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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Health Science Reports

Does Preoperative Mixed‐Growth Urine Culture Increase the Risk of Urinary Tract Infection After Ureteroscopic Stone Treatment? A Retrospective Study

Khalid Elsayed Mahmoud, Ahmad R. Al‐Qudimat, Ahmed Khaled Alhusban, Raed M. Al‐Zoubi, Mai Elaarag, Abdulkader Alobiedly, Ibrahim A. khalil, Abdulla AlAnsari

ABSTRACT Background Ureteroscopy (URS) has emerged as a leading treatment option for urinary stones, with its usage growing from 30% to 70% over the last 20 years. Post‐URS complications, particularly infectious issues like UTIs, remain a concern, occurring in up to 25% of cases. This study aims to explore the relationship between preoperative mixed‐growth urine culture and postoperative outcomes of URS, addressing a critical gap in understanding the value and influence of these cultures. Methodology This retrospec …

26.08.2026journal-article

Cancers

Immune Checkpoint Inhibitors and Platelets from Treatment-Induced Thrombocytopenia to Complex Immune and Immune-Related Adverse Events

Árpád Illés, Miklós Udvardy, Zsófia Miltényi

Immune checkpoint inhibitor-induced immune thrombocytopenia (ICI-ITP) is a rare but severe adverse event that may lead to bleeding complications and may require therapeutic changes or interventions. The clinical condition and interventions are highly complex; there are certainly tumour-type and combination-therapy differences, as well as individual ICI-agent factors that modify the risk of thrombocytopenia. ICI-ITP shares some common features, even though its pathogenesis differs markedly from that of traditional I …

26.08.2026journal-article

N.N. Priorov Journal of Traumatology and Orthopedics

COMPARATIVE ANALYSIS OF TREATMENT RESULTS IN PATIENTS WITH FRACTURES OF THE TIBIAL CONDYLES.

Magomedrauf Hadiyevich Ganiev, Akshin B. Bagirov, Najmudin Omarkadiyevich Kallaev, Alevdin Rashidkhanovich Ataev, Parviz Nizam Suvarly

Intra-articular fractures of the tibial condyles are one of the most common and complex types of injuries. The relevance of the problem of treating patients with fractures of this localization is due not only to the high prevalence, but also to the difficulties of diagnosis, as well as the complexity of repositioning and fixation of fragments, which leads to frequent unsatisfactory outcomes. Good results can be achieved with complete restoration of the cogruence of the tibial plateau, stable fixation of fragments a …

26.08.2026journal-article

Frontiers in Psychiatry

A pilot randomized controlled study of a digital art therapy paradigm for children with ASD: integrating pivotal response treatment into video animation and physical model design

Huili She, Xinyi Dai, Ting Deng, Ruhao Liu, Wenting Jiang, Xufeng Ma

Background The integration of digital technology into art therapy for children with autism spectrum disorder (ASD) represents an emerging trend, yet systematic design frameworks that translate evidence-based interventions into digital media remain underdeveloped. This study developed and evaluated a digital art therapy paradigm that structurally integrates pivotal response treatment (PRT) into video animation design while maintaining cross-media consistency with physical generalization tools. Methods Based on the b …

26.08.2026journal-article

Radiation Sciences in Oncology

Artificial intelligence usage habits in radiation oncology: A survey for patients and caregivers

Ayben Yentek Balkanay, Ecem Demir

Objective: We aimed to evaluate the usage patterns, awareness, and trust in artificial intelligence (AI) technologies among radiation oncology patients and their caregivers. Materials and Methods: A total of 83 radiation oncology patients or caregivers were surveyed using a 17-item questionnaire. The survey assessed participant demographics, AI awareness, usage patterns, trust, verification behaviors, and concerns. Statistical analyses were conducted using Chi-square and Fisher’s exact tests. Results: Of 83 partici …

26.08.2026journal-article

Thoracic Cancer

Intraoperative Contrast‐Enhanced Ultrasonography (Io‐ CEUS ) to Detect Missed Lung Nodules During Robot‐Assisted Thoracoscopic Surgery

Alfonso Fiorelli, Antonio Marella, Marco Aiello, Valentina Brancato, Marco Salvatore, Daniela Comunale, Francesco Ferrigno, Gaetana Messina

ABSTRACT Herein, we reported the use of Intraoperative‐Contrast Enhanced Ultrasonography (Io‐CEUS) during Robotic Assisted Thoracic Surgery (RATS) for identification of malignant lung nodule that was missed during previous operation. Pre‐operative CT scan with 3D reconstruction defined the prompt position of the target lesion within S8 segment of right lower lobe and the anatomic landmarks as the distance from interlobar fissure and diaphragm. The lesion was then successfully detected by Io‐CEUS. The different arte …

26.08.2026journal-article

International Journal of Molecular Sciences

HO-1 Nuclear Interactome Implications in Neuroendocrine Transdifferentiation in Prostate Cancer

Rocio Seniuk, Pablo Sanchis, Agustina Sabater, Gaston Pascual, Juan Bizzotto, Julia Lechuga, Magdalena Delfino, Peter D. A. Shepherd, Jiabin Dong, María Pia Valacco, Javier Cotignola, Elba Vazquez, Ayelen Toro, Geraldine Gueron, Estefania Labanca

Neuroendocrine prostate cancer (NEPC) is characterized by androgen receptor (AR) independence and poor response to conventional therapies, highlighting the need to unveil the molecular mechanisms behind NEPC. We previously showed that heme oxygenase 1 (HO-1, encoded by HMOX1) translocates to the nucleus exerting unexplored non-canonical functions. The present study delineates the nuclear interactome of HO-1, revealing a potential mechanism that impairs NEPC establishment. Through a proteomics approach integrated wi …

26.08.2026journal-article

British Journal of Haematology

Long‐term results of brentuximab vedotin and bendamustine for first‐line treatment of Hodgkin lymphoma in the elderly ( HALO trial)

Andrea Gallamini, Simonetta Viviani, Davide Rapezzi, Caterina Patti, Pierre Feugier, Alessandro Rambaldi, Fontanet Bijou, Anna Borra, Cécile Borel, Tanguy Pace‐Loscos, Renaud Schiappa, Stephane Chauvie, Colin Debaigt, Anna Guidetti, Olivier Humbert, Jean‐Marc Schiano De Colella

Summary The Hodgkin lymphoma treatment in the elderly (eHL) is a challenge due to a narrow therapeutic window between therapy effectiveness and toxicity. Both bendamustine (Be) and brentuximab vedotin (BV) are well‐tolerated, effective drugs in relapsing HL, but no data exist on Be‐BV frontline treatment in eHL. The prospective, open‐label, phase I/II Hodgkin lymphoma combining Adcetris® and Levact® in Old patients (HALO) study was launched (Clinical Trial.Gov Id. 02467946) to test safety and efficacy of Be‐BV in u …

26.08.2026journal-article

Frontiers in Oncology

Endoscopic nasopharyngectomy for recurrent or persistent nasopharyngeal carcinoma: a 10-year outcome from a tertiary centre in Hong Kong

Ting Cai, Calvin Chee Fung Lai, David Chun Man Yeung, Samuel Man Wai Chow

Aim To analyse the outcomes of endoscopic nasopharyngectomy for recurrent or persistent nasopharyngeal carcinoma (NPC) in Prince of Wales Hospital (PWH), a tertiary hospital in Hong Kong. Methods A retrospective review on patients who underwent endoscopic nasopharyngectomy in PWH between 2015 to 2025. Patient characteristics, disease status, operative complications, resection margins, need for adjuvant treatment, recurrence and survival outcomes were analysed. Results A total of 42 subjects, including 39 recurrent …

26.08.2026journal-article

Endoscopic Ultrasound

Expert consensus on endoscopic diagnosis and treatment of insulinoma (2026)

Shaomei Tang, Qinglin He, Wei Luo, Sibiao Su, Zhuo Yang, Aiming Yang, Enqiang Linghu, Zhendong Jin, Shanyu Qin, On behalf of the Digestive Endoscopy Branch of the Chinese Medical Association

Insulinoma is a rare functional pancreatic neuroendocrine tumor characterized by excessive insulin secretion, which causes hypoglycemia. Recent advances in endoscopic technology have provided essential tools for the diagnosis and treatment of insulinoma. Early diagnosis and timely intervention, particularly endoscopy-guided intervention in selected patients, may improve clinical outcomes and quality of life. Although existing national and international guidelines mention insulinoma, standardized criteria for its en …

26.08.2026journal-article

Frontiers in Oncology

Case Report: Two cases of pathologic complete response after upfront chemoimmunotherapy for initially unresectable gastric cancer

Megan Smith-Uffen, Prathana Nathan, Chris J. Zhang, Ken Leslie, Leah McDonald, Matthew Cecchini, Mark Vincent

Gastric cancer causes considerable morbidity and mortality. Chemoimmunotherapy has improved survival in the metastatic setting and pathologic complete response (pCR) for those with resectable disease. However, the ability of chemoimmunotherapy to convert locally advanced unresectable into resectable disease, or to lead to a pCR in this setting, is not known. Here we describe two cases of patients who were initially diagnosed with unresectable and incurable gastric cancer who, after receiving upfront chemoimmunother …

26.08.2026journal-article

Frontiers in Oncology

Borrmann type IV gastric cancer exhibits distinct clinicopathological features and extremely poor prognosis

Qingyu Lin, Zikang Li, Wei Tang, Jianqiu Liu, Chanyan Huang, Ran Wei, Tianhao Zhang, Yan Qian, Yin Li, Jianhui Chen, Shirong Cai, Jinning Ye, Ertao Zhai

Background Borrmann type IV gastric cancer (Bor-IV) is clinically recognized as an aggressive phenotype; however, its prognostic burden relative to contemporary TNM staging and its radiological correlates remain incompletely characterized. Methods We retrospectively analyzed 1236 patients with advanced gastric adenocarcinoma who underwent radical gastrectomy, including 124 Bor-IV and 1112 Non Bor-IV cases. Clinicopathological features, multimodal imaging characteristics, and survival outcomes were compared. Overall …

26.08.2026journal-article

Molecules

Carrier-Assisted Nanomaterials and Microbial Dynamics in Advanced Wastewater Treatment: A Review

Zhongchuang Liu, Siu Hua Chang, Gilles Mailhot, Mohsen Taghavijeloudar, Valentin Romanovski

Nanomaterials (NMs) have shown broad application potential in wastewater deep treatment, but the actual application is constrained by some issues such as nanoparticle (NP) aggregation and poor recyclability. Different from previous comprehensive reviews, this article systematically synthesizes data from over 100 peer-reviewed studies (2012 to 2026) to review the preparation methods, purification mechanisms, and removal efficiencies for various pollutants, and the technical and economic feasibility of NMs, with an e …

26.08.2026journal-article

Thoracic Cancer

Validity and Feasibility of the Constant‐Load Cycle Endurance Test in Lung Cancer Patients Undergoing Radiation Therapy

Junghwa Do, Sungeun Park, Sei Won Lee, A. Hyun Kim, Sang Ah Kim, Seung Hak Lee, Hwayeong Cheon, Jae Yong Jeon

ABSTRACT Purpose This study evaluated the validity of the constant‐load cycle endurance test (CET), performed at 75% of maximal power output, in patients with lung cancer undergoing radiation therapy. Its feasibility, responsiveness to pulmonary rehabilitation (PR), and clinical applicability were also examined. Methods Thirty‐three patients participated in a 4‐week PR program during radiation therapy. CET time was compared with the 6‐min walk test (6MWT) to assess concurrent validity. Patients were stratified by 6 …

26.08.2026journal-article

Radiation Sciences in Oncology

ESTRO 2026 Congress: Medical physics at the heart of innovation

Serap Çatlı Dinç

The ESTRO 2026 Congress was held in Stockholm from May 15–19 under the theme “Innovating Radiation Oncology, Together,” bringing together nearly 8,900 participants and hosting Europe’s largest radiation oncology industry exhibition. Walking through the Physics Track sessions, one thing became clear early on: the old staples of our meetings, such as calibration, QA protocols, and dose calculation, were no longer the main story. This narrative review reflects on the congress from a medical physics perspective, drawin …

26.08.2026journal-article

Seminars in Neurology

Neurologic Complications of Cancer Immunotherapy

Alexandra Balshi, Prashanth Rajarajan, Caleb R.S. McEntire, Giovanna S. Manzano

Abstract The use of oncologic-directed immunotherapies, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T cell (CAR-T) therapy, has risen exponentially in recent years. Although these therapies have been shown to improve long-term survival and quality of life in responsive patients, their nonspecific immune system activation can lead to unanticipated neurotoxicity, among other complications. Immune-related adverse events (irAEs) may involve any location in the entire neuroaxis, posing a …

26.08.2026journal-article

Frontiers in Oncology

Comparative evaluation of TACE-RFA versus monotherapies on a background of systemic therapy for recurrent hepatocellular carcinoma: a propensity score-matched analysis

Wendi Zhang, Zuhao Ye, Jinfa Wang, Xia Ren, Liping Ying, Yifeng Wu, Zongyang Wu, Chang Xin, Jiye Feng

Background The optimal locoregional treatment for recurrent hepatocellular carcinoma (rHCC) in the era of potent systemic therapy remains undefined. This study aimed to compare the efficacy, safety, and resource consumption of transarterial chemoembolization combined with radiofrequency ablation (TACE-RFA) versus TACE or RFA monotherapy, specifically when administered on a uniform background of systemic therapy (Lenvatinib plus PD-1 inhibitors). Methods We retrospectively reviewed 243 patients with rHCC who met str …

26.08.2026journal-article

Frontiers in Medicine

Baseline immune-organ 18F-FDG PET/CT metabolism is associated with immune-related adverse events in anti-PD-1-treated non-small cell lung cancer

Haixu Zhu, Renhua Na, Xiaolong Yao, Jureti Azhati, Liming Chai, Canwen Sun, Bing Liu, Zeqiang Dai, Yan Xing

Objective To investigate whether baseline 18 F-FDG PET/CT immune-organ metabolic features are associated with immune-related adverse events (irAEs) in non-small cell lung cancer (NSCLC) patients receiving anti-PD-1 therapy. Methods We retrospectively analyzed 120 stage III–IV NSCLC patients who underwent 18 F-FDG PET/CT within 4 weeks before anti-PD-1 therapy and received ≥2 treatment cycles. The endpoint was any-grade irAE (CTCAE v5.0). Candidate predictors included tumor burden; spleen, bone-marrow, and thyroid m …

26.08.2026journal-article

Frontiers in Pediatrics

Pediatric orbital solitary fibrous tumor/hemangiopericytoma presenting with isolated eyelid edema: a case report

Cheng Gai, Lijuan Zhang, Xiaofei Zhao, Bing Wang

Background Orbital solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is an exceedingly rare mesenchymal neoplasm in the pediatric population. While typical orbital tumors present with proptosis or mass effect, the clinical picture can be deceptively indolent, leading to diagnostic delay. Case presentation A 15-year-old male patient presented with a 2-year history of progressive right upper eyelid edema that had repeatedly been misdiagnosed as conjunctivitis and visual fatigue. Notably, there was an absence of pro …

26.08.2026journal-article

Endocrine-Related Cancer

Emerging insights into the pathophysiology of pituitary tumour microenvironment

Antonio C. Fuentes-Fayos, Ignacio Gil-Duque, Ana S. De la Rosa-Herencia, André Sarmento-Cabral, Álvaro Flores-Martínez, David A. Cano, Antonio J. Martínez-Fuentes, Raúl M. Luque

Abstract Pituitary tumours (PiTs) are a heterogeneous group of diseases of the anterior pituitary gland. While they are often described as rare diseases, the actual prevalence of these tumours is higher than commonly believed, accounting for at least 15% of all intracranial tumours. Yet, the high heterogeneity of the different PiTs (intra- and inter-patient heterogeneity), rooted in part in the intrinsic cellular diversity of the normal pituitary gland itself, has significantly limited the understanding of the biol …

26.08.2026journal-article

Cancer Discovery

First-in-Human Testing of a Mutant KRAS Vaccine for Pancreatic Cancer Interception in High-risk Cohorts

S. Daniel Haldar, Amanda L. Huff, Hejia Henry Wang, Zirui Zhu, Maureen Berg, Jiayun Lu, Nancy Sun, Elizabeth Abou Diwan, Hassan Sinan, Christopher J. Thoburn, Matthew Z. Guo, Takeichi Yoshida, Linda C. Chu, Anna K. Ferguson, Dimitrios N. Sidiropoulos, Luciane T. Kagohara, Won Jin Ho, Katherine M. Bever, Marina Baretti, Mark Yarchoan, Daniel A. Laheru, Julie M. Nauroth, Amy M. Thomas, Hao Wang, Nilofer S. Azad, Michael G. Goggins, Elizabeth M. Jaffee, Neeha Zaidi

Abstract Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions over a decade-plus, offering a window for interception in high-risk individuals, but current surveillance detects a minority of precursors. Mutant KRAS (mKRAS) is present in most PDACs and their precursors, making it an appealing target for immune-based interception. We conducted a phase I, first-in-human study of a peptide vaccine targeting 6 common KRAS mutations (mKRAS-VAX) in 20 individuals with hereditary PDAC predisposition and a r …

2 Zitationen
26.08.2026journal-article

Medicine and health care organization

Комплексная оценка эффективности санаторного лечения туберкулеза у детей

Елена Юрьевна Власова, Марина Эдуардовна Лозовская, Геннадий Геннадьевич Карасев, Юлия Анатольевна Яровая, Ксения Павловна Юлина, Анна Романовна Сапожникова

Введение. Санаторный этап является важным компонентом комплексной терапии и реабилитации детей, больных туберкулезом, и лиц из групп риска. Для оценки его эффективности необходим системный подход, учитывающий динамику совокупности клинико-функциональных показателей. Цель исследования. На базе ФГБУ «Детский туберкулезный санаторий “Пушкинский”» Минздрава России (ДТС) провести апробацию комплексной оценочной таблицы для определения эффективности санаторного этапа лечения, разработанную совместно кафедрой фтизиатрии Ф …

26.08.2026journal-article

Angewandte Chemie

Bacteria‐Mediated Targeted Delivery and Deep Tumor Penetration of a Pt(IV)‐Drug Enables Synergistic Chemo‐Immunotherapy

He Meng, Jinhui Wang, Bing Shi, Tao Ouyang, Kai Lu, Wenkai Lin, Yuxiang Lu, Jing Wang, Xiyu Huang, Hailong Zhao, Yufang Xiong, Zilong Xu, Zong‐Wan Mao, Wei Xia

ABSTRACT Platinum‐based drugs are clinically vital for cancer treatment but suffer from off‐target cytotoxicity and poor tumor penetration. To overcome these limitations, we designed a tumor‐targeted Pt(IV) drug‐bacteria conjugate ( Pt‐EcN‐HER2 ). This conjugate exploits the inherent tumor tropism of probiotic bacterium Escherichia coli Nissle 1917 (EcN) to achieve targeted accumulation and deep penetration within the tumor microenvironment (TME). Once localized, elevated intratumoral hydrogen peroxide (H 2 O 2 ) a …

26.08.2026journal-article

Diagnostics

RETRACTED: Amin et al. Liver Tumor Localization Based on YOLOv3 and 3D-Semantic Segmentation Using Deep Neural Networks. Diagnostics 2022, 12, 823

Javaria Amin, Muhammad Almas Anjum, Muhammad Sharif, Seifedine Kadry, Ahmed Nadeem, Sheikh F. Ahmad

Diagnostics retracts the article entitled “Liver Tumor Localization Based on YOLOv3 and 3D-Semantic Segmentation Using Deep Neural Networks” [...]