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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

National Science Review

In situ probiotic-to-postbiotic transformation for spatiotemporally controlled cancer photoimmunotherapy

Daokuan An, Xiaochen Wu, Yunsheng Shang, Yancong Zhao, Yunjie Gu, Jinjun Shao, Lu-Lu Qu, Yuxin Guo, Xiaochen Dong, Wei Huang

Abstract Current cancer phototherapy is often hindered by suboptimal immunogenicity and inevitable immune escape. Herein, a programmable bio-hybridized phototherapeutic platform is developed by chemical grafting drug-loaded phototherapeutic nano-modules on natural facultative anaerobic probiotics. Exploiting the innate hypoxia-tropic motility of probiotics, the platform achieves robust active accumulation within tumor tissues. Under the first near-infrared (NIR) laser stimulus, the platform undergoes in situ probio …

26.08.2026journal-article

Frontiers in Oncology

Comparative evaluation of TACE-RFA versus monotherapies on a background of systemic therapy for recurrent hepatocellular carcinoma: a propensity score-matched analysis

Wendi Zhang, Zuhao Ye, Jinfa Wang, Xia Ren, Liping Ying, Yifeng Wu, Zongyang Wu, Chang Xin, Jiye Feng

Background The optimal locoregional treatment for recurrent hepatocellular carcinoma (rHCC) in the era of potent systemic therapy remains undefined. This study aimed to compare the efficacy, safety, and resource consumption of transarterial chemoembolization combined with radiofrequency ablation (TACE-RFA) versus TACE or RFA monotherapy, specifically when administered on a uniform background of systemic therapy (Lenvatinib plus PD-1 inhibitors). Methods We retrospectively reviewed 243 patients with rHCC who met str …

26.08.2026journal-article

Frontiers in Medicine

Baseline immune-organ 18F-FDG PET/CT metabolism is associated with immune-related adverse events in anti-PD-1-treated non-small cell lung cancer

Haixu Zhu, Renhua Na, Xiaolong Yao, Jureti Azhati, Liming Chai, Canwen Sun, Bing Liu, Zeqiang Dai, Yan Xing

Objective To investigate whether baseline 18 F-FDG PET/CT immune-organ metabolic features are associated with immune-related adverse events (irAEs) in non-small cell lung cancer (NSCLC) patients receiving anti-PD-1 therapy. Methods We retrospectively analyzed 120 stage III–IV NSCLC patients who underwent 18 F-FDG PET/CT within 4 weeks before anti-PD-1 therapy and received ≥2 treatment cycles. The endpoint was any-grade irAE (CTCAE v5.0). Candidate predictors included tumor burden; spleen, bone-marrow, and thyroid m …

26.08.2026journal-article

International Journal of Molecular Sciences

AKR1B1 and AKR1B10 as Potential Prognostic Biomarkers of Endometrial Cancer

Maja Novak Pušić, Špela Smrkolj, Tea Lanišnik Rižner

Endometrial cancer (EC) is the most common gynecological malignancy with rising incidence, yet reliable non-invasive prognostic biomarkers for preoperative risk stratification and treatment guidance are needed. This pilot study investigated whether plasma levels of aldo-keto reductase family 1 member B1 (AKR1B1) and aldo-keto reductase family 1 member B10 (AKR1B10) could serve as non-invasive prognostic biomarkers in EC. Plasma samples were collected preoperatively from 78 postmenopausal women with histologically c …

26.08.2026journal-article

Science Translational Medicine

FUS inactivation promotes leptomeningeal metastasis of lung cancer through the up-regulation of CD36

Shouheng Lin, Kai Yin, Mei-Mei Zheng, Hai-Yan Tu, Wanjun Li, Zhiping Wu, Diwei Zheng, Youguo Long, Qiting Wu, Duo Li, Xiwei Wang, Xichen Bao, Yao Yao, Ziyuan Duan, Georgia Carson, Ben-Yuan Jiang, Lu Zeng, Zhi-Hong Chen, Qing Zhou, Jin-Ji Yang, Wen-Zhao Zhong, Xu-Chao Zhang, Hua-Jun Chen, Bin-Chao Wang, Fa-Man Xiao, Si-Yang Maggie Liu, Li-Xu Yan, Jean Paul Thiery, Yang-Si Li, Yi-Long Wu, Peng Li

The prognosis of non–small cell lung cancer (NSCLC) with leptomeningeal metastasis (LM) is dismal. The regulators of LM progression remain elusive, thus impeding effective clinical intervention. Here, we performed in vivo genome-wide CRISPR-based screens and found that fused in sarcoma (FUS) ablation promoted LM in both PC9 and A549 cells. FUS repressed CD36 expression by directly interacting with and destabilizing PPARA ( peroxisome proliferator–activated receptor α) messenger RNA. CD36 augmented fatty acid uptake …

26.08.2026journal-article

International Journal of Contemporary Pediatrics

Glucagon-like peptide-1 analog in the treatment of metabolic dysfunction-associated steatotic liver disease

Inês Eiras, Inês Magalhães, Sandrina Martins

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease in children with obesity. No pharmacological therapies are currently approved specifically for paediatric MASLD. A 12-year-old boy with obesity presented with persistent hypertransaminasemia and ultrasound-confirmed hepatic steatosis. After lifestyle interventions failed to improve liver enzymes, a glucagon-like peptide 1 (GLP-1) analog was initiated and titrated to 1.8 mg/day. Six months later, transaminases i …

26.08.2026journal-article

Frontiers in Oncology

Prediction model for survival outcome in patients with acute myeloid leukemia: a multicenter prospective cohort study from Thai Acute Leukemia Working Group

Pirun Saelue, Jakrawadee Julamanee, Adisak Tantiworawit, Thanawat Rattanathammethee, Weerapat Owattanapanich, Smith Kungwankiattichai, Chantiya Chanswangphuwana, Chantana Polprasert, Wasithep Limvorapitak, Supawee Saengboon, Kannadit Prayongratana, Chantrapa Sriswasdi, Pimjai Niparuck, Teeraya Puavilai, Chajchawan Nakhakes, Chinadol Wanitpongpun

Introduction Despite the development of advanced therapeutic approaches in the last two decades, acute myeloid leukemia (AML) has a poor prognosis, especially in older patients. The main causes of death are refractory/relapsed disease, fatal bleeding, or serious infection. A model to predict survival in patients with AML is necessary for clinicians to make decisions regarding appropriate treatment. In this study, we aimed to evaluate the predictive factors for death and generate a model to predict survival in patie …

26.08.2026journal-article

Medical Sciences

Association of Vitamin D Intake, VDR Levels, and Relevant Gene Polymorphisms in Early-Stage Thai Colorectal Cancer Patients Following Vitamin D3 Supplementation

Natthaporn Kuendee, Aunchana Rodrungnok, Kamphon Intharanut, Alisa Naladta, Oytip Nathalang, Sakda Daduang, Sophida Sukprasert

Background: Recent studies have reported associations between vitamin D receptor (VDR) gene polymorphisms and colorectal cancer (CRC). However, the findings thus far are inconsistent. This study aims to clarify the association of vitamin D intake, VDR levels, and relevant polymorphisms in early stages of CRC in Thai patients following vitamin D3 supplementation. Methods: Total RNA and genomic DNA were isolated from the buffy coats of CRC patients (n = 27). The levels of VDR, RXR, CYP27B1, and CYP24A1 were measured …

26.08.2026journal-article

Medical Sciences

Extracellular Vesicles at the Interface of Cancer Therapy and Regenerative Medicine: Biology, Bidirectional Roles, and Engineered Therapeutics

Jun-Hyeog Jang

Extracellular vesicles (EVs), including exosomes and microvesicles, are nanoscale membrane-enclosed particles that transfer proteins, lipids, mRNAs, and microRNAs between cells. The same communication system is now being developed in two apparently opposing settings: mesenchymal stem/stromal cell (MSC)-derived EVs are explored as cell-free regenerative therapeutics, whereas tumor-derived EVs can promote metastasis, immune evasion, and treatment resistance while also serving as liquid-biopsy biomarkers. Rather than …

26.08.2026journal-article

Cancer Immunology Research

Cancer Immunotherapy Using AIRE Conditioning of the Tumor Epitopeome

Alex Chen, Jose S. Pulido, Jason Tonne, Muriel Metko, Jill M. Thompson, Thanich Sangsuwannukul, Maria P. Chiriboga-Yerovi, Rosa M. Diaz, Mason J. Webb, Amanda L. Huff, Madelyn Moore, Matthew R. Schuelke, Sheeba Irshad, Elizabeth Appleton, Alan Melcher, Benjamin Kendall, Richard G. Vile

Abstract T-cell immune tolerance is established in part through the activity of the Auto-immune Regulator (AIRE) transcription factor in the medullary thymic epithelial cells (mTEC) of the thymus. AIRE induces expression of peripheral tissue–specific self-antigens for presentation to naïve T cells to promote activation/deletion of autoreactive T cells. This traditional role of AIRE in mTECs is to prevent autoimmunity. Herein, we demonstrate that tumors mimic the role of AIRE in mTECs to evade immune rejection. We f …

26.08.2026journal-article

Al-Noor Journal of Engineering Management and Computer Science

Structural, Optical, Electrical, and Magnetic Characterization of Fe<sub>2</sub>O<sub>3</sub> and ZnO Nanoparticles Synthesized by Pulsed Laser Ablation in Liquid for River Water Treatment

Alyaa H. Ali, Tahseen H. Mubarak, Nadia M. Jassim

This study aimed to prepare iron oxide (Fe2O3) and zinc oxide (ZnO) nanoparticles using pulsed laser ablation in liquid (PLAL) technology, investigate their physical properties, and evaluate their potential use in treating polluted river water. This technique is advantageous because it allows for the preparation of nanoparticles without the need to add chemicals during the preparation process, making it an important method for producing nanomaterials with properties suitable for environmental applications.X-ray dif …

26.08.2026journal-article

Environmental Research Communications

Microbiota Stability and Antibiotic Resistance in Wild Fish Over-Exposed to Filtered Wastewater treatment plant Effluents: an in situ caging experiment

Benjamin Janvier, Julie Leloup, Thierry Berthe, Nathalie Grall, Sabine Delannoy, Fabrice Alliot, Elodie Guigon, Etienne Marchand, fabienne petit, Aurelie Goutte

Abstract Antimicrobial resistance (AMR), driven by use and misuse of antibiotics, has become a major global health threat. In high-income countries, urban rivers receiving treated effluents from wastewater treatment plants (WWTPs) can be considered “hot-spot environments” that promote the dissemination of Antibiotic resistant bacteria (ARB) between humans and wildlife. Here, we assessed the role of wild fish in the dissemination of AMR in a highly urbanized river (Orge River, France), based on the One Health approa …

26.08.2026journal-article

Revista de Gestão Social e Ambiental

Constructed Wetlands and their Applicability in the Treatment of Sanitary Sewage in Small Communities

Valter Chicalo António Caripa

Objective: To analyze, based on technical and scientific literature, the applicability of constructed wetlands as a sustainable alternative for sanitary sewage treatment in small communities, based on natural water purification processes. Theoretical Framework: This research addresses constructed wetlands as a sustainable technology for treating sanitary wastewater. It presents the concepts, operating principles, and main types of these systems, highlighting the physical-chemical and biological mechanisms involved …

26.08.2026journal-article

BMC Cancer

NKAIN1 predicts poor prognosis and associated with drug resistance and immune infiltration in prostate adenocarcinoma

Xuancai Chen, Cong Wang, Xingyao Qu, Jixiang Wu, Zongming Jia, Siyu Wang, Can Hu, Wentao Yao, Tong Zhang, Ying Kong, Yuhua Huang

Abstract Background Na, K-ATPase interaction 1 (NKAIN1) is a transmembrane protein that can interact with Na, K-ATPase β1 subunit. NKAIN1 has prognostic value in several cancers, but its biomarker and carcinogenic roles in the development of prostate adenocarcinoma (PRAD) remain underexplored. Methods The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) database were used to analyze the expression and prognostic significance of NKAIN1 in PRAD. The Genomics of Drug Sensitivity in Cancer (GDSC) d …

26.08.2026journal-article

Frontiers in Medicine

Anatomical validation of ultrasound-guided retrolaminar block for the treatment of symptomatic vertebral fragility fractures

Andrés Ponce, Xavier Sala, Emili Gómez-Casanovas, Manuel Llusá, José A. Gómez-Puerta, Pilar Peris

Objective This study aimed to evaluate the anatomical feasibility and the injectate spread pattern of an ultrasound-guided retrolaminar injection in a cadaveric model as a potential approach for targeting the dorsal ramus/medial branch region in patients with symptomatic vertebral fragility fractures (VFs). Materials and methods Bilateral ultrasound-guided retrolaminar injections were administered at the T9 level in 10 fresh human cadavers. A total of 20 injections were administered using 10 mL of saline solution m …

26.08.2026journal-article

Cancers

Mechanism-Driven Diagnostic Development: A Specimen-Aware Framework Illustrated by Colorectal Cancer and Solid Tumours

Ian Daniels, Andrew J. Page, Daniel Wise

Translational oncology has moved rapidly from histopathology and single-analyte biomarkers toward multi-dimensional molecular profiling. Yet many clinically deployed tests still use reductionist biomarker strategies that under-represent cancer complexity. This review examines whether a mechanistic, multi-layered, and specimen-aware approach can improve cancer detection, classification, prognosis, minimal residual disease (MRD) assessment, and therapeutic selection. Evidence across solid tumours shows that genomic a …

26.08.2026journal-article

Frontiers in Oncology

Resistance mechanisms and countermeasures in CLDN18.2-positive tumors: from molecular networks to clinical practice

Yutao Xia, Mingfang Wang, Taosheng Huang, Kai Sun, Peng Wang

Claudin 18.2 (CLDN18.2) has rapidly become a major target in solid-tumor oncology. Zolbetuximab, the first anti-CLDN18.2 antibody, was approved in 2024 for HER2-negative, CLDN18.2-high advanced gastric and gastro-esophageal junction adenocarcinoma, and more than one hundred CLDN18.2-directed trials are now under way across monoclonal antibodies, antibody-drug conjugates, bispecific antibodies and CAR-T cells. As these agents enter the clinic, resistance has become the central challenge. This review synthesizes the …

26.08.2026journal-article

Scientific Reports

Impact of ABCB1 polymorphisms on response to anthracycline chemotherapy in breast cancer patients

Ali Abuhaliema, Al-Motassem Yousef, Nirmeen Elmadany, Nemah Awwad, Mohaned Hammad

Abstract Breast cancer is the most prevalent cancer in women, and anthracycline-based chemotherapy, such as doxorubicin, is one of the main treatments. Unfortunately, treatment response varies between individuals, and drug resistance continues to limit the effectiveness of breast cancer treatment. Genetic differences, including single nucleotide polymorphisms (SNPs), in the ATP-binding cassette subfamily B member 1 (ABCB1) gene, which encodes the efflux transporter P-glycoprotein, are believed to modify the level o …

26.08.2026journal-article

Angewandte Chemie

Boosting Diagnostic Accuracy of Prostate Cancer: Combining Clinical PSA Level and a Pair of NIR Fluorescent Probes for SLC39A1 and PSMA

Xiuzhu Huo, Fei Yang, Hong Wang, Jiao Chen, Mengyao She, Li Xue, Ping Liu, Shengyong Zhang, Jianli Li

ABSTRACT Prostate cancer (PCa) is a leading malignancy in men globally. Although serum prostate‐specific antigen (PSA) testing is prevalent for PCa screening, its inherent limitation in specificity and sensitivity frequently leads to high false‐positive and false‐negative diagnoses. To address this challenge, we present a PSA+ strategy that integrates a clinically defined PSA threshold (10 ng/mL) with a pair of complementary near‐infrared (NIR) fluorescent probes: a zinc‐complex‐based probe (Cy‐O‐NS‐a‐Zn) targeting …

26.08.2026journal-article

Nepal Journal of Public Health

Effectiveness of Multimodal Intervention on Health-Related Quality of Life And Treatment Adherence among Hypertensive Patients in Selected Community Of Jumla, Nepal

Anika Dahal, Kamal Prasad Acharya

Background: Hypertension continues to be a global health issue, with rates of prevalence rising quickly in both developed and developing nations. Adherence to or compliance with hypertensive medications has significant economic and therapeutic consequences because nonadherence patients are at greater risk of developing complications affecting their health status and overall quality of life. The research aimed to determine the effects of multimodal intervention on health related quality of life and treatment adheren …

26.08.2026journal-article

Cancer Research Communications

A Phase 1b/2 Study of Atezolizumab in Combination with Thiopurine Therapy in Patients with Metastatic Solid Tumors and Intermediate Tumor Mutational Burden

Christine Federspiel. Secher, Martin Højgaard, Iben Spanggaard, Ane Yde. Schmidt, Yuliu Guo, Luca Robinson, Daniela De Zio, Linea N. Toksvang, Frederik Otzen. Bagger, Kjeld Schmiegelow, Kristoffer S. Rohrberg

Abstract Purpose: The TEMPLE study was a phase 1b/2 trial evaluating the safety, tolerability, and efficacy of atezolizumab combined with thiopurine therapy in patients with metastatic solid tumors, aim-ing to increase tumor mutational burden (TMB) through single-nucleotide mismatching and neoepitope generation. Patients and Methods: Phase 1b was an open-label, single-arm dose de-escalation trial conducted to determine the recommended phase 2 dose (RP2D) of 6-mercaptopurine and 6-thioguanine combined with atezolizu …

26.08.2026journal-article

Frontiers in Oncology

Diagnostic accuracy of Node-RADS for lymph node metastasis in rectal cancer: a systematic review and meta-analysis

Tian Tian, Yang Li, Linfang Xu, Zhihua Lu

Objective To systematically evaluate the diagnostic accuracy and clinical value of the Node Reporting and Data System (Node-RADS) for lymph node metastasis in rectal cancer (RC). Methods The study followed PRISMA-DTA guidelines and was registered in PROSPERO (CRD420261372147). PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang, VIP, and the Chinese Biomedical Literature Database were searched from inception to April 2026. Two reviewers independently screened studies, extracted data, and assessed method …

26.08.2026journal-article

Journal of modern medicine

METHOD FOR SELECTING AND TECHNICAL ASPECTS OF SURGICAL TREATMENT FOR INFECTED PANCREATIC NECROSIS IN PATIENTS WITH DIABETES MELLITUS

N.A. Kasimov, D.M. Khakimov, G.M Khojimatov, Kh.Kh Khamdamov

<p>The scientific article presents methods and technical techniques for choosing surgical tactics for infected pancreatic necrosis (IPN) in patients with diabetes mellitus (DM). Clinical trials were conducted on 188 patients with IPN who underwent treatment at the RSCEMP AB between 2012 and 2025. Depending on the period and presence of DM, all included patients were divided into 3 groups. The control group consisted of 62 (33%) patients with IPN against the background of DM who underwent treatment in 2012-2018, whi …