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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Journal of King Saud University – Science

Eugenol extraction and characterization from clove as a potential anticancer therapeutic agent against breast cancer: Combining an in vitro and in silico molecular docking and dynamics studies

Nazifa Patel, Adil Ali, Tarun Kumar Upadhyay, Roli Mishra, Vipin Kumar Mishra, Pranav Kumar Prabhakar, Ahmed Mulfi Alharbi, Safia Obaidur Rab, Mamdouh Alshammari, Mohd Saeed

Breast cancer (BC) is leading cause of cancer-related mortality among women worldwide, with approximately 2.3 million new cases and 670,000 deaths reported in 2022. Despite advances in therapy, challenges such as drug resistance and adverse side effects necessitate the exploration of alternative treatments, particularly from natural sources. Eugenol (EUG), a bioactive compound derived from clove ( Syzygium aromaticum ), has gained attention for its antioxidant and anticancer properties. In this study, EUG was extra …

27.08.2026journal-article

Frontiers in Oncology

PD-1/PD-L1 inhibitor-related cystitis: clinical features, diagnostic exclusion, and outcomes in one definite and seven probable cases with an updated literature review

Wei Ding, Heqian Liu, Lin Li, Yingqing Liu, Jiawei Wang, Zhonglang Wang, Lingsong Tao, Xiansheng Zhang

Background PD-1/PD-L1 inhibitor-related cystitis (PD-(L)1-RC) is an uncommon urinary immune-related adverse event that may be mistaken for bacterial cystitis, tumor progression, radiation injury, stone disease, or chemotherapy-related hemorrhagic cystitis. This study describes the clinical phenotype, diagnostic exclusion process, treatment response, and updated literature context of PD-(L)1-RC. Methods We retrospectively reviewed eight patients who developed new lower urinary tract symptoms after PD-1/PD-L1 inhibit …

27.08.2026journal-article

Frontiers in Medicine

Rising burden of early-onset lung cancer among Chinese adolescents and young adults (1990–2023): a Bayesian age-period-cohort analysis with projections to 2038

Yi Dong, Yongjie Guan, Maosen Zhao, Shuang Feng, Xiaowei Wang, Mingming Wang, Maoyong Fu, Jiayu Shang, Ke Gao

Background Early-onset lung cancer (diagnosed at age 15–39 years) remains uncommon, yet incidence is rising in several world regions. China—the largest contributor to global lung cancer mortality—has not had its youth burden comprehensively characterized or projected. Methods Using the Global Burden of Disease Study 2023 (GBD 2023), we extracted annual incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) for Chinese adolescents and young adults (AYA) aged 15–39 years from 1990 to 2023. Joinp …

27.08.2026journal-article

European Respiratory Journal

The Role of Inflammation in the Pathogenesis of Pulmonary Fibrosis: Mechanisms and Treatment Implications

Nazanin Nazemi, Bruno Crestani, Doumet Georges Helou, Oliver Distler, Janine Gote-Schniering, Anna-Maria Hoffmann Vold, Carlos Machahua, Martin Kolb, Manuela Funke-Chambour

Fibrotic interstitial lung diseases (fILDs) encompass a heterogeneous group of interstitial lung diseases (ILDs) and may arise from persistent inflammation caused by systemic disease or environmental exposures. Idiopathic pulmonary fibrosis (IPF), the prototypical fILD, is characterized by progressive fibrosis, limited inflammation, and a high mortality rate. In contrast, other fILDs display variable contributions of fibrosis and inflammation that are only partially determined by the underlying diagnosis. Within mo …

27.08.2026journal-article

Pediatric Blood & Cancer

Long‐Term Restoration of Anticoagulant Function After Liver Transplantation for Severe Congenital Protein C Deficiency: A Single‐Center Experience Involving Three Pediatric Patients

Kotaro Sakaya, Akira Ishiguro, Atsushi Sakamoto, Shouichi Ohga, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara

ABSTRACT Severe congenital protein C (PC) deficiency is a rare inherited coagulation disorder that can be difficult to control with conventional medical treatment alone. We report a single‐center case series of three pediatric patients with severe congenital PC deficiency who underwent liver transplantation (LT). In all patients, plasma PC activity levels exceeded 64% after LT and remained stable without anticoagulation treatment or PC supplementation. Two patients were followed for more than 10 years, representing …

27.08.2026journal-article

Frontiers in Immunology

Mechanical properties of the tumor microenvironment: drivers of immunotherapy resistance in solid tumors

Zhen Zhang, Tianhao Deng, Wanshuang Zhou, Xiaoning Tan

The limited efficacy of immunotherapy in solid tumors is increasingly recognized to reflect not only molecular and cellular immune suppression, but also profound mechanical abnormalities within the tumor microenvironment (TME). Emerging evidence indicates that extracellular matrix (ECM) stiffening and architectural remodeling, altered cellular stiffness, elevated solid stress, abnormal fluid shear stress, and increased interstitial fluid pressure (IFP) critically shape antitumor immunity and contribute to immunothe …

27.08.2026journal-article

Advanced Science

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan

ABSTRACT Butyrate (BA) is essential for intestinal health, but its intestinal therapeutic applications are hindered by its malodorous nature, premature gastric absorption, and rapid intestinal metabolism. To address these challenges, an inodorous macromolecule β‐glucan‐BA (GLU‐BA) is synthesized via one‐step esterification, allowing for BA production in the intestine with burst yet gradual dynamics. After oral administration, GLU‐BA self‐assembles into nanomicelles, preventing premature gastric absorption. Upon rea …

27.08.2026journal-article

International Journal of Cancer

Comparison of Healthcare Utilization Before Diagnosis Between Non‐Advanced and Advanced Lung Cancer Patients: A Study Among 72,851 Cases in Germany

Josephine Küsel‐Kanbach, Oliver Riedel, Ulrike Haug

ABSTRACT There is no study from Germany on the association between stage of lung cancer (LC) and patient characteristics. We aimed to compare advanced versus non‐advanced LC cases regarding indicators of healthcare utilization. Using claims data covering 20% of the German population, we included LC patients diagnosed between 2013 and 2019. Stratified by stage (advanced vs. non‐advanced), we assessed comorbidities, hospitalizations, outpatient physician contacts and utilization of preventive measures before LC diagn …

27.08.2026journal-article

Pediatric Blood & Cancer

A Call to Action to Improve Rates of Lymph Node Sampling During Wilms Tumor Resection

Matthew M. Byrne, Korry T. Wirth, David Darcy, Marjorie J. Arca, Abdelhafeez Abdelhafeez

ABSTRACT Failure to perform lymphadenectomies for patients with Wilms tumor (WT) was recognized as a practice gap by the American Pediatric Surgical Association in 2018. An educational campaign was conducted to promote lymphadenectomy. We sought to evaluate the national patterns of lymph node sampling, examine provider‐level differences, and assess whether sampling rates changed following this initiative. This is a retrospective analysis of the ACS NSQIP‐Pediatric Participant Use Files from 2012 to 2022. Patients a …

27.08.2026journal-article

Frontiers in Oral Health

Periodontal management in patients with diabetes: the impact of periodontal treatment on cardiometabolic biomarkers

Alicia Morales, Gustavo Sáenz-Ravello, Loreto Matamala, Mauricio Baeza, Patricia Hernández-Ríos

Introduction Type II Diabetes Mellitus (T2DM) and periodontitis present an independent bidirectional relationship. While T2DM is associated with a higher prevalence, incidence, and severity of periodontitis, periodontitis might worsen glycemic control and inflammatory biomarker levels in diabetics. Although there is no standardized therapy for the treatment of diabetic patients with periodontitis, different periodontal interventions report improvements in clinical and cardiometabolic parameters. Objective To summar …

27.08.2026journal-article

Biological Products. Prevention, Diagnosis, Treatment

Inactivation of Mycoplasma gallisepticum and Mycoplasma synoviae during influenza vaccine production

N. N. Savina, M. Sh. Aliev, A. I. Reutskiy, T. V. Gorokhova, O. S. Babkina, S. V. Pankratov, N. Yu. Serova

INTRODUCTION. The use of chicken embryos in influenza vaccine production carries the risk of contaminating the final product with the avian mycoplasmas, Mycoplasma gallisepticum and M. synoviae , which pose a potential hazard to humans. Therefore, evaluating the effectiveness of inactivating these contaminants in influenza vaccine intermediates using inactivators (β-propiolactone, ultraviolet irradiation) and detergents is important. AIM. This study aimed to evaluate the inactivation dynamics of M. gallisepticum an …

27.08.2026journal-article

Frontiers in Membrane Science and Technology

Phosphate-rich municipal wastewater treatment using magnetite nanoparticles dispersed oakwood biochar-assisted pretreatment followed by air-gap membrane distillation

Prashan M. Rodrigo, Bishweshwar Pant, Sunith B. Madduri, Raghava R. Kommalapati

An integrated approach combining Fe 3 O 4 nanoparticle-loaded biochar-assisted pretreatment and air-gap membrane desalination (AGMD) was investigated for treating phosphate-rich wastewater. This study addresses key limitations of conventional coagulants, such as residual chemical load and limited removal efficiency. Fe 3 O 4 nanoparticles were co-precipitated on oakwood biochar (Fe 3 O 4 /BC). The Fe 3 O 4 /BC composite acts as a coagulant that can be rapidly separated under an applied magnetic field. This study sy …

27.08.2026journal-article

Neuro-Oncology

20 Updates on Magnetic Resonance Imaging assessment of tumour MicrOStructure in GlioblastomA: A cross-sectional study (The MIMOSA Study)

Jennifer Golten, Muhammad Akbar, Sarah Jones, Tara Davies, Lucy Hiscox, George Eralil, Kathrin Whitehouse, Najmus Sahar Iqbal, Leandro Beltrachini, Harpreet Hyare, Hannah Khirwadkar, Laura Panagiotaki, Matteo Figini, Emiliano Spezi, Kathy Seddon, Florien Siebzehnrubl, Derek Jones, Marco Palombo, James Powell

Abstract The MIMOSA (Magnetic Resonance Imaging assessment of tumour MicrOStructure in GlioblastomA) study is recruiting patients with a presumed diagnosis of glioblastoma (GBM) pre-operatively to receive advanced diffusion-weighted magnetic-resonance-imaging (DW-MRI) using the CONNECTOM microstructure MRI-scanner at Cardiff University Brain Research Imaging Centre (CUBRIC). This provides a novel non-invasive tool to explore the tumour and peritumoral zone (PTZ) over time, characterising tissue microstructure and t …

27.08.2026journal-article

Neuro-Oncology

40 Retrospective analysis of Alopecia in patient receiving Proton Beam Radiotherapy in Neuro-oncology – Single centre experience

Hasti Barot, Vandana Kushwaha, Mithushanaa Nesarajah, Adila Amariyil, Karthica Indramohan, Michelle Newman, Michael Kosmin, Naomi Fersht

Abstract Introduction Alopecia is a common and cosmetically distressing adverse effect of cranial irradiation that significantly affect quality of life in patients. Radiation induced alopecia can be short term or long term or can rarely be permanent. This study aims to evaluate the incidence of acute (≤90 days after completion) and long-term (>90 days) and permanent alopecia in brain tumour patients treated with proton beam therapy in our centre and to establish if the incidence or severity correlates with the s …

27.08.2026journal-article

Neuro-Oncology

17 Psychological and holistic consequences of delays in molecular diagnosis after neuro-oncological surgery: a qualitative study

Jay Kotecha, Shahzaib Ahmed, Kelly Dawson, Anna Mycock, Emily Lockyer, Andrew Dapaah, Simon Paine, Michael Baliousis, Stuart Smith

Abstract Introduction The 2021 WHO Classification of Tumours of the Central Nervous System supports an integrated diagnosis combining histological, immunohistochemical and molecular parameters. Advanced molecular techniques such as DNA methylome arrays and Whole Genome/Next Generation Sequencing are now required to identify certain tumour entities confidently as well as sometimes determining eligibility for clinical trials. Complex molecular analysis however can lead to extended turnaround times and significant del …

27.08.2026journal-article

Neuro-Oncology

41 Pharmacological depletion of NAD+ has single agent cytotoxicity and radiosensitises glioma stem-like cells through impaired DNA replication and repair

Kamila Rosiak-Stec, Mark Jackson, Karin Williams, Alejandro Huerta-Uribe, David Sumpton, Richard Elliott, Neil Carragher, Oliver Maddocks, Anthony Chalmers

Abstract Introduction Metabolic rewiring contributes to radioresistance and poor outcomes in glioblastoma. Nicotinamide phosphoribosyltransferase (NAMPT) is rate-limiting in the NAD salvage pathway and overexpressed in GBM; high expression correlates with poor survival. We hypothesised that the NAMPT inhibitor FK866 would overcome radioresistance in GBM models. Methods Effects on proliferation, clonogenic survival, cell cycle, gene expression and DNA damage responses were measured in genetically diverse, patient-de …

27.08.2026journal-article

Frontiers in Medicine

Effectiveness and renal safety of dupilumab in the treatment of moderate-to-severe atopic dermatitis patients with chronic kidney disease stages 4–5: a real-world cohort study in China

Gang Hu, Quanhong Zhang, Luoyao Yang, Yanglin Hu, Jinbo Chen

Background While dupilumab is widely used for atopic dermatitis (AD), its safety and effectiveness in patients with severe renal failure remain insufficiently studied. Objective To evaluate the real-world effectiveness and renal safety of dupilumab in this population. Methods This cohort study included 30 adult moderate-to-severe AD patients with Chronic Kidney Disease (CKD) stages 4–5. Patients were divided into a dupilumab-treated group ( n = 17) and a control group ( n = 13) receiving conventional therapy. Effec …

27.08.2026journal-article

Frontiers in Oncology

Quantitative MRI in the assessment of clival invasion in locally advanced nasopharyngeal carcinoma

Yuqing Lv, Fayi Yu, Xunmei Liu, Yifan Xu, Min Hu, Lulu Huang, Rensheng Wang, Tingting Zhang

Objective This study assesses the value of quantitative magnetic resonance imaging (qMRI) in evaluating clival invasion (CI) and monitoring therapeutic response in locally advanced nasopharyngeal carcinoma (LA-NPC). It also investigates the relationship between qMRI parameter changes in CI and regression of nasopharyngeal soft-tissue invasion. Methods In this prospective study, fifty-five LA-NPC patients with CI from a single-center underwent qMRI at baseline (t0), pre-radiotherapy (t1), mid-radiotherapy (t2), and …

27.08.2026journal-article

Medicina

Prognostic Significance of CDKL2 in Non-Small Cell Lung Cancer: A Favorable Association in Lung Adenocarcinoma

Minji Song, Yunha Lee, Jun-Chae Lee, An-Na Bae, Jae-Ho Lee

Background and Objectives: Non-small cell lung cancer (NSCLC) comprises biologically distinct histologic subtypes, including lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). We evaluated whether the prognostic association of cyclin-dependent kinase-like 2 (CDKL2) differs by histology. Materials and Methods: TCGA CDKL2 expression was linked to harmonized clinical data. The primary analysis used a pooled multivariable Cox model with continuous standardized CDKL2 expression, histology, and a CDKL2 × …

27.08.2026journal-article

Psycho-Oncology

Addressing Existential Distress Through Compassion: Feasibility and Preliminary Effects of Compassion With You (COMwithU), a Compassion‐Based Intervention for Patients With Cancer

Yeonkyu Choi, Jang Sub Kim, Hyejeong Ahn, Soowan Han, Min Cheol Seo, Jae Hyun Ryou, Da Eun Kim, Yoosuk An, Bhumsuk Keam, Tae‐Yong Kim, Eun Seoung Yu, Hye Yoon Park

ABSTRACT Background Cancer‐related distress extends beyond anxiety and depression to existential suffering, including loss of meaning, helplessness, uncertainty, and relational strain. Compassion‐based interventions in psycho‐oncology are promising, but existential outcomes such as demoralization and spiritual well‐being have rarely been examined. Compassion With You (COMwithU) is a brief, five‐session compassion‐based intervention that centers on cultivating self‐compassion, supported by the therapist's compassion …

27.08.2026journal-article

Bioelectricity

Natural Compounds and Electroporation in Oncology: Synergistic Approaches for Enhanced Cancer Therapy

Dilek Yonar, Burcu Baba, Çağla Zübeyde Köprü, Urszula Ciesielska, Julita Kulbacka, Anna Choromańska

This review explores the emerging integration of natural agents with electroporation (EP) techniques in oncology. Natural compounds derived from plants, microbes, and marine organisms hold promise for cancer treatment due to their multifaceted mechanisms of action, including apoptosis induction and inhibition of tumor progression. EP, a method that enhances cell membrane permeability, facilitates the efficient intracellular delivery of these bioactive compounds. This synergistic approach has demonstrated significan …

27.08.2026journal-article

Frontiers in Oncology

Genomic and epigenomic diversity of breast cancer across Western and MENA populations: implications for precision oncology

Saniyah Shaikh, Arshiya Akbar, Hafsah Tajammul Khalifey, Thaabit Raziq, Dina Abu-Saleh, Hibah Alruwaili, Shrouq Almansouri, Itika Arora, Edwin Aroke, Khalid Walid Freij, Mohammad Imran Khan, Ahmed Yaqinuddin

Breast cancer is the most common malignancy in women worldwide and is increasingly recognized as a biologically diverse disease shaped by both molecular and ancestral context. Women from the Middle East and North Africa (MENA) populations, including Saudi Arabia, often present at a younger age and with more aggressive subtypes such as HER2-positive and triple-negative breast cancer (TNBC) compared with Western cohorts. These clinical patterns reflect a distinctive genomic background marked by high consanguinity, fo …

27.08.2026journal-article

Frontiers in Oncology

Longitudinal analysis of genomic and immune differences between primary and metastatic nasopharyngeal carcinoma for precision oncology

Ying Lu, Tiantian Han, Lihui Wang, Xishan Chen, Huan Lin, Mengxiao Wang, Dongsheng Chen, Haixin Huang

Introduction Nasopharyngeal carcinoma (NPC) is a common malignancy with a high incidence in Southern China and Southeast Asia. Distant metastasis remains a major cause of poor prognosis. This study aims to explore the genomic and immune microenvironmental changes in primary and metastatic NPC through longitudinal analysis, to provide insights for guiding precision treatment strategies. Methods We analyzed tumor samples from 11 male NPC patients with distant metastasis. Paired primary and metastatic samples underwen …

27.08.2026journal-article

Molecular Biomedicine

Lactate metabolism and protein lactylation in inflammatory and tumor microenvironments

Huaqing Lei, Yulin Bai, Jiaqi Tang, Xiaoyan Pu, Jiarui Lan, Xiangyu Lei, Dan Cai, Shuang Gou, Lin Liu, Siyu Hao, Yu Chen, Yueshui Zhao, Jing Shen, Xu Wu, Mingxing Li, Meijuan Chen, Xiaobing Li, Yuhong Sun, Li Gu, Wanping Li, Zhangang Xiao, Yan Li, Yan Zhang, Hanyu Li, Fukuan Du

Abstract Lactate and lactate-mediated protein lactylation are no longer viewed merely as accompanying phenomena of enhanced glycolysis, hypoxic responses, or tissue acidification. They are now recognized as an important regulatory axis that links local metabolic stress to chromatin regulation and altered protein function. With the rapid development of research on histone and non-histone lactylation, lactate-related signals have been implicated in inflammatory injury and repair, fibrotic remodeling, tumor immune esc …