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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Journal of Innovative Optical Health Sciences

Diabetes mellitus progression exacerbates post-stroke damage and diminishes the efficacy of urokinase

Shaojun Liu, Jiawei Huang, Tingting Yu, Valery V. Tuchin, Dongyu Li, Dan Zhu

Stroke is a leading cause of global mortality, and diabetes mellitus (DM) is an independent risk factor for ischemic stroke. Although longer DM duration is associated with increased stroke risk, how disease progression influences post-stroke pathology and thrombolytic efficacy remains poorly understood. This study investigated the impact of different durations of DM on vascular structure and function after an ischemic stroke, as well as the efficacy of urokinase thrombolysis in male streptozotocin-induced type 1 di …

1 Zitationen
28.08.2026journal-article

Psychotherapy and Psychosomatics

Back to gut feelings. Latent class analysis of daily perceived health variations identifies later responses to antidepressant treatment

Laura Di Lodovico, Charles Westphalen, Chloé Tezenas du Montcel, Loïck Le Tertre, Philippe Courtet, Philip Gorwood

Major depressive disorder (MDD) is a prevalent and disabling condition, yet predicting individual response to antidepressants remains difficult. Traditional symptom-based assessments, typically conducted weeks apart, may miss early and dynamic changes. Daily self-reported measures of wellbeing dimensions, particularly via simple tools such as visual analog scales (VAS), could provide ecologically valid and patient-centered markers of early treatment response. This study aimed to identify distinct early trajectories …

28.08.2026journal-article

International Journal of Social Sciences and Public Administration

A Control-Based Differentiated Framework for the Content Governance Obligations of Generative Artificial Intelligence Service Providers

Shengtao Tai

The content governance obligations of generative artificial intelligence (GAI) service providers constitute a central issue in contemporary AI regulation. Existing legal frameworks, however, impose substantially uniform content governance obligations on GAI service providers without adequately accounting for the significant differences among various service models. Drawing upon risk-control theory, this Article argues that the content governance obligations of GAI service providers should be differentiated accordin …

28.08.2026journal-article

Frontiers in Public Health

Meteorological drivers and short-term prediction of dengue fever in a tropical region of China: evidence from Hainan Province

Yiyao Lian, Yan Jin, Yufei Wang, Li Qiu, Jingjing Chen, Yuqing Guo, Rui Jiang, Dapeng Yin, Wenbiao Hu, Liping Wang

Objective Meteorological factors influence dengue transmission through nonlinear and lagged effects. This study assessed these associations in Hainan Province and developed an early risk prediction index. Methods Weekly dengue case and meteorological data from Hainan Province (2018–2019 and 2023–2024) were analyzed using distributed lag non-linear models (DLNMs). An early risk prediction index(ERPI) was constructed from DLNM-derived cumulative meteorological risk signals and imported cases. Predictive performance w …

28.08.2026journal-article

Frontiers in Medicine

The impact of preoperative inflammatory indices on retinal vessel density and macular perfusion after anti-VEGF treatment in branch retinal vein occlusion (BRVO) using wide-field SS-OCTA

Rong Hu, Chen Zeng, Hao Cui, Ming Li, Chong Tang, Qi Li

Background This study aimed to comprehensively explore the macular perfusion and topographic distributions of retinal vessel alterations in branch retinal vein occlusion (BRVO)-affected eyes that had been treated with an anti-vascular endothelial growth factor (anti-VEGF) intravitreal injection for 1 month prior, using swept-source optical coherence tomography angiography (SS-OCTA). Methods Thirty BRVO-affected patients with macular edema (ME) who had received anti-VEGF treatment were included in this observational …

28.08.2026journal-article

Frontiers in Public Health

The Age Friendly Supermarket Index: a Delphi study and psychometric analysis

Sok Leng Che, Wai In Lei, Sok Man Leong

Background and objectives Person–environment interactions shape how individuals evaluate their surroundings, and perceived age friendliness influences intentions to age in place. Supermarkets, as essential components of daily urban life, play a critical role in supporting older adults’ community participation. This study aimed to develop and validate the Age Friendly Supermarket Index (AFSI), a comprehensive tool to assess and enhance supermarket age friendliness for older customers. Methods Indicators were generat …

28.08.2026journal-article

Journal of Health Organization and Management

The link between negative workplace gossip and employee creativity in healthcare organizations – a moderated mediation model

Hany M. Galal, Rania M. El Morsy

Purpose This study aims to investigate how negative workplace gossip (NWG), defined as informal and critical talk about absent colleagues, reduces employee creativity in healthcare organizations. Drawing on social cognitive theory (SCT) and self-determination theory (SDT), the study examines how proactive personality (PP), a stable tendency to initiate change, and organization-based self-esteem (OBSE), employees’ context-specific sense of value and competence, function as protective psychological resources. Specifi …

28.08.2026journal-article

International Journal of Clinical Pharmacy

Developing a core competency framework for psychiatric pharmacists: a Europe-wide e-Delphi consensus study conducted by the European Society of Clinical Pharmacy Mental Health Special Interest Group

Ivana Tašková, Rosalind Gittins, Nikolaus Riesenhuber, Matej Stuhec, Martina Hahn, Nicole Šafářová, Daniela Fialová, Ita Fitzgerald

Abstract Introduction Consensus on essential clinical activities of psychiatric pharmacists is currently unavailable. Agreement on core non-clinical roles relating to research, education, leadership and management is also unavailable. Consensus on the core clinical and non-clinical functions of psychiatric pharmacists is urgently required to standardise the training of specialist pharmacists in psychiatric pharmacy and ensure the provision of high-quality patient care. Aim The European Society of Clinical Pharmacy …

28.08.2026journal-article

Medicine

Patterns of non-psychotropic medication use and polypharmacy in patients with psychiatric disorders

Yoriyasu Uju, Tetsuto Kanzaki, Riho Hosoi, Seisuke Mimori, Tsuyoshi Takizawa, Tatsuro Hayakawa

Patients with psychiatric disorders often have various physical diseases that may be associated with an increase in the number of prescribed drugs. Although clinical guidelines addressing antipsychotic polypharmacy are well established, there is limited evidence of non-psychotropic polypharmacy. To elucidate the actual state of inappropriate polypharmacy, this study examined the number and classes of prescribed medicines stratified by age and comorbidities in patients with psychiatric disorders. This cross-sectiona …

28.08.2026journal-article

Medicine

Bilateral advancement flaps in the treatment of divided nevus of the eyelid

Yan Yu, Fan Dai, Jie Gao, Tao Liu, Haijuan Sun, Yanrong Li

Divided eyelid nevus can affect facial appearance and is difficult to reconstruct after excision. We conducted a retrospective case series (N = 11) and reported the study according to the STROBE guidelines. Eleven patients aged 1–10 years with congenital divided eyelid nevi underwent single-stage excision followed by bilateral advancement flaps and canthal anchoring. Outcomes were evaluated using the Vancouver Scar Scale (VSS) and parent/guardian satisfaction scores. The median VSS score was 1 (interquartile range, …

28.08.2026journal-article

The Cardiothoracic Surgeon

Combined radiographic and ultrasonographic assessment of postoperative diaphragmatic dysfunction after cardiac surgery: incidence, predictors, and clinical outcomes — a prospective cohort study

Mohamed Khaled Elnagar, Mohamed Moustafa Abdelaal, Wael Mohamed Elfeky, Mohamed Gamal Shaat, Amr Ahmed Ettish

Abstract Background Reported incidences of postoperative diaphragmatic dysfunction vary widely, largely because diagnostic criteria differ and preoperative imaging is seldom available; whether anatomical elevation, contractile impairment, or their combination carries clinical consequence is undefined, and the reproducibility of any composite definition has not been established. We prospectively studied 169 adults undergoing cardiac surgery, pairing standardised pre- and postoperative chest radiography with quantita …

28.08.2026journal-article

JMIR Nursing

Radar-Based Contactless Monitoring in Different Inpatient Nursing Care Settings: Mixed Methods Feasibility Study

Madeleine Ritter-Herschbach, Sebastian Hofstetter, Dominik Behr, Melina Hager, Burkhard Mueller, Patrick Jahn

Abstract Background Monitoring of vital signs is a critical component of nursing care, facilitating the early detection of complications, enabling the observation of the progression of health status, and providing a foundation for diagnosis and therapeutic decision-making. It is instrumental in ensuring quality of care. Contactless measurement methods, such as radar-based sensors, have the potential to enable continuous monitoring of respiration, heart rate, and bed activity without disturbing or stressing vulnerab …

28.08.2026journal-article

Sports Medicine

Biomechanics of Rugby Tackle Techniques in Youth and Adult Players: A Systematic Review of Age-Specific Injury Risk and Performance Implications

Henry C. A. Edgington, Bernard X. W. Liew, Sharief. Hendricks, Benjamin Jones, Behnam Gholami, Matthew Barrett, Abishek Gurung, Jason Moran

Abstract Background Tackling is a vital skill in rugby that greatly influences both performance outcomes, such as carry distance and possession gain, and injury risk, such as the frequency of concussions and cervical injuries. Approximately 72% of head impacts in rugby occur during tackles, leading to concussions and cervical trauma. Technical skill in tackle mechanics is therefore central to player safety. Objectives This systematic review evaluates tackle biomechanics across age groups to identify differences in …

28.08.2026journal-article

Bioengineering

Burn Extent and Fitzpatrick Skin Tone Assessment from Clinical Photographs: Systematic and Random Error in Multimodal Large Language Models

Ibrahim Güler, Armin Kraus, Gerrit Grieb, Henrik Stelling

Background: Burn extent guides triage, transfer and fluid resuscitation, yet its clinical estimation is imprecise and observer-dependent. Multimodal large language models (MLLMs) process clinical photographs without task-specific training, but their error has rarely been separated into systematic and random components or their performance across skin tones characterized. Methods: Three state-of-the-art MLLMs (Gemini 3.1 Pro, GPT-5.6 Sol, and Fable 5) each assessed 153 burn photographs five times under an identical …

28.08.2026journal-article

Hacettepe University Faculty of Health Sciences Journal

Classification Profile of Swimmers with Physical Impairments in Turkey

Nazli Busra Cigercioglu, Sercan Yıllı, Büşra Kalkan Balak

Objectives: The purpose of this study was to examine the classification profile of swimmers with physical disabilities in Turkey.Materials and Methods: In this cross-sectional study, 192 physically impaired swimmers (132 males, 60 females; mean age 20.8 ± 4.2 years) were evaluated. Athletes were classified according to the IPC functional classification system (S1–S10) based on standardized medical and technical assessments in line with World Para Swimming Classification Rules. Descriptive statistics and chi-square …

28.08.2026journal-article

Advanced Healthcare Materials

Biodegradable Biomimetic Nanoplatform Orchestrating an Oxygen–Lactate Cascade to Enhance Photothermal Immunotherapy

Shuo Gao, Yu Chen, Yan‐Xi He, Cong‐Min Huo, Hui‐Yu Cen, Si‐Ye Tong, Rui Huang, Chen Luo, Houjuan Zhu, Wei Xue, Jing‐Yi Zhu

ABSTRACT A biodegradable biomimetic nanoplatform (HMCDL@TK‐M) was constructed by combining hydrogen‐doped H x MoO 3 nanoparticles, dual‐drug loading, and a hybrid spinach–cancer cell membrane coating. The system features pH‐responsive biodegradability, tumor‐homing capability, and high NIR‐II photothermal conversion. An oxygen–lactate cascade, formed via thylakoid membrane‐mediated H 2 O 2 decomposition and lactate oxidase‐driven lactate oxidation, alleviates hypoxia and depletes lactate in the tumor microenvironme …

28.08.2026journal-article

Magnetic Resonance in Medicine

SeqEyes : An Open‐Source Toolbox for Synchronized Waveform/Trajectory Visualization in Pulseq

Xingwang Yong, Zheng Liu, Yiyun Dong, Haotian Hong, Yuting Chen, Paul Dubovan, Qiang Liu, Jiye Kim, Unay Dorken Gallastegi, Yohan Jun, Berkin Bilgic

ABSTRACT Pulseq enables vendor‐neutral description of MRI pulse sequences in human‐readable .seq files and is widely used for sequence development and sharing. During design and debugging, rapid evaluation of sequence timing across RF pulses, gradient waveforms, and ADC events is essential. This is particularly challenging for non‐Cartesian acquisitions, where waveform timing does not readily reveal the underlying k ‐space trajectory. Existing tools, however, provide limited interactive capabilities for this task. …

28.08.2026journal-article

Greenation International Journal of Engineering Science

Design and Development of a Web-Based Informed Consent Information System to Improve the Efficiency and Legal Compliance of Healthcare Administrative Services

Syifa Putri Carissa Candraningtyas, Yuyun Yunengsih, Rina Kurniawati

This study aims to design a web-based Informed Consent Information System to improve administrative efficiency and support the legality of healthcare services. The research method used is the Waterfall method, encompassing the stages of requirements analysis, system design, implementation, testing, and maintenance. The resulting system is a web-based application featuring patient data management, physician data management, medical procedure data, electronic medical procedure consent forms, electronic signatures, as …

28.08.2026journal-article

BMC Geriatrics

Psychometric properties and age- and gender-specific normative values of the Patient Health Questionnaire-4 among older adults aged 60 years and above

Nikolay Dimitrov, Elmar Brähler, Andreas Hinz, Bjarne Schmalbach, Jörg M. Fegert, Markus Zenger

Abstract Background Mental health problems in older adults are often underrecognized despite their substantial impact on health and well-being. Brief, valid screening tools with age-specific normative data are needed for this growing population. This study examined the psychometric properties of the Patient Health Questionnaire-4 (PHQ-4) and established age- and gender-specific normative values for adults aged 60 years and older in Germany. Methods Data were drawn from four nationally representative face-to-face ho …

28.08.2026journal-article

RSV

Promoção da saúde bucal no ambiente escolar

AYLLA LORENA GOMES LÔBO PALMA

Este estudo analisa estratégias de promoção da saúde bucal no ambiente escolar e sua articulação com a Atenção Primária à Saúde. Realizou-se pesquisa bibliográfica, de abordagem qualitativa, por meio de revisão narrativa de artigos científicos, legislação e documentos institucionais nacionais e internacionais. Os resultados mostram que a escola constitui espaço estratégico para formar hábitos de autocuidado, identificar necessidades e aproximar estudantes dos serviços públicos de saúde. Entretanto, ações educativas …

28.08.2026journal-article

Nursing Reports

Evaluation of the Impact and Satisfaction of Creating a Mother–Child Educational Podcast by University Nursing Students

Sergio Martínez-Vázquez, Rocío Adriana Peinado-Molina, María Antonia Díaz-Ogállar, Antonio Hernández-Martínez, Juan Miguel Martínez-Galiano

Aim: To evaluate the effect of a student-generated podcast intervention focused on maternal–child health topics on nursing students’ self-perceived knowledge, educational satisfaction, and gameful engagement. Introduction: Health education is essential for promoting healthy lifestyles and preventing disease, making the acquisition of effective communication skills vital for nursing undergraduates. While digital audio media and podcasts are increasingly popular pedagogical tools, traditional applications rely on pas …

28.08.2026journal-article

Oncologie

Gut microbiota-mediated programmed cell death in colorectal cancer: implications for precision medicine

Wei Liu, Wei Zhang

Abstract Colorectal cancer (CRC) remains a major global health burden, with marked interindividual variability in disease progression and therapeutic response. Emerging evidence suggests that the gut microbiota shapes CRC biology not only through inflammation and metabolism, but also by regulating programmed cell death (PCD) pathways that may influence tumor cell fate and treatment sensitivity. This review summarizes recent advances in microbiota-mediated regulation of major PCD modalities relevant to CRC, includin …

28.08.2026journal-article

Archives of Orthopaedic and Trauma Surgery

Patient-reported outcomes after lateral unicompartmental and total knee arthroplasty: a propensity score-matched cohort study

Mustafa Hariri, Reza Sorbi, Babak Moradi, Johannes Weishorn, Raphael Trefzer, Tobias Reiner, Tilman Walker, Timo Albert Nees

Abstract Introduction Comparative evidence on patient-reported outcomes (PROs) after lateral unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) remains limited. We compared PROs between cohorts matched for demographic characteristics and baseline knee function. Materials and methods Prospectively collected single-center data were retrospectively analyzed. Lateral UKA was performed for isolated lateral-compartment osteoarthritis and TKA predominantly for multicompartmental disease. One-to-one …

28.08.2026journal-article

Frontiers in Oncology

Combination therapy with Nifuroxazide and Lenvatinib exerts superior anti-hepatocellular carcinoma effect by enhancing the anti-tumor immune response

Jing Yang, Jiaxin Geng, Yue Yin, Kangle Wang, Leyao Tian, Jingyi Wang, Huijie Jia, Lei Wang, Yongxi Zhang, Tiesuo Zhao

Background Lenvatinib is a first-line multi-target tyrosine kinase inhibitor for hepatocellular carcinoma (HCC) that exerts anti-angiogenic effects by blocking VEGF signaling. However, its clinical efficacy is often compromised by adaptive resistance. Nifuroxazide, an anti-diarrheal agent, has been identified by our group as a potent inhibitor of PD-L1 expression in HCC. Objective This study aimed to evaluate the therapeutic potential and underlying molecular mechanisms of nifuroxazide combined with lenvatinib agai …