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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Research on Social Work Practice

An Initial Outcome Evaluation of Assisted Outpatient Treatment Under Tim's Law in Kentucky

Aubrey E. Jones, Aaron R. Brown, Opeyemi Daramola, Olivia Raley, Tara Brewer, David T. Susman, Sheila Barnhart, Justin “Jay” Miller

Purpose The purpose of this study was to assess four outcomes among participants in Kentucky's assisted outpatient treatment (AOT) program, which was created under Tim's Law, enacted in 2017. AOT is a court-ordered, community-based treatment approach for individuals living with serious mental illness. Method Quantitative data were collected for 220 AOT participants in Kentucky from July 2020 through December 2025 using administrative data, provider-completed administrative interviews, and structured interviews with …

26.08.2026journal-article

Diagnostics

Genotyping and Cytology Co-Testing for Anal Cancer Screening: Exploratory Evaluation of Cumulative HPV Genotype Burden as a New Potential Marker for Risk Stratification

Cristina Sani, Claudia Giachini, Giampaolo Pompeo, Alessandra Mongia, Irene Paganini, Stephanie Pacella, Sara Galastri, Serena Giunti, Ornella Cutaia, Luigi Pisano, Giuseppe Gorini, Alessandro Senape, Martina Turco, Jacopo Farini, Filippo Caminati, Claudio Elbetti, Iacopo Giani, Nicola Pimpinelli, Stefania Cannistrà, Simonetta Bisanzi

Background/Objectives: Anal squamous cell carcinoma (SCCA) is a rare Human Papillomavirus (HPV)-related disease in the general population but its incidence is increasing among high-risk populations, i.e., men who have sex with men (MSM), HIV+ patients and women with a history of cervical/vulvar dysplasia. The objectives of this study were: (i) to investigate the prevalence of high-risk (HR) and low-risk (LR) anal HPV infections in a high-risk cohort; (ii) to correlate specific HPV genotypes with cytological and his …

26.08.2026journal-article

Frontiers in Oncology

Clinical stratification utility of HER2, PD-L1, MSI/MMR, and CLDN18.2 in conversion therapy for gastric cancer: narrative review

Tao Ding, Peiqiang Chen, Huajiong Yu

Most patients with gastric cancer considered for conversion therapy present with locally advanced or metastatic disease, where surgery alone or conventional chemotherapy often provides limited benefit. Conversion therapy aims to reduce tumor burden through systemic treatment, reassess treatment response over time, and create an opportunity for radical surgery with complete tumor removal. This approach is mainly considered for patients with initially unresectable, borderline resectable, or limited metastatic disease …

26.08.2026journal-article

Neurosurgery

Systemic Adverse Effects of Intensive Blood Pressure Treatment After Craniotomy for Tumor Resection

Fatima Gauhar, Breanne Reisen, Jaiden Sutaria, Nick De Oliviera, Zhiguo Zhao, Fei Ye, Patrick D. Kelly

BACKGROUND AND OBJECTIVES: Postcraniotomy hypertension is commonly treated with intravenous (IV) antihypertensives to reduce hemorrhage risk. Intensive systolic blood pressure (SBP) control has been associated with adverse effects in hospitalized patients, but its impact after craniotomy is unclear. This study evaluated whether IV nicardipine use to achieve an SBP target <140 mm Hg is associated with hypoperfusion and other adverse outcomes after craniotomy. METHODS: We retrospectively reviewed 1997 adult craniotom …

26.08.2026journal-article

Cancer Immunology Research

Targeting ERO1A enhances antitumor immune response by recruiting CD8+T cells and synergizing with PD-L1 blockade in liver cancer

Jing Mao, Xu Sun, Caiyun Chu, Yujiu Liang, Jian Chu, Yinhang Wu, Shuwen Han

Abstract Despite the availability of various treatment modalities for liver cancer, its mortality rate remains high. Immunotherapy represents an emerging approach for liver cancer. However, the response rate to single-agent immune checkpoint blockade therapy is suboptimal. Endoplasmic reticulum oxidoreductase 1-alpha (ERO1A), a potential therapeutic target associated with endoplasmic reticulum (ER) stress, is implicated in impeding protective antitumor immunity. In this study, we found that targeting ERO1A in liver …

26.08.2026journal-article

Behavioral Sciences

Psychological Assessment of Parenting Stress and Emotional Support: A Moderated Mediation Model of Psychological Distress and Well-Being Among Childbearing-Age Women with Thyroid Cancer

Yinfeng Li, Min Peng, Yin-Ping Zhang

Women of reproductive age diagnosed with thyroid cancer face a distinctive psychological burden arising from the concurrent demands of disease management and primary caregiving, yet the mechanisms linking parenting stress to diminished well-being in this group remain poorly characterized. The present study applied a stress-buffering framework to examine whether psychological distress (anxiety and depressive symptoms) statistically mediated the association between parenting stress and well-being, and whether social …

26.08.2026journal-article

Scientific Reports

Exercise modality-specific acute myokine response and anti-cancer potential in breast cancer cell lines in vitro

Linda Laizane, Valdis Pirsko, Deina Vilite, Ingrida Mirte, Kristiana Rozensteina, Jelena Raudeniece, Gundega Akuratere, Ilze Justamente-Pilena, Diana Lismane, Maksims Zolovs, Alina Zolova, Aija Klavina, Arvids Irmejs, Carmen Ramírez-Castillejo, Bart Roelands, Dace Reihmane

Abstract Exercise-induced myokines mediate the systemic communication between muscle and tumor cells. However, how exercise-conditioned serum (ECS) affects different breast cancer (BC) subtypes remains largely unknown. This study investigated the intensity-dependent effects of an acute session of aerobic exercise on the myokine profile and the subsequent anti-cancer effect (ACE) of ECS on BC cell lines in vitro. In a crossover design, 18 premenopausal women completed three visits: a baseline measurement session fol …

26.08.2026journal-article

Frontiers in Oncology

MiR-150-5p suppresses high-grade transformation of lacrimal adenoid cystic carcinoma by downregulating COL1A1

Xiaoyu Zhu, Jinjie Liu, Meixia Jiang, Xun Liu, Shuang Chen, Tingting Lin, Limin Zhu

Lacrimal adenoid cystic carcinoma (LACC) is the most common malignant epithelial tumor of the lacrimal gland, with particularly high recurrence and mortality in cases with high-grade transformation (HGT-LACC). This study aims to investigate the functional role of miR-150-5p in regulating the HGT of LACC. MiRNA microarray and proteomic mass spectrometry were performed on paired LACC and HGT-LACC tissues to identify differentially expressed miR-150-5p and its potential target COL1A1. The miR-150-5p/COL1A1 interaction …

26.08.2026journal-article

Frontiers in Oncology

A journey mapping study of healthcare professionals’ involvement in fertility preservation for cancer patients

Di Xue, Aijun Zhu, Hongyuan Song, Meijuan Cheng, Zhenhua Lu, Huaijie Yang

Objective Based on journey mapping, this study aimed to identify the main tasks, key pain points, and emotional experiences of healthcare professionals throughout their involvement in fertility preservation for cancer patients, and to provide evidence for designing targeted interventions and optimizing fertility preservation services. Methods This qualitative study adopted purposive sampling to recruit 24 healthcare professionals from the departments of breast and thyroid surgery, oncology, and related departments …

26.08.2026journal-article

Frontiers in Neuroscience

Preliminary study on optimizing head position for endovascular treatment of anterior communicating artery aneurysms

Jin-Rong Zhang, Jing-Yu Li, Shu-Gai Liu, Zheng-Jun Wu, Qiu-Xia Liang, Xiao-Hong Yin, Bo Tan, Qiao-Jun Peng, Xiao-Ming Wang

Objective To evaluate the effects of optimized head positioning on procedural efficiency, device utilization, safety, and short-term postoperative activities of daily living in patients undergoing endovascular treatment for anterior communicating artery aneurysms (ACoAA), compared with conventional head positioning, and thereby assess its clinical value. Methods In this single-center randomized controlled study, 86 patients with ACoAAs scheduled for endovascular treatment at Guangyuan Central Hospital, Affiliated t …

26.08.2026journal-article

Current Opinion in Allergy & Clinical Immunology

Mechanisms and prospects of fecal microbiota transplantation in urticaria treatment via the gut skin axis

Xueli Yao, Keyang Wang, Ping Wang

Purpose of review This review focuses on fecal microbiota transplantation (FMT) for urticaria via the gut skin axis, highlighting its timeliness and clinical relevance as an emerging strategy for refractory urticaria. Recent findings Recent studies confirm that gut microbiota dysbiosis drives urticaria pathogenesis via immune regulation and mast cell activation, with preliminary clinical data showing FMT can alleviate symptoms and restore gut barrier function. Summary FMT holds promise as a novel therapeutic option …

26.08.2026journal-article

Angewandte Chemie International Edition

Boosting Diagnostic Accuracy of Prostate Cancer: Combining Clinical PSA Level and a Pair of NIR Fluorescent Probes for SLC39A1 and PSMA

Xiuzhu Huo, Fei Yang, Hong Wang, Jiao Chen, Mengyao She, Li Xue, Ping Liu, Shengyong Zhang, Jianli Li

ABSTRACT Prostate cancer (PCa) is a leading malignancy in men globally. Although serum prostate‐specific antigen (PSA) testing is prevalent for PCa screening, its inherent limitation in specificity and sensitivity frequently leads to high false‐positive and false‐negative diagnoses. To address this challenge, we present a PSA+ strategy that integrates a clinically defined PSA threshold (10 ng/mL) with a pair of complementary near‐infrared (NIR) fluorescent probes: a zinc‐complex‐based probe (Cy‐O‐NS‐a‐Zn) targeting …

26.08.2026journal-article

Head & Neck

Real‐World Treatment Trajectories Following Near‐Infrared Photoimmunotherapy in Head and Neck Cancer: Implications for Clinical Decision‐Making

Ryota Iinuma, Tomohiro Hasegawa, Takuro Tsunoki, Hiroshi Okuda, Ryoukichi Ikeda, Takenori Ogawa

ABSTRACT Purpose Near‐infrared photoimmunotherapy (PIT) is a relatively new locoregional treatment for head and neck cancer. However, real‐world data on its use in clinical practice, particularly regarding treatment trajectories, remain limited. This study described the clinical patterns following PIT in a real‐world setting. Methods This retrospective single‐center case series included 12 patients with head and neck cancer treated with PIT. Patients were grouped into four patterns based on their clinical courses: …

26.08.2026journal-article

JAMA Network Open

Surgical Management of Early-Onset Breast Cancer Among Young BRCA1 and BRCA2 Carriers

Stephanie M. Wong, Eva Blondeaux, Virginia Delucchi, Florence Coussy, Rinat Bernstein Molho, Sabine Linn, Antonio Di Meglio, Ava Kwong, Katarzyna Pogoda, Elisa Agostinetto, Ines Nevelsteen, Judith Balmaña, Halle C. F. Moore, Angela Toss, Alberta Ferrari, Christine Rousset-Jablonski, Tiphaine Renaud, Kelly-Anne Phillips, Fedro A. Peccatori, Maria Agustina Ipina, Shani Paluch-Shimon, Jai Min Ryu, Wanda Cui, Minna Lee, Robert Fruscio, Mariya Rozenblit, Claudio Vernieri, Alexios Matikas, Maria Vittoria Dieci, Fergus J. Couch, Laura De Marchis, Shelley E. Hwang, Dione Aguilar y Mendez, Deniz Can Guven, Monique Swain, Caterina Gianni, Stefano Spinaci, Giacomo Montagna, Matteo Lambertini, Hee Jeong Kim

Importance Young BRCA carriers may undergo breast-conserving surgery (BCS) or mastectomy with or without contralateral risk-reducing mastectomy at the time of an index breast cancer diagnosis. A variety of factors may influence surgical decision-making. Objective To explore surgical patterns of care and factors associated with uptake of bilateral mastectomy among affected BRCA1 or BRCA2 ( BRCA1/2 ) carriers diagnosed with early-onset breast cancer. Design, Setting, and Participants The BRCA BCY Collaboration is an …

26.08.2026journal-article

Tropical Medicine and Infectious Disease

Circulating Leukocytes and Antibody Isotype Reactivity in Rats Experimentally Infected with Different Burdens of Strongyloides venezuelensis, Before and After Treatment with Ivermectin or Dexamethasone

João Gustavo Mendes Rodrigues, Guilherme Silva Miranda, Genil Mororó Araújo Camelo, Caio Brandão Goes Gouveia, Deborah Aparecida Negrão-Corrêa

Strongyloidiasis is a neglected, potentially lifelong disease caused by Strongyloides stercoralis that can lead to a high mortality rate in immunocompromised hosts; therefore, it is necessary to increase the accuracy of infection diagnosis. In the current study, we used Wistar rats experimentally infected with different burdens of Strongyloides venezuelensis to characterize circulating leukocytes and IgM, IgG, IgG1, IgG2a, and IgA reactivity before and after anthelmintic treatment or immunosuppression. Infection, e …

26.08.2026journal-article

Frontiers in Oncology

Cytomegalovirus infection in patients receiving bispecific antibodies for multiple myeloma and B-cell malignancies: a single-center cohort and meta-analysis

Eduardo Aparicio-Minguijón, Isabel Rodríguez-Goncer, Nieves López-Muñoz, María Asunción Pérez-Jacoiste Asín, Guillermo Bartolomé Herguedas, Jorge Boán, Adolfo Jesús Sáez Marín, José María Sánchez-Pina, Joaquín Martínez-López, María Calbacho, José María Aguado, Mario Fernández-Ruiz

Background Bispecific antibodies (BsAbs) are transformative therapies for multiple myeloma (MM) and B-cell malignancies. Cytomegalovirus (CMV) infection has been reported as a potential complication of unclear clinical magnitude. Methods We conducted a retrospective study of MM patients treated with BsAbs at our institution (2020–2025), alongside a systematic review and meta-analysis of clinical trials and observational studies evaluating BsAbs for MM, B-cell lymphoma, and acute lymphoblastic leukemia. Study outcom …

26.08.2026journal-article

Obesity

Body Composition and Lifestyle Interventions in Pharmacological Treatment of Acquired Hypothalamic Obesity: A Systematic Review of Randomized Controlled Trials

Hanhan Yu, Jieping Wang, Mingyue Yin, Lili Ji, Shanshan Guo, Tiemin Liu, Ru Wang

ABSTRACT Objective This review aimed to systematically evaluate the effects of pharmacological interventions on body composition outcomes and lifestyle intervention as background therapy in patients with acquired hypothalamic obesity (aHO). Methods Searches were conducted in PubMed, Embase, the Cochrane Library, CINAHL, and CNKI for studies published between July 24, 2015, and November 8, 2025. Eligible studies were full‐text randomized controlled trials (RCTs) evaluating pharmacological and/or lifestyle weight man …

26.08.2026journal-article

Frontiers in Psychiatry

Agitation/excitement in male patients with treatment-resistant schizophrenia is associated with lower total cholesterol levels

Zhenkuo Li, Peng Xie, Cheng Yang, Lei Xia, Huanzhong Liu

Background Treatment-Resistant Schizophrenia (TRS) in males with agitation/excitement poses a clinical challenge. The pathophysiological mechanisms of agitation/excitement in Male TRS remain unclear. This study explores these mechanisms and investigates potential biomarkers for agitation/excitement. Method 180 Male TRS patients and 100 healthy controls were enrolled. Psychiatric symptoms and agitation/excitement were assessed using the Positive and Negative Syndrome Scale 5-factor model (PANSS-5F) and the PANSS-Exc …

26.08.2026journal-article

Frontiers in Neurology

Serum inflammatory cytokines predict 90-day outcome after endovascular treatment in acute ischemic stroke

Guo-Qing Zhao, Zi-Ai Zhao, Xiao-Tong Tang, Wei Zhang, Hui-Sheng Chen

Background and objective Inflammation plays a critical role in acute ischemic stroke (AIS) pathophysiology and may influence outcomes after endovascular treatment (EVT). However, the incremental prognostic value of inflammatory cytokines beyond conventional predictors remains unclear. This study aimed to investigate the association of cytokines with 90-day functional outcomes in EVT-treated AIS patients and evaluate their value in prognostic modeling. Methods Based on the prospective DETECT2-China registry, we incl …

26.08.2026journal-article

Frontiers in Medicine

Acupuncture-related therapies for opioid-induced constipation in patients with cancer: a systematic review and network meta-analysis

Xinkun Liu, Huaqiang Shao, Jiayue Yang, He Chen, Ruimin Jiao, Guangxian Yu, Jiaxiang Shi, Wenquan Su, E. Zhang, Yiqi Liang, Zhishun Liu, Weiming Wang

Objectives To evaluate the efficacy and safety of acupuncture-related therapies for opioid-induced constipation (OIC) in patients with cancer through pairwise and network meta-analysis (NMA). Methods We searched eight electronic databases from inception to June 28, 2025, and identified randomized controlled trials (RCTs) evaluating acupuncture-related therapies for OIC in cancer patients, with or without laxatives. Pairwise and Bayesian NMA were performed using R. Primary outcomes included constipation-related symp …

26.08.2026journal-article

Virchows Archiv

Assessment of EGFR and HER2 expression in penile cancer as potential therapeutic targets

Jan Niklas Mink, Jonas Boehle, Markus Eckstein, August Fiegl, Oybek Khalmurzaev, Alexey Pryalukhin, Carol Geppert, Stefan Lohse, Kristof Bende, João Lobo, Rui Henrique, Hagen Loertzer, Joachim Steffens, Carmen Jerónimo, Heiko Wunderlich, Rainer M. Bohle, Michael Stöckle, Vsevolod Matveev, Arndt Hartmann, Kerstin Junker

Abstract Penile cancer (PC) is a rare but aggressive malignancy with limited systemic treatment options, particularly in advanced stages. Targeted therapies against receptor tyrosine kinases such as EGFR and HER2 have demonstrated clinical benefit in other cancer types, yet their role in PC remains poorly defined. Understanding their expression patterns in primary tumors and metastases is essential for identifying new therapeutic avenues. In this study, we aimed to systematically assess the expression of EGFR and H …

26.08.2026journal-article

PLOS Global Public Health

Past hurts, present hurdles: Analyzing the impact of adult socioeconomic status and healthcare access on cancer screening among childhood abuse survivors

Qaidar Alizai, Azza Sarfraz, Meher Angez, Areesh Mevawalla, Odysseas P. Chatzipanagiotou, Abdulaziz Elemosho, Rida Ejaz, Kizuki Yuza, Sebastian Ekenze, Timothy M. Pawlik

Childhood abuse is associated with long-term health consequences and may influence uptake of preventive healthcare. We evaluated whether adult socioeconomic experiences and healthcare access modify the association between childhood abuse and adherence to U.S. Preventive Services Task Force (USPSTF) cancer screening guidelines. We analyzed 2020 Behavioral Risk Factor Surveillance System (BRFSS) data among respondents who answered the childhood abuse item and were eligible for colorectal (CRC; 50–74years), cervical ( …

26.08.2026journal-article

Rare Metals

A Locally Retentive HfO 2 –STING Nano‐Radiosensitizer Hydrogel for Enhanced Radioimmunotherapy in Esophageal Cancer

Dongdong Wang, Yubao Lyu, Yu Du, Yiping Lu, Chang He, Bo Yin, Dayu Huang, An Wang

ABSTRACT Esophageal squamous cell carcinoma (ESCC) remains associated with frequent local recurrence and distant metastasis despite advances in radiochemotherapy and immunotherapy, highlighting the need for therapeutic strategies that improve both local tumor control and systemic antitumor immune responses. Herein, we developed an Hf‐based radio‐immunotherapeutic platform composed of HfO 2 @PDA/cGAMP‐PEG nanoparticles (HPG NPs) embedded in a catechol‐modified methacrylated chitosan photocurable adhesive hydrogel (H …