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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
20.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Effects of tDCS combined with unstable resistance training on knee muscle strength and neuromuscular control in community-dwelling older adults: a randomized controlled trial

Di Peng, Shengnian Zhang, Yu Zhang, Han Wu, Xu Zou, Guanyue Zhang, Yuan Ma, Tongxin Ma, Lejun Wang

Abstract Background Age-related declines in knee muscle strength are not fully explained by muscle loss and may also involve alterations in neuromuscular control. Unstable resistance training (URT) increases stabilization and sensorimotor demands during exercise. Transcranial direct current stimulation (tDCS) may modulate corticospinal excitability during training. This study investigated whether tDCS combined with URT enhances knee strength and electromyography (EMG)-derived neuromuscular control in older adults. …

20.08.2026journal-article

Humanities and Social Sciences Communications

The operationalization of autonomy in qualitative studies of people living with dementia: a scoping review

Avery Beavers, Erin McKenzie, Andrew Douglas Heslop Stumpf

Abstract The concept of personal autonomy is fundamental to person-centred care, particularly for people living with cognitive impairments due to conditions such as dementia. Many empirical studies investigating autonomy in people living with dementia do not provide consistent and theoretically grounded definitions of the term “autonomy,” leading to a problematic lack of conceptual clarity. The aim of this study is to identify and evaluate how autonomy is defined and operationalized in qualitative research involvin …

20.08.2026journal-article

Artefactum - revista de estudos interdisciplinares

INCLUSION AND JOB RETENTION OF PEOPLE WITH AUTISM SPECTRUM DISORDER: AN ANALYSIS OF PUBLIC POLICIES AND AFFIRMATIVE ACTIONS IN MATO GROSSO DO SUL

Nicole Cuchereave Busato, Larissa Mascaro Gomes da Silva

This article analyzes the inclusion and job retention of people with Autism Spectrum Disorder (ASD), focusing on public policies and affirmative actions existing in the state of Mato Grosso do Sul, particularly in the municipality of Três Lagoas. The research problem is to determine whether the existing legal framework and public policies are sufficient to ensure not only the entry, but also the retention and professional development of people with ASD in the labor market. The research is bibliographic and document …

20.08.2026journal-article

Integration of Mankind and Society

The comparison of satisfaction levels among salaried and self-employed people

Anila Shakil, Rao Muhammad Zain Ul Abideen, Rao Akmal Ali, Sumona Akter

Work-life balance and occupational burnout are now seen as crucial psychological factors that affect employee well-being, productivity, and mental health. Salaried employees often deal with organizational pressures, deadlines, and role expectations, while self-employed individuals face unique stressors like income instability, long work hours, and difficulty separating work from personal life. This study aimed to compare work-life balance and burnout between self-employed and salaried individuals, as well as to exp …

20.08.2026journal-article

eLife

Multiple molecular pathways to longevity with opposing gene expression programs defining distinct aging strategies in Caenorhabditis elegans

Zenith D Rudich, Jiaxi Guan, Aura A Tamez Gonzalez, Grant F Booth, Sonja K Soo, Ulrich Anglas, Meeta Mistry, Megan M Senchuk, Jeremy M Van Raamsdonk

While aging is the greatest risk factor for the development of neurodegenerative disease, the role of aging in these diseases is poorly understood. Our previous work has shown that targeting aging pathways can be neuroprotective in animal models of neurodegenerative disease. Based on these findings, we believe that by gaining insight into the aging process that knowledge can be applied to identify novel therapeutic targets for neurodegenerative disease. To advance our understanding of aging, we used a genomics appr …

20.08.2026journal-article

Pharmaceuticals

Mechanistic and Preliminary Safety Profiling of a Multicomponent Natural Product-Based Injectable Formulation Targeting Skin Aging-Related Pathways: A Network Pharmacology and Single-Dose Toxicity Study

Ji Hye Hwang, Chul Jung

Background/Objectives: Skin aging involves interconnected inflammatory, oxidative, hormonal, extracellular matrix (ECM), and cellular senescence-related mechanisms, supporting the need for multitarget approaches. This study aimed to evaluate the effects of a multicomponent natural product-based injectable formulation developed in Korean medicine practice, Dong-An Pharmacopuncture (DAP), on skin aging-related pathways. Methods: A network pharmacology approach was used to identify the active compounds, predicted mole …

20.08.2026journal-article

Journal of Agricultural and Food Chemistry

Pulsed Electric Field-Induced Ethanol Cluster Assembly: A Molecular Mechanism Accelerating Baijiu Aging

Heng Yang, Xinyue Jiang, Yuqun Xie

Abstract Pulsed electric fields (PEF) accelerate Baijiu aging, yet the molecular mechanism remains unclear. A simplified ethanol–water-ester-acid model system combined with multiscale characterization and molecular dynamics (MD) simulations revealed PEF triggers cascaded hydrogen-bond network reorganization, proceeding from aqueous network dissociation to ethanol cluster assembly and subsequent hydrophobic microdomain expansion. The resulting ethanol clusters serve as binding sites that preferentially solubilize hy …

20.08.2026journal-article

Nicotine & Tobacco Research

A comparison of the characteristics of Aboriginal and Torres Strait Islander people who vape, dual-use, and smoke commercial tobacco and want to quit: Cross-sectional findings from the Which Way? Quit Pack study

Kade Booth, Felicity Collis, Raglan Maddox, Jamie Bryant, Kayden Roberts-Barker, Zabowie Mills, Sian Maidment, Tanika Lee Ridgeway, Catherine Chamberlain, Billie Bonevski, Catherine Segan, Aboriginal Health and Medical Research Council NSW, Michelle Kennedy

Abstract Introduction To compare the characteristics of people who vape, smoke commercial tobacco, or engage in dual use among a cohort of Aboriginal and Torres Strait Islander people participating in the Which Way? Quit Pack study. Methods An online cross-sectional survey was conducted with Aboriginal and Torres Strait Islander people who: were aged 16 and above; resided in New South Wales, Victoria, and the Australian Capital Territory; smoked commercial tobacco and/or vaped; and wanted to quit. Data were collect …

20.08.2026journal-article

Frontiers in Psychiatry

“It gave me a sense of control in a treatment where I felt I had none”: the use of social stories and preferences to reduce the use of restraint during nasogastric tube feeding in young people with anorexia nervosa

Fiona Duffy, Rachel Freak, Imogen Peebles, Julie Cockburn, Kibbe Watson, Chloe Manning, Helen West, Amelia Austin

Objective Nasogastric tube (NGT) feeding can be used in inpatient care, and in certain incidences is necessary under physical restraint. While at times essential, it is highly distressing and a high proportion of young people who receive NGT feeding under restraint may be Autistic. This service evaluation explored patient and staff perspectives of autism-affirming resources, including social stories and an individual preference sheet, embedded in a larger quality improvement (QI) project to reduce NGT feeding under …

20.08.2026journal-article

The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences

The Respective Roles of Negative and Positive Views of Aging in Predicting Rehabilitation Outcomes

Asil Mansour, Yaakov Hoffman, Amit Shrira

Abstract Objectives Subjective views of aging (VoA) predict health outcomes, yet most studies rely on specific measures of VoA in relatively healthy samples. Referring to multidimensional (generalized and personal) and multidirectional (negative and positive) VoA constructs, we examined whether these VoA differentially predict rehabilitation outcomes among older adult patients coping with hip fracture and stroke. Methods One hundred and fifty-eight geriatric rehabilitation patients (mean age=77.15, SD=6.71) reporte …

20.08.2026journal-article

npj Aging

Carrying specific HLA alleles decreases the chance of reaching healthy old age

D. Álvarez Sirvent, N. Tesi, M. Hulsman, A. N. Salazar, N. M. van Schoor, M. Huisman, Y. Pijnenburg, W. M. van der Flier, E. M. M. Strijbis, B. M. J. Uitdehaag, M. J. T. Reinders, S. van der Lee, H. Holstege

Abstract Human leukocyte antigen ( HLA ) genes regulate immune function and influence disease susceptibility, but their role in healthy aging is unclear. We investigated whether disease-associated HLA alleles affect the likelihood of becoming a cognitively healthy centenarian (CHC). Using imputed HLA genotypes from 3632 individuals—including 353 CHCs and 3279 middle-aged healthy Dutch individuals—we examined 59 HLA alleles previously linked to 12 diseases, including Alzheimer’s disease (AD), ten autoimmune disorder …

20.08.2026journal-article

PLOS Global Public Health

Barriers and facilitators to viral load suppression among adolescents and young people living with HIV receiving intensive adherence counselling in east central Uganda: A COM-B model-informed qualitative study

David Livingstone Ejalu, Nangendo Joan, Peter Simon Okello, Sabrina Bakeera-Kitaka, Achilles Katamba, Joan Kalyango, Adithya Cattamanchi, Fred C. Semitata, Moses R. Kamya, Anne R. Katahoire

Suboptimal viral load (VL) suppression among adolescents and young people living with HIV (AYPLHIV) remains a major challenge to HIV control in Uganda. Although Intensive Adherence Counselling (IAC) is implemented as a structured intervention for individuals with unsuppressed viral loads, suppression rates among AYPLHIV remain low. Evidence on the contextual factors shaping VL suppression after IAC remains limited. This study explored barriers and facilitators to optimal adherence and engagement in IAC as a pathway …

20.08.2026journal-article

Frontiers in Public Health

From sedentary volume to sedentary content in older inpatients with type 2 diabetes: a multicenter study

Jing Cui, Na Zhang, Ju Ma, Yixiang Hu, Dongdong Wang, Xueyan Huang, Mengchi Li, Xinkun Wang, Wenhui Jiang

Background Sedentary behavior is common in older inpatients with type 2 diabetes mellitus (T2DM) and may coexist with poor metabolic control and functional decline. Objective To identify factors associated with high sedentary time status and examine screen-based sedentary content in this population. Methods This multicenter cross-sectional study recruited 419 older inpatients with T2DM from three tertiary hospitals in northwestern, central and southern China. Sedentary time and 10 types of sedentary content were as …

20.08.2026journal-article

Frontiers in Public Health

Exploring care adoption intention among older adults using XGBoost: a rural case in Anhui, China

Jingli Liu, Ziwei Yang

Introduction With the development of digital rural construction and rural mutual-aid care for older adults, smart mutual-aid care for older adults has become an important way to improve rural pension services, yet low digital literacy and insufficient adoption intention among rural older adults hinder the popularization of smart care services for older adults. Methods Based on the Technology Acceptance Model, this study collected 320 valid questionnaires from rural older adults in Anhui Province and combined tradit …

20.08.2026journal-article

npj Digital Medicine

Exploring a dynamic digital biomarker of illness severity in older ICU patients via interpretable time-series deep learning modeling

Zhenyue Gao, Yuqiang Wang, Lijing Jia, Lin Chen, Minjie Duan, Pan Hu, Chao Liu, Yue Zhang, Sicheng Hao, Wei Yan, Muyang Yan, Zhongheng Zhang, Zhengbo Zhang, Hongjun Kang, Yuhong Liu, Xiaoli Liu

Abstract Older adults admitted to intensive care units (ICUs) experience rapid physiological deterioration, pronounced heterogeneity, and limited physiological reserve, necessitating continuous and individualized assessment of illness severity. Dynamic digital biomarkers derived from high-frequency electronic health record data offer a promising solution for capturing evolving patient states in real time, yet their development and validation in elderly ICU populations remain limited, particularly with respect to in …

20.08.2026journal-article

PLOS Global Public Health

Barriers and facilitators of hypertension control among older adults living with hypertension: A mixed-methods study

Prabha Shrestha, Biraj Man Karmacharya, Jennifer Merrilees, Yunika Acharya, Indu Poudel, Kedar Marahatta, Victor Valour

Hypertension is a major public health challenge in Nepal, particularly among older adults, with nearly half affected and many unaware of their condition. This study explored barriers and facilitators of hypertension management among older adults in Nepal using a parallel mixed-methods design. The study was conducted in Dhulikhel Municipality between September 2024 and March 2025. The quantitative component included 197 older adults (≥60 years) with hypertension. Blood pressure and body mass index (BMI) were measure …

20.08.2026journal-article

Findings

Changing Activity Durations, Timing, and Travel Among Older Adults in a Fast-Aging Society: The Korean Time Use Survey, 2004–2024

Jungyeon Yi, Jae Hyun Lee

This study measures older adults’ activity change in duration and timing across five Korean Time Use Surveys (2004–2024) in one of the fastest-aging OECD societies. Weekday personal care (+28 minutes) and sport (+15) rose while social interaction (−20) fell; Sunday changes were parallel, mostly larger (work −43). Weekday travel time held near 72 minutes throughout; only Sunday travel fell (−12). In timing, sport and religion re-timed most among common activities (religion: weekdays only), and sleep changed little. …

20.08.2026journal-article

AGING MEDICINE

Impact of Acute Functional Decline on Frailty and Mortality in Acutely Hospitalized Older Persons

Ali Vahedi, Maria Eriksdotter, Hege Ihle‐Hansen, Torgeir Bruun Wyller, Anne Rita Øksengård, Brynjar Fure

ABSTRACT Objectives Older persons are often referred to emergency departments due to acute functional decline, that is, reduced activities of daily living occurring in the days before hospitalization, frequently driven by acute medical conditions. We aimed to describe frailty in the oldest hospitalized patients presenting with acute functional decline and evaluate predictors of death, severe frailty and nursing home admission after 3–6 months. Methods We included 119 persons with acute functional decline, aged ≥ 80 …

20.08.2026journal-article

Child and Adolescent Social Work Journal

Supporting Young Minds: Mental Health Interventions and the Role of Social Work for Children and Young People

Emma Prunty, Laura Castledine, Nussrat Kazmi, Jordan Savage, Megan Tudor, Joanna Harrison

Abstract Mental health problems for children and adolescents are continuing to rise, with a risk of poor outcomes into adulthood for those affected. For children who are vulnerable, the risk of deteriorating mental health increases further. Preventative measures are needed to help improve mental health in children and young people, particularly for those experiencing adversity or a lack of support. A systematic review by McGovern et al. (2022) explored secondary preventative interventions for reducing mental health …

01.09.2026journal-article

Hepatology Communications

A randomized trial of viral vector and adjuvanted protein HBV therapeutic vaccine in people with chronic hepatitis B on nucleos(t)ide analogs

Wen-Juei Jeng, Chi-Jen Chu, Apinya Leerapun, Anchalee Avihingsanon, Stefan Zeuzem, Stefan Bourgeois, Man-Fung Yuen, Manuel Romero-Gomez, Sheng-Shun Yang, Cristina Cravcenco, Bruno Salaun, Meng Shi, Ventzislav Vassilev, Joon Hyung Kim, Kristien Swinnen, and the TH HBV VV-001 Study Group

Background: This study assessed the safety, efficacy, and immunogenicity of a therapeutic immunization strategy aimed at reaching a functional cure for chronic hepatitis B (CHB), relying on a heterologous prime-boost with viral vectors ChAd155-hIi-HBV and MVA-HBV, combined with sequential or concomitant administration of adjuvanted recombinant HBV proteins (HBc-HBs/AS01 B ). Methods: This single-blind, randomized, controlled, first-in-human, phase 1/2 trial enrolled adults aged 18–65 years with HBeAg-negative CHB, …

20.08.2026journal-article

The Open AIDS Journal

Cannabis and Tinnitus in People with and without HIV

Chukwuemeka N. Okafor, Deanna Ware, Andrew Edmonds, Anjali Sharma, Deborah Gustafson, Cecile D. Lahiri, Todd T. Brown, Gayle Springer, Peter Torre III, Allison G Abraham, Howard J. Hoffman, Mirjam-Colette Kempf, Phyllis Tien, Bradley E. Aouizerat, Valentina Stosor, Ken Ho, Deborah L. Jones, Kathleen M. Weber, Kara W. Chew, Ducel Jean-Berluche, Michael Plankey

Introduction/Objective The relationship between cannabis use and tinnitus is unclear, particularly among people with HIV. The relationship between cannabis use and tinnitus prevalence and its severity in the MACS/WIHS Combined Cohort Study (MWCCS) was examined. Methods Cross-sectional data collected between October 1, 2020, and September 30, 2022, were drawn from the MWCCS. Tinnitus was defined as bothersome ringing, roaring, or buzzing in the ears or head that lasted for 5 minutes or more in the past 12 months. Ti …

20.08.2026journal-article

Frontiers in Microbiology

Skin microbiome and cutaneous aging mechanisms and clinical implications

Jhommara Bautista, Andrea Iñiguez-Ramírez, Jaime Andrés Villegas-Chávez, Doménica Bunces-Larco, Andrés López-Cortés

The skin microbiome is an integral component of the cutaneous ecosystem and contributes to barrier, immune, and metabolic homeostasis. Available evidence is examined across three distinct levels: microbial community structure, functional activity, and host biological response. This ecological–functional distinction is necessary because taxonomic abundance alone does not establish microbial activity, biological effects, or causality. Age-associated microbial variation is considered within the physiological context o …

24.08.2026journal-article

Schizophrenia Bulletin

Suicide and Self-Harm Risk in Young People at Clinical High Risk of Psychosis: Exploring Comorbid Risk Factors and Potential Points for Intervention

Samuel McKay, Jo Robinson, Patrick McGorry, Cassandra Wannan, Melissa Kerr, Paul Amminger, Hok Pan Yuen, Jessica Spark, Nicky Wallis, Andrea Polari, Barnaby Nelson

Abstract Background Suicide is a leading cause of death among young people, and those at clinical high risk (CHR) of psychosis face increased suicide risk. Despite recommendations for routine suicide monitoring in CHR individuals, identifying effective intervention points remains challenging. This study investigates clinical correlates of suicidality in CHR youth, with particular focus on depression severity and DSM-5 diagnoses. Hypotheses We expected suicidality to be positively associated with depressive symptoms …

20.08.2026journal-article

Aging Cell

Surviving Fibroblasts After Treatment With Mitomycin C Exhibit SASP ‐Like Phenotype After Glaucoma Filtration Surgery

Akitoshi Kimura, Tomokazu Fujimoto, Satoshi Iraha, Kei‐Ichiro Yasunaga, Miyuki Inoue‐Mochita, Naofumi Funagura, Shunsuke Tanigawa, Daisuke Kurotaki, Tomoaki Koga, Fumika Watanabe‐Kitamura, Utako Tsutsumi‐Kuroda, Mitsuyoshi Nakao, Toshihiro Inoue

ABSTRACT The clinical outcomes of trabeculectomy, a standard glaucoma filtration surgery (GFS), have dramatically improved with the introduction of mitomycin C (MMC), an antimetabolite widely used to inhibit postoperative scarring. MMC exerts anti‐scarring effects primarily by promoting apoptosis and suppressing fibroblast proliferation at the surgical site. However, despite these beneficial effects, MMC also induces the production of inflammatory cytokines, and its full mechanism of action remains incompletely und …