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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Healthcare

Educational Workplace Dietary Interventions and Occupational Well-Being Among Healthcare Professionals: A Scoping Review

Maria Antoniadou, Theodora Kalogerakou, Polyxeni Mangoulia, Theodoros Varzakas

Background: Educational workplace dietary interventions have emerged as a promising approach to supporting occupational well-being among healthcare professionals. This scoping review mapped and synthesized the available evidence on such interventions across healthcare settings. Methods: A scoping review was conducted in accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines. PubMed, Scopus, and the Cochrane Library were searched f …

24.08.2026journal-article

International Journal of Molecular Sciences

The Role of Monoclonal Antibody Targeted Therapy (Panitumumab) in the Treatment of Metastatic Colorectal Cancer—A Narrative Review of Current Evidence and Emerging Therapeutic Strategies

Lidia Kwiatkowska, Małgorzata Szczuko

Metastatic colorectal cancer (mCRC) remains one of the leading causes of cancer deaths worldwide. Mutations of the RAS and BRAF genes and the location of the primary tumor determine the choice of systemic therapy. Panitumumab—a fully human anti-EGFR monoclonal antibody—is well-established in the treatment of patients with wild-type RAS and BRAF and left-sided tumor localization. The aim of this review is to summarize the role and potential of targeted therapies for colorectal cancer with monoclonal antibodies such …

24.08.2026journal-article

Frontiers in Bioengineering and Biotechnology

Gene therapy for genodermatoses at the crossroads of innovation and clinical translation

Alessandra Fabrizi, Marta Valenti, Silvia Zacchino, Katia Russo, Erica Baschetti, Laura De Rosa, Michele De Luca

Inherited genodermatoses are a heterogeneous group of rare monogenic disorders. Among these, epidermolysis bullosa (EB) and ichthyoses represent paradigmatic disorders characterized by severe skin fragility and hyperkeratosis, respectively, and impaired barrier function, often with profound effects on quality of life and systemic health. Current management remains largely palliative, underscoring the urgent need for disease-modifying therapies. Over the past 2 decades, advances in epithelial stem cell biology, vect …

24.08.2026journal-article

International Journal of Basic & Clinical Pharmacology

Underrecognized phototoxicity from prolonged doxycycline therapy: a case highlighting early nail involvement

Kashish Jindal, Prakash Tendulkar, Ravi Kant, Dheeraj Dheeraj

A 27-year-old man developed photo-onycholysis and a facial phototoxic rash after taking doxycycline, cefuroxime and aceclofenac for about 40 days following incision and drainage of a wrist abscess. He had no other illness. The wound healed well and his laboratory results were unremarkable, but several fingernails turned reddish-brown and became so tender that light pressure was painful, and both cheeks developed erythematous maculopapular lesions. The toenails were normal. There was no separation of the nail plate, …

24.08.2026journal-article

Indian Journal of Ophthalmology

New pharmacological and biotechnological approaches for the treatment of neurotrophic keratopathy: From growth factors to gene therapy

Mukaddes Damla Ciftci, Mehmet Gurdal, Ozlem B Selver

Neurotrophic keratopathy (NK) is a serious ocular surface disease that develops due to a reduction or loss of corneal innervation. Conventional therapeutic approaches, such as the use of artificial tears and autologous serum, primarily serve as symptomatic relief measures and do not target the underlying neurodegenerative process. The introduction of recombinant human nerve growth factor (rhNGF, cenegermin) has marked the first disease-modifying pharmacological therapy for NK, providing evidence of enhanced epithel …

24.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

Validity and reliability of the six-minute pegboard and ring test for assessing upper limb functional capacity in patients with rheumatoid arthritis

Başak Kavalcı Kol, Merve Fırat, Figen Tuncay, Ceren Demir

Background Rheumatoid arthritis (RA) is a disease that affects upper extremity function early on, leading to significant limitations in activities of daily living. Therefore, assessing upper extremity function using reliable and valid measurement methods is clinically important. Objective The aim of study was to determine the validity and reliability of the six-minute pegboard and ring test (6-PBRT) in patients with RA. Methods The study included forty RA patients (32 females, 8 males; age 57.90 ± 10.82 years). All …

24.08.2026journal-article

Frontiers in Medicine

Case Report: Dynamic susceptibility-informed therapy for bile leak-associated intra-abdominal Stenotrophomonas maltophilia infection

Zhipeng Yang, Bin Zhu, Jianfeng Chen

Iatrogenic bile leak complicated by intra-abdominal infection is a rare but serious complication after laparoscopic cholecystectomy. Stenotrophomonas maltophilia is intrinsically resistant to carbapenems and is an uncommon but clinically relevant pathogen of intra-abdominal infection, particularly in patients with immunosuppression, indwelling drains, and broad-spectrum antibiotic exposure. We report the case of a 55-year-old immunosuppressed man who developed bile leak due to Hem-o-lok clip-associated common bile …

24.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Concurrent chemotherapy and external radiation therapy (ConCERT): phase 3 noninferiority randomized clinical trial of cisplatin weekly vs every 3 weeks in locally advanced squamous cell carcinoma of the head and neck

Atul Sharma, Manish Kumar Choudhary, Suman Bhasker, Akash Kumar, Alok Thakar, Raja Pramanik, Ahitagni Biswas, Kapil Sikka, Surya V S Deo, Ashok Kumar, Supriya Mallick, Amit Chirom Singh, Pooja Sethi, Amit Sehrawat, Vishnubhatla Sreenivas, Rajeev Kumar, Saphalata Baghmar, Aanchal Kakkar, Vinod Sharma, Babita Kataria, Ranjit Sahoo, Aman Sharma, Prasanth Ganesan, Sudhir Kumar, Amol Patel, Smriti Panda, Sanjay Thulkar, Sandeep Seth, Shikha Halder, Manoj Gupta, Ashish Dutt Upadhyay

Abstract Introduction Concurrent chemoradiotherapy with cisplatin (100 mg/m² every three weeks) is the standard for locally advanced head and neck squamous cell carcinoma (LA-HNSCC), but it is uncertain if weekly cisplatin (40 mg/m²) is non-inferior. Method This open-label, multicentre, phase III non-inferiority trial randomised patients with non-nasopharyngeal LA-HNSCC in a ratio of 1 1 to receive either the standard cisplatin regimen (100 mg/m² every three weeks) or the experimental weekly regimen (40 mg/m²), bot …

24.08.2026journal-article

JMIR Formative Research

Quality Evaluation Using the Mobile App Rating Scale for Speech Therapy in Parkinson Disease: Systematic Search and Evaluation

Tooba Haris, Harshvi Shah, Jose F Florez-Arango

Abstract Background As the global population ages, Parkinson disease (PD) has emerged as the second most prevalent neurodegenerative condition after Alzheimer disease. People with PD often experience speech problems, including reduced volume, monotone pitch, breathiness, and word slurring. Interventions such as speech therapy through mobile apps provide reassurance and easier access to care for patients having this neurodegenerative condition. Mobile apps offer patients with PD greater access to care and the reassu …

24.08.2026journal-article

Arthroscopy, Sports Medicine, and Rehabilitation

Over Half of Patients Progress to Cartilage Restoration After Initial Cartilage Biopsy in a Military Population

Ryan M. Sanborn, Natalia A. Pluta, Kenneth J. Fellows, Christian A. Cruz, Jeanne C. Patzkowski, Daniel J. Cognetti

Purpose To evaluate the rate of matrix‐induced autologous chondrocyte implantation (MACI) after cartilage biopsy in a military population. Methods A retrospective review was conducted of all patients who underwent a cartilage biopsy at 2 large regional military health centers between January 2021 and May 2023. Patients 17 years of age or older who underwent an index biopsy more than 2 years prior to chart review were eligible for inclusion. The primary outcome was progression from cartilage biopsy to MACI. Secondar …

24.08.2026journal-article

The American Surgeon™

Early Recurrent Arteriovenous Fistula Stenosis: Identifying Patients Most Likely to Benefit From Drug-Coated Balloon Therapy

Peijin Bai, Zhi Wang, Genghuang Lin, Juan Pei, Jun Zhang, Shizhi Chen, Linghui Zhou, Leping Shao, Xiuhua Xu

Objective To evaluate the outcomes of drug-coated balloon (DCB) vs high-pressure balloon (HPB) angioplasty for the treatment of early recurrent arteriovenous fistula (AVF) stenosis. Methods This retrospective study analyzed 164 maintenance hemodialysis patients treated for early recurrent AVF stenosis (recurrence within 6 months) between 2019 and 2024. Patients were stratified into DCB and HPB groups. Propensity score matching (PSM) was utilized to balance baseline characteristics, resulting in 60 pairs for final a …

24.08.2026journal-article

Frontiers in Surgery

Nutritional supplementation is associated with improved wound reduction during negative pressure wound therapy in complex wounds: a retrospective cohort study

Can Yahya Boztug, Ilgiz Tuzken, Attila Ulkucu, Pinar Ari, Omer Arda Cetinkaya

Background Negative pressure wound therapy (NPWT) is central to the management of complex wounds, but wound contraction and granulation require adequate metabolic substrate. We evaluated the association between nutritional supplementation and wound healing outcomes in patients treated with NPWT. Methods This retrospective cohort study included 48 adults who underwent negative pressure wound therapy for complex wounds. Patients were grouped according to receipt of nutritional supplementation. The primary outcome was …

24.08.2026journal-article

Revista de Geopolítica

O MODELO DE PERÍCIA PSICOLÓGICA EM SAÚDE MENTAL RELACIONADA AO TRABALHO: NOVOS PARÂMETROS PARA MENSURAR DANO PSÍQUICO OCUPACIONAL

Maria Fernanda Mendes Costa, Melquizedec Arcos Rodrigues, Wesley Soares Ramos, Paulo Magnum Sousa Herculano De Lima, Matheus Pessanha Vieira, Marco Sousa Herculano De Lima, Flavio Rui Bezerra De Souza Junior, Danilo Victor do Cazal Quinta

O crescimento dos litígios e das demandas previdenciárias envolvendo o adoecimento mental relacionado ao trabalho tornou a perícia psicológica peça central do sistema de justiça e de proteção social, exigindo um modelo tecnicamente estruturado para mensurar o dano psíquico ocupacional. Este artigo analisa esse modelo, articulando suas etapas, seus instrumentos e os parâmetros de mensuração do dano. Adotou-se revisão integrativa da literatura, de natureza qualitativa, reunindo o referencial da perícia psicológica fo …

24.08.2026journal-article

Journal of Acute Care Physical Therapy

Translating Confidence From the Simulation Laboratory to Student Doctor of Physical Therapy Inpatient Practice

Amy J. Rich, Rebecca D. Downey, Melissa C. Hofmann

ABSTRACT Introduction: Patient care in inpatient settings is challenging for health care students and requires adaptive behavioral, cognitive, and technical skills that can be enhanced with simulation-based education (SBE). This study investigates how repeated SBE experiences created in line with the Academy of Acute Care Physical Therapy Core Competencies for Entry-Level Practice in Acute Care Physical Therapy (AACPT-CCACPT) during Doctor of Physical Therapy (DPT) coursework affect self-confidence with patient man …

24.08.2026journal-article

Nursing in Critical Care

Gamified Cardiopulmonary Rehabilitation in a Child Undergoing LVAD Bridging Therapy to Heart Transplantation: A Case Report

Xiaomin Shan, Jiajia Zhu, Jiajia Li, Xiaomin Tang, Weihong Jiang

ABSTRACT This report details the comprehensive, gamified cardiopulmonary rehabilitation of a 6‐year‐old girl undergoing a complex clinical journey from left ventricular assist device (LVAD) bridge therapy to successful heart transplantation. Given the paucity of standardised protocols for this high‐risk population, a structured, multidisciplinary team (MDT)‐guided pathway was implemented, adapting interventions to the distinct phases of LVAD support and post‐transplant recovery. Key nursing and rehabilitation strat …

24.08.2026journal-article

Current Oncology

Combining Radiation Therapy and Tumor-Infiltrating Lymphocyte Therapy: Biological Rationale, Clinical Synergies, and Future Directions

Sean Maroongroge, Heather M. McGee, Kelly Mahuron, Savita Dandapani, Terence M. Williams, Yan Xing, Myo Htut, Colton J. Ladbury, Yufei Liu, Arya Amini

Tumor-infiltrating lymphocyte (TIL) therapy is the first adoptive cellular therapy approved to treat solid tumors and has demonstrated durable responses in advanced melanoma. However, its clinical implementation is limited by the need for tumor harvesting, manufacturing delays, and lymphodepleting conditioning. These logistic challenges are also opportunities for physicians and scientists to consider combining TIL therapy with radiation therapy (RT), a modality with well-established roles in cancer care. RT exerts …

24.08.2026journal-article

Frontiers in Immunology

Immunosuppressive cells as barriers to cancer therapy: mechanisms and emerging solutions

Mengmeng Liu, Yichen Zhu, Hemiao Liang, Yu Li, Huaimin Liu, Jia Li

Tumor microenvironment-resident immunosuppressive cells-comprising myeloid-derived suppressor cells, regulatory T cells, and tumor-associated macrophages-constitute primary obstacles to effective cancer immunotherapy. Advances in single-cell and spatial multi-omics have uncovered their substantial functional heterogeneity, tissue-adaptive reprogramming, and organ-specific architectures distinguishing primary tumors from metastatic lesions. Beyond canonical immune checkpoint pathways, non-canonical regulatory layers …

24.08.2026journal-article

INTERNATIONAL JOURNAL OF APPLIED SCIENCE AND MATHEMATICAL THEORY

Mathematical Modelling of Terrorism Dynamics and the Impact of Jail and Rehabilitation Interventions

Imrana Jega Aliyu

Terrorism remains a critical global security challenge, causing significant loss of life, economic disruption, and social instability. While previous mathematical models have explored terrorism propagation, few have explicitly incorporated correctional and rehabilitation compartments as explicit control mechanisms. This study develops a deterministic compartmental model extending existing frameworks by integrating jailed and rehabilitated populations. The model stratifies the population into six compartments: Susce …

24.08.2026journal-article

Physiotherapy Research International

Physiotherapy in Mental Health: A Mixed Methods Systematic Review of Practitioner and Student Knowledge, Attitudes, and Perceptions

Farahdina Bachtiar, Chiara Mastrogiovanni, Grace McKeon, Davy Vancampfort, Holly Seale, Dicky C. Pelupessy, Afsana Anwar, Hilmi Zadah Faidullah, Brendon Stubbs, Simon Rosenbaum

ABSTRACT Background and Purpose Mental health physiotherapy is increasingly recognised as a specialised area of practice. Adequate knowledge and positive attitudes are essential for ensuring safe evidence‐based care and for directly influencing the quality of services delivered. Despite this, research on mental health literacy and attitudes within physiotherapy remains fragmented. This study aims to synthesise evidence on the knowledge, attitudes and perceptions of physiotherapists and physiotherapy students regard …

24.08.2026journal-article

Frontiers in Public Health

Digital health interventions for reducing occupational burnout in nurses: a systematic review and meta-analysis

Yange Yang, Jinpeng Wen, Hejia Wan, Qiaoju Yang, Jiayi Guan, Lijun Min, Songbo Jia, Zhenzhen Wang, Joston Gary

Objective To systematically evaluate and meta-analyze the effectiveness of digital health interventions (DHIs) in reducing occupational burnout among nurses and nursing staff compared with usual care, waitlist control, or non-digital interventions. Methods Following PRISMA 2020 guidelines, six electronic databases (PubMed/MEDLINE, CINAHL, Embase, Web of Science, PsycINFO, and Scopus) were searched from January 2015 to March 2025 for randomized controlled trials and quasi-experimental studies. Risk of bias was asses …

24.08.2026journal-article

Dermatology Reports

New-onset alopecia areata during calcitonin gene-related peptide inhibitor therapy: first reported case

Luca Valtellini, Mauro Barbareschi, Silvia Mariel Ferrucci, Angelo Valerio Marzano, Andrea Sechi

Dear Editor, Calcitonin gene-related peptide (CGRP) is a neuropeptide with potent vasodilatory effects and a key role in trigeminovascular signaling, underlying the pathogenesis of migraine. Consequently, the inhibition of CGRP activity has been demonstrated to reduce the incidence of acute migraine attacks. Based on this evidence, monoclonal antibodies against CGRP or its receptor have been approved by the European Medicines Agency for prevention of both episodic and chronic migraine. Among CGRP inhibitors, galcan …

24.08.2026journal-article

ACS Applied Materials & Interfaces

A Chloroplast-Inspired Theranostic Nanoplatform for Self-Sustaining Oxygen-Elevating Photodynamic Therapy and Glutathione-Triggered Carbon-Centered Radical Synergistic Therapy

Jitong Gong, Yu Liu, Qingkun Yang, Ruohao Zhang, Yukai Cheng, Jing Feng, Hongjie Zhang

Abstract Achieving precise drug delivery to the tumor site can minimize systemic side effects caused by off-target effects. As a therapy that depends on oxygen content, photodynamic therapy (PDT) is significantly constrained by the hypoxic nature of the tumor microenvironment (TME). Compared with the limited efficacy of single PDT, the combination of multiple treatment modalities can achieve synergistic enhancement and superior therapeutic outcomes. Since carbon radical therapy does not rely on oxygen as a reactive …

24.08.2026journal-article

Frontiers in Neurology

Group mindfulness-based cognitive therapy associated with reduced professional caregiver burden and improved quality of care in dementia: a multi-method study

Longyun Chen, Bencheng Wang, Ting Li, Nan Li, Xuanxuan Chen, Fei Liu, Tao Lv

Purpose To evaluate the association between an 8-week group Mindfulness-Based Cognitive Therapy (MBCT) program and changes in professional dementia caregiver burden, perceived stress, and patient neuropsychiatric symptoms. Methods This retrospective multi-method study included 94 professional dementia caregivers at a psychiatric hospital in China (intervention: n = 48; control: n = 46). The intervention group participated in an 8-week group MBCT program, while the control group received routine education. Caregiver …