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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Frontiers in Pharmacology

Digital twin technology for HIV patient virtual modeling: a novel approach to treatment optimization

Yuan Zhang, Tingting Li, Jie Chen, Huanhuan Ba, Jiajia Li, Jinling Yin, Kangxiao Ma, Huanqing Liu, Juan Jin

Background Human immunodeficiency virus (HIV) infection remains a global health challenge, necessitating personalized treatment strategies to optimize patient outcomes. Digital twin technology—synchronized with real-world entities—offers a pathway to precision medicine in HIV care. Methods We analyzed 5,436 HIV patients (2016–2024) with demographic, immunologic, and antiretroviral therapy (ART) information. Core algorithms comprised gradient boosting and random forest ensembles; deep architectures (LSTM and Transfo …

28.08.2026journal-article

Frontiers in Veterinary Science

Embedding laboratory animal welfare- and ethics-related techniques into a comparative medicine laboratory course: an educational reform study

Jian Zhang, Lingyan Zhang, Xingtao Zhang, Gang Yao

Background Animal welfare and ethics education is essential for laboratory animal science training, but students often struggle to translate ethical principles into practical experimental procedures. This study explored an embedded teaching approach that integrated animal welfare- and ethics-related techniques into a comparative medicine laboratory course using the bilateral ovariectomy (OVX) mouse model as an authentic teaching scenario. Methods A pre–post educational intervention design was adopted. Students firs …

28.08.2026journal-article

International Journal of Social Sciences and Public Administration

The Mechanism of Consumer Premium Payments in Agricultural Live-Streaming under Dual Emotional Appeals: A Perspective on Warmth and Humour

Ziyi Zhou

Against the backdrop of China's transition from poverty alleviation to rural revitalisation, agricultural live-streaming commerce has become an indispensable pathway for sustaining hard-won poverty reduction gains and advancing high-quality rural development. This paper adopts the Elaboration Likelihood Model (ELM) as its fundamental research framework, introduces emotional resonance and perceived entertainment value as mediating variables, and constructs a theoretical model examining the impact of different emotio …

28.08.2026journal-article

Hacettepe University Faculty of Health Sciences Journal

University Students' Experiences During COVID-19: Insights from Online/Distance Education

Rabia Kıvanç, Çiğdem Aytekin

Objectives: The COVID-19 pandemic caused unprecedented disruptions in higher education, compelling a rapid transition to distance learning and altering students’ academic and psychosocial functioning. This study aimed to examine perceived stress levels among university students enrolled in Child Development departments and to identify the educational deprivations they experienced during pandemic-related remote instruction. Materials and Methods: A convergent mixed-methods design was employed. Data were collected fr …

28.08.2026journal-article

Hacettepe University Faculty of Health Sciences Journal

An Analysis of Graduate Theses Based on Watson’s Human Caring Model in Nursing

Cemal Özalp

Objectives: The aim of this review is to examine the postgraduate theses based on Watson's Human Care Model in the field of nursing in Türkiye.Materials and Methods: Within the scope of the review, theses registered in the National Thesis Centre were scanned with the keywords ‘Watson’ and ‘human care’ in Türkiye between 1-15 December 2024. The theses were analyzed in terms of application group, sample, method, research type and results.Results: It was determined that 28 theses in the field of nursing in Türkiye inc …

28.08.2026journal-article

Revista chilena de nutrición

Vitamin D fortification of dairy products: strategies, technologies, and health impacts

Macarena Ortiz, Andrés Bustamante, Francisco Perez-Bravo, Rodrigo Valenzuela, Catalina Espejo, Lissette Duarte

Vitamin D deficiency is a widespread global health concern driven by limited dietary sources, reduced sun exposure, and lifestyle changes. This narrative review synthesizes current evidence on the rationale, technologies, efficacy, and public health implications of vitamin D fortification of dairy products. A literature search was conducted in PubMed, Web of Science, and Scopus for English-language studies, including original research, randomized controlled trials, systematic reviews, meta-analyses, and relevant re …

28.08.2026journal-article

Critical Care & Emergency Medicine

Ultrasonido a pie de cama para diagnóstico y drenaje percutáneo de absceso hepático piógeno en choque séptico: Reporte de caso en entorno de recursos limitados

Fausto Maldonado Coronel, Katherine Maldonado Coronel, Cristina Muñoz Lalangui, Oswaldo Bolaños Ladinez, Paula Olivos Massa

Abstract: Point-of-care ultrasound has revolutionized medical practice, offering personalized treatment, diagnostic accuracy, continuous monitoring with follow-up interventions, and enhanced patient safety. We report the case of a 47-year-old woman admitted with abdominal pain, progressive hemodynamic deterioration, multiple organ failure, and septic shock with elevated acute-phase reactants. Point-of-care ultrasound was performed to identify the source of infection, revealing multiple liver abscesses. Given the li …

28.08.2026journal-article

Medicine

The application and effectiveness of acceptance and commitment therapy on psychological resilience in the primary caregivers of ostomy patients

Li Teng, Xin Wu, Huili Xu, Yun Wang, Tian Luo, Adan Fu

Background: This study aims to investigate the effects of acceptance and commitment therapy (ACT) on enhancing psychological resilience, psychological flexibility, caregiving capacity, and benefit-finding among caregivers of ostomy patients. Methods: A total of 106 primary caregivers of ostomy patients were recruited from a tertiary hospital in Wuhan. Participants were randomly assigned to the intervention or control group in a 1:1 ratio using a computer-generated random sequence. Allocation was concealed using seq …

28.08.2026journal-article

Medicine

Association of serum, follicular fluid, and embryo culture media homocysteine levels with embryo quality and pregnancy rates in assisted reproductive techniques

Xuxin Zhan, Xiaoting Wang, Jinxia Xie, Jing Zhao, Hongli Zhu

Homocysteine (Hcy) is involved in reproductive metabolism, but the associations of Hcy levels in different reproductive microenvironments with embryo development and pregnancy outcomes remain unclear. This study investigated these associations in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). This prospective study included 66 women undergoing IVF/ICSI treatment. Serum and follicular fluid (FF) samples were collected on the day of oocyte pick-up, and Hcy concentrations were mea …

28.08.2026journal-article

Medicine

Body roundness index as a novel marker of periodontitis in US adults

Jun Fang, Minghua Wang, Yanni Sun, Xunxia Wang, Ruichun Wang

This study aimed to investigate the association between the Body Roundness Index (BRI) and periodontitis (PD) in U.S. adults. Data from 10,790 participants in the 2009–2014 National Health and Nutrition Examination Survey (NHANES) were analyzed. Propensity score matching (PSM, 1:1) balanced baseline characteristics. Logistic regression was used to assess the association between BRI and periodontitis, with BRI modeled as both a continuous and a categorical variable. All subsequent statistical analyses were performed …

28.08.2026journal-article

Medicine

Treatment of elderly patients with advanced (M1) gallbladder cancer – Aggressive or conservative?

Bin He, Ti Zhou, Penghua Weng, Haibin Lan

The optimal treatment strategy for elderly patients with distant metastatic gallbladder cancer (GBC, M1) remains controversial. We extracted data from the Surveillance, Epidemiology, and End Results (SEER) database for 528 elderly patients (aged ≥ 60 years) diagnosed with M1 GBC between 2000 and 2020. Patients were stratified by age (60–69, 70–79, ≥80 years) and treatment received: no surgery or chemotherapy (Group N), surgery alone (Group S), chemotherapy alone (Group C), or surgery combined with chemotherapy (Gro …

28.08.2026journal-article

Medicine

Exploring the mechanism of Shengmai San in treating lung adenocarcinoma based on bioinformatics and molecular dynamics simulation

Xiaoling Zhou, Diyao Wu, Xiaohui Zhang, Xinyou Zhang

To investigate the mechanism of Shengmai San (SMS) in the treatment of lung adenocarcinoma (LUAD) based on an integrated strategy combining “network pharmacology, bioinformatics, molecular docking, and molecular dynamics simulation,” aiming to provide a precise combination therapy strategy and identify potential bioactive compounds. Differentially expressed genes in LUAD were identified from the Gene Expression Omnibus database using R (originally developed at Bell Laboratories and currently managed by Lucent Techn …

28.08.2026journal-article

Medicine

Traditional Chinese medicine treatment in a patient with severe COVID-19

Ming Zhong, Shiqi Sun, Fengjun Zhang, Wei Zhang

Rationale: Elderly patients with severe COVID-19 frequently develop chronic critical illness marked by prolonged ventilation, multidrug-resistant infections, enteral-nutrition (EN) intolerance, and persistent inflammation–immunosuppression–catabolism syndrome, making liberation from the ventilator and recovery difficult. Integrative Chinese and Western medicine (ICWM) is hypothesized to modulate immunity and the gut–lung axis and to stabilize frail physiology during long ICU courses. Patient concerns: An 87-year-ol …

28.08.2026journal-article

Medicine

Analysis of sex-specific stroke risk factors in middle-aged and elderly Chinese population based on machine learning approach

Xiaolong Huang, Qiangji Bao, Yunling Sun, Xiaofang Yang, Xiaoqiang Zhang

Stroke is a leading cause of global mortality and disability, yet comprehensive sex-specific stroke predictors are lacking. This study aimed to identify sex-specific stroke risk factors in middle-aged and elderly Chinese to improve early detection. 12,975 participants (7079 females, 5896 males) aged ≥45 from the China Health and Retirement Longitudinal Study 2011 to 2020 were analyzed. Sex-stratified correlations of 27 health indicators were examined. Eight machine learning algorithms identified significant stroke …

28.08.2026journal-article

Medicine

Translation and validation of the Chinese version of the Pancreatic Exocrine Insufficiency Questionnaire in patients after pancreatectomy

Huiping Yu, Wang Su, Lei Cui, Jianjian Wang, Kuirong Jiang, Xiaoping Fang

Pancreatic exocrine insufficiency (PEI) is common after pancreatic resection, but no Simplified Chinese PEI-specific patient-reported measure has undergone published cross-cultural evaluation. We translated and adapted the Pancreatic Exocrine Insufficiency Questionnaire (PEI-Q) and evaluated selected psychometric properties in patients after pancreatectomy. Following Beaton guidelines, the PEI-Q was translated and cross-culturally adapted. This single-center cross-sectional study included 163 patients. Item analysi …

28.08.2026journal-article

Medicine

Atypically presented flank pain in a patient with pulmonary embolism; a case report and literature review of a diagnostic dilemma

Mohammed Alra’e, Maaweya Jabareen, Hanan Qunibi, Saleh Juneidi, Wasef Alhroub, Walid Tamimi, Musad Shawar

Rationale: Pulmonary embolism (PE) is a potentially life-threatening condition with a broad spectrum of clinical presentations, making diagnosis challenging. Although dyspnea, pleuritic chest pain, and cough are common manifestations, atypical presentations may lead to delayed diagnosis and treatment. Patient concerns: We report the case of a 44-year-old woman who presented with acute right-sided flank pain as her predominant symptom, without evidence of urinary or gastrointestinal pathology. Diagnoses: Initial abd …

28.08.2026journal-article

Clinical Cancer Research

Long-term Results of Multiantigen Stimulated Cell Therapy I, Alone or in Combination with Chemotherapy, as First-line Maintenance Therapy in Advanced Sarcoma: A Multicenter, Phase I Trial

Xing Zhang, Bushu Xu, Qiuzhong Pan, Ruiqing Peng, Desheng Weng, Jingjing Zhao, Xizhi Wen, Qiyan Cai, Wei Li, Hongcheng Hu, Ruihua Xu

Abstract Purpose: Advanced sarcomas lack effective maintenance therapies after first-line chemotherapy. We present long-term phase I results evaluating multiantigen stimulated cell therapy I (MASCT-I), a novel immunotherapy integrating dendritic cell vaccination with adoptive T-cell transfer, as maintenance treatment (NCT03034304). Patients and Methods: Thirty-one patients with disease control after chemotherapy received MASCT-I alone (n = 17) or with ifosfamide (n = 14). The primary endpoint was safety. Secondary …

28.08.2026journal-article

Global Spine Journal

Association of Postoperative Slip Reduction With Patient-Reported Outcomes at Two Years After Fusion Surgery for Low-Grade Degenerative Spondylolisthesis: A Single-Center Study

Tom Folkerts, Julia Wimmer, Lukas Schönnagel, Anna-Maria Mielke, Bruno Verna, Pedro Rocha Torres, Paul Köhli, Jiaqi Zhu, Jennifer Shue, Rolando Duculan, Andrew A. Sama, Federico P. Girardi, Frank P. Cammisa, Carol A. Mancuso, Marco D. Burkhard, Alexander P. Hughes

Study Design Retrospective cohort study of prospectively enrolled patients. Objectives To evaluate the association between postoperative slip reduction and improvement in disability and low back pain (LBP) after lumbar fusion for low-grade degenerative spondylolisthesis (DLS), and to determine whether outcomes are independently associated with slip reduction or with sagittal alignment changes. Methods 160 patients undergoing lumbar fusion for low-grade DLS were analyzed. Slip reduction was quantified on lateral rad …

28.08.2026journal-article

Research Involvement and Engagement

Building meaningful partnerships: engaging and co-developing a patient advisory council to inform the implementation of person-centred quality indicators in Alberta primary care

Matthew Luzentales-Simpson, Ingrid Nielssen, Fakhriyya Aghabayli, Sadia Ahmed, Kalpana Thapa Bajgain, Ifrah Anjum, Veronika Kiryanova, Safa Ahmed, Kim Giroux, D’Arcy Duquette, Eleanor Benterud, Paul Fairie, Maria J. Santana

Abstract Background Effective primary care improves patient outcomes by providing comprehensive, continuous, and person-centred care. The Patient’s Medical Home vision positions primary care as the central entry point to high-quality health care in Canada. In Alberta, Person-centred Care Quality Indicators (PC-QIs) were developed with patients and health system stakeholders, are being implemented across the province to assess and report patient experiences in primary care. To ensure that patients are central to thi …

28.08.2026journal-article

Occupational Medicine

Contact dermatitis among marking nut workers in rural India

U Kawalkar, R Sangale, A Gaidhane, A Mankar, P Kogade, S Aggarwal

Abstract Background Informal processing of Semecarpus anacardium (marking nut) provides livelihood to many women in rural India. The nut contains potent phenolic compounds with strong irritant and allergenic properties, yet occupational contact dermatitis related to this exposure remains poorly documented in community settings. Aims To describe the prevalence, clinical severity and occupational determinants of contact dermatitis among female informal workers involved in marking nut processing in rural Vidarbha, Ind …

28.08.2026journal-article

Palliative Medicine

Palliative care needs and experiences of patients with advanced heart failure and family caregivers in Asia: A mixed methods systematic review

Jingjing Li, Ping Guo, Hao Liu, Nikolaos Efstathiou

Background: The high prevalence of heart failure in Asia highlights the growing need for palliative care. However, access to palliative care remains limited. Understanding the palliative care needs and experiences of patients with heart failure and families is essential to inform policy and service development in diverse Asian contexts. Aims: To identify, appraise and synthesise recent evidence on palliative care needs and experiences of patients with advanced heart failure and family caregivers in Asia. Design: Mi …

28.08.2026journal-article

Clinical and Translational Discovery

Computational strategies to address therapeutic resistance in estrogen receptor‐positive breast cancer: A narrative review of molecular docking, molecular dynamics simulations, and emerging therapeutic targets

Emmanuel Ifeanyi Obeagu, Yaregal Asres

Abstract Background Estrogen receptor‐positive (ER+) breast cancer represents the most common molecular subtype of breast cancer and remains highly responsive to endocrine therapy. However, therapeutic efficacy is frequently compromised by acquired or intrinsic endocrine resistance, particularly through ESR1 mutations, altered receptor conformation, co‐regulatory mechanisms, and activation of compensatory signaling pathways such as PI3K/AKT/mTOR. Conventional drug‐discovery approaches are often slow, resource‐inten …

28.08.2026journal-article

American Journal of Physical Education and Health Science

Effect of Maitland Mobilization Combined with Kendall Corrective Exercise on Pain and Postural Alignment of Patients with Upper Cross Syndrome: Pilot Study

Naeem Ullah, Fatima Amjad, Qamar Jan, Wagma Wajid, Aamir Niaz, Komal Hameed

Upper Cross Syndrome (UCS) is a prevalent postural dysfunction resulting from muscle imbalances that causes forward head posture, rounded shoulders and thoracic kyphosis. Although manual therapy and corrective exercises are frequently performed, studies comparing the two have not been conducted extensively.To determine the feasibility and effectiveness of Maitland mobilizations alongside Kendall exercises in patients with UCS.A pilot single-blinded randomized controlled trial was performed involving 28 subjects (14 …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Personalization of therapy for infections caused by N. gonorrhoeae, C. trachomatis, M. genitalium and T. vaginalis. Part II. Evaluation of the clinical effectiveness of personalized therapy

E.S. Negasheva, N.V. Frigo, A.E. Guschin, A.Yu. Khachaturyan, I.R. Baskakova, O.V. Zhukova

Background. Currently used antimicrobial agents, their doses, and treatment durations are clearly defined by standards and clinical guidelines. Nevertheless, treating patients with sexually transmitted infections presents significant challenges despite the availability of highly effective drugs. In this connection, the transition to personalized treatment is relevant, which is consistent with the provisions of the Strategy for Research and Technological Development of the Russian Federation adopted in 2024. Objecti …