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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Journal of Adolescent and Young Adult Oncology

Delivery of Guideline Concordant Supportive Care for AYAs with Cancer in a Statewide Population-Based Cohort

Jacob N. Stein, Christopher D. Baggett, Emily R. Haines, Nicole Knape, Jennifer L. Lund, Hannah C. Winslow, KyungSu Kim, Jordan Lodato Hunt, Alison Manikowski, Catherine Habashy, Andrew B. Smitherman, Katherine E. Reeder-Hayes

Purpose: In the past two decades, there has been a growing recognition of the unique needs of adolescent and young adult (AYA) cancer patients. Alongside this recognition is the emergence of guidelines for high-quality AYA cancer care. Despite such tailored guidelines, preliminary studies suggest a gap between recommended versus received care among AYAs. We sought to examine patterns in receipt of guideline-concordant care among this population using a state-wide claims database. Methods: We conducted a retrospecti …

26.08.2026journal-article

Biomedicines

Low Serum LDL-C Is Associated with Poorer Overall Survival and Lipid-Related Molecular Features in Colorectal Cancer

Juan Wang, Yifang Hsieh, Wenhong Wang, Jing Xu

Background/Objectives: We investigated whether preoperative serum low-density lipoprotein cholesterol (LDL-C) is associated with prognosis and midkine (MK; encoded by MDK)-related molecular features in colorectal cancer (CRC). Methods: This exploratory translational study integrated a retrospective cohort of 437 surgically treated patients, CRC-focused public transcriptomic analyses of MDK, independent functional enrichment of STRING-derived MK interactors, and immunohistochemistry in tumors from the lowest and hig …

26.08.2026journal-article

Biomolecules and Biomedicine

ESAT-6-specific antibody features and Fcγ receptor expression during pulmonary tuberculosis treatment: Implications for therapeutic monitoring

Christian Elugo, Sandra Palma Albornoz, Yomara Romero, Sandra Delgado-Málaga, Iskra Tuero

Tuberculosis (TB) remains a leading cause of global mortality, yet the long-term dynamics of antibody-mediated immunity during successful treatment are not fully understood. This study aimed to characterize how ESAT-6-specific antibody profiles, Fc gamma receptor (FcγR) expression, and antibody effector functions change in pulmonary TB patients undergoing treatment. In this exploratory longitudinal study, 21 adults with active pulmonary TB, who completed standard six-month therapy and achieved microbiological cure, …

26.08.2026journal-article

Frontiers in Oncology

Diffuse large B‑cell lymphoma followed by myelodysplastic syndrome with TP53 mutation: a case report and literature review

Xue Wu, Jingyuan Zhao, Yongli Fan, Xiaofeng Yang, Xinhong Yang

Background Secondary myelodysplastic syndrome (sMDS) is increasing as more individuals survive treatment for a primary cancer diagnosis, which is associated with many factors, such as prior alkylator therapy, topoisomerase II inhibitors and higher-dose pretransplant irradiation, hematopoietic cell transplantation (HCT) and graft purging. Materials and methods We report a unique case of sMDS diagnosed 34 months after a sequential treatment regimen consisting of chemotherapy, autologous hematopoietic stem cell transp …

26.08.2026journal-article

Journal of Neuro-Oncology

The intersection of chemokine signaling with the hallmarks of cancer in glioblastoma

Rafal Chojak, Jillyn R Turunen, Noah B Drewes, Lara Koutah, Jawad Fares, Rebecca X Chen, Ruochen Du, Umme H Faisal, Hasaan A Kazi, Clare Kelley, Jason Miska, Amy B Heimberger, Atique U Ahmed, Maciej S. Lesniak

Abstract Purpose Glioblastoma, IDH-wildtype, is characterized by diffuse invasion, profound immunosuppression, treatment resistance, and near-inevitable recurrence. Although canonical genetic alterations establish malignant capacity, they do not fully explain how glioblastoma cells adapt to hypoxic, perivascular, invasive, immunosuppressive, metabolically constrained, and treatment-injured microenvironments. We examined how chemokine signaling contributes to these adaptive behaviors. Methods We used the hallmarks o …

26.08.2026journal-article

Frontiers in Oncology

Integrating domain-specific convolutional features with Swin Transformers for transparent cervical cancer diagnostics

Md. Abdur Rahman, Md Tofael Ahmed Bhuiyan, Md Fokrul Islam Khan, Md. Zia Uddin, Ulysse Teller Masao Côté-Allard, Abdul Kadar Muhammad Masum

Introduction Cervical cancer screening relies heavily on manual cytopathological evaluation, which is subjective and prone to inter-observer variability. While deep learning offers automated alternatives, existing models often struggle to capture both global cellular context and fine-grained biological nuances. To address this, we propose CAMF-Swin, a novel hybrid architecture for precise cervical cell classification. Methods The CAMF-Swin framework integrates a hierarchical Swin Transformer backbone with four doma …

26.08.2026journal-article

Frontiers in Bioengineering and Biotechnology

Verbascoside-rich Buddleja davidii extract in liposomal systems: modulation of release behavior for topical wound treatment

Adeela Yasmin, Luca Casula, Alessio Pittiu, Claudia Massoni, Francesco Lai, Andrea Carpi, Renzo Dal Monte, Giorgia Barbolini, Paola Brun, Michele Schlich, Chiara Sinico

Introduction: Chronic wounds represent a major clinical challenge due to their complex pathophysiology, characterized by persistent inflammation, excessive production of reactive oxygen species (ROS), high risk of microbial contamination, and impaired tissue regeneration. Despite several plant extracts offering antioxidant, anti-inflammatory, and antibacterial properties, their therapeutic use is limited by poor stability and rapid clearance of the active compounds from the wound site, particularly in the case of h …

26.08.2026journal-article

Health Science Reports

Association Between Conservative Treatment Modalities and Clinical Outcomes in Patients With Lumbosacral Disc Herniation Following Short Term and Long Term Treatments: A Retrospective Cohort Study

Bina Eftekharsadat, Shadi Khodaei, Raha Markazi‐Movaghar, Fatemeh ojaghlou, Azizeh Farshbaf‐Khalili, Soraya Babaie

ABSTRACT Background and Aims Lumbar disc herniation (LDH), a leading cause of low back pain, necessitates effective conservative management to mitigate surgical interventions. This retrospective observational study evaluated the short‐term (6 months–2 years) and long‐term (3–6 years) efficacy of conservative therapies in 194 LDH patients from Iran. Methods Data were collected via medical records, demographic questionnaires, and the numerical rating scale (NRS) for pain, with analyses adjusting for covariates such a …

26.08.2026journal-article

Russian Bulletin of Obstetrician-Gynecologist

Comparison of laparoscopic and robot-assisted approaches in the surgical treatment of patients with endometrial cancer and morbid obesity. Preliminary results

A.A. Popov, Yu.V. Senkina, I.D. Klyushnikov, T.A. Glebov, O.Yu. Rebrova, A.R. Fattakhov

Endometrial cancer ranks 2nd after cervical cancer in the structure of oncogynecological diseases worldwide and 1st in economically developed countries. Among patients with endometrial cancer, the incidence of concomitant obesity can reach 60%. Minimally invasive techniques such as laparoscopic or robot—assisted approaches are often used in the treatment of patients with endometrial cancer, especially patients with morbid obesity. Compared to traditional open surgery, these approaches can reduce the risk of complic …

26.08.2026journal-article

Physics in Medicine & Biology

A programmable electroculture platform for direction-dependent alternating electric field delivery in cancer cell models

Fatih Senturk, Ismail Cengiz Kocum, Eda Sevval Aksan, Ugur Duzen

Abstract Objective. Alternating electric fields (AEFs) at intermediate frequencies have been shown to disrupt mitosis and inhibit the proliferation of rapidly dividing tumor cells. Here, we developed a programmable in vitro AEF exposure system (0–500 kHz, 1–3 V cm −1 ) featuring an electroculture platform compatible with standard 12-well tissue culture plates. The system enables investigation of cellular responses to fixed orthogonal field orientations and periodic polarization switching (PPS), defined as sequentia …

26.08.2026journal-article

International Journal of Contemporary Pediatrics

Clinical insights on nutrition support in pediatric cancer care: a survey of pediatric oncologists

Sripriya Venkiteswaran, Sangeeta Mudaliar, Purvi Kadakia, Uma Seshadri, Purnota D. Bahl, Anju Morarka

Cuddles Foundation, an NGO in India providing comprehensive nutrition care to children with cancer, conducted a nationwide survey among pediatric oncology professionals to understand the perceived impact of nutrition intervention programs on clinical outcomes, treatment tolerance, and caregiver empowerment for pediatric oncology patients. Responses from 48 pediatric oncology doctors, including residents, consultants, and department heads, revealed overwhelmingly positive perceptions of nutrition in improving patien …

26.08.2026journal-article

Frontiers in Oncology

How advances in machine learning drive early detection and risk prediction of early-onset colorectal cancer

Sudha S. Murthy, Anna Schuh

Early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed before age 50, is rising across high- and middle-income settings whilst organised screening stays anchored to older age thresholds. Blood-based liquid biopsy, combined with machine learning, is the most plausible route to early detection in this group because it does not depend on bowel preparation, endoscopy capacity, or adherence to stool-based testing. The gap is structural: incidence climbs fastest in the population below the age at w …

26.08.2026journal-article

Japanese Journal of Clinical Oncology

Conversion surgery for gastric cancer: current status and future perspectives

Itaru Yasufuku, Yusuke Okuma, Syunpei Tonomura, Seito Fujibayashi, Wakana Chikaishi, Masahide Endo, Yuji Hatanaka, Masahiro Fukada, Ryuichi Asai, Yuta Sato, Jesse Yu Tajima, Akitaka Makiyama, Yoshihiro Tanaka, Nobuhisa Matsuhashi

Abstract Conversion surgery, defined as surgical resection with curative intent after a favorable response to systemic chemotherapy in patients with initially unresectable gastric cancer, has attracted considerable attention as a potential treatment strategy for metastatic disease. Observational studies suggest that long-term survival may be achieved when R0 resection is accomplished. However, the therapeutic landscape has changed with advances in systemic treatment, including immune checkpoint inhibitor–based regi …

26.08.2026journal-article

Journal of Medical Internet Research

AI Adoption in US Cancer Centers: National Cross-Sectional Study of Institutional and Policy Determinants

Jingjing Gao, Muinat Abolore Idris, Eric C Jones, Louis D Brown, Jack Tsai

Abstract Background AI is increasingly being integrated into cancer screening, treatment, and patient care. However, AI adoption across cancer centers varies, raising concerns about unequal access to AI-enabled cancer care. Objective This study examined publicly visible AI adoption among National Cancer Institute (NCI)–designated cancer centers in the United States and assessed whether adoption was associated with institutional characteristics, socioeconomic context, geographic distribution, and state-level politic …

26.08.2026journal-article

Clinical Case Reports

Roadmap for Mental Health Treatment Utilizing Pharmacogenomic Testing: Case Report

Allison P. Swanson, Emily K. Mewborn, Garyung Bae

Key Clinical Message Pharmacogenomic testing is a valuable precision health tool for managing depression and other mental health conditions, from treatment‐naïve patients to those with multiple medication failures. It can reduce trial‐and‐error prescribing, guide dosing, and improve therapy tolerance, supporting more individualized and effective care.

26.08.2026journal-article

Advanced Healthcare Materials

Spatiotemporally Controlled Prodrug Release From Light‐Triggered Azo‐Bond‐Cleaved BODIPY Nanoplatform for Trimodal Synergistic Ovarian Cancer Therapy

Jiaqi Wang, Jie Zhang, Dongping Xu, Yiming Zhang, Xueqing Xia, Shuo Li, Xin‐Dong Jiang, Jiangli Fan, Xiaojun Peng, Gaowu Qin

ABSTRACT Chemotherapy (CT) suffers from poor selectivity and systemic toxicity, while photodynamic therapy (PDT) and photothermal therapy (PTT) are inherently limited by tumor hypoxia and thermoresistance. Herein, we develop a trimodal synergistic nanoplatform ( PDM‐BDP NPs) for ovarian cancer treatment by integrating PDT, mild PTT (mPTT), and CT into a single azo‐bond‐linked prodrug system. Upon 808 nm laser irradiation , PDM‐BDP NPs generate reactive oxygen species and mild hyperthermia, while simultaneously trig …

26.08.2026journal-article

The Journal of Vascular Access

Global research landscape of vascular access device-related complications in oncology: A bibliometric analysis

Derya Gezer, Seçil Taylan

Background: Vascular access devices (VADs) are essential for delivering systemic anticancer therapies, yet device-related complications remain a major challenge in oncology care. Objectives: To analyze global research trends and the knowledge structure of vascular access-related complications in oncology using bibliometric methods. Research design: Bibliometric analysis. Subjects: A total of 3072 articles and reviews published between 1977 and 2026 and indexed in the Web of Science Core Collection. Measures: Biblio …

26.08.2026journal-article

Frontiers in Oncology

Efficacy and safety of neoadjuvant treatment with PD-1 inhibitor in locally advanced head and neck squamous cell carcinoma

Shaowei Xu, Hongxin Zheng, Xiaoqi Liao, Manyu Jiang, Hanwei Peng, Muyuan Liu

Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumor. Traditional treatments have unstable efficacy, with risks of relapse, drug resistance and side effects. Immunotherapy has achieved good results in recurrent/metastatic advanced HNSCC, but relevant research on its neoadjuvant application is insufficient. This study retrospectively analyzes clinical data to evaluate the efficacy and safety of PD-1 inhibitors as neoadjuvant therapy for LA-HNSCC, providing a scientific basis for treatment strate …

26.08.2026journal-article

Psycho-Oncologie

The positive effects of psychosocial support on psychological resilience and long-term quality of life in cancer patients

Yan Li, Shujun Xiao

Objective: The aim of this study was to explore the positive effects of psychosocial support on psychological resilience and long-term quality of life of cancer patients through a subgroup study. Methods: One hundred and thirty-one cancer patients who attended our oncology department from January 2024 to February 2026 were selected and randomly divided into an intervention group (66 patients) and a control group (65 patients). All patients received conventional treatment, the control group received conventional car …

26.08.2026journal-article

Nano LIFE

Protein Nanomedicine in Breast Cancer Therapy: Targeting Strategies, Clinical Applications and Future Perspectives

Samah Hamed Almurisi, Chua Hsuan Kai, Foo Yoong Kitt, Seow Wen En, Ngeow Qing Lun, Wee Hooi Yee, Bernice Chan Wen Jing, Annie Ling Hsiang Lan, Khater AL-Japairai, Dinesh Kumar Chellappan, Rana M. F. Sammour, Thiagarajan Madheswaran

The challenges of breast cancer treatment still exist despite significant progress. The challenges include tumor heterogeneity, drug resistance and systemic toxicity. However, the development of protein nanomedicine provides a good option to address these. The present review examines the possibilities of using protein-based nanomedicine in breast cancer treatment. It looks at targeted drug delivery, immune modulation and the mechanism of enhanced permeability and retention (EPR) for the precise targeting of the tum …

26.08.2026journal-article

Cancers

Long-Term Outcomes and Prognostic Factors in Metastatic ALK-Rearranged Non-Small Cell Lung Cancer Treated with ALK Tyrosine Kinase Inhibitors: Real-World Evidence from a High-Volume Thoracic Diseases Center

Abdülkadir Koçanoğlu, Oktay Ünsal, Fatih Kuş, Nesrin Gürçay, Esra Zeynelgil, Yakup Düzköprü, Serdar Karakaya

Background/Objectives: ALK tyrosine kinase inhibitors (TKIs) have improved outcomes in patients with metastatic ALK-rearranged non-small cell lung cancer (NSCLC). However, real-world data on long-term outcomes, prognostic factors, and treatment sequencing remain limited. This study aimed to evaluate treatment outcomes, prognostic factors, and lorlatinib efficacy in different treatment settings. Methods: We retrospectively analyzed 83 patients with metastatic ALK-rearranged NSCLC treated with ALK TKIs at a tertiary …

26.08.2026journal-article

Journal of Cancer Research and Therapeutics

Accurate differentiation of metastatic and ultrasound-atypical reactive hyperplastic lymph nodes using a fusion model integrating ultrasound radiomics and habitatomics: A multicenter study

Jiafei Shen, Zhiyan Jin, Xiaoxian Li, Jincao Yao, Yang Zhang, Tian Jiang, Ke Zhang, Lujiao Lv, Bin Li, Jianhua Zhou, Liping Wang, Dong Xu, Liyu Chen

ABSTRACT Background: The significant sonographic overlap between metastatic and ultrasound-atypical reactive hyperplastic lymph nodes remains a challenge in subjective, experience-based ultrasound diagnosis. Consequently, clinicians rely on biopsy, which is an invasive procedure associated with complications such as bleeding and infection, as well as the risk of false-negatives that exacerbate patient anxiety. Materials and Methods: In this multicenter retrospective study, patients with suspicious lymph nodes from …

26.08.2026journal-article

Asia Pacific Journal of Clinical Medical Research

Machine Learning-Based Prediction of Fear of Cancer Recurrence in Gastrointestinal Cancer Survivors: A Cross-Sectional Study

Meijuan Wu, Qin Li, Weixin Xiong

Aims: To explore the current status of fear of cancer recurrence (FCR) in gastrointestinal (GI) cancer survivors, and analyze its influencing factors based on random forest algorithms. Design: A cross-sectional study design. Method: A convenient sampling method was used to select GI cancer survivors who were hospitalized in a tertiary Grade A hospital in Guangdong Province from April 2024 to May 2025. Patients were surveyed using the General Information Questionnaire, Fear of Progression Questionnaire-Short Form (F …

26.08.2026journal-article

Medicina

Thoracic Epidural Analgesia in Major Cancer Surgery: An Update

Cyrus Motamed, Marie Josée Caballero

Background and Objectives: Postoperative pain after major cancer surgery contributes to pulmonary, cardiovascular, metabolic, and functional complications. Thoracic epidural analgesia [TEA] has traditionally been considered the standard analgesic technique for open thoracic and upper abdominal oncologic surgery, although minimally invasive techniques and ERAS pathways have prompted a re-evaluation of its role. Methods: This narrative review summarizes evidence from PubMed and MEDLINE published between 1995 and June …