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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Cancers

Inflammation Without Effective Immunity in Ovarian Cancer: From Early Translational Observations to Histotype-Dependent Immunometabolic Ecosystems

Manuela Neri, Paolo Albino Ferrari, Valerio Vallerino, Gabriele Sole, Antonio Macciò

Epithelial ovarian cancer (EOC) comprises biologically and immunologically distinct histotypes and frequently develops within a chronically inflamed tumor microenvironment, particularly in advanced disease with malignant ascites. This narrative review revisits translational observations from the 1990s–2000s showing impaired lymphomonocyte proliferation, altered Fas/CD25 signaling, and abundant cytokine release in ovarian cancer effusions. These findings are interpreted as direct evidence of dysfunctional immune act …

27.08.2026journal-article

Diagnostics

Prognostic Implications of Tumor Spread Through Air Spaces in Patients with Resected Lung Adenocarcinoma

Marco Andolfi, Nicolò Scarsi, Martina Mandarano, Guido Bellezza, Renato Colella, Lucrezia Burico, Domenico Pourmolkara, Francesco Ferrante, Francesca Fratturelli, Jacopo Vannucci

Background: Spread through air spaces (STAS) consists of micropapillary clusters, solid nests, and/or single neoplastic cells into the air spaces of the lung parenchyma beyond the edge of the primary tumor. To date, its prognostic role in patients with lung adenocarcinoma is crucial, resulting in an independent negative factor for both overall survival (OS) and disease-free survival (DFS). The study aims to assess the prognostic impact of STAS in patients with lung adenocarcinoma undergoing curative resection. Meth …

27.08.2026journal-article

Neuro-Oncology

30 Delivering Global Skull Base Education By WhatsApp – Experience From The January 2025 Vestibular Schwannoma Challenge

Delaina Rajendran, Luke Galloway, Aimee Goel, Andrew Kay

Abstract Aim Virtual learning is increasingly used in medical education, with emerging evidence supporting its feasibility and impact. The Vestibular Schwannoma (VS) Challenge delivered a free 30-day programme on VS diagnosis and management to a global audience using WhatsApp. This study assessed the effectiveness of WhatsApp as a platform for skull base education and gathered user feedback to inform future programme design. Methods A Birmingham-based collaboration of skull base multidisciplinary team members, resi …

27.08.2026journal-article

Neuro-Oncology

2 Age-Related Disparities in Clinical Characteristics and Survival Outcomes of High-Grade Spinal Cord Gliomas: A Retrospective Analysis of 219 Patients

Khalid Sarhan, Mohammed A Azab

Abstract Introduction High-grade spinal cord gliomas exhibit significant age-dependent disparities in survival and clinical management. This study evaluates how age influences prognosis and the utilization of treatment modalities like radiation and chemotherapy. Methods A retrospective analysis was conducted on 219 patient records, categorized into four age groups: Children (N = 41), AYA (N = 71), Older adults (N = 76), and Elderly (N = 31). Statistical measures included median survival, 1, 3, and 5-year survival r …

27.08.2026journal-article

European Journal of Nutrition

Mediterranean diet adherence, healthy sleep, and lung cancer risk: a prospective study of 192,034 UK Biobank participants

Yiming Chen, Enyu Tong, Xiaoman Jin, Yufeng Rao, Evan Y. W. Yu, Abdulmohsen H. Al-Zalabani, Maurice Zeegers, Anke Wesselius

Abstract Purpose Diet and sleep have each been associated with cancer risk, but their joint association with lung cancer risk remains unclear. We investigated the association between a joint Mediterranean diet-sleep pattern and lung cancer risk in the UK Biobank. We also evaluated whether siesta modified the association between Mediterranean diet adherence and lung cancer risk. Methods Participants were drawn from the UK Biobank. Mediterranean diet adherence was assessed using an adapted Mediterranean Diet Adherenc …

27.08.2026journal-article

Pediatric Blood & Cancer

High Responsiveness of Head and Neck Kaposiform Hemangioendothelioma Without Kasabach–Merritt Phenomenon to Sirolimus Monotherapy

Yulang Xu, Jiangyuan Zhou, Yuru Lan, Linyu Yang, Yunhan Zhang, Yi Ji

ABSTRACT Objective Sirolimus is the cornerstone therapy for Kaposiform hemangioendothelioma (KHE). The purpose of this study was to evaluate whether anatomical location independently predicts radiologic response to sirolimus monotherapy in KHE without Kasabach–Merritt phenomenon (KMP). Patients and Methods We included 21 patients with head and neck KHE without KMP and 50 matched patients with non‐head and neck KHE without KMP, all treated with sirolimus monotherapy in five tertiary referral centers in China. The pr …

27.08.2026journal-article

Pediatric Transplantation

Treatment Adaptation to Surgical Timing in Pediatric Hepatoblastoma: A 19‐Year Single‐Center Experience With Resection and Liver Transplantation

Claudia Pellegrinelli, Laura Cavalleri, Michela Bravi, Paolo Marra, Clarissa Valle, Lisa Licini, Domenico Pinelli, Massimo Provenzi, Sandro Sironi, Lorenzo D'Antiga

ABSTRACT Background The management of hepatoblastoma (HB) relies on chemotherapy combined with surgery, either liver resection (LR) or liver transplantation (LT), with reported overall survival (OS) of 80%, cardiac toxicity of 6%, nephrotoxicity of 21%, ototoxicity of 32%–46%. In clinical practice, deviations from protocol‐defined chemotherapy are often required to achieve resectability or bridge to transplantation. We aimed to evaluate the impact of treatment adaptation to surgical timing on OS and toxicity in a s …

27.08.2026journal-article

Molecular Cancer

A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer

Lucia A. Torres-Fernández, Volker Boehm, Joel Kaufmann, Jonas P. Becker, Maria Garcia-Marquez, Beaunelle de Bruijn, Agnieszka Rumińska, Christian Müller, Graziella Bosco, Nazanin Alavinejad, Laura Lovric, Johanna Bihler, Hanna Schulte, Poorya Davoodi, Anna Schöllhorn, Kian R. Weihrauch, Laura Kaiser, Olta Ibruli, Fanyu Liu, Ariadne Androulidaki, Nina Wobst, Marcel Schmiel, Justinas Valiulis, Lukas Maas, Joshua D’Rozario, Vignesh Sakthivelu, Bianca Göbel, Marian Touet, Johannes Brägelmann, Katja Höpker, Felix John, Jürgen Wolf, Stefan Knapp, Alexander Quaas, Maria Cartolano, Silvia von Karstedt, Filippo Beleggia, Hans-Georg Rammensee, Cécile Gouttefangeas, Hans A. Schlößer

Abstract Small cell lung cancer (SCLC) is one of the most aggressive malignancies, characterized by rapid metastatic dissemination and poor overall survival. Despite harboring excessive alterations, expectedly resulting in immunogenic neoantigens, patients with SCLC remain largely refractory to immunotherapy. We found abundant frameshift mutations in SCLC, regarded as highly immunogenic, counterbalanced by a hyperactive nonsense-mediated decay (NMD) pathway, responsible for frameshift-mRNA degradation. NMD activity …

27.08.2026journal-article

British Journal of Dermatology

Can a Treatment-Responsive Molecular Clock Independently Timestamp Psoriatic Skin?

Danli Zhong

This Letter discusses a methodological concern in the transcriptomic analysis by Zhan et al., in which ZeitZeiger was used to infer sampling time in psoriatic skin datasets. Because several treatment-responsive clock genes may also contribute to molecular time prediction, additional diagnostics are needed to distinguish restoration of temporal immune organization from treatment-related predictor drift.

27.08.2026journal-article

Advanced Science

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2 + sEVs Driving M2 Polarization of TAMs

Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen

ABSTRACT Background and Aims Tumors actively remodel the tumor microenvironment (TME) to foster therapy resistance. However, the underlying mechanisms remain poorly defined. This study aims to characterize how colorectal cancer (CRC) cells drive TME remodeling to promote radioresistance. Methods A radioresistant CRC cell line was established via serial in vivo irradiation. Single‐cell RNA sequencing characterized TME alterations. The role of tumor‐derived small extracellular vesicles (sEVs) in macrophage polarizati …

27.08.2026journal-article

Clinical Journal of Health Sciences

Treatment of Borderline Personality Disorder in Cognitive Behavioral Therapy: A Case Report

Berk İşlek, Meryem Karaaziz

Borderline Personality Disorder (BPD) is a personality structure characterized by significant instability in affect regulation, interpersonal relationships, and self-concept, leading to substantial impairment in functioning. This case report presents the Cognitive Behavioral Therapy (CBT) process applied to a 26-year-old female client for whom a clinical diagnosis of BPD was considered. Clinical interviews conducted in accordance with DSM-5 diagnostic criteria, together with findings obtained from the Minnesota Mul …

27.08.2026journal-article

Neuro-Oncology

103 A Medulloblastoma brain slice culture radiotherapy platform to dually assess therapeutic efficacy and toxic

Kristy Kehoe, Louisa Taylor, Melanie Beckett, Glyn Nelson, Samantha Jepson Gosling, Janice Law, Mike Tseung, Connie Mackenzie-Gray Scott, Christopher Cowie, Fiona LeBeau, Rebecca Hill, Steve Clifford

Abstract Introduction Medulloblastoma is the most common malignant childhood brain tumour. Radiotherapy (RT) forms a key treatment pillar but is associated with significant late effects. Ex vivo brain slice cultures present a translational model that overcomes limitations of existing in vitro and in vivo alternatives. Slice cultures provide a native “scaffold”, with representative cellular architecture and extracellular matrix (ECM), upon which cancer cell growth and invasion can be tracked in real-time. We describ …

27.08.2026journal-article

Neuro-Oncology

69 Review of outcomes at a tertiary cancer centre of procarbazine (third line) and etoposide (fourth line) chemotherapy for recurrent gliomas

Chloë May, Victoria Yu, Stephanie Thomas, Helen Wong, Shaveta Mehta, Aditya Shenoy

Abstract Introduction There is no standard recommended third- or fourth-line chemotherapy treatment for patients with recurrent gliomas. At our tertiary cancer centre, CCNU, procarbazine and etoposide are commonly used sequentially as second-, third- and fourth-line treatments. This review assessed progression free survival (PFS), overall survival (OS) and tolerability of single agent procarbazine and etoposide chemotherapy. Methods All patients coded glioma, WHO grade 2 – 4, who commenced third line procarbazine o …

27.08.2026journal-article

International Journal of Engineering Research and Science & Technology

Explainable and Efficient AI-Based System for Automated Breast Cancer Diagnosis Using EfficientNet-B3, CBAM, and Grad-CAM

Velpula Siva Parvathi

Breast cancer is one of the leading causes of cancerrelated deaths among women worldwide, making early and accurate diagnosis essential for improving patient survival and treatment outcomes. Traditional histopathological examination is considered the gold standard for breast cancer diagnosis; however, manual analysis is time-consuming, labor-intensive, and subject to inter-observer variability. To address these challenges, this paper presents an Explainable and Efficient AI-Based System for Automated Breast Cancer …

27.08.2026journal-article

Chronic Diseases and Translational Medicine

Efficacy and Safety of Durvalumab and Tremelimumab in Metastatic Non‐Small Cell Lung Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Ikhwan Rinaldi, Eric Ricardo Yonatan, Tasia Esterita

ABSTRACT Purpose Immune checkpoint inhibitors have transformed treatment strategies for metastatic non‐small cell lung cancer (mNSCLC). This study aimed to assess the efficacy and safety of durvalumab combined with tremelimumab compared with those of standard chemotherapy, particularly in patients with low or negative PD‐L1 expression, and in the overall population. Methods A systematic review and meta‐analysis of randomized controlled trials (RCTs) was conducted following PRISMA 2020 guidelines. Pooled efficacy an …

27.08.2026journal-article

Philosophical Transactions of the Royal Society B: Biological Sciences

Epidermal growth factor receptor dysregulation and climate change: insights into pollution-promoted lung cancer

Taysia Nikaido-Landry, Yujia Zhang, Emilia L. Lim

Abstract The global increase of fine particulate matter pollution, intensified by anthropogenic activity, has been increasingly implicated in lung cancer risk, particularly among never-smokers. We discuss how air pollution contributes to respiratory diseases through interactions with the epidermal growth factor receptor (EGFR) signalling pathway. In particular, recent evidence has shown that fine particulate matter promotes lung cancer in cells harbouring a pre-existing EGFR mutation. As such, we also outline how o …

1 Zitationen
27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Mechanisms and treatment of metabolic dysfunction-associated fatty liver disease after liver transplantation

Jun-Rong Liu, Liu Zhao, Qing-Hui Niu, Jin-Zhen Cai, Han-Yun Liu

Metabolism dysfunction-associated fatty liver disease (MAFLD) has emerged as a frequent complication for liver transplant (LT) recipients. In view of the high incidence of MAFLD after LT, research on MAFLD is of considerable clinical significance. Key research areas include the mechanisms responsible for the development of MAFLD following LT, therapeutic strategies, and the optimization of immunosuppressive regimens to achieve a balance between graft protection and metabolic protection. Most existing studies relati …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Pelvic floor rehabilitation improves anorectal function after sphincter-preserving surgery for low rectal cancer

Xiao-Jun Liu, Ming-Li Wei, Li-Li Liu, Jing-Jing Qin

BACKGROUND Sphincter-preserving surgery with prophylactic colostomy is the benchmark treatment for low rectal cancer, although postoperative anorectal dysfunction significantly reduces quality of life. Although pelvic floor muscle training seems effective in functional recovery, there is currently little systematic evidence regarding the efficacy of this therapy in this specific population. AIM To investigate whether structured pelvic floor muscle rehabilitation training provides better anorectal functioning than s …

27.08.2026journal-article

Neuro-Oncology

73 Modification of Tryptanthrin Enhances Drug Activity in Glioblastoma Cells

Aoife Hurrell, Sofie Edwards, Sally Prior, Christopher Gabbutt, Anke Brüning-Richardson

Abstract Introduction Glioblastoma (GBM) is the most aggressive adult brain tumour, with a poor prognosis and limited therapeutic approaches. We recently showed ARHGAP12 regulates cell morphology and contributes to tumour recurrence, with co-expression of ARHGAP29 linked to reduced survival after treatment. As Glycogen Synthase Kinase 3 (GSK-3) signalling regulates this, we hypothesised that targeting ARHGAP12 in combination with migrastatic drugs could enhance GBM cell migration inhibition. Previous investigations …

27.08.2026journal-article

Electronics

TSF U-Net: A Texture-Span and Frequency-Gated U-Net for Brain Tumor MRI Segmentation

Xia Wang, Longde Mao, Jianing Tang, Zhongbin Dai

Accurate brain tumor magnetic resonance imaging (MRI) segmentation is essential for objective lesion assessment and treatment planning, yet it remains challenging because tumors exhibit large-scale variations, irregular morphologies, heterogeneous internal textures, and indistinct boundaries. Conventional U-Net variants commonly improve either spatial feature extraction or skip connection fusion, but they do not jointly address the adaptive representation of pathological texture changes and the semantic filtering o …

27.08.2026journal-article

CVIR Endovascular

Identifying research areas in peripheral artery disease treatment—a Delphi consensus approach

Stefan Müller-Hülsbeck, Franziska Reiter, Andreas H. Mahnken, Nathalie Kaufmann, Robert A. Morgan

Abstract Background The multitude of existing techniques for the endovascular treatment of peripheral artery disease (PAD), as well as newly emerging technologies combined with the diversity of patient profiles highlight the need for further research in this area. We conducted a Delphi consensus study, an established method utilising an iterative approach to reach consensus within a group of experts over several rounds, to identify gaps and new areas of research in the field of PAD. Results Using a four-round Delph …

27.08.2026journal-article

Current Oncology

Return to Intended Oncologic Therapy After Brain Metastasis Surgery: Mapping the Early Postoperative Pathway

Alexis Hadjiathanasiou, Martin Liebisch, Johanna Dahn, Johannes Lemcke, Patrick Schuss

Surgery for brain metastases (BM) is embedded in a multidisciplinary oncologic pathway. This study evaluated oncologic readiness and return to intended oncologic therapy (RIOT) after surgery for BM. Patients undergoing surgery for histologically confirmed BM were retrospectively identified. Oncologic readiness was defined as sufficient postoperative clinical and neurological recovery to allow the next indicated oncologic treatment. RIOT was defined as postoperative radiotherapy and/or systemic treatment within 30 d …

27.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Timing of mental disorders in relation to cancer-specific mortality in cancer patients

Mingyi Li, Zhengyi Deng, Minji Jung, Kevin L'Espérance, Michael Baiocchi, David Spiegel, Benjamin I Chung, Marvin E Langston, Melissa L Bondy

Abstract Background To evaluate whether mental disorders identified before cancer diagnosis, within one year, or 2-5 years after cancer diagnosis are associated with cancer-specific mortality, and whether having both pre- and post-diagnosis disorders displays the highest mortality. Methods We conducted a cohort study of 22,281 UK Biobank participants linked to cancer and death registries. Mental disorders were ascertained from inpatient and outpatient diagnoses and psychiatric prescriptions, then categorized by per …

27.08.2026journal-article

Angewandte Chemie International Edition

Harnessing the E3 Ligase KLHL12 for Tumor‐Selective Protein Degradation

Shicheng Xu, Xian Zhang, Shunbo Hu, Xinyi Wang, Yuxin Ge, Ziquan Zhao, Tianbao Zhu, Nan Wang, Limin Du, Qidong You, Xiaoke Guo, Zhengyu Jiang

ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are currently constrained by a reliance on ubiquitously expressed E3 ligases, which compromises tumor selectivity and raises toxicity risks. Here, we identified KLHL12 as a potentially tumor‐selective E3 ligase and reported the development of the first‐in‐class KLHL12‐recruiting PROTACs. Guided by a structure‐based macrocyclization strategy, we obtained a high‑affinity cyclic peptide, cp4 , as a KLHL12‑binding ligand and constructed novel PROTACs against oncogenic B …