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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Frontiers in Medicine

Acute otitis media complicated by mastoiditis and otogenic transverse-sigmoid sinus thrombosis in an adult: a case report on infectious pathogenesis and multidisciplinary therapy

Fabián Darío Arias Rodríguez, Mercedes Larenas, María Roxana Gastañaga, María Eva Casal, Mónica Maya-Castro, Juan S. Izquierdo-Condoy

Background Acute otitis media is usually a self-limited bacterial infection; however, in rare cases, contiguous spread to the mastoid and adjacent dural venous sinuses may result in life-threatening intracranial complications. Otogenic transverse-sigmoid sinus thrombosis is uncommon in adults and represents a diagnostic and therapeutic challenge because its early presentation may be nonspecific and evidence guiding management remains limited. Case presentation We report the case of a 32-year-old man with no relevan …

24.08.2026journal-article

Revista Sustinere

Explorando o potencial do ChatGPT-3 como uma ferramenta para a tomada de decisões clínicas relacionadas a terapêutica medicamentosa em odontopediatria

Michelle Alonso Coutinho, Hislena Oliveira Ramos, Andréa Vaz Braga Pintor, Marcela Baraúna Magno

Avaliou-se o potencial do ChatGPT-3 como ferramenta clínica na terapêutica medicamentosa em odontopediatria, analisando a qualidade das respostas fornecidas. Foram feitas 45 perguntas sobre a forma terapêutica mais indicada (n=1), analgésicos (AN, n=17), anti-inflamatórios (AI, n=17) e anestésicos locais (AL, n=10) em diferentes cenários clínicos. As respostas foram analisadas quanto à precisão (0 a 5), completude (0 a 2), objetividade (0 a 2) e pontuação total (0 a 9). Os grupos de medicamentos foram comparado pel …

24.08.2026journal-article

Healthcare

From Awareness to Adoption: Barriers and Facilitators of Telerehabilitation in Jordanian Physiotherapy Practice

Sami Elmahgoub, Wesam A. Debes, Rama Al-rawajfeh, Fares G. Daradkeh, Bodor Bin Sheeha, Aseel Aburub

Background/Objectives: Telerehabilitation is increasingly used globally to deliver physiotherapy services remotely, yet its adoption in Jordan remains limited. This quantitative cross-sectional study aimed to explore the awareness, perceptions, and willingness of Jordanian physiotherapists regarding telerehabilitation, and to identify barriers and facilitators to its adoption. Methods: An online self-administered questionnaire was completed by a convenience sample of 200 physiotherapists (111 males, 89 females; age …

24.08.2026journal-article

Biomedicines

Photodynamic Therapy in Cancer: Mechanisms, Photosensitizer Technology, Vitamin Modulation, and Rational Combination Design

Ilaf Naser, Dorota Bartusik-Aebisher, Barbara Smolak, Klaudia Dynarowicz, Edward Kowalczyk, Wiesław Guz, David Aebisher, Gabriela Henrykowska

Photodynamic therapy (PDT) is a minimally invasive anticancer modality based on the interaction of a photosensitizer, light of an appropriate wavelength, and molecular oxygen, resulting in reactive oxygen species (ROS)-mediated tumor injury. This review discusses PDT as a mechanism-dependent therapeutic platform and evaluates how photosensitizers, vitamin A, vitamin D, nanotechnology, and combination strategies may influence its efficacy. The article synthesizes mechanistic and translational evidence concerning pho …

24.08.2026journal-article

Journal of Endovascular Therapy

The ECO-PLUG Technique: Ultrasound-Guided Optimization of Haemostasis After Percutaneous Femoral Access – a Pictorial Technical Note

Edoardo Pasqui, Leonardo Pasquetti, Manfredi Giuseppe Anzaldi, Giuseppe Galzerano, Gianmarco de Donato

Purpose: To describe the ECO-PLUG technique, a standardised ultrasound-guided workflow for percutaneous femoral access and plug-based closure, and to report its feasibility and clinical performance in patients undergoing peripheral artery revascularization procedures. Technique: The ECO-PLUG protocol incorporates continuous ultrasound guidance throughout all procedural phases: femoral access, closure device deployment, and post-procedural haemostasis verification. Five predefined checkpoints (C1-C5) structure the w …

24.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

Temporal effects of Palmitoylethanolamide (PEA) in modulating knee osteoarthritis symptoms: A randomized, double-blind, placebo-controlled trial

Shalini Srivastava, Sagar Karvir, Trupti Shende

Background Osteoarthritis involves cartilage degradation, driven by elevated matrix metalloproteinases and inflammatory signalling, while available therapies offer only symptomatic relief. Palmitoylethanolamide (PEA), an endogenous fatty acid amide with anti-inflammatory and analgesic activity, modulates inflammation and downregulates chondrocyte metalloproteinase. This study evaluates dose-dependent nociceptive effect of PEA supplementation in individuals with knee pain. Methods In this randomized placebo-controll …

24.08.2026journal-article

Healthcare

Professional Quality of Life and Occupational Stress Among Nurses in Pediatric Palliative and Related Pediatric Care Settings: A Cross-Sectional Study in Croatia

Mia Rebernik, Krešimir Dolić, Matea Dolić

Background/Objectives: Pediatric palliative care is a highly demanding field requiring nurses to maintain professional competence and emotional resilience. Continuous exposure to suffering, dying, and death may increase the risk of psychological distress among healthcare workers. The objective of this study was to examine compassion satisfaction, burnout, and secondary traumatic stress among nurses working in pediatric palliative and related pediatric care settings in Split-Dalmatia County, Croatia, and to explore …

24.08.2026journal-article

Human Gene Therapy

Engineering Human Hematopoietic Stem and Progenitor Cells for Antigen Expression in Antigen-Presenting Cells

Clara Heider, Meg Louise Donovan, Carina Walpole, Peter R. Murphy, Louisa Alim, Irina Buckle, Liam O’Brien, Maki Nakayama, Simon C. Barry, Stuart I. Mannering, Kristen J. Radford, Raymond J. Steptoe

Gene therapy achieved through genetic manipulation and transfer of hematopoietic stem and progenitor cells (HSPC) is becoming an increasingly attractive option for personalized medicine. In the current clinical scenarios, use is restricted to overcoming genetic disorders, but it is envisioned that more diverse applications will be developed in the future. Immunotherapy of malignant disease already employs non-HSPC-based gene therapies, and there is a body of evidence that HSPC-mediated gene therapy has potential as …

24.08.2026journal-article

South African Journal of Arts Therapies

Reviewing the Past, Celebrating the Present, and Envisioning the Future

Carol Lotter, Sherri Symons, Andeline dos Santos

The University of Pretoria’s Master’s programme in Music Therapy convened a hybrid symposium to celebrate 25 years of accredited training. Based on audio-visual recordings of the event that were transcribed for the present manuscript, this report provides an account of the day’s contributions, organised around three interlinked themes: looking back on programme development, reflecting on clinical practice, and celebrating research trajectories while envisioning future collaborations. Speakers revisited the programm …

24.08.2026journal-article

Journal of Applied Clinical Medical Physics

Dynamic modulated arc therapy (DMAT): A time‐aware, modulation‐steered optimization framework for next‐generation radiotherapy delivery

Taoran Li, Esa Kuusela, Emmi Ruokokoski, Heini Hyvönen, Jerry Jaboin, Mirko Myllykoski, Jussi Nurminen, Riku Paananen, Jarkko Peltola, Marko Rusanen, Martin Sabel, Kevin Moore, Christopher Boylan

Abstract Background Conventional VMAT optimization largely treats delivery time and deliverability as emergent properties of simplified, control‐point‐centric models that often ignore finite acceleration and other dynamic limits. As modern linacs continue to increase maximum axis speeds and dose rates, there is a growing need for a planning paradigm that makes the plan quality‐time trade‐off explicit and steerable, especially when shorter treatments can provide clinical benefits beyond throughput. Purpose This work …

24.08.2026journal-article

Journal of Speech, Language, and Hearing Research

DELV-ing Into the Psychometrics of Dialect: An Item-Level Analysis With School-Aged African American Children

Lee Branum-Martin, Julie A. Washington, Katherine T. Rhodes

Purpose: Measuring language proficiency in the presence of nonmainstream dialect variation is a crucial task for clinicians and language researchers. Evaluations of the Diagnostic Evaluation of Language Variation–Screening Test (DELV-ST) have suggested that its items do not conform to the recommended scoring rules. The current article evaluates the items from both parts of the DELV-ST. Method: Participants included 853 African American students in Grades 1–5. We used a priori confirmatory factor models to evaluate …

24.08.2026journal-article

Journal of Endovascular Therapy

Individual Patient Data Meta-Analysis of GORE VIABAHN Endoprosthesis with Heparin Bioactive Surface for Treatment of Femoro-Popliteal Arterial Disease (INSIGHT VSX)

Hilde Wetzels, Suzanne Holewijn, Stijn Zomer, Osamu Iida, Sho Nakao, Takao Ohki, Tanja Böhme, Florian Wolf, Richard Saxon, Michel M.P.J. Reijnen

Objective: This study aims to analyze available data on patients the latest-generation heparin-bonded Viabahn endoprosthesis in the femoropopliteal artery. Design: This study is an individual patient data (IPD) meta-analysis. Methods: This study incorporated all available cases from databases that reported outcomes of patients treated with the heparin-bonded Viabahn endoprosthesis in the femoropopliteal artery. The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 IPD Guidelines were …

24.08.2026journal-article

Radiation Protection Dosimetry

Assessment of occupational radiation exposure among radiology workers in Ghana using cytogenetic biomarkers and thermoluminescent dosimetry

James Owusu, Daniel Gyingiri Achel, David Okoh Kpeglo, Sandra Agbenyegah

Abstract Occupational exposure to ionizing radiation remains an important radiation protection concern among radiology workers. This study assessed cytogenetic damage among radiology workers in Ghana using the dicentric chromosome assay and cytokinesis-block micronucleus assay alongside routine thermoluminescent dosimeter (TLD) records. Eleven occupationally exposed workers and thirteen controls were recruited. No dicentric chromosomes were observed in either group. The mean annual occupational TLD dose was 3.89 ± …

24.08.2026journal-article

Journal of Clinical Medicine

Clinical and Radiological Outcomes of Oral Bisphosphonate Therapy Combined with Conservative Treatment in Subchondral Bone Marrow Edema of the Knee: A Retrospective Cohort Study

Goker Yurdakul, Murat Korkmaz, Irfan Karadak, Abdullah Iyigun, Muhammed Kazez, Nezih Yayli, Mustafa Fatih Erkoc, Fatih Golgelioglu

Background/Objectives: Subchondral bone marrow edema (BME) of the knee often causes persistent pain despite conservative treatment, and evidence supporting oral bisphosphonates is limited. We compared conservative treatment alone with conservative treatment plus oral alendronate. Methods: This retrospective cohort study included 82 patients with MRI-confirmed subchondral BME of the knee treated between January 2020 and January 2025. Patients received conservative treatment alone (n = 44) or conservative treatment p …

24.08.2026journal-article

SDÜ SAĞLIK BİLİMLERİ DERGİSİ

The Effect of Research Methods Education on Scientific Values, Epistemological Beliefs, and Research Attitudes in Physiotherapy Students

Mesut Ergan, Tahir Keskin, Ferdi Başkurt, Zeliha Başkurt

Objective: The aim of this study was to examine the effect of a research methods course on physiotherapy and rehabilitation students’ epistemological beliefs, tendencies toward scientific values, and attitudes toward scientific research.Methods: The study was conducted using a single-group pretest–posttest quasi-experimental design. A total of 85 undergraduate students who were enrolled in the research methods course during the relevant semester and voluntarily agreed to participate were included. Data were collect …

24.08.2026journal-article

International Journal of Dental Hygiene

Efficacy of Laser Therapy, Mechanical Scaling, and Scaling With Hand Instruments in Microbiological and Clinical Indices Alteration After Nonsurgical Periodontal Treatment: A Systematic Review and Network Meta‐Analysis

Zohreh Afshari, Javad Abbasi, Arefeh Esfandpour, Sima Kiani

ABSTRACT Introduction The major role of chronic periodontal diseases in impairing human oral health shows the importance of seeking the most efficient implement to address this prevalent issue. The objective of this study is to compare nonsurgical treatment tools, including Gracey's curette, sonic/ultrasonic, and laser instruments, considering their effect on subgingival microbial flora and clinical indices. Methods Following a search in six databases, clinical studies using Gracey's curette, sonic/ultrasonic, or l …

24.08.2026journal-article

The Journal of Vascular Access

A scoping review of the aseptic non-touch technique in intravenous therapy: Principles, applications, and training models

Qi Jiajia, Hu Jie, Chen Jie

The aseptic non-touch technique (ANTT) constitutes a standardized clinical framework designed to minimize infectious complications during intravenous therapy. Though widely acknowledged internationally, its uptake and supporting evidence within China’s healthcare system have not been systematically clarified. This scoping review was conducted following the Arksey and O’Malley framework. We searched PubMed, Web of Science, Embase, and CNKI from 2000 to August 2025 for literature on ANTT’s principles, efficacy, train …

24.08.2026journal-article

British Journal of Occupational Therapy

Feasibility of a culturally adapted virtual reality cognitive rehabilitation program (COVERT) delivered via a hybrid model for stroke survivors in Singapore: A pilot study

Wei Shan, Tan Amanda Pei Xuan, Teoh Ai Lin, Tegan Kate Plunkett, Christopher Kuak Wee Keong, Alicia Lim Mei Zhi, Mohamed Damiri Mohamed Hosain, Kong Keng He

Introduction: Virtual reality (VR) is an emerging modality for cognitive rehabilitation, but evidence in Singapore is limited. This pilot study examined the feasibility and preliminary effectiveness of a localized cognitive VR-based training program (COVERT) for individuals with post-stroke cognitive impairment, delivered using a hybrid model. Method: Nine participants (mean age = 54.0, SD = 10.0) were recruited from Hospital A and Hospital B over 19 months. Participants completed a 4-week VR program through tele-r …

24.08.2026journal-article

International Journal of Basic & Clinical Pharmacology

A prospective, randomized, open label, comparative study of efficacy and tolerability of oral itraconazole versus combination therapy with oral itraconazole and oral terbinafine in treatment of dermatophytosis

Srinjoy Bhattacharya, Kumaraswamy Girish, Nandini Albur Shankaraiah

Background: Superficial dermatophytosis, caused by fungi like Trichophyton and Microsporum, affects skin, hair and nails, presenting as round, red, scaly patches with itching. Generally, topical antifungals are common preferred treatment, while extensive infections and immunocompromised patients often require systemic oral treatments due to frequent relapses and resistance to topical terbinafine. This study compares itraconazole monotherapy with combination therapy of itraconazole and terbinafine to optimize treatm …

24.08.2026journal-article

International Journal of Innovative Technologies in Social Science

OPTIMIZATION OF REHABILITATION PROTOCOLS AFTER ELECTIVE HIP REPLACEMENT IN LIGHT OF CURRENT SCIENTIFIC EVIDENCE

Weronika Winiarska, Wiktoria Bełcikowska-Skowron, Aleksandra Siegmund, Marzena Chrapczyńska, Agnieszka Filarecka, Piotr Przybyszewski, Emilia Przybyszewska, Julia Gatniejewska, Paulina Prudzic, Martyna Sienicka

Introduction: Hip replacement is one of the most effective treatments for advanced degenerative disease, but the optimal postoperative rehabilitation model remains a matter of debate. Objective: The aim of this study was to evaluate current rehabilitation protocols used after elective hip replacement and identify their most important and best-documented elements. Methods: A narrative literature review was conducted, encompassing 34 publications from 2015–2025, including randomized controlled trials, systematic revi …

24.08.2026journal-article

Indian Journal of Medical Research

Immunotherapeutic effect of MIP vaccine along with multidrug therapy (MDT) in leprosy: A systematic review and meta-analysis

Madhumathi Jayaprakasam, Jigisha Chaudhary, Deenadayalan Boopalan, Rizwan Suliankatchi Abdulkader, Nivedita Gupta

Background and objectives Leprosy is a neglected tropical disease caused by Mycobacterium leprae often resulting in nerve damage, numbness, disfiguring lesions, and disability. India accounts for ∼52% of the world’s new leprosy patients. Immunotherapy has been reported to achieve faster bacterial clearance in multi-bacillary (MB) leprosy patients. We conducted this systematic review to synthesise the global evidence available for the efficacy and safety of the MIP vaccine ( Mycobacterium indicus pranii ), previousl …

24.08.2026journal-article

Plant Disease

Phage Cocktail Therapy for Biocontrol of Kiwifruit Bacterial Canker Caused by Pseudomonas syringae pv. actinidiae

Xinyan Jiang, Chunhua Kou, Mingming Yang, Leilei Yang, Mengsi Zhang, Shengzhi Guo, Xihui Shen, Yao Wang, Yingfei Ma, Lili Huang

Kiwifruit bacterial canker (KBC), caused by Pseudomonas syringae pv. actinidiae (Psa), threatens global kiwifruit production. Traditional control methods face challenges like bacterial resistance and environmental issues. In this study, four lytic phages (pSM43, pGZ41, pWA51, and pSO21) were isolated and characterized using Psa M228 as the host bacterium. Notably, the phage pGZ41 represents a novel phylogenetic lineage, and the four-phage cocktail demonstrates significant advantages over previously reported single …