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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

International Journal of Innovative Technologies in Social Science

TIZANIDINE IN THE MANAGEMENT OF MUSCULOSKELETAL PAIN, WITH PARTICULAR EMPHASIS ON BACK PAIN: MECHANISM OF ACTION, EFFICACY, SAFETY, AND CLINICAL USE – A LITERATURE REVIEW

Krystian Kaczmarek, Wiktoria Zawada, Zofia Jadwiga Leszczyńska, Vladyslav Romaniuk, Urszula Szuleta, Agnieszka Benecka, Jakub Pietrończyk, Alicja Benecka, Zuzanna Wieczorek, Iga Tartas, Natalia Prankiewicz

Musculoskeletal pain, including back pain, is a leading cause of disability worldwide and often coexists with increased paraspinal muscle tension and painful muscle spasm. This narrative review aimed to summarize current knowledge on the mechanism of action, clinical efficacy, safety profile, and clinical use of tizanidine in musculoskeletal pain, with particular emphasis on back pain. The review included clinical trials, systematic reviews, case reports, clinical practice guidelines, prescribing information, and t …

28.08.2026journal-article

Jurnal Farmasi SYIFA

Kepuasan Pasien terhadap Pelayanan Kefarmasian Berbasis Patient-Oriented Care: Literatur Review

Imam Yunus, Aang Hanafiah Wangsaatmadja, Siti Wakhidatun Suciyati

Pelayanan kefarmasian saat ini tidak hanya berfokus pada penyediaan obat, tetapi juga pada kebutuhan pasien sebagai penerima layanan. Pendekatan patient-oriented care menempatkan pasien sebagai pusat pelayanan, sehingga apoteker berperan dalam memberikan informasi, edukasi, konseling, serta pendampingan dalam penggunaan obat. Kepuasan pasien menjadi salah satu indikator penting untuk menilai mutu pelayanan kefarmasian, terutama dalam aspek komunikasi, pemberian informasi obat, empati, responsivitas pelayanan, waktu …

28.08.2026journal-article

Critical Care & Emergency Medicine

Trombosis venosa cerebral puerperal: implicaciones neurocríticas de un caso clínico

Omar Mendoza, Vanessa Campozano, Ralph Naranjo, Xavier Montenegro, Oswaldo Bolaños

Background: Cerebral venous thrombosis (CVT) is an uncommon cerebrovascular emergency with heterogeneous clinical expression. During pregnancy and the puerperium, early recognition is challenging because neurologic symptoms overlap with obstetric and neurocritical differential diagnoses. Case presentation: We report a 30-year-old woman in the immediate puerperium after emergency cesarean delivery complicated by placenta accreta, hypovolemic shock and hysterectomy, who developed akinetic mutism and bilateral brachia …

28.08.2026journal-article

World Journal of Gastroenterology

P-element-induced wimpy testis-interacting RNA: A biomarker for gastric cancer diagnosis, progression, and prognosis

Yu-Wei Liu, Yi-Ke Chen, Jin-Yang Yan, Hua Shen, Fang-Ming Mai, Zheng-Hui Kong, Hui-Long Chen, Li-Ping Li, Wei-Ping Liu, Yong Gao, Lun Zhang

P-element-induced wimpy testis (PIWI)-interacting RNAs are a class of small non-coding RNAs, typically 24–31 nucleotides in length. They function by binding to PIWI proteins and play important roles in gene regulation. Initially identified in germline cells, PIWI-interacting RNAs (PiRNAs) mediate transposon silencing and maintain genomic integrity. Accumulating evidence indicates that, beyond their roles in mammalian germ cells, PiRNAs are also aberrantly expressed in a variety of human cancers, where they particip …

28.08.2026journal-article

Gastroenterologie a hepatologie

Severe upadacitinib-induced anemia in a multi-refractory Crohn’s disease patient – a case report

Anna Gojdicova, Igor Sturdik, Juraj Toth, Stanislav Majna, Jana Skubakova, Michaela Granak-Pytliakova, Tibor Hlavaty

Úvod: Inhibítory Janusovej kinázy (JAK) predstavujú účinnú perorálnu liečebnú možnosť pri stredne ťažkej až ťažkej forme zápalového ochorenia čriev (IBD), ktoré nereaguje na konvenčné a biologické lieky. Boli hlásené hematologické nežiaduce účinky, avšak závažná myelosupresia je zriedkavá a jej klinické zvládnutie – najmä rozhodnutie o pokračovaní liečby u pacientov, ktorí z nej majú podstatný prínos – naďalej predstavuje výzvu. Popis prípadu: Predkladáme prípad 45-ročnej ženy s Crohnovou chorobou postihujúcou hrub …

28.08.2026journal-article

Nurse Educator

The Detective Nurse Practitioner: A Clinical Reasoning Pathway to Enhance Advanced Health Assessment Skills

Rashmi P. Momin

Background: Clinical reasoning is frequently underdeveloped in graduate nurse practitioner (NP) education. The National Organization of Nurse Practitioner Faculties Role Competencies define what NP students must achieve, and the Professional-Reporter-Interpreter-Manager-Educator-Nurse Practitioner (PRIME-NP) Model describes the sequence in which they develop. Problem: Advanced Health Assessment students can perform a thorough physical examination but struggle to determine relevant findings, prioritize working diffe …

28.08.2026journal-article

Journal of Shelter Medicine and Community Animal Health

Association Between Rabbit Café Visitor Experiences and Motivations to Feed Feral Rabbits in Vancouver, British Columbia

Lexis H. Ly, Silvija Grava, Oceania C. Kreutzer, Alexandra Protopopova

In Vancouver, British Columbia, feeding feral rabbits is prohibited due to risks to animal welfare and public health, yet feeding remains an ongoing issue in areas where populations of abandoned pet rabbits persist. One potential alternative to feeding animals in the wild is engaging in human–animal interaction opportunities in controlled settings such as rabbit cafés. This short report examined factors associated with visitors’ reported likelihood of feeding feral rabbits after visiting a rabbit café. Non-parametr …

28.08.2026journal-article

eLife

Understanding pain in women with polyendocrine metabolic ovarian syndrome: health risks and treatment effectiveness

Tess Cherlin, Stephanie Mohammed, Samantha Strydesky, Sasha Ottey, Katherine Sherif, Shefali Setia Verma

Background: Polycystic ovary syndrome (PCOS), recently renamed as polyendocrine metabolic ovarian syndrome (PMOS), is a prevalent endocrine disorder in women, often accompanied by various symptoms, including significant pain, such as dysmenorrhea, abdominal, and pelvic pain, which remains underexplored. Methods: This retrospective study examines electronic health records (EHR) data to assess the prevalence of pain in women with PMOS. Conducted in January 2026, using data from 120 Health Care Organizations within th …

28.08.2026journal-article

Clinical Pharmacology & Therapeutics

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju

Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to contribute substantially to preventable morbidity and mortality. Long‐acting therapeutics (LATs) may help address selected pediatric health priorities by sustaining the …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Dermatoses as an iatrogenic complication of invasive device-based procedures

O.I. Letyaeva, T.V. Trapeznikova, V.O. Gubina

Background. In modern cosmetology, high-intensity energy-based technologies, which utilize the interaction of physical modalities with biological tissues, are effectively and widely used. These manipulations will disrupt the epithelial barrier, activating the tissue regeneration process. In some cases, adverse events or iatrogenic complications may develop, requiring additional medical intervention. Dermatitis after invasive device-based procedures can arise from clinician non-compliance with treatment protocols or …

28.08.2026journal-article

Italian Journal of Medicine

Prospective observational studies in clinical research: pros and cons

Luca Bertolaccini, Matteo Nicoletto, Paola Piccolo, Fulvio Pomero

Prospective observational studies are essential in clinical research, mainly when randomized controlled trials (RCTs) are infeasible, unethical, or impractical. These studies involve the prospective collection of data from cohorts stratified by exposure status, allowing investigators to observe the natural progression of outcomes while preserving temporality. Their main strengths include measuring incidence, assessing multiple outcomes, and avoiding recall bias, thus offering valuable insights into real-world clini …

28.08.2026journal-article

Journal of Patient Safety and Risk Management

Patient safety in hospital dentistry: A model for dentists without operating room privileges

Amal Al-Khotani, Reem Turkiastani, Hiba Alahmadi

A lack of compliance with professional privileging and training requirements is the most common cause of dental malpractice. In hospital dentistry, some dental specialties are trained to treat patients in the operating room, whereas others, including restorative dentists, endodontists, prosthodontists, and periodontists, are occasionally required for dental management under general anesthesia, yet typically hold no operating room privileges. This creates a gap in standardized care and patient-safety compliance. To …

28.08.2026journal-article

BMC Health Services Research

E-Health technology as a catalyst for enhancing clinical communication: observational insights into overcoming doctor–patient barriers

Wasib Bin Latif, Ida Md Yasin, Mohammad Bin Amin, Farzana Nusrat, Md. Atikur Rahaman, Judit Oláh

Abstract Background Effective doctor–patient communication is essential for building trust and improving health care outcomes. The specific dynamics of communication within E-Health are limited, while it is known to enhance satisfaction and treatment adherence. Objective This study aimed to assess the patients’ response on recommended E-Health technology to remove the communication barriers between doctors and patients. Methods A descriptive cross-sectional study was conducted among 208 adult patients at Dhaka Medi …

28.08.2026journal-article

Journal of Pediatric Rehabilitation Medicine

Profile of individuals with full-scale intelligence quotient (FSIQ) scores in the National Spina Bifida Patient Registry (NSBPR)

Heidi Castillo, Sophia Drewry, Amy Heffelfinger, Jennifer T. Queally, Kurt A. Freeman, Vanessa Avemil, Richard Adams, Pamela Murphy, Kathryn Smith, Audrey Roach, Gregory Heuer, William Walker, Jonathan Castillo, Catharine Riley

Purpose Although intelligence quotient (IQ) testing can help identify cognitive issues, data on IQ testing in the spina bifida (SB) population is limited and difficult to collect. This study aimed to identify factors influencing IQ test reporting among individuals in the National Spina Bifida Patient Registry (NSBPR). Methods A descriptive analysis of 1,017 individuals aged 4 to 22 years from five NSBPR clinics was conducted. Characteristics of participants with a full-scale intelligence quotient (FSIQ) score (n=43 …

28.08.2026journal-article

Healthcare

Cross-Cultural Adaptation and Preliminary Psychometric Evaluation of the Malay Orthodontic Patient Satisfaction Questionnaire and Patient Satisfaction Following Fixed Orthodontic Treatment in Malaysia

Al Imran Shahrul, Yap Jia Qi, Shawn Tan Jun Xue, Rohaya Megat Abdul Wahab, Alizae Marny Fadzlin Syed Mohamed

Background: Orthodontic treatment is a long-term intervention in which patient satisfaction is an important outcome alongside clinical measures. This study aimed to translate and culturally adapt the Orthodontic Patient Satisfaction Questionnaire (OPSQ) into Malay (M-OPSQ), evaluate its content validity, face validity, internal consistency and structural validity, and assess satisfaction following fixed appliance treatment. Methods: Content validity was evaluated by eight orthodontists using the Content Validity In …

28.08.2026journal-article

Interdisciplinary CardioVascular and Thoracic Surgery

Tumor-to-tumor metastasis: a rare case of clear cell renal cell carcinoma metastasizing into lung adenocarcinoma

Valerio Sebastianelli, Silvia De Maria, Paolo Graziano, Marco Anile

Abstract Tumor-to-tumor metastasis (TTM) is a very rare condition in which a malignant tumor (donor) metastasizes into another primary neoplasm, either benign or malignant (recipient). We report the case of a 74-year-old man previously surgically treated for a clear cell renal cell carcinoma(ccRCC) who developped a new subsolid nodule in the right upper pulmonary lobe discovered at a four-year follow-up CT scan. The patient underwent a right uniportal thoracoscopic S1 segmentectomy and mediastinal lymph node dissec …

28.08.2026journal-article

Medicine

Efficacy, safety and outcome of selective IL-23 inhibitor risankizumab in induction and maintenance of CD and ulcerative colitis

Muhammad Waqas Afzal, Abdul Haseeb, Ushna Ali, Muhammad Rizwan Ashraf, Asad Mehmood, Abida Perveen

Background: Crohn disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases characterized by immune dysregulation. Despite biologic advancements, many patients experience treatment failure. Risankizumab (RZB), a selective interleukin-23 inhibitor, has emerged as a promising therapy for moderate-to-severe inflammatory bowel diseases. This systematic review evaluates its efficacy, safety, and therapeutic outcomes. Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Anal …

28.08.2026journal-article

Medicine

Risk of hepatitis B reactivation in COVID-19 patients receiving corticosteroid therapy

Hatun Öztürk Çerik, Özlem Aldemir, Bilge Katirci, Burcu Demirhan Kapicioğlu, Zeynep Banu Ramazanoğlu, Arzu Altunçekiç Yildirim

COVID-19 and HBV are significant public health issues, and managing their co-infection remains unclear. Corticosteroid therapy improves survival in severe COVID-19 but may increase the risk of HBV reactivation (HBVr). Evidence regarding the incidence and outcomes of HBVr in COVID-19 patients remains limited. This study aimed to investigate the frequency, determinants, and clinical consequences of HBVr among COVID-19 patients with current or past HBV infection treated with corticosteroids. This retrospective study e …

28.08.2026journal-article

Medicine

A retrospective study of disproportionality analysis signals between proprotein convertase subtilisin/kexin 9 inhibitor use and respiratory, thoracic, and mediastinal disorders

Hongzhu Chen, Lijing Li

This study aims to investigate emerging signals and clinical characteristics associated with adverse event reports of respiratory, thoracic, and mediastinal diseases (RTMD) related to proprotein convertase subtilisin/kexin 9 inhibitors (PCSK9i) in the FDA Adverse Event Reporting System (FAERS) database. PCSK9i-related RTMD adverse event reports were extracted from the FAERS database (covering the period from the first quarter of 2016 to the fourth quarter of 2023), and the clinical characteristics and onset times o …

28.08.2026journal-article

Research, Society and Development

Angiografia por fluorescência com verde de indocianina na cirurgia colorretal: Impacto na prevenção da fístula anastomótica e na tomada de decisão intraoperatória

Rafael Marques Braga, Maria Clara Peres de Castelo Branco, Ana Carolina Delfina de Brito Guimarães, Maryanna Alves Correia, Iasmim Rosa Morena Alves da Cruz, João Vitor de Almeida Cardoso, Leonardo Duarte Alves

A fístula anastomótica permanece uma das principais complicações após cirurgias colorretais, sendo a perfusão tecidual inadequada um de seus fatores potencialmente modificáveis. A angiografia por fluorescência com verde de indocianina (ICG-FA) permite avaliar intraoperatoriamente a vascularização intestinal e pode modificar a estratégia cirúrgica antes da confecção da anastomose. Este estudo teve como objetivo analisar as evidências sobre o impacto da ICG-FA na prevenção da fístula anastomótica e na tomada de decis …

28.08.2026journal-article

Critical Care & Emergency Medicine

Deterioro hemodinámico cerebral tras la administración de bicarbonato de sodio en acidosis metabólica grave: reporte de un caso

Ricardo Bañuelos-Huerta, Nancy Gutiérrez-Vega, Socorro Figueroa-Rivera, Maribel García-Cantú, Montserrat Ramírez-Barranco, Wendy Sartillo-Guerra, Eduardo Yahir Aguilar-Lazcano

Abstract: Sodium bicarbonate ($\text{NaHCO}_3$) is used in selected scenarios of severe metabolic acidosis; however, its administration may be associated with complex physiological effects, particularly at the cerebral level. The generation of $\text{CO}_2$ following its administration promotes its rapid diffusion across the blood–brain barrier, which may contribute to paradoxical intracellular acidosis, alterations in cerebral vasoreactivity, and increased intracranial pressure. We present the case of a 70-year-ol …

28.08.2026journal-article

World Journal of Gastroenterology

Clinical efficacy and safety of laparoscopic hybrid surgery for simultaneous resection of colorectal cancer liver metastases

Tian-Shuai Zhang, Xiao-Ming Zhu, Rong-Bo Wen, Le-Qi Zhou, Hai-Feng Gong, En-Da Yu, Hao Wang, Gang Li, Wei-Ping Zhou, Li-Qiang Hao, Guan-Yu Yu, Wei Zhang

BACKGROUND Simultaneous resection of colorectal cancer liver metastases (CRLM) has been widely adopted; however, clinical efficacy still varies across different surgical approaches, and the best surgical strategy remains controversial. AIM To investigate the efficacy and safety of laparoscopic hybrid surgery (LHS) vs total open surgery (TOS) the in simultaneous resection of CRLM. METHODS This was an observational study conducted at a tertiary medical center, enrolling 266 patients who undergoing simultaneous resect …

28.08.2026journal-article

Journal of Perinatal Medicine

Ultrasound-based prediction of fetal hyperinsulinemia: development of a fetal metabolic score

Roberto Noya Galluzzo, Karine Souza Da Correggio, Aldo von Wangenheim, Heron Werner, Edward Araujo Júnior, Gustavo Yano Callado, Alexandre Sherlley Casimiro Onofre

Abstract Objectives Gestational diabetes mellitus (GDM) is associated with fetal hyperinsulinemia, excessive adiposity, and adverse perinatal outcomes; sonographic markers of fetal adiposity, liver enlargement, and septal thickening may allow direct assessment of fetal metabolic adaptation. This study aimed to develop an ultrasound-based fetal metabolic score (FMS) estimating the risk of fetal hyperinsulinemia. Methods The FMS was developed from a prospective cohort of 223 pregnant women (128 with GDM, 95 controls) …

28.08.2026journal-article

Education in Medicine Journal

Fostering Excellence in English Academic Writing Among Health Profession Students and Lecturers: An Action Research

Izzudeen Ayub, Megat Mustaqim Megat Iskandar, Siti Yusrina Nadihah Jamaludin, Yasrul Izad Abu Bakar, Mohd Salami Ibrahim

Academic writing is a critical skill for researchers and educators. However, many, especially in nonnative English-speaking contexts, face challenges in mastering it. This study employed action research (AR) involving 27 participants to address these challenges through the design and implementation of an academic writing workshop for postgraduate students and lecturers from the Facultiesof Medicine, Health Sciences, and Pharmacy. The AR workshop integrated hands-on learning, structured guidance, and innovative tool …