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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

International Journal of Psychosexual Therapy

306: Sex Therapy with Neuro-spicy Couples

Lena Fenton

Clinicians working in sex and relationship-focused (SF) therapy must be thoroughly trained in understanding how sensory features impact sensuality, sexuality, and eroticism for autistic individuals and couples. Sensory sensitivities are highly prevalent in autistic populations and can significantly influence experiences of intimacy, connection and sexual functioning (Minshew & Hobson, 2008). These sensitivities may manifest as heightened or diminished responses to touch, sound, light, or other sensory inputs, which …

25.08.2026journal-article

Drug Metabolism and Personalized Therapy

Assessment of the impact of valproic acid co-administration on clozapine plasma concentrations in Tunisian patients

Syrine Ben Hammamia, Safa Souissi, Mariem Bettoumia, Mouna Ben Sassi, Khouloud Ferchichi, Mouna Daldoul, Hanene El Jebari, Mohamed Zouari, Issam Salouage, Rim Charfi, Riadh Daghfous, Emna Gaies, Sameh Trabelsi

Abstract Objectives Reports on drug-drug interactions between Valproic Acid (VPA) and Clozapine (CLZ) are very inconsistent. Previous reports demonstrate that VPA may exhibit either inhibitory or inductive effects or have no effect on CLZ pharmacokinetics. The aim of this study was to investigate the impact of VPA on plasma CLZ concentrations in a series of Tunisian patients. Methods This retrospective study was conducted from 2010 to 2025 at the Clinical Pharmacology Department of the Tunisian National Pharmacovig …

25.08.2026journal-article

Frontiers in Cardiovascular Medicine

Novel echocardiographic tools for predicting a good response to cardiac resynchronization therapy: a narrative review

Beata Uziębło-Życzkowska, Despina-Manuela Toader, Magdalena Potapowicz-Krysztofiak

Despite significant progress in new echocardiographic techniques, the role of echocardiography in qualifying patients for cardiac resynchronisation therapy (CRT) remains limited solely to the assessment of left ventricular ejection fraction (LVEF). This review aims to present the current knowledge on new echocardiographic methods that may be useful in predicting the response to resynchronization. Recent advances in speckle-tracking echocardiography (STE) have introduced several promising parameters. Measures such a …

25.08.2026journal-article

Language, Speech, and Hearing Services in Schools

Estimated Prevalence of Developmental Language Disorder Risk in West Virginia Schools

Megan Israelsen-Augenstein, Michelle W. Moore, Tracy Toman, Allison Rosborough

Purpose: Developmental language disorder (DLD) is linked to long-term academic and social difficulties. Despite these lasting impacts, state-level prevalence estimates are limited. This study estimated prevalence among early-elementary students in West Virginia who may be at risk for DLD and examined variation by grade, locale, and assessment instrument. Method: A cross-sectional screening battery was administered to 252 students in Grades 1–2 across six Title I schools. Children with Kaufman Brief Intelligence Tes …

25.08.2026journal-article

International Journal of Hematology

Persistent parkinsonism with dopaminergic denervation following axicabtagene ciloleucel therapy for diffuse large B cell lymphoma: a case report

Wataru Kinoshita, Michiaki Sato, Yuya Kurihara, Arika Shimura, Akira Honda, Yosuke Masamoto, Ayaka Seki, Meiko Maeda, Wataru Satake, Mineo Kurokawa

Abstract While immune effector cell-associated neurotoxicity syndrome (ICANS) remains one of the major adverse events in CD19-targeted CAR-T cell therapy, neurodegenerative-like movement disorders are characteristically associated with BCMA-targeted therapies, not CD19. We report a distinct case of persistent parkinsonism that became evident during recurrent neurological deterioration accompanied by a decline in ICE score in a patient treated with axicabtagene ciloleucel for relapsed diffuse large B cell lymphoma. …

25.08.2026journal-article

Statistics in Medicine

Dynamic Predictions and Predictimands for Salvage Therapy in Recurrent Prostate Cancer Using Joint Models

Lukas Owens, Dimitris Rizopoulos, Jonathan Fainberg, Sigrid Carlsson, Nicole Liso, Sean McBride, Vincent Laudone, Ruth Etzioni, Jeremy M. G. Taylor

ABSTRACT Prostate cancer patients with biochemical recurrence (BCR) face a decision of whether to start salvage therapy (ST), which may reduce the probability of metastatic progression at the cost of side effects. To inform the decision to start ST at or after BCR, models that make counterfactual predictions incorporating treatment are highly desirable. However, estimation of such models using observational data requires care due to time‐varying confounding by the longitudinal biomarker prostate‐specific antigen (P …

25.08.2026journal-article

Artefactum - revista de estudos interdisciplinares

OCCUPATIONAL FATIGUE IN HYBRID AND REMOTE WORK REGIMES: IMPLICATIONS FOR MENTAL HEALTH AND WORK SAFETY IN THE AGRICULTURAL SECTOR

Giovane Moreno, Josefa Moreno, Danielly Veloso Blanck, Thompson Ricardo Weiser Meier, Neivair Sponchiado Pastore, José Barbosa Duarte Júnior

Recent digital transformations have significantly changed work organization, expanding the adoption of remote and hybrid work arrangements across different sectors. Although these modalities provide benefits such as flexibility, autonomy, and reduced commuting, they have also introduced new challenges related to mental health, ergonomics, and occupational safety. In the agricultural sector, these factors may be intensified by the combination of field activities, travel, technical responsibilities, and digital deman …

25.08.2026journal-article

Life

Adjunctive Synbiotic Therapy for Helicobacter pylori Eradication: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

Chonticha Romyasamit, Thitinat Duangchan, Yosita Leepromma, Morteza Saki, Phoomjai Sornsenee

Background: Synbiotics may improve the effectiveness of antibiotic-based Helicobacter pylori eradication therapy; however, the available evidence remains limited. This systematic review and meta-analysis updated the evidence on the efficacy and safety of adjunctive synbiotics for H. pylori eradication and treatment-related adverse events. Methods: This systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines and was registered in PR …

25.08.2026journal-article

Frontiers in Human Neuroscience

Advanced imaging–integrated rTMS therapy for frontal network recovery after traumatic brain injury

Nan Hu, Zhiling Chen, Jiante Li, Yang Zheng

Background Traumatic brain injury is frequently followed by persistent executive dysfunction linked to disruption of frontal and frontoparietal networks. High-frequency repetitive transcranial magnetic stimulation (rTMS) targeting the dorsolateral prefrontal cortex (DLPFC) has been proposed as a potential adjunctive intervention to support frontal-network recovery. Still, evidence remains heterogeneous and biomarker-guided interpretation is limited. Methods This retrospective multicenter observational cohort study …

25.08.2026journal-article

Frontiers in Public Health

Occupational stress and psychological wellbeing among critical care nurses in private hospitals in Somalia: a national cross-sectional study

Abdullahi Hassan Elmi, Rasha Kadri Ibrahim, Rayaan Abdirahman Hassan, Fahma Hussein Ibrahim

Background Critical care nurses operate in some of the most demanding environments within the health system, and their psychological wellbeing is closely tied to patient outcomes and workforce sustainability. Somalia's fragile healthcare system, marked by persistent resource shortages and limited regulation, presents additional pressures that may elevate stress among ICU nurses. However, evidence from the Somali context has been lacking. This study examined the relationship between occupational stress and psycholog …

25.08.2026journal-article

Phytochemical Analysis

Can Herbal Supplement Be a Suitable Alternative of Ferrous Iron Oral Therapy to Bypass Gastrointestinal Side Effects

Anuradha Sharma, Kiran Gill, Mary Chatterjee

ABSTRACT Introduction Iron deficiency anemia (IDA) is one of the most common nutritional problems. Although it works, traditional oral ferrous iron therapy frequently causes gastrointestinal (GI) side effects such as diarrhea, nausea, constipation, and abdominal discomfort, which makes patients less likely to comply. Objectives This review aims to evaluate whether herbal supplements can serve as suitable alternatives to conventional oral ferrous iron therapy for reducing GI side effects. This review addresses the p …

25.08.2026journal-article

JMIR Research Protocols

Efficacy of Corticosteroid Therapy on Neurological Outcomes in Near-Hanging Patients With Altered Sensorium: Protocol for a Multicenter, Double-Blinded, Placebo-Controlled, Randomized Trial (CHANGING Trial)

Ramadoss Ramu, Dineshbabu Sekar, Aswin K, Ashish Behera, Manu Ayyan, Harichandra Kumar KT, Kavitha B, Mohan Kumar Hanumanthappa, Sree Naga Sowndary Rajendran

Abstract Background In India, hanging is the leading method of suicide, and survivors of near-hanging often present with altered sensorium due to cerebral edema from cervical vascular compression and hypoxia. Management typically involves supportive care and antiedema measures, such as mannitol, hypertonic saline, and dexamethasone. Dexamethasone, a corticosteroid that crosses the blood-brain barrier, is commonly used for presumed cerebral edema. However, evidence supporting its efficacy is limited, and there are n …

25.08.2026journal-article

Nursing Reports

How the Camel’s Back Breaks: A Scoping Review of Cumulative Occupational Distress and the Conceptual Absence of Micro-Trauma in Nursing

Megan Dale, Maude Chapman, Caryn West

Background/Objectives: Nursing involves repeated exposure to emotionally, morally, and psychologically distressing experiences, yet the mechanisms through which low-intensity occupational stressors accumulate and contribute to psychological harm remain conceptually unclear. This scoping review examined how the nursing literature conceptualises the cumulative effects of repeated occupationally distressing experiences and identified the conceptual gap created by the absence of a unifying term such as micro-trauma. Me …

25.08.2026journal-article

Physiotherapy Quarterly

A randomized controlled trial assessing the impact of Pilates exercise on the static and dynamic balance ability and balance confidence of geriatric individuals aged 60–69 years: preliminary study

Li Jiang, Archrawadee Srijaroon, Yada Thadanatthaphak

Introduction This study aims to investigate the effect of Pilates exercise on static and dynamic balance abilities, as well as balance confidence, in elderly individuals aged 60 to 69 years following a 12-week Pilates exercise intervention. Methods The 43 participants were recruited from the Chongqing Hongshan Community Elderly Care Service Center, China. They were randomly assigned to the control group (22 persons) and the experimental group (21 persons). The experimental group spent 12 weeks performing specially …

25.08.2026journal-article

International Journal of Psychosexual Therapy

Editor’s Introduction

Caleb Jacobson

It is with great pleasure that we present the first supplemental edition of the International Journal of Psychosexual Therapy, dedicated to the abstracts presented at the 3rd Annual International Symposium on Sex Therapy. This special issue reflects both the continued growth of the symposium and the expanding international dialogue surrounding psychosexual therapy as a distinct and evolving clinical discipline. The International Symposium on Sex Therapy serves as the annual scientific meeting of the International A …

25.08.2026journal-article

International Journal of Psychosexual Therapy

Intellectual Pluralism and Editorial Authority: A Response to the Journal of Sexual and Relationship Therapy’s Statement on ‘Sex Addiction’

Caleb Jacobson

Upon reading the recent “Statement on behalf of the editorial board…” by Twist et al. (2025), I briefly revisited the masthead to confirm that I was indeed engaging with a scholarly journal rather than a manifesto framed within academic typography. The concern extends beyond tone. The article adopts a posture that appears to foreclose dialogue rather than invite it, positioning addiction oriented models of sexual behavior as implicitly religiously motivated and therefore professionally suspect. It collapses diverse …

25.08.2026journal-article

Brain Sciences

Online Comprehensive Care Therapy Complementary Program Improves Quality of Life in People with Parkinson’s Disease

Diego Santos García, Pablo Campo Prieto, Carmen M. Breijo García, Lucía Dafonte Gil, Juan Pereiro Nogueira, Jessica Blanco López, Francisco Doblas

Objectives: Non-pharmacological therapies are a cornerstone of Parkinson’s disease (PD) treatment, but there is not enough evidence of their benefit when delivered altogether online. Our objective was to analyze the efficacy and safety of an online comprehensive care therapy program (OL-CCTP) in people with PD (PwP). Material and methods: This was a proof-of-concept experimental, prospective, 6-month interventional study comparing a PD treatment group (PwP-T) with a control group (PwP-C). The OL-CCTP included group …

25.08.2026journal-article

BMC Endocrine Disorders

From local control to systemic management: radiotherapy and sequential methotrexate therapy in an adult BRAF-negative hypothalamic-pituitary Langerhans cell histiocytosis – a case report with 15-month follow-up

Chi Feng, Zhiming Chen, Liang Chen, Jun Qin, Desheng Wei, Lei Mou

Abstract Background Langerhans cell histiocytosis (LCH) is a rare clonal neoplastic disorder characterized by the proliferation of CD1a+/Langerin+ dendritic cells. Hypothalamic-pituitary region (HPR) involvement in adults—particularly when followed by multisystem progression after local therapy—remains poorly characterized. We report a 35-year-old female with HPR-LCH who achieved durable local metabolic remission after radiotherapy but later developed systemic progression, which was successfully managed with system …

25.08.2026journal-article

Frontiers in Molecular Medicine

Spinal muscular atrophy in the disease-modifying therapy era: successes, limitations and future directions

Madison M. Sexton, Emma W. Crow, Congyue Annie Peng

Spinal Muscular Atrophy (SMA) is a rare and debilitating neurodegenerative disease characterized by the progressive loss of motor neurons in the spinal cord, leading to muscle weakness, respiratory failure, and premature mortality. The pathogenesis of SMA is highly complex and the investigation of downstream pathways and specific cellular mechanisms is still ongoing. In recent years, three FDA-approved disease-modifying therapies, nusinersen, risdiplam, and onasemnogene abeparvovec, have improved the quality of lif …

25.08.2026journal-article

Sensors

Recent Advances in Sensor-Based Upper-Limb and Hand Exoskeletons for Post-Stroke Rehabilitation: A Technical and Biomedical Review

Alberto Borboni, Matteo Verzeletti, Alireza Rastegarpanah, Jorge Hugo Villafañe

Background: Recent advancements in enabling technologies, including artificial intelligence and telemedicine, alongside robust clinical study outcomes, have led to significant progress in upper limb and hand exoskeletons utilised for post-stroke rehabilitation. Objectives: This review aims to synthesize the recent scientific literature (2010–2025) on post-stroke upper-limb and hand exoskeletons, with particular attention to the sensing architectures—sensing modalities, signal processing, sensor fusion, and sensor-d …

25.08.2026journal-article

Frontiers in Digital Health

The representational bottleneck in rehabilitation AI: from human-cognitive proxies to pathway-based clinical representations

Eun Joo Yang, Seung Hyun Chung

Artificial intelligence (AI) in healthcare is often framed as a problem of model performance. This view overlooks a prior representational problem: many clinical data are human-cognitive proxies built for communication, documentation, classification, or administration rather than high-fidelity computational access to clinical phenomena. In rehabilitation medicine, movement quality, compensatory strategy, sensorimotor integration, fatigue-related deterioration, and postural instability are frequently compressed into …

25.08.2026journal-article

Frontiers in Medicine

Spontaneous conception and successful live birth during hormone replacement therapy in a patient with iatrogenic premature ovarian insufficiency: a case report

Jung Min Lee, Ju Seok Yang, Ji Eun Park, Jong Chul Baek, Jae Yoon Jo, Hyen Chul Jo

Background Premature ovarian insufficiency (POI) is defined as loss of ovarian function before the age of 40 years. It has a profound impact on patients’ quality of life, particularly due to infertility and menopausal symptoms related to estrogen deficiency. Although most patients diagnosed with POI require assisted reproductive technologies (ART) or oocyte donation to achieve pregnancy, a small subset experiences a spontaneous resumption of ovarian function, leading to natural conception in approximately 5 to 10% …

25.08.2026journal-article

Frontiers in Oncology

The double-edged sword of SASP in breast cancer: from tumor suppression to progression and therapy resistance

Xianneng Gao, Yunlong Zhang, Yue Sun, Tiefeng Xu

The senescence-associated secretory phenotype (SASP) represents a complex and dynamic collection of bioactive factors secreted by senescent cells, which exerts dual regulatory effects on breast cancer (BC) progression. When SASP is transiently expressed, it promotes tumor suppression by recruiting immune cells to enhance immunosurveillance against senescent cells, and by transmitting paracrine signals that inhibit cancer cell proliferation. In contrast, when senescent cells cannot be cleared in a timely manner and …

25.08.2026journal-article

OTJR: Occupational Therapy Journal of Research

Evidence-Informed Occupational Therapy Decision Support Using Graph Retrieval-Augmented Generation

Ichiro Kutsuna, Naoki Tomiyama, Akira Masuo, Kyosuke Yorozuya, Shinya Onda, Aiko Hoshino

Occupational therapy clinical decision-making requires support that is both evidence-informed and traceable. To develop and evaluate a clinical decision-support system (CDSS) for occupational therapy using the Japanese Association of Occupational Therapists (JAOT) Case Report Corpus. A total of 3,023 cases were included, with 90% used as a reference case set and 10% as a test case set. A knowledge graph linking assessment findings, goals, and intervention plans was constructed from the reference case set. Using GPT …