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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Neuro-Oncology

11 Single-nucleus and spatially resolved multi-omics uncover intracranial germinomas’ microenvironment and associated molecular features

Ho-keung Ng

Abstract Introduction Germinoma is the most common intracranial germ cell tumor and has a high incidence in East Asia. It is unique in having an intense immune-cell infiltration. Method We studied the tumor microenvironment (TME) of 51 cases by snRNA-seq, spatial transcriptomics (STs) and imaging mass cytometry (IMC). Results Specific TME types were related to the interferon gene module which was inversely correlated with M2-macrophages. Macrophage migration inhibitory factor (MIF) was the main signaling pathway fr …

27.08.2026journal-article

Neuro-Oncology

27 Development of Precision Virotherapies for Diffuse Midline Gliomas

Mariana Varela Pereira, Emily A Bates, Florian Siebzehnrubl, Chris Jones, William Gray, Alan L Parker

Abstract Introduction Diffuse Midline Gliomas (DMGs) are highly aggressive paediatric brainstem tumours with a median survival of 9-11 months - a figure unchanged for over four decades. This indicates a critical need for targeted therapies. The VITAL lab has developed Ad5NULL-RGD, an engineered adenovirus modified to ablate binding to native adenovirus receptors minimising off-target effects. The vector was redirected to αvβ3/5 integrins highly expressed in several brain tumours, via an RGD motif, enhancing tumour- …

27.08.2026journal-article

Cancer Research

Cross-talk between Schwann Cells and CD4+ T Cells Promotes Perineural Invasion in Colorectal Cancer

Huayuan Liu, Yiqiao Deng, Yi Yang, Junshuai Xue, Nuersimanguli Maimaitiming, Bingzhi Wang, Yujing Xin, Jinxue Zhou, Xiaomeng Liu, Chengyao Guo, Lang Yang, Zhen Huang, Haitao Zhou, Jianqiang Cai, Hong Zhao

Abstract Perineural invasion (PNI) is a common pathologic feature associated with poor prognosis in colorectal cancer. A better understanding of the mechanisms underlying PNI formation could help identify potential strategies to inhibit tumor progression. In this study, we revealed an integral role of CD4+ T cells in the development and progression of PNI in colorectal cancer. Single-cell RNA sequencing, spatial transcriptomics, and multiplex IHC profiling uncovered a distinct HSPA6+ CD4+ T-cell subset expressing T …

27.08.2026journal-article

Pigment International

Optimizing Lip Vitiligo Treatment: The Role of Microneedling with 5-Fluorouracil

Aruna Chintaginjala, Mani Deepika Atmuri, Mohana Rao Telu Sathyananda, Ramya Vetapalem, Kolisetty Venkata Sridevi, Lakshmi Kamcharala

Background: Vitiligo is an autoimmune disease characterized by depigmented macules and patches over the skin or mucosa and is of great aesthetic concern. It affects 2% of the world’s population with an average age of 20 years. Lip vitiligo is a distinct focal subtype of vitiligo accounting for 16% of total cases and has a significant impact on life, including lowered self-esteem. Though there are many topical and systemic agents available, it is often resistant to medical treatment, and there is an unmet medical ne …

27.08.2026journal-article

BMC Medicine

miR-155-5p drives coordinated tumor and macrophage reprogramming across multiple cancer entities

Theresa Kordaß, Ann-Katrin Schlosser, Marijan Czygan, Luisa Vieira Codeco Marques, Melisa Wartusch, Eric Nerenz, Vincencia Stefanie Muliawan, Stephan Kersting, Wolfram Osen, Stefan B. Eichmüller

Abstract Background T cell-based immunotherapies have improved cancer treatment, however their efficacy is frequently limited by tumor-intrinsic resistance mechanisms and by the immune suppressive tumor microenvironment, counteracting tumor specific immune responses through impaired antigen presentation and the accumulation of M2-like tumor-associated macrophages. MicroRNAs have emerged as regulators of tumor cell – immune cell interactions, yet the miRNAs’ capacity to coordinate anti-tumor effects across different …

27.08.2026journal-article

International Journal of Biology and Life Sciences

Integrated Traditional Chinese and Western Medicine Treatment of Oral Squamous Cell Carcinoma

Hualin He

The most prevalent of all oral cancers is the oral squamous cell carcinoma (OSCC), and it constitutes over 90 percent of this group. Its occurrence has only been on the rise in recent years, mostly because of the high use of betel nut, tobacco, and alcohol. The traditional treatment procedures mostly consist of approaches relying on Western medicine, as surgery is the dominant form of treatment, and this is complemented by chemotherapy and/or radiotherapy. Though these methods have short-term ability to treat tumor …

27.08.2026journal-article

Current Oncology

Real-World Toxicities and Outcomes of Pembrolizumab in Early-Stage Triple-Negative Breast Cancer

Emmanuel Joran Boujeke, Aaron Catalan, Laurice Arayan, Alfred Patrick Mina, Christian Edward James-McDonald, Rasna Gupta, Swati Kulkarni, Abdullah Nasser, Deepro Chowdhury, Muriel Brackstone, John Mathews, Caroline Hamm

Purpose: Pembrolizumab combined with chemotherapy is the standard of care for early-stage triple-negative breast cancer (TNBC) following KEYNOTE-522. However, real-world data on immune-related adverse events (irAEs) remain limited. We evaluated the incidence, severity, and clinical consequences of irAEs in a real-world cohort and compared outcomes with KEYNOTE-522. Methods: We conducted a retrospective cohort study of patients with stage II–III TNBC treated according to the KEYNOTE-522 regimen at two Ontario cancer …

27.08.2026journal-article

Financial Economics Research

Recognition of Data Assets in Financial Statements: A Systematic Literature Review on Concept Discrimination, Accounting Treatment and Management Systems

Ruzhen Zhang

In the context of the rapidly growing digital economy, data has become an essential component of production, and the recognition of data assets in financial statements and the related accounting problems have also drawn much of the attention of scholars and the business world. It is through this research that a systematic literature review methodology is used to follow the conceptual development and definitional requirements of data assets in the local, as well as in global environments, defining the conceptual dis …

27.08.2026journal-article

Neuro-Oncology

20 Design and development of a novel digital shared decision making aid for glioblastoma patients

Jasmine Hughes, Stephen Price

Abstract Introduction Facilitating shared decision-making (SDM) and incorporating patient decision aids are recommended by the National Institute for Health and Care Excellence (NICE). However, there is a lack of SDM aids for the specific treatment of high-grade glioma patients. The objective of this study was to describe the design and development process of a digital SDM aid for glioblastoma patients. Methods Following the International Patient Decision Aid Standards (IPDAS), the aid was developed through an iter …

27.08.2026journal-article

Neuro-Oncology

72 Primary care coding and psychotropic prescribing in young cancer survivors: mental health morbidity misclassification and implications for brain tumour survivorship

Emanuela Molinari, Valentina Fenech

Abstract Introduction Survivors of childhood, teenage and young adult (CTYA) brain tumours experience higher rates of depression and anxiety than other CTYA cancer survivor groups. As secondary care data alone underestimate this burden, we evaluated whether integrating primary care and psychotropic prescribing data improves measurement of mental health morbidity in young cancer survivors. Method We linked secondary care, primary care and prescribing data via DataLoch for 8,862 five-year cancer survivors diagnosed b …

27.08.2026journal-article

Neuro-Oncology

152 Re-irradiation for recurrent paediatric diffuse midline glioma: an international, multi-institutional retrospective study

Ajay Thomas Alex, Sean Hasson, Helen Benghiat, Liam Herbert, Claire Esler, Louise Brookes, Molly Bamber, Derek Tsang

Abstract Introduction Children with recurrent diffuse midline gliomas (DMG) have limited therapeutic options at recurrence. Re-irradiation (RT2) may be used at progression but with uncertainty about benefit. Method We conducted a multi-institutional retrospective study of children aged <18 with DMG treated at three centres (Toronto, Canada; Birmingham, UK; Nottingham, UK). Patients with radiologic progression after first radiation (RT1) were included. Overall survival (OS) was calculated from the date of progres …

27.08.2026journal-article

Neuro-Oncology

82 Proton versus photon stereotactic radiotherapy for brain metastases unsuitable for single-fraction stereotactic radiosurgery: a dosimetric comparison with robustness analysis

Vanita Gandhi, Andrew Poynter, Sarah Gulliford, Michael Kosmin

Abstract Introduction Fractionated stereotactic radiotherapy (SRT) is a recognised treatment for brain metastases unsuitable for single-fraction stereotactic radiosurgery, particularly large tumours, lesions near critical structures, or postoperative cavities. Proton beam therapy (PBT) may improve dose conformity and organ-at-risk sparing, although data remain limited. As advances in systemic therapy prolong survival, intracranial re-irradiation may increase, rendering cumulative dose to uninvolved brain clinically …

27.08.2026journal-article

Neuro-Oncology

66 Case report: successful targeted treatments in NTRK fusion and BRAFV600E mutant gliomas

Chloë May, Stephanie Thomas

Abstract Introduction It is rare to find targetable mutations in gliomas. The evidence for using targeted agents remains limited. NICE recommends performing Next Generation and Whole Genome Sequencing (NGS, WGS) for all patients with brain tumours, to identify targets for treatment. This abstract reports treating 2 patients, 1 with an NTRK fusion optic pathway glioma and 1 with a BRAFV600E mutant Grade 3 Pleomorphic Astrocytoma (PXA). Method Testing NGS and WGS is routine for all brain tumour patients at our tertia …

27.08.2026journal-article

Neuro-Oncology

37 Outcomes of a National Specialist Counselling Service for People Affected by Brain Tumours

Jen Boilestad, Joanna Moss

Abstract Introduction A brain tumour diagnosis profoundly affects physical, emotional and mental health. Surveys by The Brain Tumour Charity highlighted that 41% of people affected reported unmet emotional needs after diagnosis, and 91% shared that their mental health was impacted, yet less than half had access to counselling. In response, the Charity launched a free professional counselling service in 2022 to help patients and loved ones navigate the psychological challenges that accompany a brain tumour diagnosis …

27.08.2026journal-article

JMIR Research Protocols

Epigenetic Profiling for Early Detection and Treatment Response Monitoring in Non–Small Cell Lung Cancer: Protocol for a Prospective Translational Biomarker Study

Rajiv Kumar, Safia May Farry, Mark Ezegbogu, Glen Reid, Euan James Rodger, Ben Brockway, Aniruddha Chatterjee

Abstract Background Non–small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide and continues to have poor survival outcomes, with most patients diagnosed at advanced stages of disease. In New Zealand, NSCLC contributes substantially to cancer inequities, with Māori communities experiencing disproportionately high incidence and mortality rates. Although low-dose computed tomography screening can improve early detection, major limitations remain, including false-positive findings, o …

27.08.2026journal-article

Insights into Imaging

Performance of dual-layer spectral CT-based extracellular volume fraction to assess Ki-67 proliferation status in rectal cancer: comparison with diffusion kurtosis imaging

Zhuofeng Liang, Danfeng Wang, Liyan Tang, Fengping Chen, Anni Pan, Xiaohua Du, Xiaomin Liu, Zhijie Huang, Xian Liu, Weicui Chen

Abstract Objective To evaluate and compare MRI-based diffusion kurtosis imaging (DKI), diffusion-weighted imaging (DWI), and dual-layer spectral CT (DLSCT)-derived extracellular volume (ECV) fraction for predicting the Ki-67 proliferation index in rectal cancer (RC). Materials and methods This retrospective study included 117 patients with pathologically confirmed rectal adenocarcinoma who underwent preoperative MRI and DLSCT. Patients were divided into high (Ki-67 > 50%) and low (Ki-67 ≤ 50%) Ki-67 groups based on …

27.08.2026journal-article

Frontiers in Oncology

E3 ubiquitin ligases orchestrate chemo-resistance in gastrointestinal malignancies: from DNA damage response to therapeutic targeting

Teng Ma, Yongzhu Zhou, Xiaojun Li, Junhong Guan

Therapy resistance in gastrointestinal tumors remains a critical challenge in clinical oncology, severely compromising therapeutic efficacy and long-term patient survival. E3 ubiquitin ligases, as core enzymes involved in the protein ubiquitination process, have been demonstrated to play indispensable roles in regulating key biological processes in tumor cells, including DNA damage repair, cell cycle progression, apoptosis, cancer stem cell maintenance, and immune evasion. Additionally, E3 ligases are key regulator …

27.08.2026journal-article

Nature Communications

An FGF21-IGFBP1 tumor-liver relay drives musculoskeletal defects in colorectal cancer cachexia

Joshua R. Huot, Urja R. Kamdar, Caleb J. Gammon, Patrick D. Livingston, Fabrizio Pin, Nicholas A. Jamnick, Natalia M. Weinzierl, Chandler S. Callaway, Paul A. Roberson, Alyson L. Essex, Jing Xu, Luis Felipe Cardona Polo, Michael W. Devereaux, Aimee L. Anderson, Colin T. Shearn, Ronald J. Sokol, Schuyler Lee, Bifeng Gao, Meher P. Boorgula, Andrew Goodspeed, Leah J. Novinger, Douglas J. Adams, Andrea Bonetto

Abstract Colorectal cancer (CRC) is frequently accompanied by cachexia, a wasting syndrome characterized by progressive loss of muscle and bone that worsens physical function and survival. Although liver dysfunction is increasingly recognized in cachexia, whether tumor-induced liver signaling contributes directly to musculoskeletal decline remains unclear. Here we show that CRC establishes a tumor-liver endocrine relay in which tumor-derived fibroblast growth factor 21 (FGF21) stimulates hepatic production of the h …

27.08.2026journal-article

Physics in Medicine & Biology

Patient-Specific Stopping Power Calibration of Treatment Planning X-Ray CT Using Integrated Depth-Dose Profiles Acquired by Proton Transmission Imaging - A Feasibility Study

Ines Butz, Katia Parodi, Chiara Gianoli

Abstract Objective: Range uncertainties in proton therapy largely arise from the semi-empirical conversion of X-ray computed tomography (CT) Hounsfield Units to stopping power relative to water (RSP), requiring generous safety margins or robust optimization. Pencil beam-wise integrated depth-dose profiles (IDDs), obtained via proton transmission imaging using a particle integrating detector, can be combined with the treatment planning CT to obtain patient-specific conversion curves. Existing calibration approaches …

27.08.2026journal-article

Cancer Immunology Research

A Patient-Derived Screen Identifies HDAC Inhibitors as Enhancers of Phagocytosis and Potent Immunotherapy Partners

Mona Khalaj, Andrew T. Burden, Madison L. Gutierrez, Sophia C. Hoonsbeen, Parisa Nejad, Tal Raveh, Jacob S. Young, Faranak Fattahi, Irving L. Weissman

Abstract Glioblastoma multiforme (GBM) is a lethal brain tumor with limited treatment options. Tumor-associated macrophages and microglia (TAM) drive immune suppression and tumor progression, making them a key therapeutic target for GBM. Enhancing TAM phagocytosis in GBM has shown promise, particularly with innate checkpoint inhibitors, such as CD47-blocking antibodies. However, small-molecule approaches, which offer tunable and potentially synergistic mechanisms, remain underexplored in this context. In this study …

26.08.2026journal-article

Frontiers in Immunology

The paracrine effects of tumor cells on endothelial cells and macrophages in brain metastases with different primary sites

Tamer A. Kaya, Klaus-Peter Stein, Belal Neyazi, Ali Rashidi, Ulf D. Kahlert, Christian Mawrin, I. Erol Sandalcioglu, Claudia A. Dumitru

Background Brain metastases (BrMs) represent the most common intracranial tumors, which occur at a significantly higher incidence than primary brain neoplasms. Although some studies addressed the modulation of endothelial cells (ECs) and macrophages in lung and breast BrMs, it is still unclear how these cells are modulated in other BrM types. Methods Tumor cells (TCs) were isolated from human melanoma, lung and gastrointestinal (GI) BrM tissues, using individual patient isolates (n=2 per tissue origin) as the prima …

26.08.2026journal-article

Frontiers in Oncology

Effects of embedded micro-mindfulness on psychological symptoms in patients with advanced cancer receiving palliative care: a prospective controlled study

Qin Zhang, Qianer Li, Aiping Deng, Dan Yang, Dan Jia

Objective To evaluate changes in psychological distress, anxiety and depressive symptoms, sleep problems, and pain intensity associated with participation in an embedded micro-mindfulness program among patients with advanced cancer receiving palliative care, and to explore factors associated with psychological symptom response. Methods This single-center, prospective, non-randomized observational study included 243 patients with advanced cancer receiving palliative care at West China Hospital. Patients who particip …

26.08.2026journal-article

Frontiers in Oncology

PLK1/FOXM1-associated tumor-cell state and macrophage-related immune features in endometrial cancer

Longwei Li, Yunyun Xiao, Yaping Wang, Guangyao Song, Ming Liu, Xueling Qu, Lu Han

Background Polo-like kinase 1 (PLK1) and forkhead box M1 (FOXM1) have been widely studied in various cancers; however, their expression characteristics in endometrial cancer (EC) and their potential association with tumor microenvironment remodeling remain insufficiently characterized. Methods This study integrated The Cancer Genome Atlas uterine corpus endometrial carcinoma cohort, Gene Expression Omnibus, pan-cancer transcriptomic data, Human Protein Atlas/Clinical Proteomic Tumor Analysis Consortium, and local i …

26.08.2026journal-article

Cancer Immunology Research

EphA4 Mediates Pro- and Antitumoral Effects Through Upstream Negative Regulation of AKT in Head and Neck Squamous Cell Carcinoma

Sophia Corbo, Khalid N.M. Abdelazeem, Diemmy Nguyen, Shilpa Bhatia, Benjamin Van Court, Nicholas A. Olimpo, Jacob Gadwa, Chloe A. Hodgson, Jessica I. Beynor, Von G. Samedi, Enrique Sanz-Garcia, Lillian L. Siu, Anthony J. Saviola, Lynn E. Heasley, Elena B. Pasquale, Michael W. Knitz, Sana D. Karam

Abstract Head and Neck Head and Neck Squamous Cell Carcinoma (HNSCC) is driven by an immunosuppressive tumor microenvironment (TME). We examined the immune-modulatory role of EphA4 in HNSCC using spatial analysis, multi-compartment RNA-sequencing from Oral Cavity Squamous Cell Carcinoma (OCSCC), and three genetically engineered mouse models. Within the HNSCC TME, EphA4 is primarily expressed in Tregs, macrophages, CD8+ T cells, and HNSCC cancer cells. EphA4 in Tregs promotes tumor growth, whereas EphA4 in myeloid c …