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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Medicine

Risk of hepatitis B reactivation in COVID-19 patients receiving corticosteroid therapy

Hatun Öztürk Çerik, Özlem Aldemir, Bilge Katirci, Burcu Demirhan Kapicioğlu, Zeynep Banu Ramazanoğlu, Arzu Altunçekiç Yildirim

COVID-19 and HBV are significant public health issues, and managing their co-infection remains unclear. Corticosteroid therapy improves survival in severe COVID-19 but may increase the risk of HBV reactivation (HBVr). Evidence regarding the incidence and outcomes of HBVr in COVID-19 patients remains limited. This study aimed to investigate the frequency, determinants, and clinical consequences of HBVr among COVID-19 patients with current or past HBV infection treated with corticosteroids. This retrospective study e …

28.08.2026journal-article

Medicine

A retrospective study of disproportionality analysis signals between proprotein convertase subtilisin/kexin 9 inhibitor use and respiratory, thoracic, and mediastinal disorders

Hongzhu Chen, Lijing Li

This study aims to investigate emerging signals and clinical characteristics associated with adverse event reports of respiratory, thoracic, and mediastinal diseases (RTMD) related to proprotein convertase subtilisin/kexin 9 inhibitors (PCSK9i) in the FDA Adverse Event Reporting System (FAERS) database. PCSK9i-related RTMD adverse event reports were extracted from the FAERS database (covering the period from the first quarter of 2016 to the fourth quarter of 2023), and the clinical characteristics and onset times o …

28.08.2026journal-article

Research, Society and Development

Angiografia por fluorescência com verde de indocianina na cirurgia colorretal: Impacto na prevenção da fístula anastomótica e na tomada de decisão intraoperatória

Rafael Marques Braga, Maria Clara Peres de Castelo Branco, Ana Carolina Delfina de Brito Guimarães, Maryanna Alves Correia, Iasmim Rosa Morena Alves da Cruz, João Vitor de Almeida Cardoso, Leonardo Duarte Alves

A fístula anastomótica permanece uma das principais complicações após cirurgias colorretais, sendo a perfusão tecidual inadequada um de seus fatores potencialmente modificáveis. A angiografia por fluorescência com verde de indocianina (ICG-FA) permite avaliar intraoperatoriamente a vascularização intestinal e pode modificar a estratégia cirúrgica antes da confecção da anastomose. Este estudo teve como objetivo analisar as evidências sobre o impacto da ICG-FA na prevenção da fístula anastomótica e na tomada de decis …

28.08.2026journal-article

Critical Care & Emergency Medicine

Deterioro hemodinámico cerebral tras la administración de bicarbonato de sodio en acidosis metabólica grave: reporte de un caso

Ricardo Bañuelos-Huerta, Nancy Gutiérrez-Vega, Socorro Figueroa-Rivera, Maribel García-Cantú, Montserrat Ramírez-Barranco, Wendy Sartillo-Guerra, Eduardo Yahir Aguilar-Lazcano

Abstract: Sodium bicarbonate ($\text{NaHCO}_3$) is used in selected scenarios of severe metabolic acidosis; however, its administration may be associated with complex physiological effects, particularly at the cerebral level. The generation of $\text{CO}_2$ following its administration promotes its rapid diffusion across the blood–brain barrier, which may contribute to paradoxical intracellular acidosis, alterations in cerebral vasoreactivity, and increased intracranial pressure. We present the case of a 70-year-ol …

28.08.2026journal-article

World Journal of Gastroenterology

Clinical efficacy and safety of laparoscopic hybrid surgery for simultaneous resection of colorectal cancer liver metastases

Tian-Shuai Zhang, Xiao-Ming Zhu, Rong-Bo Wen, Le-Qi Zhou, Hai-Feng Gong, En-Da Yu, Hao Wang, Gang Li, Wei-Ping Zhou, Li-Qiang Hao, Guan-Yu Yu, Wei Zhang

BACKGROUND Simultaneous resection of colorectal cancer liver metastases (CRLM) has been widely adopted; however, clinical efficacy still varies across different surgical approaches, and the best surgical strategy remains controversial. AIM To investigate the efficacy and safety of laparoscopic hybrid surgery (LHS) vs total open surgery (TOS) the in simultaneous resection of CRLM. METHODS This was an observational study conducted at a tertiary medical center, enrolling 266 patients who undergoing simultaneous resect …

28.08.2026journal-article

Journal of Perinatal Medicine

Ultrasound-based prediction of fetal hyperinsulinemia: development of a fetal metabolic score

Roberto Noya Galluzzo, Karine Souza Da Correggio, Aldo von Wangenheim, Heron Werner, Edward Araujo Júnior, Gustavo Yano Callado, Alexandre Sherlley Casimiro Onofre

Abstract Objectives Gestational diabetes mellitus (GDM) is associated with fetal hyperinsulinemia, excessive adiposity, and adverse perinatal outcomes; sonographic markers of fetal adiposity, liver enlargement, and septal thickening may allow direct assessment of fetal metabolic adaptation. This study aimed to develop an ultrasound-based fetal metabolic score (FMS) estimating the risk of fetal hyperinsulinemia. Methods The FMS was developed from a prospective cohort of 223 pregnant women (128 with GDM, 95 controls) …

28.08.2026journal-article

Education in Medicine Journal

Fostering Excellence in English Academic Writing Among Health Profession Students and Lecturers: An Action Research

Izzudeen Ayub, Megat Mustaqim Megat Iskandar, Siti Yusrina Nadihah Jamaludin, Yasrul Izad Abu Bakar, Mohd Salami Ibrahim

Academic writing is a critical skill for researchers and educators. However, many, especially in nonnative English-speaking contexts, face challenges in mastering it. This study employed action research (AR) involving 27 participants to address these challenges through the design and implementation of an academic writing workshop for postgraduate students and lecturers from the Facultiesof Medicine, Health Sciences, and Pharmacy. The AR workshop integrated hands-on learning, structured guidance, and innovative tool …

28.08.2026journal-article

Journal of Clinical Medicine

The Three Faces of IgA Nephropathy: Clinicopathological Heterogeneity and Urinary Albumin-to-Protein Ratio in a Case Series

Anna Masajtis-Zagajewska, Blazej Kieszek, Michał Nowicki

Background/Objectives: IgA nephropathy (IgAN) is a highly heterogeneous glomerular disease with variable clinical presentation and response to therapy. Standard histopathology provides a static assessment and may not fully reflect dynamic podocyte injury. The objective of this case series was to characterize distinct clinical phenotypes of IgAN and explore the relationship between urinary protein composition assessed by the urine albumin-to-protein ratio (uAPR) and ultrastructural glomerular injury. Methods: We ret …

28.08.2026journal-article

Tropical Medicine and Infectious Disease

Application of Genomics to Prevent and Combat Emerging Infectious Disease Threats in Latin America: Perspectives from an Overseas U.S. Navy Research Command

Hugo O. Valdivia, Maria Silva, Cristopher D. Cruz, Paul Rios, Marisa E. Lozano, Julia S. Ampuero, Yeny Tinoco, Jeffrey Spiro, Yuliya S. Johnson, Alden S. Estep, Steev Loyola, Carmen Flores-Mendoza, Gissella M. Vasquez, Jose A. Garcia-Rivera, Henju Marjuki

Endemic and (re)emerging infectious diseases pose a major threat to public health and military readiness in Central and South America. The high biodiversity and the differing transmission pathways require the use of highly sensitive methods to track the emergence and spread of these diseases. High-throughput sequencing technologies have become a critical resource for the field of infectious disease monitoring, specifically for tracking pathogen evolution, antimicrobial resistance, and transmission. This review prov …

28.08.2026journal-article

Hippocrates Medical Journal

When Artificial Intelligence Speaks For The Obstetrician: Multilingual Accuracy On Real Patient Questions

Alihan Tığlı, Yakup Baykuş, Rulin Deniz, Sefer Üstebay, Muammer Hayri Bektaş, Çağdaş Çöllüoğlu

BackgroundThe use of generative large language models (LLMs) in healthcare is rapidly increasing, offering easier access to medical information. However, comprehensive data on their multilingual accuracy and the reliability of cited scientific references remain limited. This study aimed to compare the response accuracy and reference quality of three free LLMs (ChatGPT, Google Gemini, DeepSeek) in Turkish and English using common pregnancy-related questions.MethodsIn this comparative observational study, 14 frequent …

28.08.2026journal-article

Gynecology Obstetrics & Reproductive Medicine

Longitudinal Assessment of Fetal Ductus Arteriosus Morphometry: Establishing Gestational Age-Specific Reference Values

Murat Cagan, Umutcan Kayikci, Erdem Fadiloglu, Ayse Cigdem Bayrak, Edip Alptug Kir, Hayrettin Hakan Aykan, Ozgur Deren

OBJECTIVES: To longitudinally evaluate fetal ductus arteriosus (DA) morphometric changes and establish normative reference values between 18 and 36 weeks of gestation. STUDY DESIGN: This prospective cohort study included 29 pregnant women with structurally normal singleton fetuses and confirmed gestational ages. Each participant underwent serial standardized ultrasound examinations to evaluate DA length and proximal, mid, and distal diameters. We defined weekly growth trends using regression analyses and assessed c …

28.08.2026journal-article

Clinical and Experimental Pharmacology and Physiology

Brucea javanica Oil Emulsion Promotes Breast Cancer Cell Autophagy and Apoptosis by Regulating PAX6 mRNA Stability Through the hsa_circ_0001589/ G3BP1 Axis

Ke Li, MeiXia Li, XueQiang Pan, JiaWen Xu, Rui Jiang

ABSTRACT Background and Objective Brucea javanica oil emulsion (BJOE), a traditional Chinese medicine extract, has been demonstrated to possess antitumor activity in multiple cancers. However, its molecular mechanisms in breast cancer, particularly those involving circRNAs, remain unclear. This study investigates whether BJOE exerts its anti‐breast cancer effects by inducing autophagy and apoptosis through regulating hsa_circ_0001589/G3BP1/PAX6 signalling axis. Methods After BJOE treatment of MCF‐7 cells, cell viab …

28.08.2026journal-article

European Journal of Plastic Surgery

A novel indication of Glyaderm®: its use as a nerve wrap in the treatment of compression neuropathies

Milly van de Warenburg, Claire van Houdt, Stefan Hummelink, Till Wagner

Abstract Background Fibrotic changes following surgical decompression of nerve entrapment can restrict nerve regeneration, and exert pressure on the nerve, leading to symptoms of recurring entrapment. This case series reports on the outcomes of using Glyaderm® (ETB-BISLIFE Multi Tissue Center, The Netherlands) as a low-cost, customizable, and biocompatible nerve wrap in patients with recurrent or post-traumatic compression neuropathies, highlighting its potential benefits as a neuroprotective shield. Methods We rev …

28.08.2026journal-article

Journal of Innovations in Materials and Manufacturing Engineering

Influence of Heat Treatment and Thermal Aging on the Fatigue Performance of LPBF Fabricated AlSi10Mg Alloy

Edel Arrieta, Luis A. Marquez, Lawrence E. Murr, Diego A. Ariza, Mark Benedict, Jason Thomas, James Carney, Francisco Medina

This investigation explores fatigue performance of laser powder bed fusion (LPBF)-fabricated AlSi10Mg alloy subjected to various post-processing treatments: stress relief (SR), Hot Isostatic Pressing (HIP), and HIP + T6, all followed by prolonged thermal aging at 177 °C for up to 1000 h. Microstructural evolution, hardness, density, and uniaxial fatigue performance, including SEM fractography, were examined to recommend practical service life thresholds. Microstructural analysis confirmed that HIP and HIP + T6 trea …

28.08.2026journal-article

Bioengineering

Wearable Technologies for Gait Instability Rehabilitation: Mechanisms, Clinical Evidence, and Future Directions

Lijin Liu, Changfa Huang, Zhongyin Ji, Yujie Zhou, Zihua Li, Xueyi Zhang, Zhihong Wu

Wearable technologies are reshaping gait rehabilitation by shifting assessment and therapy from intermittent, clinic-based observation to continuous, data-driven, and adaptive care. This narrative review synthesizes the biomechanical basis of gait instability, the architecture and classification of wearable rehabilitation systems, and the clinical evidence for motion sensors, smart insoles, biofeedback devices, robotic and orthotic wearables, neuromodulatory systems, immersive platforms, and artificial intelligence …

28.08.2026journal-article

Measurement Science and Technology

An event-based machinery fault diagnosis method via incremental retention and condition-aware alignment

Linfei Ji, Siyuan Liu, Gangzhu Qiao, Li Wang

Abstract An event camera,as an emerging dynamic visual sensor,provides a new test method for non-contact fault diagnosis in complex industrial environments.However,most existing studies follow the offline static assumption.Aiming at the continual learning challenges brought by the constant change of operating conditions and dynamic evolution of fault categories in industrial online monitoring,this paper proposes a continual learning framework based on event-based dynamic vision.Specifically,a Condition-aware MixSty …

28.08.2026journal-article

Medicine

Network analysis of symptoms and psychological distress in patients with sudden sensorineural hearing loss

Jiemei Wang, Yifang Li, Wei Song, Li Xie, Changju Tao

Sudden sensorineural hearing loss (SSNHL) is characterized by rapid-onset, unexplained hearing impairment, frequently accompanied by symptoms such as tinnitus, dizziness, and nausea. Patients with SSNHL often experience psychological distress, including anxiety and depression, which are interconnected, offering insights for holistic management. This study aims to elucidate these connections, with a focus on anxiety and depression, using network analysis to inform holistic management strategies. Network analysis was …

28.08.2026journal-article

Medicine

Association between serum antibodies against oral microorganisms and vitamin D deficiency among US adults

Li Tan, Si-qun Xu

Vitamin D deficiency is common and may contribute to periodontal disease by affecting periodontal pathogens. Most studies analyzing this association have focused mainly on a specific periodontal bacterium ( P gingivalis ) and have involved relatively small study populations (tens or hundreds of individuals). To address this gap, a sizable, nationally representative adult population was utilized to investigate the association between the prevalence of Vitamin D deficiency and immunoglobulin G (IgG) antibodies to 19 …

28.08.2026journal-article

Medicine

Sex‑specific associations between multiple hormone axes and dynapenic obesity in middle‑aged and older patients with type 2 diabetes

Di Yu, Qin Ou, Bo Xie, Yinghao Li, Kun Liao, Rong Li, Mei Mei, Bo Zhou

Accumulating evidence indicates that hormones play a critical role in the pathogenesis of dynapenic obesity (DO), although the precise relationships and underlying mechanisms remain elusive. This study aimed to investigate sex-stratified associations between multiple hormones and prevalence of DO in type 2 diabetes mellitus (T2DM) populations. In this cross-sectional study of 557 T2DM patients, body composition was assessed by dual-energy X-ray absorptiometry, and hormones from pituitary-target gland axes and the v …

28.08.2026journal-article

Small

Phage‐Derived Protein‐Guided Nanozymes for the Treatment of MRSA‐Infected Acute Otitis Media

Bin Hong, Jie Wang, Bing Hu, Gongxi Qiao, Qun Ma, Ming Yang, Zhaoyang Ke, Xiyun Yan, Daji Wang

ABSTRACT Nanozymes with peroxidase‐like activity have been identified as promising nanomaterials against antimicrobial resistance. However, their in vivo efficacy is significantly limited due to the lack of bacterial targeting ability. Furthermore, the substantial accumulation of nanozymes in nontarget tissues raises concerns of potential nanotoxicity. Here, we report a single‐atom nanozyme (mFeP‑gCBD) by coupling ferriporphyrin containing monocarboxyphenyl (mFeP) and cell wall binding domain of endolysin from Stap …

28.08.2026journal-article

The International Journal of Tuberculosis and Lung Disease

Peer-led education on treatment success and patient-reported outcomes in drug-susceptible pulmonary TB

M.G. Workie, F. Ambaw, M.A. Asemahegn

<sec><title>BACKGROUND</title>Peer-led education has shown effectiveness in improving adherence and psychosocial outcomes for HIV and chronic disease through shared experience and social learning. Despite its potential, peer involvement remains underutilised in TB care, particularly in low-income settings. Existing studies primarily focus on microbiological cure and treatment completion with minimal attention to patient-reported outcomes such as quality of life, disability, and mental health.</sec><sec><title>OBJEC …

27.08.2026journal-article

Frontiers in Medicine

Efficacy and safety of 2 Hz versus 100 Hz electroacupuncture for pain-dominant shoulder periarthritis: a study protocol for a single-center randomized controlled trial

Chengyu Liu, Shiwei Zhuang, Yi Shang, Xiangzhen Miao, Hongfeng Wang, Bing Yan

Background Pain-dominant shoulder periarthritis is characterized by shoulder pain, restricted range of motion (ROM), and impaired daily function. Electroacupuncture (EA) is a controllable acupuncture modality used for shoulder pain disorders; however, direct evidence comparing 2 Hz and 100 Hz EA in this disease stage remains limited. Objective This study aims to compare the efficacy and safety of low-frequency EA (2 Hz) and high-frequency EA (100 Hz) for pain-dominant shoulder periarthritis. Methods This is a singl …

27.08.2026journal-article

International Journal of Computer Assisted Radiology and Surgery

Systematic evaluation of foundation models for organ-level classification on CT scans

Jan Tagscherer, Sarah de Boer, Fennie van der Graaf, Lena Philipp, Colin Jacobs, Ewoud J. Smit, Alessa Hering

Abstract Purpose Foundation models are increasingly used as frozen feature extractors for CT classification tasks, yet the determinants of their downstream performance remain unclear. We assess how foundation model choice, feature aggregation strategy, and abnormality type are associated with performance in organ-level abnormality classification. We further evaluate whether more expressive aggregation strategies outperform simple pooling, and whether performance varies by abnormality type. Methods We evaluate five …

27.08.2026journal-article

Frontiers in Pain Research

Exploring the associations of cortical connectivity-modulation with clinical and psychological measures in acute low back pain

Sabina Hotz-Boendermaker, Bart Boendermaker, Roman Buechler, Lars Michels

Background Low back pain (LBP) represents a significant global health burden. Transitioning from the traditional “self-limiting” perspective, emerging evidence suggests that neural plasticity and central maladaptation in the acute phase are pivotal in the progression to chronicity. Objectives This study investigated whole-brain functional connectivity and sensorimotor processing during acute LBP. Methods Thirteen participants with acute LBP (&lt;4 weeks duration) underwent clinical, psychometric, and functional mag …