen glycemic control and inflammatory biomarker levels in diabetics. Although there is no standardized therapy for the treatment of diabetic patients with periodontitis, different periodontal interventions report improvements in clinical and cardiometabolic parameters. Objective To summar …

27.08.2026journal-article

Biological Products. Prevention, Diagnosis, Treatment

Inactivation of Mycoplasma gallisepticum and Mycoplasma synoviae during influenza vaccine production

N. N. Savina, M. Sh. Aliev, A. I. Reutskiy, T. V. Gorokhova, O. S. Babkina, S. V. Pankratov, N. Yu. Serova

INTRODUCTION. The use of chicken embryos in influenza vaccine production carries the risk of contaminating the final product with the avian mycoplasmas, Mycoplasma gallisepticum and M. synoviae , which pose a potential hazard to humans. Therefore, evaluating the effectiveness of inactivating these contaminants in influenza vaccine intermediates using inactivators (β-propiolactone, ultraviolet irradiation) and detergents is important. AIM. This study aimed to evaluate the inactivation dynamics of M. gallisepticum an …

27.08.2026journal-article

Frontiers in Membrane Science and Technology

Phosphate-rich municipal wastewater treatment using magnetite nanoparticles dispersed oakwood biochar-assisted pretreatment followed by air-gap membrane distillation

Prashan M. Rodrigo, Bishweshwar Pant, Sunith B. Madduri, Raghava R. Kommalapati

An integrated approach combining Fe 3 O 4 nanoparticle-loaded biochar-assisted pretreatment and air-gap membrane desalination (AGMD) was investigated for treating phosphate-rich wastewater. This study addresses key limitations of conventional coagulants, such as residual chemical load and limited removal efficiency. Fe 3 O 4 nanoparticles were co-precipitated on oakwood biochar (Fe 3 O 4 /BC). The Fe 3 O 4 /BC composite acts as a coagulant that can be rapidly separated under an applied magnetic field. This study sy …

27.08.2026journal-article

Neuro-Oncology

20 Updates on Magnetic Resonance Imaging assessment of tumour MicrOStructure in GlioblastomA: A cross-sectional study (The MIMOSA Study)

Jennifer Golten, Muhammad Akbar, Sarah Jones, Tara Davies, Lucy Hiscox, George Eralil, Kathrin Whitehouse, Najmus Sahar Iqbal, Leandro Beltrachini, Harpreet Hyare, Hannah Khirwadkar, Laura Panagiotaki, Matteo Figini, Emiliano Spezi, Kathy Seddon, Florien Siebzehnrubl, Derek Jones, Marco Palombo, James Powell

Abstract The MIMOSA (Magnetic Resonance Imaging assessment of tumour MicrOStructure in GlioblastomA) study is recruiting patients with a presumed diagnosis of glioblastoma (GBM) pre-operatively to receive advanced diffusion-weighted magnetic-resonance-imaging (DW-MRI) using the CONNECTOM microstructure MRI-scanner at Cardiff University Brain Research Imaging Centre (CUBRIC). This provides a novel non-invasive tool to explore the tumour and peritumoral zone (PTZ) over time, characterising tissue microstructure and t …

27.08.2026journal-article

Neuro-Oncology

40 Retrospective analysis of Alopecia in patient receiving Proton Beam Radiotherapy in Neuro-oncology – Single centre experience

Hasti Barot, Vandana Kushwaha, Mithushanaa Nesarajah, Adila Amariyil, Karthica Indramohan, Michelle Newman, Michael Kosmin, Naomi Fersht

Abstract Introduction Alopecia is a common and cosmetically distressing adverse effect of cranial irradiation that significantly affect quality of life in patients. Radiation induced alopecia can be short term or long term or can rarely be permanent. This study aims to evaluate the incidence of acute (≤90 days after completion) and long-term (>90 days) and permanent alopecia in brain tumour patients treated with proton beam therapy in our centre and to establish if the incidence or severity correlates with the s …

27.08.2026journal-article

Neuro-Oncology

17 Psychological and holistic consequences of delays in molecular diagnosis after neuro-oncological surgery: a qualitative study

Jay Kotecha, Shahzaib Ahmed, Kelly Dawson, Anna Mycock, Emily Lockyer, Andrew Dapaah, Simon Paine, Michael Baliousis, Stuart Smith

Abstract Introduction The 2021 WHO Classification of Tumours of the Central Nervous System supports an integrated diagnosis combining histological, immunohistochemical and molecular parameters. Advanced molecular techniques such as DNA methylome arrays and Whole Genome/Next Generation Sequencing are now required to identify certain tumour entities confidently as well as sometimes determining eligibility for clinical trials. Complex molecular analysis however can lead to extended turnaround times and significant del …