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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Journal of modern medicine

RESULTS OF SURGICAL TREATMENT FOR HYPERTROPHIC PSEUDOARTHROSIS OF THE HUMERUS DIAPHYSIS

A.M. Dursunov, O.Sh. Ruziqulov

<p>Introduction. Diaphyseal fractures of the humerus, complicated by incorrect selection of osteosynthesis technique, insufficient consideration of clinical risk factors, violation of orthopedic regimen by the patient, etc., lead to significant changes not only in the segment but also in the function of the upper limb. In this regard, an important stage is not only the clinical and radiological assessment of the condition of the injured limb and the type of false joint, but also the assessment of the significance o …

26.08.2026journal-article

Frontiers in Cellular and Infection Microbiology

NLRC4 and NLRP3 in tissues as potential biomarkers for the diagnosis of non-small cell lung cancer in pulmonary tuberculosis

Zetian Zhang, Zhikai Zhao, Shuanshuan Xie, Boyu Guo, Chenlei Cai, Chunyan Wu, Xiaohui Hao, Jian Ni, Haiyan Cui, Mengting Xiong

Background Distinguishing non-small lung cancer (NSCLC) with tuberculosis from pulmonary tuberculosis (PTB) is still a major clinical problem. Misdiagnosis or missed diagnosis can lead to missed opportunities for optimal treatment, making highly sensitive diagnostic criteria crucial. Methods Database analysis and histological analysis were used at the same time. A total of 55 patients were included in the histological analysis, including 20 patients with both NSCLC and PTB (NSCLC-PTB group), 20 patients with NSCLC …

26.08.2026journal-article

Frontiers in Oncology

Deep learning-radiomics-SUVmax integration from 18F-FDG PET/CT predicts synchronous distant metastasis in nasopharyngeal carcinoma

Yun Zhang, Ying Cao, Shanshan Xu, Yan Tang, Jian He, Jing Chen, Ziwei Nie, Yuxiao Hu

Objectives This study aimed to develop and evaluate deep learning (DL) models of primary tumor (T) and cervical metastatic lymph nodes (CMLNs) using fluorine-18 fluorodeoxyglucose positron emission computed tomography ( 18 F-FDG positron emission tomography/computed tomography (PET/CT)) imaging for predicting synchronous distant metastasis (SDM) in nasopharyngeal carcinoma (NPC) patients, integrating radiomic features, primary tumor maximum standardized uptake value (SUVmax-T) and clinical features. Methods A two-c …

26.08.2026journal-article

Frontiers in Public Health

Efficacy of traditional Chinese medicine nursing for lung cancer: a systematic review and meta-analysis using the Donabedian model to investigate heterogeneity

Ting Duan, Yuxin Liu

Background Lung cancer patients frequently experience a reduced quality of life and psychological distress during treatment. Traditional Chinese Medicine (TCM) nursing shows promise, but substantial heterogeneity in the evidence base limits clinical interpretation. Methods A comprehensive literature search identified 15 randomized controlled trials (RCTs) involving 1,135 participants. A meta-analysis was conducted using RevMan 5.4 and Stata 17. Following the Donabedian framework, data were categorized into structur …

26.08.2026journal-article

Frontiers in Medicine

Clinical efficacy, safety evaluation, and mechanism of acetylcysteine in improving first-line anti-tuberculosis treatment of newly diagnosed pulmonary TB: an open-label, randomized, single-center trial

Huan Zhang, Ming Liu, Lu Shi, Xianlei Wang, Jiong Xie, Qingyan Ma

Objective To investigate the clinical efficacy, safety and mechanism of N-acetylcysteine combined with conventional antituberculosis drugs in the treatment of newly diagnosed pulmonary tuberculosis. Methods A total of 90 newly diagnosed pulmonary tuberculosis patients were randomly assigned to a Control group ( n = 30), Aerosol NAC group ( n = 30), or Oral NAC group ( n = 30). The Control group received standard HRZE therapy, whereas the Aerosol NAC and Oral NAC groups received additional nebulized N-acetylcysteine …

26.08.2026journal-article

Biological Products. Prevention, Diagnosis, Treatment

Antiviral activity of interferon α-2b against SARS-CoV-2 in Calu-3 human lung adenocarcinoma cell culture

D. M. Khokhlova, A. V. Gracheva, E. R. Korchevaya, A. S. Maslennikova, I. A. Leneva, O. A. Svitich, V. V. Zverev, E. B. Faizuloev

INTRODUCTION. Despite the reclassification of the SARS-CoV-2 coronavirus as an etiological agent of seasonal respiratory viral infections, the problem of developing drugs against COVID-19 remains relevant. The development of antiviral drugs requires an adequate cellular model of infection to search for and test inhibitors of viral reproduction. AIM. To study the feasibility of using a Calu-3 human lung adenocarcinoma cell culture-based test system to evaluate the antiviral activity of recombinant human interferon α …

26.08.2026journal-article

Nursing Edição Brasileira

Epidemiologia-Global-do-Cancer-de-Prostata.pdf

Carolina Cardoso Coelho, Guilherme Caldeira Trevisan, Isadora Sirena Salame

A criptorquidia, definida como a falha na descida de um ou ambos os testículos para a bolsa escrotal, representa a anomalia congênita do trato urogenital mais comum em recém-nascidos do sexo masculino, apresentando implicações clínicas significativas a longo prazo, como o risco aumentado de infertilidade e neoplasia testicular. A prevalência desta condição é mais elevada em prematuros e recém-nascidos de baixo peso, exigindo um monitoramento cuidadoso durante o primeiro ano de vida, visto que a descida testicular e …

26.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Addressing the impact of tobacco and alcohol use on cancer-related health outcomes

Hang Zhou, Babalola Faseru, Farhad Islami, Nigar Nargis, Maria Elena Martinez, Roy A Jensen, S Gail Eckhardt, Roy S Herbst

Abstract Tobacco and alcohol use are known modifiable risk factors contributing to cancer morbidity and mortality globally. Recognizing the synergistic effects of these substances and their implications for cancer prevention and treatment, a national workshop titled Addressing the Impact of Tobacco and Alcohol Use on Cancer-Related Health Outcomes was convened in Washington, DC, in March 2025. This workshop brought together leading researchers in behavioral, basic, and clinical sciences; clinicians; public health p …

26.08.2026journal-article

FEMS Microbiology Letters

Development of Linezolid and Daptomycin resistance in Vancomycin Resistant Enterococcus Faecium During Antibiotic Treatment

Simone Rønager Grim, Peder Worning, Farah Hammadi Batti Gburi, Anette Hammerum, Mette Damkjær Bartels, Lillian Marie Søes

Abstract The increasing incidence of vancomycin-resistant enterococci (VRE) over the past decade has reduced treatment options largely to linezolid and daptomycin. However, the emergence of resistance to both agents further complicates the management of VRE infections. While the mechanisms of linezolid resistance are relatively well understood, those underlying daptomycin resistance remain less clearly defined. In this study, we analyzed genomic changes associated with the development of linezolid and daptomycin re …

26.08.2026journal-article

Australian Endodontic Journal

Intraoperative Pain During Tagger Hybrid Thermomechanical Compaction Technique in Single‐Visit Treatment of Necrotic Teeth: A Prospective Single‐Arm Observational Study

Ricardo Machado, Stella Maria Glaci Reinke, Divya Reddy, Alexandre Kowalczuck, Everdan Carneiro, Sergio Aparecido Ignacio, Ulisses Xavier da Silva Neto

ABSTRACT This prospective single‐arm observational clinical study evaluated intraoperative pain during root canal obturation using the Tagger hybrid thermomechanical compaction technique (THTCT) in necrotic teeth treated in a single visit. A total of 151 necrotic teeth from 151 patients aged 12–90 years (mean ± SD: 39.7 ± 17.9 years) were included. All teeth underwent standardised chemomechanical preparation and were obturated using the THTCT with EndoFill sealer. Immediately after thermomechanical compaction, pati …

26.08.2026journal-article

Cancer Medicine

Efficacy and Safety of First‐Line Chemotherapy With Gemcitabine Plus Nab‐Paclitaxel in Unresectable Gallbladder Cancer

Yue Yang, Ziyou Wu, Yidi Zhu, Yu Zhang, Zhe Zhou, Xiaoling Song, Ziyi Yang, Shilei Liu, Runfa Bao, Xuefeng Wang, Xiangsong Wu, Wei Gong

ABSTRACT Purpose The purpose of this study is to evaluate the efficacy and safety of nab‐paclitaxel combined with gemcitabine (AG regimen) as a first‐line chemotherapy for patients with unresectable gallbladder cancer (GBC). Materials and Methods A retrospective analysis was conducted on patients diagnosed with GBC via histological examination. Inclusion criteria included locally advanced or metastatic gallbladder cancer deemed unresectable by multidisciplinary team (MDT) consensus; age 18–75 years; ECOG performanc …

26.08.2026journal-article

International Journal of Molecular Sciences

Methylation-Associated Differentiation Features Define Biological and Prognostic Heterogeneity in CMS4 Colorectal Cancer

Kaiyuan Xing, Liangshuang Li, Shuang Feng, Ting Yang, Yongjun He, Yingnan Ma, Wei Luo, Jiang Zhu

Consensus molecular subtype 4 (CMS4) colorectal cancer (CRC) is associated with an aggressive clinical course and poor survival, yet the biological basis of heterogeneity within this subtype remains incompletely understood. DNA methylation is an epigenetic mechanism involved in transcriptional regulation, cellular differentiation, and colorectal tumorigenesis. Here, we integrated single-cell RNA sequencing (scRNA-seq), bulk data, and promoter DNA methylation data to characterize CMS4-associated cancer cell states a …

26.08.2026journal-article

Frontiers in Cardiovascular Medicine

TRI-SCORE based risk stratification across contemporary treatment strategies for isolated tricuspid regurgitation: a multicenter retrospective analysis

Sara Gharehdaghi, Liesbeth Rosseel, Monika Beles, Marc Vanderheyden, Bernard Stockman, Filip Casselman, Raffaella Mistrulli, Ivan Degrieck, Karel Van Praet, Jerrold Spapen, Sofie Brouwers, Frank Van Praet, Martin Penicka, Guy Van Camp

Background The TRI-SCORE is a disease-specific risk model developed to predict outcomes after isolated tricuspid valve surgery. Although its prognostic value has been demonstrated across contemporary treatment strategies, independent external validation in multicenter cohorts across a broader clinical and etiological spectrum remains limited. We evaluated the prognostic performance of the TRI-SCORE in patients with isolated ≥ moderate tricuspid regurgitation (TR) treated with medical therapy, surgery, or transcathe …

26.08.2026journal-article

Journal of Imaging Informatics in Medicine

Enhancing Robustness of Deep Learning to Batch Effects from Multi-site Data for Segmentation of Clinically Significant Prostate Cancer on MRI

Sumedh Sonawane, Pranav Sompalle, Dihitha Baddula, Minoti Kedare, Natasha Setiadi, Abhishek Midya, Sena Azamat, Zelin Zhang, Dattatraya Patil, Allison Yang, Elias Kikano, Danielle Hill, Thomas Massuti, Martin G. Sanda, Anant Madabhushi, Clinton D. Bahler, Rakesh Shiradkar

Abstract Deep learning (DL) has shown promise in segmenting clinically significant prostate cancer (csPCa) on MRI. However, batch effects arising from multi-site variations impact their generalizability. This study investigates the impact of training data harmonization, diversity, and few-shot fine-tuning on DL in segmenting csPCa on multi-site MRI. 3 T prostate MRI from N = 1822 patients of four sites (public: D₁, N = 1500; D₂, N = 157; institutional: D₃, N = 47; D₄, N = 118) was leveraged. Bi-parametric MRI (T2-w …

26.08.2026journal-article

Proceedings of the National Academy of Sciences

Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individuals

Johanna Mirsch, Ratna N. Cordoni, Cornelia Schmitt, Melina I. Dehnert, Alicia Schulze, Danuta Galetzka, Sebastian Zahnreich, Peter Scholz-Kreisel, Thomas Hankeln, Manuela Marron, Maria Blettner, Cécile M. Ronckers, Heinz Schmidberger, Markus Löbrich

DNA double-strand breaks (DSBs) which arise in G1- or G0-phase normal human cells are repaired by nonhomologous end-joining (NHEJ), a pathway which is important for cell survival but can cause mutations at the break sites. DSB repair by NHEJ is very efficient at high damage levels of 1 or more DSBs per cell, much less efficient at lower damage levels and almost absent if only ~0.05 DSBs per cell are induced. Here, we have analyzed the repair of high and low levels of radiation-induced DSBs in primary fibroblasts fr …

26.08.2026journal-article

Frontiers in Oncology

Externally validated explainable 3D CNN ensemble model for non-invasive prediction of IDH and MGMT status in gliomas

Rafail C. Christodoulou, Georgios Vamvouras, Rafael Pitsillos, Kleoniki Roka, Elena E. Solomou, Christina Kalogeropoulou, Peter Zampakis, Michalis F. Georgiou

Introduction To develop and externally validate an explainable 3D convolutional neural network (CNN) ensemble for non-invasive prediction of IDH mutation and MGMT promoter methylation status in gliomas using routine MRI. Methods Multi-institutional MRI data were curated from the UCSF-PDGM and UPENN-GBM cohorts for training and testing, with independent external validation on the MU-Glioma-Post dataset. Separate 3D CNNs were trained for IDH and MGMT classification, and the models were combined into an ensemble metac …

26.08.2026journal-article

Frontiers in Pharmacology

Transition from drug lag to drug loss in pediatric oncology: a comprehensive evaluation of the Japan-U.S. approval gap

Kana Yamada, Hiroyuki Sato, Akihiro Hirakawa

Introduction Pediatric drug development in Japan faces significant challenges caused by the case rarity and limited commercial incentives. Although the United States (U.S.) RACE Act in 2017 has accelerated pediatric oncology approvals in the U.S., it has coincided with a widening approval gap between the U.S. and Japan. This retrospective observational study aimed to clarify the current status of pediatric oncology drug lag and apparent drug loss through 2025 and to explore structural factors associated with pediat …

26.08.2026journal-article

BMC Oral Health

Why patients delay or decline treatment for gingival recession: a qualitative study

Omid Fakheran, Erfan Davari Dolatabadi, Sajede Sheydaei, Majid Shahmoradi

Abstract Background Gingival recession is a common mucogingival condition associated with esthetic concerns, dentin hypersensitivity, and root-surface complications that may impair oral health-related quality of life. Nevertheless, some patients delay or decline treatment despite being aware of the condition. This study explored patient-perceived barriers to seeking treatment for gingival recession. Methods Semi-structured, face-to-face interviews were conducted with 15 participants who were aware of their gingival …

26.08.2026journal-article

International Archives of Medical Research

Treatment of Multiple Cairo RT2 Gingival Recessions with the Tunnel Technique and a Subepithelial Connective Tissue Graft: A Case Report

Bülent Ulaştan

Multiple Cairo RT2 gingival recessions present esthetic and functional challenges in periodontal therapy. This case report describes the treatment of multiple Cairo RT2 gingival recessions using the tunnel technique combined with a subepithelial connective tissue graft in a 42-year-old woman. Clinical evaluation at 6 and 12 months demonstrated complete root coverage at most treated sites, increased keratinized tissue width, shallow probing depths, and complete resolution of dentin hypersensitivity. The patient was …

26.08.2026journal-article

FASEB BioAdvances

Supraphysiological 25‐Hydroxyvitamin D 3 and Calcipotriol Induce Reactive Oxygen Species, Mitochondrial Dysfunction and Apoptosis in HeLa Cervical Cancer Cells

Hoi Ching Cherry Chan, Sachin Bhoora, Esther Zhou, Sumari Marais, Tahir S. Pillay, Rivak Punchoo

ABSTRACT Cervical cancer remains a major global health challenge, necessitating continued advances in therapeutic strategies. Emerging evidence suggests that vitamin D derivatives may exert anti‐cancer effects, including induction of apoptosis, potentially through redox‐dependent mechanisms. This study investigated whether vitamin D exposure is associated with reactive oxygen species (ROS) accumulation, mitochondrial dysfunction, and apoptosis in cervical cancer cells. HeLa cells were exposed to physiological, inte …

26.08.2026journal-article

Behavioral Sciences

Behavioral and Psychosocial Predictors of Treatment Response in Emergency Psychiatric Admissions for Substance Use Disorders in a Socioeconomically Vulnerable Region of Southeastern Romania: A Five-Year Retrospective Study

Ionela-Violeta Ragea, Simona-Dana Mitincu-Caramfil, Rusu-Negraia Magdalena, Cătălin Pleșea-Condratovici, Valeriu Ardeleanu, Ramona-Oana Roșca, Laurențiu Drăguș, Lavinia-Alexandra Moroianu

Substance use disorders (SUDs) represent a major psychiatric and public health burden. Although integrated biopsychosocial approaches combining pharmacotherapy with psychosocial and behavioral interventions are recommended by international guidelines, real-world evidence on their effectiveness in acute emergency settings remains scarce, particularly in Eastern European healthcare contexts. This single-center, retrospective, observational study examined behavioral and psychosocial predictors of clinical response and …

26.08.2026journal-article

Health Science Reports

The Therapeutic Effects of Crocus sativus L . and Its Constituents on the Improving Treatment of Azoospermia: A Narrative Review

Faraz Khakshour, Melika Hadad Tehran, Jamal Jalili Shahri, Farid Zeynali, Fahimeh Lavi Arab

ABSTRACT Background and Aims Azoospermia, defined as the complete absence of sperm in the ejaculate, is a major cause of male infertility and is classified into obstructive and non‐obstructive forms. While obstructive azoospermia is primarily mechanical in origin, non‐obstructive azoospermia (NOA) is characterized by impaired spermatogenesis and is frequently associated with oxidative stress, inflammation, and hormonal dysregulation. Crocus sativus L . and its bioactive constituents exhibit antioxidant and anti‐inf …

26.08.2026journal-article

Journal of Surgical Oncology

Unplanned Healthcare Utilization Following the Surgical Management of Musculoskeletal Tumors: A Retrospective Cohort Study

Devika A. Shenoy, William C. Cruz, Kevin A. Wu, Aaron D. Therien, Malcolm DeBaun, Christian A. Pean, Brian Brigman, Julia D. Visgauss, William C. Eward

ABSTRACT Background and Objectives Orthopaedic oncology patients are susceptible to unplanned return to the emergency department (RTED) and readmission postoperatively. This study aims to explore factors contributing to unplanned healthcare utilization in patients undergoing surgery for musculoskeletal tumors. Methods We conducted a single‐institution retrospective cohort study of orthopaedic oncology patients from 2017 to 2023. Demographic variables (race, ethnicity, language, insurance, age) and procedure details …

26.08.2026journal-article

International Surgery Journal

Oncological treatment and upper lip reconstruction in basal cell carcinoma: case report and review of reconstructive options

Carla M. Cruz Rocha, Jose D. Tellez Gonzalez, Danna Gonzalez Delgado, Liliana A. Cuevas Mejia, Besser I. Irias Vasquez, Daniela I. Sanchez Lozano, Carlos A. Bautista Lopez, Maria del C. Torres Gonzalez

Basal cell carcinoma (BCC) is the most common cutaneous malignancy and frequently affects sun-exposed facial regions. Lesions of the upper lip are considered high risk due to their tendency for local invasion, recurrence, and involvement of critical functional and aesthetic subunits. Optimal management requires complete oncologic excision followed by anatomically precise reconstruction. We report the case of a 66-year-old woman with a recurrent nodular BCC of the upper lip after prior incomplete excision. Margin-co …