npj Women's Health
Multi-omics investigation of metabolomic and microbial features in bacterial vaginosis
Abstract Bacterial vaginosis (BV) affects 23–29% of reproductive-age women globally and recurs in over half of cases within 6 months, yet the coordinated metabolic and genomic mechanisms underlying it remain incompletely understood. In this cross-sectional study of 111 Swedish women (29 with BV, 82 controls), we combined shotgun metagenomics, targeted liquid chromatography–mass spectrometry metabolomics, and Gardnerella metagenome-assembled genome (MAG) analysis, integrating these layers with supervised (DIABLO) an …