Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Alle Themen · Seite 41

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Palliative Medicine

Palliative care needs and experiences of patients with advanced heart failure and family caregivers in Asia: A mixed methods systematic review

Jingjing Li, Ping Guo, Hao Liu, Nikolaos Efstathiou

Background: The high prevalence of heart failure in Asia highlights the growing need for palliative care. However, access to palliative care remains limited. Understanding the palliative care needs and experiences of patients with heart failure and families is essential to inform policy and service development in diverse Asian contexts. Aims: To identify, appraise and synthesise recent evidence on palliative care needs and experiences of patients with advanced heart failure and family caregivers in Asia. Design: Mi …

28.08.2026journal-article

Clinical and Translational Discovery

Computational strategies to address therapeutic resistance in estrogen receptor‐positive breast cancer: A narrative review of molecular docking, molecular dynamics simulations, and emerging therapeutic targets

Emmanuel Ifeanyi Obeagu, Yaregal Asres

Abstract Background Estrogen receptor‐positive (ER+) breast cancer represents the most common molecular subtype of breast cancer and remains highly responsive to endocrine therapy. However, therapeutic efficacy is frequently compromised by acquired or intrinsic endocrine resistance, particularly through ESR1 mutations, altered receptor conformation, co‐regulatory mechanisms, and activation of compensatory signaling pathways such as PI3K/AKT/mTOR. Conventional drug‐discovery approaches are often slow, resource‐inten …

28.08.2026journal-article

American Journal of Physical Education and Health Science

Effect of Maitland Mobilization Combined with Kendall Corrective Exercise on Pain and Postural Alignment of Patients with Upper Cross Syndrome: Pilot Study

Naeem Ullah, Fatima Amjad, Qamar Jan, Wagma Wajid, Aamir Niaz, Komal Hameed

Upper Cross Syndrome (UCS) is a prevalent postural dysfunction resulting from muscle imbalances that causes forward head posture, rounded shoulders and thoracic kyphosis. Although manual therapy and corrective exercises are frequently performed, studies comparing the two have not been conducted extensively.To determine the feasibility and effectiveness of Maitland mobilizations alongside Kendall exercises in patients with UCS.A pilot single-blinded randomized controlled trial was performed involving 28 subjects (14 …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Personalization of therapy for infections caused by N. gonorrhoeae, C. trachomatis, M. genitalium and T. vaginalis. Part II. Evaluation of the clinical effectiveness of personalized therapy

E.S. Negasheva, N.V. Frigo, A.E. Guschin, A.Yu. Khachaturyan, I.R. Baskakova, O.V. Zhukova

Background. Currently used antimicrobial agents, their doses, and treatment durations are clearly defined by standards and clinical guidelines. Nevertheless, treating patients with sexually transmitted infections presents significant challenges despite the availability of highly effective drugs. In this connection, the transition to personalized treatment is relevant, which is consistent with the provisions of the Strategy for Research and Technological Development of the Russian Federation adopted in 2024. Objecti …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Drug-induced sarcoid-like reaction during BRAF/MEK inhibitor therapy for metastatic melanoma

A.N. Khlebnikova, V.E. Shikina, A.V. Semenkov, A.I. Zotov, G.R. Setdikova

In recent years, targeted therapy with BRAF/MEK inhibitors has been successfully used for treating metastatic melanoma. Although generally well tolerated, it may lead to the development of both systemic and cutaneous side effects. The most frequently reported adverse events include nausea, vomiting, diarrhea, pyrexia, chills, and hypertension. Cutaneous side effects manifest as alopecia, acneiform rash, maculopapular rash, dry skin, and photosensitivity reactions. Cases of squamous cell carcinoma and keratoacanthom …

28.08.2026journal-article

Pharmaceuticals

Precision Pharmacotherapy for Obstructive Sleep Apnea: Matching Targeted Drugs to Patient Endophenotypes

Jayoung Oh, Ji Ho Choi

Background: Obstructive sleep apnea (OSA) remains under-treated because continuous positive airway pressure, though efficacious, is frequently limited by poor tolerance and adherence. Long considered a purely anatomical disease refractory to drugs, OSA is now understood as the shared endpoint of four measurable endotypes—a collapsible upper airway, poor pharyngeal dilator-muscle responsiveness, high loop gain, and a low arousal threshold—each a distinct pharmacological target. This review synthesizes the mechanisti …

28.08.2026journal-article

JAMA

Cardiovascular Magnetic Resonance to Guide Defibrillator Implantation for LVEF of 36% to 50%

Joseph B. Selvanayagam, John G. F. Cleland, Graham S. Hillis, Sivabaskari Pasupathy, Laurent Billot, Katherine E. George, John J. Atherton, Colin Berry, Ivaylo Tonchev, Chris Gianacas, Werner Jung, Sanjay K. Prasad, Carmine G. De Pasquale, Johannes Brachmann, Anand Ganesan, Cardiovascular Magnetic Resonance–Guided Management of Mild to Moderate Left Ventricular Systolic Dysfunction Trial Investigators, Rajiv Ananthakrishna, Margaret Arstall, Niall Campbell, Derek T Connelly, David Ferreira, Daniel Garofalo, Jemima Gore, Suchi Grover, John Hill, Nicola Johnston, Alamgir Kabir, David Kaye, Sau Lee, Tina Lin, Scott Lorensini, Jakob Lüker, Paul D MacIntyre, Christian Mahnkopf, Andrew Martin, Gerry P McCann, Ashley Nisbet, Gaetano Nucifora, Bhupesh Pathik, Andreas Pflaumer

Importance Current guidelines do not recommend primary prevention implantable cardioverter-defibrillators (ICDs) unless a patient’s left ventricular ejection fraction (LVEF) is 35% or less. Many sudden cardiac deaths (SCD) occur when LVEF is 36% to 50%. Myocardial scar (a key arrhythmic substrate) can be assessed by late gadolinium enhancement on cardiovascular magnetic resonance (CMR), but robust evidence is lacking regarding a scar-based approach to ICD insertion. Objective To determine whether implantation of IC …

28.08.2026journal-article

Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale

08 | Monitoring chronic diseases and risk stratification through clinical data repository in the Local Health Authority of Enna

V. Calabrese, M. C. Burgio, P. La Paglia, A. Di Pasquale, L. Gritti, N. La Grotteria, R. Miserendino, M. Zappia, A. Allotta, A. Cristaldi, V. Restivo, S. Scondotto

Background. Chronic diseases represent a major public health priority due to population ageing and the increasing burden of multimorbidity. Reliable tools for estimating disease prevalence and stratifying the population are essential to plan health assistance level, according to the objectives of the Italian National Chronicity Plan. The Clinical Data Repository (called Banca Dati Assistiti, BDA) is a valuable resource for population health management and the implementation of community-based care pathways. Materia …

28.08.2026journal-article

Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale

03 | Knowledge about human papillomavirus and its vaccination and willingness to accept human papillomavirus vaccination in a population of students from the Local Health Authorities of Agrigento, Palermo and Trapani, Western Sicily

C. Amodeo, F. Cacioppo, N. Bonaccorso, M. Sciortino, E. Zarcone, M. Tocco, L. Pipitone, A. Carubia, L. D'Azzo, G. Bosco, R. Asciutto, V. Di Gaetano, G. Canzoneri, F. Di Gregorio, L. Vitale, L. Vinci, A. Graceffa, V. Spoto, D. Mirabile, S. Palmeri, S. Paolizzo, F. Vitale, A. Casuccio, E. Amodio, A. Pieri, G. Graziano, W. Mazzucco, C. Costantino

Background. Human papillomavirus (HPV) is one of the most common sexually transmitted infection and is associated with the development of several diseases, including malignancies such as cervical, anal, vulvar, vaginal penile, oropharyngeal cancers and benign lesions such as genital warts. HPV vaccination is a highly effective and safe primary prevention intervention; however, uptake of vaccination programs is strongly influenced by the level of knowledge and perceptions of the target population, particularly among …

28.08.2026journal-article

International Journal For Multidisciplinary Research

Clinical Efficacy of Agnikarma in Karnini Yoni Vyapada Associated With Infertility – A Case Report

Sweta Raiyani, Shilpa Donga

Introduction: Infertility is a multifactorial condition in which cervical factors, including chronic inflammation and abnormal tissue changes, play a significant role. Among various treatment modalities, Agnikarma, a parasurgical thermal cauterization procedure, is known for its ability to remove unhealthy tissue and alleviate chronic inflammation. Case Description: A 25-year-old female presented to the OPD of Prasuti Tantra and Stri-Roga at ITRA, Jamnagar, with complaints of per vaginal white discharge and itching …

28.08.2026journal-article

Frontiers in Medicine

Association between blood urea nitrogen-to-creatinine ratio and mortality risk in critically ill patients with ventilator-associated pneumonia: a retrospective study

Lei Liu, Qiuli He, Muhuo Ji, Jun Liu

Background Ventilator-associated pneumonia (VAP) is a frequent complication of mechanical ventilation that increases mortality and strains healthcare resources. The blood urea nitrogen-to-creatinine ratio (UCR) is a readily available marker of renal function and hydration status. We investigated the association between UCR and short-term mortality in critically ill patients with VAP. Methods This retrospective cohort study used data from the MIMIC-IV database and included 2,037 patients with VAP admitted to the int …

28.08.2026journal-article

Journal of Molecular Modeling

Molecular insights and ADMET profiling of iridoids as candidate leads for erectile dysfunction therapy

Marcos Aurélio Carpina de Oliveira Filho, Jacilene Silva, Victor Moreira de Oliveira, Damião Sampaio de Sousa, Matheus Nunes da Rocha, Márcia Machado Marinho, Emmanuel Silva Marinho

Abstract Context Erectile dysfunction (ED) significantly affects male psychosocial health and has an increasing incidence. Although phosphodiesterase 5 (PDEi-5) inhibitors are the first-line therapy, the occurrence of visual side effects resulting from cross-inhibition of the PDE-6 isoform limits their adoption. In this context, the plant Veronica anagallis-aquatica L. emerges as a promising source of bioactive therapeutic compounds. This work investigated the inhibitory potential and selectivity of eight iridoid g …

28.08.2026journal-article

American Journal of Occupational Therapy

GenAI in Occupational Therapy: A Survey of Adoption, Ethical Concerns, and Training Needs

Adam Lockwood, Ryan Farmer, Tara Mansour

Importance Occupational therapy practitioners are rapidly adopting generative artificial intelligence (GenAI) tools in clinical settings, yet little is known about current usage patterns, ethical concerns, or training needs specific to the profession. Objective To examine how occupational therapy practitioners are using GenAI in practice and explore their ethical concerns, and training needs. Design Cross-sectional survey study. Participants 277 occupational therapists; 77 occupational therapy assistants with a mea …

28.08.2026journal-article

Frontiers in Public Health

Subnational inequalities and preventable gaps in drowning premature mortality and non-fatal health loss among population younger than 20 years

Gengfeng Su, You Zeng, Wenyi Jin, Queran Lin, Shihao Wang, Pi Guo, Junyan Xi, Lian Liang, Jiajia Wang, Bingying Fan, Min Huang, Jingxuan Jia, Xiaoliang Huang, Xiao Lin

Background Drowning remains a preventable cause of premature mortality among children and adolescents. National estimates can monitor progress, but may not identify subnational locations where risk remains high. We examined drowning burden in the population younger than 20 years in 2023, focusing on age patterns, national differences, subnational variation, and frontier gaps. Methods We analyzed 1990–2023 population health estimates for drowning. Deaths, disability-adjusted life-years (DALYs), death rates, and DALY …

28.08.2026journal-article

Informatica

Explainable Graph Convolutional Network Framework for Robust ECG Arrhythmia Classification and Patient-Level Risk Stratification

Abu Monsur Mohammad Fahim, Md. Eftekhar Alam, Md Saiful Islam, Riadul Islam Rabbi, Ekramul Haque Tusher, Md. Jakir Hossen, Aritra Mohajan

Accurate and interpretable detection of arrhythmias from electrocardiogram (ECG) signals plays a critical role in the early cardiac risk assessment and patient management. This paper presents a novel, explainable framework that leverages a dynamic Graph Convolutional Network (GCN) to model ECG beat sequences as graphs, where beats act as nodes and temporal RR-interval relationships forms edges. Our approach integrates comprehensive preprocessing steps, including feature selection, Synthetic Minority Oversampling Te …

28.08.2026journal-article

Frontiers in Pharmacology

Chinese medicine interventions for cerebral small vessel disease-related cognitive impairment: a systematic review and meta-analysis

Miaomiao Zhao, Xiangyi Zheng, Yulin Mu, Genming Zhang, Xinxing Lai

Background Cerebral small vessel disease–related cognitive impairment (CSVD-CI) is a common and clinically important challenge of cerebral small vessel disease, but effective therapeutic options remain limited. Chinese medicine interventions (CMIs) may be beneficial, although the evidence is uncertain. Purpose To evaluate the efficacy and safety of CMIs for adults with CSVD-CI and assess evidence certainty. Study design Systematic review and meta-analysis of randomized controlled trials. Methods Eight databases wer …

28.08.2026journal-article

Journal of Innovative Optical Health Sciences

Diabetes mellitus progression exacerbates post-stroke damage and diminishes the efficacy of urokinase

Shaojun Liu, Jiawei Huang, Tingting Yu, Valery V. Tuchin, Dongyu Li, Dan Zhu

Stroke is a leading cause of global mortality, and diabetes mellitus (DM) is an independent risk factor for ischemic stroke. Although longer DM duration is associated with increased stroke risk, how disease progression influences post-stroke pathology and thrombolytic efficacy remains poorly understood. This study investigated the impact of different durations of DM on vascular structure and function after an ischemic stroke, as well as the efficacy of urokinase thrombolysis in male streptozotocin-induced type 1 di …

1 Zitationen
28.08.2026journal-article

Psychotherapy and Psychosomatics

Back to gut feelings. Latent class analysis of daily perceived health variations identifies later responses to antidepressant treatment

Laura Di Lodovico, Charles Westphalen, Chloé Tezenas du Montcel, Loïck Le Tertre, Philippe Courtet, Philip Gorwood

Major depressive disorder (MDD) is a prevalent and disabling condition, yet predicting individual response to antidepressants remains difficult. Traditional symptom-based assessments, typically conducted weeks apart, may miss early and dynamic changes. Daily self-reported measures of wellbeing dimensions, particularly via simple tools such as visual analog scales (VAS), could provide ecologically valid and patient-centered markers of early treatment response. This study aimed to identify distinct early trajectories …

28.08.2026journal-article

International Journal of Social Sciences and Public Administration

A Control-Based Differentiated Framework for the Content Governance Obligations of Generative Artificial Intelligence Service Providers

Shengtao Tai

The content governance obligations of generative artificial intelligence (GAI) service providers constitute a central issue in contemporary AI regulation. Existing legal frameworks, however, impose substantially uniform content governance obligations on GAI service providers without adequately accounting for the significant differences among various service models. Drawing upon risk-control theory, this Article argues that the content governance obligations of GAI service providers should be differentiated accordin …

28.08.2026journal-article

Frontiers in Public Health

Meteorological drivers and short-term prediction of dengue fever in a tropical region of China: evidence from Hainan Province

Yiyao Lian, Yan Jin, Yufei Wang, Li Qiu, Jingjing Chen, Yuqing Guo, Rui Jiang, Dapeng Yin, Wenbiao Hu, Liping Wang

Objective Meteorological factors influence dengue transmission through nonlinear and lagged effects. This study assessed these associations in Hainan Province and developed an early risk prediction index. Methods Weekly dengue case and meteorological data from Hainan Province (2018–2019 and 2023–2024) were analyzed using distributed lag non-linear models (DLNMs). An early risk prediction index(ERPI) was constructed from DLNM-derived cumulative meteorological risk signals and imported cases. Predictive performance w …

28.08.2026journal-article

Frontiers in Medicine

The impact of preoperative inflammatory indices on retinal vessel density and macular perfusion after anti-VEGF treatment in branch retinal vein occlusion (BRVO) using wide-field SS-OCTA

Rong Hu, Chen Zeng, Hao Cui, Ming Li, Chong Tang, Qi Li

Background This study aimed to comprehensively explore the macular perfusion and topographic distributions of retinal vessel alterations in branch retinal vein occlusion (BRVO)-affected eyes that had been treated with an anti-vascular endothelial growth factor (anti-VEGF) intravitreal injection for 1 month prior, using swept-source optical coherence tomography angiography (SS-OCTA). Methods Thirty BRVO-affected patients with macular edema (ME) who had received anti-VEGF treatment were included in this observational …

28.08.2026journal-article

Frontiers in Public Health

The Age Friendly Supermarket Index: a Delphi study and psychometric analysis

Sok Leng Che, Wai In Lei, Sok Man Leong

Background and objectives Person–environment interactions shape how individuals evaluate their surroundings, and perceived age friendliness influences intentions to age in place. Supermarkets, as essential components of daily urban life, play a critical role in supporting older adults’ community participation. This study aimed to develop and validate the Age Friendly Supermarket Index (AFSI), a comprehensive tool to assess and enhance supermarket age friendliness for older customers. Methods Indicators were generat …

28.08.2026journal-article

Journal of Health Organization and Management

The link between negative workplace gossip and employee creativity in healthcare organizations – a moderated mediation model

Hany M. Galal, Rania M. El Morsy

Purpose This study aims to investigate how negative workplace gossip (NWG), defined as informal and critical talk about absent colleagues, reduces employee creativity in healthcare organizations. Drawing on social cognitive theory (SCT) and self-determination theory (SDT), the study examines how proactive personality (PP), a stable tendency to initiate change, and organization-based self-esteem (OBSE), employees’ context-specific sense of value and competence, function as protective psychological resources. Specifi …

28.08.2026journal-article

International Journal of Clinical Pharmacy

Developing a core competency framework for psychiatric pharmacists: a Europe-wide e-Delphi consensus study conducted by the European Society of Clinical Pharmacy Mental Health Special Interest Group

Ivana Tašková, Rosalind Gittins, Nikolaus Riesenhuber, Matej Stuhec, Martina Hahn, Nicole Šafářová, Daniela Fialová, Ita Fitzgerald

Abstract Introduction Consensus on essential clinical activities of psychiatric pharmacists is currently unavailable. Agreement on core non-clinical roles relating to research, education, leadership and management is also unavailable. Consensus on the core clinical and non-clinical functions of psychiatric pharmacists is urgently required to standardise the training of specialist pharmacists in psychiatric pharmacy and ensure the provision of high-quality patient care. Aim The European Society of Clinical Pharmacy …