Medizin: neue Gesundheitspublikationen – Seite 28

27.08.2026journal-article

Frontiers in Medicine

Real-world safety profile of alectinib: a 10-year pharmacovigilance study based on the FDA adverse event reporting system

Le Zhang, DanDan Li, ChenJing Luo, Li Fan, Min Hu, Fei Ye, Peng Gu

Objective Alectinib is the standard first-line therapy for treatment-naïve ALK-positive non-small cell lung cancer (NSCLC). Given its increasing clinical utilization, a comprehensive pharmacovigilance evaluation of its adverse events (AEs) is warranted. Methods We assessed alectinib-associated AEs using the FDA Adverse Event Reporting System (FAERS) database from Q4 2015 to Q3 2025. AEs were categorized per MedDRA, and four disproportionality analysis algorithms were used to detect potential safety signals. Results …

27.08.2026journal-article

Frontiers in Medicine

Aggregate index of systemic inflammation and glaucoma status: population-based evidence with clinical validation

Songxin Yang, Li Li, Xianming Ouyang, Rui Zhang, Gang Lin, Sunkun Pan, Guiquan Xie, Zhen Lv, Dieran Huang, Guoyan Luo, Kunpeng Pang

Objective Glaucoma is a major cause of irreversible visual impairment, but evidence on the association between the aggregate index of systemic inflammation (AISI) and glaucoma remains limited, particularly with clinical validation. Methods We analyzed National Health and Nutrition Examination Survey (NHANES) data from participants aged 40 years and older. Weighted multivariable logistic regression models were used to examine the association between AISI and glaucoma. The primary outcome was composite glaucoma, defi …

27.08.2026journal-article

Frontiers in Medicine

Reduced heart rate variability is associated with disease severity in AL amyloidosis: a retrospective cohort study

Xiao-hang Pei, Su-qiong Zuo, Pan Zhou, Rong-jun Ma, Zun-min Zhu, Xiao-li Yuan

Background Autonomic nervous system involvement is common in systemic amyloidosis, yet the clinical relevance of heart rate variability (HRV) in immunoglobulin light-chain (AL) amyloidosis remains incompletely defined. Methods In this retrospective cohort study, 56 patients with biopsy-proven AL amyloidosis and 33 age- and sex-comparable healthy controls underwent 24 h Holter monitoring. Time- and frequency-domain HRV parameters were recorded. Associations of HRV with cardiac involvement assessed by cardiac magneti …

27.08.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Effects of Semaglutide versus Bariatric Surgery on Noninvasive Markers of Hepatic Steatosis and Fibrosis in Obesity with MASLD

Paula Lünswilken, Katarzyna Worobiec, Lara S Braun, Julia Altrogge, Andrea Schenk, Lina Jegodzinski, Britta Wilms, Jens U Marquardt, Svenja Meyhöfer

Abstract Aims Obesity is a key driver of metabolic dysfunction-associated steatotic liver disease (MASLD). Beyond lifestyle modification, pharmacological and surgical therapies were recently established. This study compared the effects of lifestyle therapy, lifestyle plus semaglutide, and bariatric surgery on non-invasive markers of hepatic steatosis and fibrosis. Materials and Methods In this single-center, prospective, observational cohort study, ninety-two adults with obesity were analyzed over 72 weeks. Patient …

27.08.2026journal-article

Frontiers in Medicine

Research progress of cerebroplacental ratio in obstetric complications

Xinran Bi, Ruotong Qi, Haiying Chen

Cerebroplacental ratio (CPR), defined as fetal middle cerebral artery pulsatility index (MCA-PI)/umbilical artery pulsatility index (UA-PI), quantifies intrauterine hemodynamic redistribution driven by the fetal brain-sparing response to placental insufficiency. With the advancement of ultrasonic technology and in-depth clinical research, CPR has been widely applied in early screening, condition assessment, prognosis evaluation and intervention guidance of various obstetric complications, especially showing unique …

27.08.2026journal-article

Exploration of Musculoskeletal Diseases

Hypophosphatasia: current concepts in diagnosis and management of a rare metabolic disorder

Maritza Vidal, Tiara Gill, Richard Keen, Judith Bubbear

Hypophosphatasia (HPP) is a rare inherited metabolic disorder caused by deficient activity of tissue non-specific alkaline phosphatase (TNSALP). The resulting accumulation of its substrates, particularly inorganic pyrophosphate (PPi) and pyridoxal-5-phosphate (PLP), impairs skeletal and dental mineralization and disrupts vitamin B6 metabolism, contributing to multisystem manifestations. The clinical spectrum is highly heterogeneous, ranging from severe, life-threatening forms in the perinatal period to milder muscu …

27.08.2026journal-article

Neurology and Clinical Neuroscience

Early and Unusual Restenosis Following Carotid Endarterectomy for Symptomatic Carotid Web: A Case Report

Haruki Hoshikawa, Yasuhisa Akaiwa, Yoshiyuki Matsumoto, Issei Takano, Kensuke Suzuki, Kohei Miyagawa, Toshiki Nakamura, Mari Tada, Tomoyuki Miyamoto

ABSTRACT A 52‐year‐old man presented with acute motor aphasia. Brain MRI revealed embolic infarctions in the left middle cerebral artery territory. CT angiography and carotid ultrasonography demonstrated a shelf‐like projection arising from the posterior wall of the left carotid bulb, consistent with a carotid web (CW). Transcranial Doppler ultrasonography detected microembolic signals, supporting the diagnosis of artery‐to‐artery embolism associated with the CW. Carotid endarterectomy (CEA) was performed to preven …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Predictors of the technical success of ultrasound-guided percutaneous transhepatic biliary drainage for biliary obstruction

Yun Song, Guang-Hai Chen, Lu Peng, Jian Du, Shu-Ming Tan

BACKGROUND Percutaneous transhepatic biliary drainage (PTBD) is a critical minimally invasive intervention for biliary obstruction, with technical success being a key determinant of clinical outcomes. AIM To identify and quantify the clinically modifiable factors predicting technical success of ultrasound-guided PTBD, and thereby to develop an evidence-based framework for procedural triage and standardization. METHODS A total of 263 ultrasound-guided PTBD procedures performed at three tertiary hospitals (2019-2024) …

27.08.2026journal-article

Journal of Pediatric Orthopaedics B

Radiological and clinical outcomes following pelvic support osteotomy with limb length equalization in children

Vikaas Ethanur Thuppale, Arulmurugan Arikrishnan, Jonathan Reddy, Abhay Gahukamble, Thomas Palocaren

Pelvic support osteotomy (PSO), when done in children, is subject to remodeling. This study aimed to assess the extent of remodeling at the osteotomy site and functional outcome post-PSO. A total of 28 patients were selected with a minimum follow-up of 2 years. PSO was combined with limb length equalization procedures including distal femoral lengthening, epiphysiodesis, or shoe raise, as indicated, because all patients had limb length discrepancy as part of their underlying pathology. The valgus osteotomy angle in …

27.08.2026journal-article

Nursing Ethics

Neonatal nurses’ moral agency in raising medication and treatment safety concerns in high-risk NICUs

Osama Mohamed Elsayed Ramadan, Manar Fayez Alruwaili, Reda Samy, Hamda Ahmed Mohamed Eldesoky, Ghada Elsaid Ali Elsayed

Background In neonatal intensive care units (NICUs), nurses may recognise medication or treatment risk before others do. Raising a concern is an ethical act, but moral agency extends beyond voice behaviour. Research question/aim/objectives How do neonatal nurses experience and enact moral agency when raising medication and treatment concerns in high-risk NICUs? We examined risk recognition, enactment of voice, contextual influences, and responsibility after voice. Research design Qualitative Interpretive Descriptio …

27.08.2026journal-article

HIV Medicine

Wellbeing of trans and gender‐diverse people with HIV in the United Kingdom: Results from Positive Voices 2022

H. Kitt, C. Kelly, A. Aghaizu, M. Ross, F. C. Lampe, C. J. Smith, V. Martin, C. Humphreys, A. Brown, A. Sparrowhawk, M. Kall, J. Sewell, E. Wainwright, V. Delpech, G. Davis, A. Farah, A. Fasanya, A. J. Rodger, T. Đuretić, PV2022 Study Group

Abstract Objectives This national cross‐sectional observational study aimed to assess mental health, quality of life, supportive network, experiences of HIV‐related stigma in healthcare and unmet service need among trans and gender‐diverse people with HIV, compared to cisgender people with HIV. Methods Positive Voices 2022 is a questionnaire survey of people accessing HIV care in England, Scotland and Wales carried out in 2022 and 2023 that included measures of depression and anxiety symptoms and suicidal ideation …

27.08.2026journal-article

Journal of Intensive Care Medicine

Acute Severe Asthma in the Intensive Care Unit: From Bronchodilators to Extracorporeal Membrane Oxygenation

Parisa Abedi, Geoffrey Chupp, Gabriella Wilson, Sandra Zaeh, Astha Chichra

Acute severe asthma exacerbations are life-threatening critical care emergencies characterized by profound airflow obstruction, respiratory acidosis, and risk for cardiopulmonary arrest. For the purposes of this review, the term ‘acute severe asthma’ is used to encompass what has variably been described as near-fatal asthma, status asthmaticus, and life-threatening asthma in the literature. Early recognition of impending respiratory failure, timely intubation and a stepwise approach to supportive interventions are …

27.08.2026journal-article

Measurement Science and Technology

Fault diagnosis of connection loosening in fast-swapping battery case for electric heavy trucks based on vibration-electric signal synergy

Yifan Zheng, Xianglong You, Yuepan Lv, Minzhang Zhao, Zhuohang Han, Jianjuan Liu, Hang Yuan

Abstract As the core energy storage unit of fast-swappable battery cases in electric heavy trucks, power batteries are particularly prone to connection loosening faults under complex operating conditions, such as frequent battery swapping, continuous vibration, and mechanical shocks. These faults are highly concealed and difficult to detect at an early stage, posing significant challenges for fault detection and diagnosis. To address this issue, this study proposes a vibration-electric synergy-based method for faul …

27.08.2026journal-article

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

Pediatric Vascular Anomalies in a Specialized Interdisciplinary Center: A 10-Year Cohort Analysis of Diagnosis, Imaging, and Treatment Pathways

Céline Gärtner, Haneen Sadick, Felix Struebing, Daniel Svoboda, Anke Dippmar, Christel Weiss, Klaus Amendt, Maliha Sadick

Abstract This study uses original data from a 10-year cohort analysis of diagnosis, imaging, and treatment pathways in pediatric vascular anomalies at a specialized interdisciplinary center. The study examines the role of radiology in establishing diagnostic and therapeutic algorithms for interdisciplinary management of children with vascular anomalies. A total of 331 children were included in this study. Patient characteristics, the location, and anatomical site of the vascular anomaly and associated pain levels w …

27.08.2026journal-article

Healthcare

Regular AREDS2 Supplement Use in Age-Related Macular Degeneration: Factors Associated with Supplementation, Medication Adherence, and Patient-Reported Barriers

Hasan Öncül, Umut Dağ, Mehmet Fuat Alakuş

Background/Objectives: Age-related macular degeneration (AMD) is a leading cause of irreversible visual impairment, and AREDS2-based nutritional supplementation is recommended for clinically eligible patients to reduce the risk of disease progression. However, successful implementation depends on regular supplement use and sustained adherence. This study investigated demographic, socioeconomic, clinical, and physician-related factors associated with regular AREDS2 supplement use and evaluated medication adherence, …

27.08.2026journal-article

Neuro-Oncology

59 Early psychosocial support after a brain tumour diagnosis: a collaborative model between Southmead Hospital and Brain Tumour Support

Lucy Wilkinson, Emma McKeown

Abstract Introduction A pilot referral pathway between Southmead Hospital and Brain Tumour Support (BTS) was introduced to provide early psychosocial support to patients diagnosed with a brain tumour and their families. This evaluation assessed uptake, perceived value, and service impact. Method Over six months, 115 patients and family members were referred to BTS; 10 declined or did not respond. Referrals included newly diagnosed patients, individuals undergoing investigations and supporting relatives. Tumour type …

27.08.2026journal-article

Journal of Clinical Medicine

A Decade of Data from an IVF Center: Factors Contributing to Infertility, Their Prevalence, and Impact on Live Birth Rates

Hale Bayram, Yaprak Dönmez Çakıl, Belgin Selam, Mehmet Cıncık

Background: Infertility is increasingly recognized as a significant global public health concern. A thorough understanding of the diverse causes of infertility and their influence on treatment outcomes is essential for optimizing therapeutic strategies and improving success rates. Methods: In this study, we analyzed data from 9132 couples who underwent IVF treatment at a fertility center in Istanbul, Turkey, between 2010 and 2020. Results: Female factor infertility was the most prevalent among all participants (35. …

27.08.2026journal-article

American Journal of Hematology

Impact of Response to Hypomethylating Agent‐Based Therapy on Survival Outcomes in the Context of Baseline Clinical‐Molecular Risk and Transplant Status in Patients With Higher‐Risk Myelodysplastic Syndromes/Neoplasms: An analysis From the International Consortium for MDS (icMDS)

Benjamin Rolles, Jan Philipp Bewersdorf, Tariq Kewan, Ondrej Blaha, Jessica M. Stempel, Luca Lanino, Najla H. Al Ali, Amy E. DeZern, Mikkael A. Sekeres, Geoffrey L. Uy, Samuel Urrutia, Hetty E. Carraway, Pinkal Desai, Elizabeth A. Griffiths, Eytan M. Stein, Andrew M. Brunner, Christine McMahon, Rory M. Shallis, Joshua F. Zeidner, Michael R. Savona, Shougat Barua, Namrata Sonia Chandhok, Constantine Logothetis, Aram Bidikian, Ted M. Getz, Gail J. Roboz, Eunice S. Wang, Amyah C. Harris, Maria L. Amaya, Hayley Hawkins, Somedeb Ball, Justin Grenet, Parisa Abedi, Shai Shimony, R. Coleman Lindsley, Zhuoer Xie, Yazan F. Madanat, Yasmin Abaza, Talha Badar, Torsten Haferlach

ABSTRACT Baseline IPSS‐M risk, response to hypomethylating agent (HMA) therapy, and receipt of allogeneic stem cell transplant (allo‐HCT) have all been individually shown to impact overall survival (OS) in patients with myelodysplastic syndromes (MDS). However, the prognostic impact of response when adjusting for IPSS‐M risk and treatment strategy remains unclear. Hence, we used the VALIDATE database of the International Consortium for MDS (icMDS) to evaluate the impact of International Working Group (IWG) 2023 bes …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Multistakeholder Consultations on Programmatic Progress, Challenges, and Policy Priorities for Lymphatic Filariasis Elimination in India

Muhammed Jabir, Raja Jeyapal Dinesh, Adinarayanan Srividya, Anju Viswan, Manikandan Kishanthini, Richa Sharma, Manju Rahi

ABSTRACT. This report presents the key proceedings and outcomes of three regional consultative workshops convened to review progress, identify challenges, and propose strategic actions for lymphatic filariasis elimination in India. The workshops were organized by the Indian Council of Medical Research-Vector Control Research Centre, Puducherry in collaboration with the Women’s Collective Forum, New Delhi from June 2025 to August 2025. Consultations were held in three endemic states representing different regions of …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Malaria Vaccine Rollout in Nigeria: Current Status and Challenges

Samuel Adeniyi Oyegbade, Samson Olusola Adeboye, Gbotemi Jerry Oni, Abosede Peace Oyegbade, James Joy Oziohu, Zawu Yoowa Duyann, Oluwatoyin Comfort Owoyemi

ABSTRACT. Malaria remains a leading cause of morbidity and mortality in Nigeria, particularly among children under 5 years of age, despite ongoing control efforts. The introduction of RTS,S/AS01, and R21/Matrix-M vaccines provides a promising complementary prevention strategy. This systematic review assessed malaria vaccine rollout in Nigeria, focusing on implementation, awareness, acceptance, willingness to pay, and health system readiness. A comprehensive search of PubMed, ScienceDirect, Google Scholar, African I …

27.08.2026journal-article

Revista ft

Segurança do paciente: estratégias de enfermagem para prevenção de erros na administração de medicamentos

Marcos Leal Rodrigues Pereira, Gerson Luiz Pereira Emerim da Silva, João Lucas Vaz Macedo, Leandro Ghilardi

This study aimed to analyze the nursing strategies used to prevent medication administration errors and promote patient safety. This is an integrative literature review conducted in the SciELO, LILACS, MEDLINE/PubMed, BDENF, and DOAJ databases, considering publications from January 2020 to July 2026 in Portuguese, English, and Spanish. The initial search identified 18 studies, of which 8 comprised the final sample after application of the inclusion and exclusion criteria. The main strategies identified included con …

27.08.2026journal-article

Evolution, Medicine, and Public Health

Running wild: Forest running enhances performance, enjoyment, mood and future exercise intentions

Matthew J Putland, Stephen J Bailey, Bryna C R Chrismas, Stacy Clemes, Morgan Ewers, Yu-Ling Ho, Eloise Jones, Adelina Lintuluoto, Kirsten McEwan, Riddhi Naik, Hanna Lal Rahimi, Hongbin Xiang, Erik P Willems, Colin N Shaw, Daniel P Longman

ABSTRACT Background and objectives Physical inactivity remains widespread despite the well-established physical and mental health benefits of regular physical activity (PA). There is an urgent need for strategies that increase both uptake and long-term adherence. The Environmental Mismatch Hypothesis proposes that natural environments may increase both engagement and performance of PA. Methodology Forty-seven healthy adults (16 females) completed a randomised, counterbalanced crossover trial. Participants undertook …

27.08.2026journal-article

Frontiers in Public Health

Psychological capital, perceptions of clinical stressors, and bullying experiences among Chinese nursing students during clinical practice: a latent profile and mediation analysis

Fangfei Zhao, Hongchen Zhang, Ke Hui, Haixin Zheng, Zhihui He

Background Bullying experiences during clinical practice threaten nursing students' learning and professional development. However, existing studies mainly focused on variable-centered associations, with limited exploration of heterogeneous subgroups from a person-centered perspective. This study aimed to examine the mediating role of perceptions of clinical stressors (PCS) in the relationship between psychological capital (PsyCap) and bullying experiences, while identifying latent profiles of bullying experiences. …

27.08.2026journal-article

Arab Media Renewal Journal

معالجة الأزمات الإنسانية في الصحافة الرقمية المصرية والأمريكية: دراسة تحليلية مقارنة

شروق حسنين قاسم

استهدفت الدراسة رصد وتحليل معالجة الصحافة الرقمية الأمريكية والمصرية للأزمات الإنسانية، بالتطبيق على موقعَي «اليوم السابع» المصري، و»USA Today» الأمريكي، وذلك في إطار نظرية المسؤولية الاجتماعية، ونظرية المشاركة الديمقراطية. وقد اعتمدت الدراسة على استخدام منهج المسح، وأسلوب المقارنة المنهجية، بالاعتماد على استمارة تحليل المضمون لجمع بيانات الدراسة، التي شملت (603) موضوعًا صحفيًا إنسانيًا تم نشرها خلال فترتين زمنيتين مختلفتين، هما (يناير-أبريل 2017) و(يناير-أبريل 2022) بموقعي الدراسة.وأظهرت النتائج تقاربًا في الحجم ا …

Was ist neu im Gesundheitswesen?

Aktuelle Forschung nach Fachgebiet

Real-world safety profile of alectinib: a 10-year pharmacovigilance study based on the FDA adverse event reporting system

Aggregate index of systemic inflammation and glaucoma status: population-based evidence with clinical validation

Reduced heart rate variability is associated with disease severity in AL amyloidosis: a retrospective cohort study

Effects of Semaglutide versus Bariatric Surgery on Noninvasive Markers of Hepatic Steatosis and Fibrosis in Obesity with MASLD

Research progress of cerebroplacental ratio in obstetric complications

Hypophosphatasia: current concepts in diagnosis and management of a rare metabolic disorder

Early and Unusual Restenosis Following Carotid Endarterectomy for Symptomatic Carotid Web: A Case Report

Predictors of the technical success of ultrasound-guided percutaneous transhepatic biliary drainage for biliary obstruction

Radiological and clinical outcomes following pelvic support osteotomy with limb length equalization in children

Neonatal nurses’ moral agency in raising medication and treatment safety concerns in high-risk NICUs

Wellbeing of trans and gender‐diverse people with HIV in the United Kingdom: Results from Positive Voices 2022

Acute Severe Asthma in the Intensive Care Unit: From Bronchodilators to Extracorporeal Membrane Oxygenation

Fault diagnosis of connection loosening in fast-swapping battery case for electric heavy trucks based on vibration-electric signal synergy

Pediatric Vascular Anomalies in a Specialized Interdisciplinary Center: A 10-Year Cohort Analysis of Diagnosis, Imaging, and Treatment Pathways

Regular AREDS2 Supplement Use in Age-Related Macular Degeneration: Factors Associated with Supplementation, Medication Adherence, and Patient-Reported Barriers

59 Early psychosocial support after a brain tumour diagnosis: a collaborative model between Southmead Hospital and Brain Tumour Support

A Decade of Data from an IVF Center: Factors Contributing to Infertility, Their Prevalence, and Impact on Live Birth Rates

Impact of Response to Hypomethylating Agent‐Based Therapy on Survival Outcomes in the Context of Baseline Clinical‐Molecular Risk and Transplant Status in Patients With Higher‐Risk Myelodysplastic Syndromes/Neoplasms: An analysis From the International Consortium for MDS (icMDS)

Multistakeholder Consultations on Programmatic Progress, Challenges, and Policy Priorities for Lymphatic Filariasis Elimination in India

Malaria Vaccine Rollout in Nigeria: Current Status and Challenges

Segurança do paciente: estratégias de enfermagem para prevenção de erros na administração de medicamentos

Running wild: Forest running enhances performance, enjoyment, mood and future exercise intentions

Psychological capital, perceptions of clinical stressors, and bullying experiences among Chinese nursing students during clinical practice: a latent profile and mediation analysis

معالجة الأزمات الإنسانية في الصحافة الرقمية المصرية والأمريكية: دراسة تحليلية مقارنة