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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Muscles, Ligaments and Tendons Journal

Gua Sha therapy reduces thoracolumbar fascia thickness and improves lumbar flexibility: A pilot randomized controlled trial

Beibei Wang, Yang Hu, Yuan Xie, Wichai Eungpinichpong

Background: Chronic low back pain (LBP) is associated with changes in the thoracolumbar fascia (TLF) structure. Gua Sha is a traditional manual therapy that can relieve LBP, but there is a lack of clinical evidence on whether it can affect fascial properties. Objectives: To investigate the immediate effects of Gua Sha on TLF thickness and functional parameters in healthy adults. Methods: In this pilot randomized controlled trial, 24 healthy participants were randomly assigned to a Gua Sha group (n = 12) or a contro …

24.08.2026journal-article

American Journal of Speech-Language Pathology

Engaging Children in Brain–Computer Interface (BCI) Development: Utilizing an Interactive iPad Tool to Capture Picture-Based P300-Based BCI Augmentative and Alternative Communication Design Preferences

Kevin M. Pitt, Amber Thiessen, Grace Fowler, Elena Butler

Introduction: P300-based brain–computer interface augmentative and alternative communication (P300-BCI-AAC) systems show promise for supporting communication for children with severe speech and physical impairments. However, little is known about how children prefer these displays to be designed. This study examined children's design choices and the rationales guiding those choices to inform the development of user-centered, pediatric BCI-AAC displays. Method: Thirty-eight typically developing children (8–12 years …

24.08.2026journal-article

International Journal of Basic & Clinical Pharmacology

Melasma-like facial hyperpigmentation associated with long-term dasatinib therapy in Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia: a rare cutaneous adverse event

Kavya Ronanki, Reshma Benson, Arjun Kacchwaha, Uttam Kumar Nath

Tyrosine kinase inhibitors (TKIs) have significantly improved survival in Philadelphia chromosome-positive leukemias, including chronic myeloid leukemia (CML) and Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). Dasatinib, a second-generation TKI, is frequently used in Ph+ ALL due to its potent BCR-ABL inhibition and ability to cross the blood-brain barrier. While common adverse effects of dasatinib include cytopenias and fluid retention, cutaneous side effects are rare, particularly pigmentary changes …

24.08.2026journal-article

Frontiers in Pediatrics

Microbiological spectrum and antimicrobial resistance patterns in pediatric acute appendicitis: implications for evidence-based empirical therapy

Jia Zhang, Huaiwei Zhang, Yan Peng, Yubin Li

Background Acute appendicitis is one of the most common surgical emergencies in children, and timely empirical antimicrobial therapy is particularly important in complicated cases. However, antibiotic selection is increasingly challenged by regional variability in pathogen distribution and antimicrobial resistance. This study aimed to characterize the microbiological spectrum and antimicrobial susceptibility profiles of purulent specimens from pediatric patients with acute appendicitis and to provide evidence for o …

24.08.2026journal-article

Applied Sciences

C-MCSS-Mamba: Counterfactual Mechanism-Contrastive Selective Scan Within Mamba for Block-Causal Speech Deepfake Detection

Gaopeng Zhang, Shidong Liu, Dengtao Zhang, Liang Tang

Speech deepfake detection (SDD) is commonly formulated as offline utterance-level binary classification, which limits early decisions in streaming communication and provides little mechanism-level evidence for a spoofing prediction. We propose C-MCSS-Mamba, a block-causal SDD framework that processes fixed-duration audio blocks with a partially fine-tuned XLS-R frontend and carries detection states across blocks through Mamba. Its selective scan is replaced by the proposed Counterfactual Mechanism-Contrastive Selec …

24.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Auditory–Somatosensory Influences on Vocal Motor Control in Primary Muscle Tension Dysphonia

Adrianna C. Shembel, Elizabeth D. Young, Julianna Smeltzer, Roozbeh Behroozmand

Purpose: Auditory and somatosensory systems jointly support vocal motor control, yet their relative contributions in primary muscle tension dysphonia (pMTD) remain poorly understood. This study examined how auditory and somatosensory feedback influence vocal motor control and adaptation in individuals with and without pMTD. Method: Fifty-eight participants (pMTD: n = 17; controls: n = 41) completed a 200-trial altered auditory feedback paradigm involving sustained vowel productions with fundamental frequency downwa …

24.08.2026journal-article

Frontiers in Stroke

Access to stroke rehabilitation services for patients discharged from the Mulago National Referral Hospital Neurology unit, Kampala—Uganda: a mixed-methods study

Ronald Bwambale, Ronald Ssenyonga, Mark Kaddumukasa, Martha Sajatovic, Aggrey David Mukose

Introduction Rehabilitation is the primary form of therapy for stroke survivors. However, there is a dearth of information regarding access to stroke rehabilitation services following discharge from hospitalization. This study, therefore, examined the level of access and experiences of accessing stroke rehabilitation services following discharge from the Mulago National Referral Hospital (MNRH) Neurology unit, Kampala, Uganda. Methodology This was a concurrent mixed-methods study. Quantitative data were collected u …

24.08.2026journal-article

Journal of Clinical Medicine

Factors Associated with Adherence to Cardiac Rehabilitation: A Retrospective Cohort Study

Jessica Campo-Álvarez, Mónica Rincón-Roncancio, Eduardo Tuta-Quintero, Yuli Fuentes, Claudia Mondragón-Rinta, Liliana García-Gutiérrez

Introduction: Cardiac rehabilitation (CR) is an evidence-based secondary prevention strategy that improves functional capacity, quality of life, and cardiovascular outcomes. However, adherence to CR programs remains suboptimal, limiting their effectiveness. Methods: A retrospective multicenter cohort study was conducted among patients enrolled in outpatient CR programs at two specialized cardiovascular centers. Adherence was defined as attendance at ≥70% of the prescribed sessions (≥25 of 36 sessions). Bivariate an …

24.08.2026journal-article

Journal for Person-Oriented Research

Treatment of anxiety in athletes using cognitive behavioral therapy: A single-case experimental design with multiple baselines.

Rebecka Ekelund, Stefan Holmström, Andreas Stenling

Anxiety is one of the most prevalent mental health problems in athletes, yet the inclusion of athletes with clinical mental health problems in intervention studies remains limited. Furthermore, no studies to date have investigated the mechanisms of cognitive behavioral therapy (CBT) on anxiety and positive affect in athletes. Hence, the aim of the current study was to examine the effect of CBT on moderate to severe symptoms of anxiety and positive affect in athletes, as well as to investigate the mediated effects o …

24.08.2026journal-article

Healthcare

Four-Year Management of Severe COPD–OSA Overlap Syndrome with Phased, Closed-Loop Respiratory Rehabilitation: A Case Report

Qiufeng Peng, Dajun Liu, Hongbo Xue, Haoyang Hei, Hua Guo, Jingchun He, Kui Ye

Background: Severe COPD–OSA overlap syndrome remains challenging to manage, and existing approaches rarely combine guideline-directed OSA therapy with sustained pulmonary rehabilitation, leaving patients vulnerable to recurrent acute exacerbations. Case Presentation: A 71-year-old male with severe overlap syndrome had been hospitalized three times for hypercapnic encephalopathy requiring invasive ventilation. Following admission in 2021, we implemented a four-year, three-stage closed-loop rehabilitation program com …

24.08.2026journal-article

International Journal of Basic & Clinical Pharmacology

A retrospective evaluation of anti-retroviral therapy regimen modifications due to adverse drug reactions in a tertiary care hospital

Deepika K. K., Syed Mohsin Ahmed, Basavanna P. L.

Background: Antiretroviral therapy (ART) has transformed HIV infection into a chronic manageable disease and substantially improved survival among people living with HIV. Despite these advances, adverse drug reactions (ADRs) remain a major cause of treatment modification, potentially affecting adherence, treatment continuity, and long-term outcomes. Real-world pharmacovigilance data describing ADR-driven ART regimen changes in Indian settings remain limited. Aim was to evaluate the frequency and pattern of ART regi …

24.08.2026journal-article

International Journal of Basic & Clinical Pharmacology

CRISPR gene therapy: a review

Sanjeyan N., Gobika G., Harshini Reethu S., Renuka A.

The adaptive immune system of prokaryotes is the source of CRISPR-Cas9, a ground-breaking genome editing technique that uses RNA-guided nucleases to precisely alter DNA sequences. An summary of CRISPR/Cas9's discovery, structural elements, mode of action, therapeutic uses, and present limitations is given in this article. The Cas9 nuclease and guide RNA work together to identify particular DNA targets and cause double-strand breaks in the system. Cellular processes like homology-directed repair or non-homologous en …

24.08.2026journal-article

International Journal of Molecular Sciences

Coumarin and Curcumin-Metal Complexes as Next-Generation Photosensitizers in Cancer Photodynamic Therapy

Siu Kan Law, Albert Wing Nang Leung, Chuanshan Xu

To explore the emerging role of natural ligands, specifically coumarin and curcumin, and their coordination with the transition metals ruthenium (Ru) and iridium (Ir) as photosensitizers (PSs) in photodynamic therapy (PDT) for cancer. This highlights the integration of natural compounds and transition metals to overcome limitations in photophysical properties, hypoxia tolerance, and clinical translation. Regarding PDT oncology, this examines an immunological effect on Ru/Ir complexes and natural ligand-metal hybrid …

24.08.2026journal-article

Veterinary Evidence

Efficacy of vincristine-ivermectin combination therapy in the treatment of canine transmissible venereal tumour (CTVT)

Athulya Prakash

PICO Question In dogs diagnosed with canine transmissible venereal tumour (CTVT), does treatment with vincristine combined with ivermectin, compared to treatment with vincristine alone, lead to improved clinical outcomes? Clinical bottom line Category of research Treatment. Number and type of study designs reviewed Two randomised controlled trials. Strength of evidence Weak. Outcomes reported The studies collectively indicate that the combination of vincristine and ivermectin may be an effective and well-tolerated …

24.08.2026journal-article

Advanced Science

A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Yan Zhao, Yufei Lan, Min‐Goo Lee, Jinjun He, Yueran Pan, Eunji Kim, Xin Fu, Sungwook Jung, Wanxia Lu, Jinyue Fan, Haoxiang Chen, Yuanbo Zhao, Yuling Xu, Jong Seung Kim, Chao Zhang

ABSTRACT Precision control over nucleic acid delivery remains a critical challenge in cancer therapy, particularly for siRNA‐based gene silencing, where off‐target effects limit clinical translation. Herein, we report a programmably engineered DNA nanocircuit with cascaded dual‐AND logic gates, which enables the development of a spatiotemporally controlled siRNA delivery strategy for precision cancer therapy. The DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extrac …

24.08.2026journal-article

Electronics

Global Perspectives on AI-Based Digital Twins in Smart Rehabilitation and Physiotherapy: Convergence of IoMT, Multiphysics Modeling, and Wireless Bio-Integrated Sensing

Emilia Mikołajewska, Jolanta Masiak, Ewelina Panas, Urszula Rogalla-Ładniak, Dariusz Mikołajewski

Artificial intelligence (AI)-based digital twins (DTs) are emerging as a groundbreaking paradigm in rehabilitation and physiotherapy, enabling the creation of dynamic virtual representations of patients for continuous monitoring, prognostic assessment and personalised therapeutic interventions. This article presents a global, interdisciplinary review of AI-based DT technologies in rehabilitation settings utilising the Internet of Medical Things (IoMT), with particular emphasis on the integration of wearable and imp …

24.08.2026journal-article

Current Opinion in Obstetrics & Gynecology

Management of menopausal hormone therapy

Julia Switzer, Lindsey Vignali, Jonathan Vignali, Rebecca Jackson

Purpose of review The purpose of this review is to provide practical guidance on managing menopausal hormone therapy (MHT) and to provide updated guidance on the risks and benefits of MHT. Recent findings Reanalysis of the Women’s Health Initiative and recent studies have demonstrated the protective role of estrogen in cardiovascular disease (CVD) and bone health, particularly when initiated before the age of 60. There is an increased risk of venous thromboembolism (VTE) with oral formulations, but formulations usi …

24.08.2026journal-article

Jurnal Kebidanan

Factors Associated with Hyperemesis Gravidarum among First-trimester Pregnant Women in the Midwifery Ward of RSDKH Balangan

Sintia Wulandari, Darmayanti Wulandatika, Siti Fatimah, Kristina Yuniarti

Background:Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting in pregnancy that may cause dehydration, weight loss, electrolyte disturbances, and impaired quality of life. Early identification of women who require closer assessment may support timely antenatal care.Objective:This study aimed to examine the associations of maternal age, education level, economic status, and parity with HG among first-trimester pregnant women treated in the Midwifery Ward of RSDKHBalangan.Methods:A retrospective anal …

24.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Phonological Awareness and Reading Impairments in Cantonese Speakers With Congenital Amusia: Comorbid Dyslexia Traits Matter

Yuhong Zhu, William Choi, Jiwei Ma, Caicai Zhang

Purpose: This study investigated the nature and underlying mechanisms of phonological awareness and literacy impairments in Cantonese-speaking adults with congenital amusia (amusia hereafter) while accounting for the potential role of dyslexia traits. Method: Twenty-one Cantonese speakers with amusia and 21 matched controls were assessed using segmental (onset phoneme deletion and spoonerism) and suprasegmental (tone oddity) phonological awareness tasks, literacy tasks (word reading, 1-min word reading, and dictati …

24.08.2026journal-article

International Journal of Biology and Life Sciences

The Metabolic Reprogramming of Immune Cells in the Tumor Microenvironment and the Mechanism of Immune Therapy Resistance

Ganyu Yi

The efficacy of immune checkpoint inhibitors (ICIs) is often limited by primary and acquired resistance induced by the tumor microenvironment (TME), with the metabolic reprogramming of immune cells being the core mechanism. This review systematically analyzes the three key metabolic stresses in the TME: glucose deprivation, lactate accumulation, and adenosine accumulation. How these metabolic stresses, by reshaping the metabolic states and functions of T cells, macrophages, and dendritic cells, jointly construct an …

24.08.2026journal-article

JMIR Rehabilitation and Assistive Technologies

Effects of Using a Lumbar-Type Hybrid Assistive Limb by Older Adults With Frailty on Exercise Self-Efficacy: Retrospective Analysis Based on the Kanagawa Prospective ME-BYO Cohort Study

Makoto Nagasawa, Sho Nakamura, Yoshinobu Saito, Yuko Oguma, Takashi Kasukawa, Kaname Watanabe, Hiroto Narimatsu

Abstract Background Improving exercise self-efficacy (ESE) is a key strategy for promoting sustained physical activity among older adults with frailty. The lumbar-type Hybrid Assistive Limb (HAL), a wearable device that supports voluntary movement through bioelectric signals, may facilitate mastery experiences in individuals with low baseline self-efficacy via adjustable assistance. However, its effects on ESE remain unclear. Objective This study evaluated the effects of lumbar-type HAL exercise on ESE in older adu …

24.08.2026journal-article

South African Journal of Arts Therapies

A Field in Formation

Sinethemba Makanya

This paper examines the development of Art Therapy in South Africa through a synthesis of practitioner reflections from four arts therapists working across the field. Rather than presenting a unified account, the paper engages thepartial, divergent, and at times contradictory perspectives that emerge from these reflections. Drawing on thematic analysis, the paper explores how Art Therapy in South Africa has been shaped through ongoing negotiations around origin, professionalisation, epistemological authority, acces …

24.08.2026journal-article

South African Journal of Arts Therapies

Looking back to move forward

Linda Mdena-Thibedi

This article reviews the history and development of the Drama Therapy programme at the University of the Witwatersrand in South Africa, reflecting on its past to prepare for and address future challenges and growth. Both personal reflections from the author and interviews with the programme’s founders, Tamara Gordon-Roberts and Warren Nebe, inform the article. A key consideration is the Drama Therapy programme’s position within Drama for Life, the postgraduate department dedicated to using the arts as a medium for …

24.08.2026journal-article

English Language Teaching and Linguistics Studies

An Analysis of Request Speech Acts in Jane Eyre: A Corpus-Based Local Grammar Approach

Keyi Zhang

Request speech acts are key elements in literary text construction, and Jane Eyre offers an ideal exemplar for their examination, with ample scope for interpretation. This study attempts to analyse the local grammatical patterns of request speech acts in Jane Eyre using a custom-built corpus. It aims to identify the types and frequencies of these patterns, to explore how different characters deploy requests, and to examine how such differences reflect the characters’ social status, personality traits, and psycholog …