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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

The impact of combination therapy for vulvar lichen sclerosus et atrophicus on the quality of life, psychoemotional profile and sexual function of women

N.I. Chernova, M.I. Proskurina, O.V. Dolya, I.S. Zadorozhnaya

Increasing incidence of vulvar lichen sclerosus et atrophicus (VLSA), chronic nature of the disease, severity of itching, and late complications with changes in the anatomy of the external genital organs lead to the development of a number of disorders, including psychoemotional and sexual dysfunctions, and significantly deteriorate the quality of life of patients. Long-term use of topical glucocorticosteroids (tGCSs) has a number of side effects, requires patient compliance, and does not ensure long-lasting diseas …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Nail lesions in a patient with vitiligo

R.V. Saranyuk

Vitiligo is a chronic skin disease of unknown etiology. The appearance of focal depigmentation of various localizations on the skin is its primary clinical manifestation. Vitiligo is considered one of the most common skin diseases. According to various authors, its prevalence ranges from 0.1% to 4%. This dermatosis has a significant impact on the quality of life of patients, especially when the foci of skin depigmentation are localized on visible areas of the body. In addition to the skin, vitiligo can affect hair …

28.08.2026journal-article

Malignant tumours

The mDCF combination as first-line therapy in patients with locally advanced or metastatic esophageal squamous cell carcinoma

V. V. Sokolovskiy, E. A. Dinaeva, A. A. Margusheva, A. A. Tryakin

Introduction. There is no consensus regarding the optimal first-line chemotherapy regimen for locally advanced or metastatic esophageal squamous cell carcinoma. The efficacy of standard chemotherapy combinations is limited and therefore has to be improved. Due to the limited accessibility of modern immunotherapy, chemotherapy remains a valuable commonly used option. We conducted a non-randomized prospective study to evaluate the efficacy and tolerability of the triple combination mDCF. Materials and Methods. The ma …

28.08.2026journal-article

Scientific Bulletin of the Dnipro State University of Internal Affairs

НОРМИ ПРАВА ЯК ДЖЕРЕЛА ОРГАНІЗАЦІЇ ПУБЛІЧНОГО КОНТРОЛЮ ЗА ДОДЕРЖАННЯМ ЗАКОНОДАВСТВА НА ТРАНСПОРТІ

Андрій СОБАКАРЬ, Володимир ШАТОХІН

У статті досліджено норми права як джерела організації публічного контролю за додержанням законодавства на транспорті. Обґрунтовано, що сучасне правове регулювання транспортної сфери в Україні формується в умовах поєднання національних і міжнародних нормативних засад, а ефективність контрольних процедур значною мірою залежить від рівня імплементації міжнародно-правових стандартів у внутрішнє законодавство. Установлено, що особливого значення у цій сфері набувають міжнародні договори, акти Європейського Союзу, а так …

28.08.2026journal-article

Health and Quality of Life Outcomes

Ordinal scaling properties of the WHO-5 among young adolescents in Moldova and North Macedonia: a Mokken Scale Analysis

Antonio Piolanti, Christina Glasauer, Yulia Shenderovich, Dennis Wienand, Judit Simon, Bojan Shimbov, Heather M. Foran

Abstract Background The World Health Organization Five Well-Being Index (WHO-5) is commonly applied to assess subjective well-being. However, evidence on its ordinal measurement properties among young adolescents, especially in low- and middle-income countries, is scant. In particular, there is a lack of studies that have comprehensively evaluated key Mokken model assumptions, including scalability, monotonicity and invariant item ordering. Evaluating these properties is important as they support the ordinal interp …

28.08.2026journal-article

Advancements in Health Research

Virtual reality-induced dopamine reward hypothesis for opioid addiction

Sarah Katz

While the opioid epidemic continues to plague the globe, scant research exists into the opportunities of virtual reality (VR) therapy for opioid addiction treatment. Furthermore, few to no studies have explored the potential of VR as a dopamine replacement solution for the dopamine deficiency caused by opioid withdrawal. Therefore, this theoretical research article sought to address this research gap by proposing a hypothesis framework involving VR exposure immediately following administration of the tapered opioid …

28.08.2026journal-article

Frontiers in Medicine

Mechanisms of and mitigating strategies for cellular immune responses to CRISPR-associated nucleases in genome editing therapy

Bryan Hu, Venkata Sumanth Reddy Gutty, Roland W. Herzog, Dongsheng Duan

Immunogenicity of CRISPR-associated nucleases (Cas) is a critical barrier to the development of safe and effective genome editing therapies. These proteins inherently pose a risk of immune recognition due to their prokaryotic origins. A multitude of factors, such as the delivery vehicle, the route of administration, components of the therapeutics, tissue microenvironment, and pre-existing immunity, also contribute to the complexity of the host immune response to Cas proteins. As CRISPR-based therapies advance into …

28.08.2026journal-article

European Geriatric Medicine

A survey among geriatricians on geriatric oncology and geriatric surgical oncology models in Europe

Paula Sobrini-Morillo, Isabelle Moens, Alfonso Cruz-Jentoft, Andrea Sebastiano Ciccone, Jugdeep K. Dhesi, Nicolas M. Gonzalez-Senac, Marije Hamaker, Cecilia Lund, Francesco Mattace-Raso, Nina Neuendorff, Siri Rostoft, David Shipway, Giuseppe Dario Testa, Anja Velghe, Harmke A. Polinder-Bos, on behalf of the SIG Perioperative Geriatric Medicine and the SIG Gero-Oncology of the European Geriatric Medicine Society

Abstract Purpose To provide an up-to-date overview of geriatricians’ involvement in oncological and onco-surgical care for older adults across Europe. Methods An anonymous 35-item online survey was distributed via (inter)national societies between 10 April and 23 May 2025. The responses were summarized, and associations between comprehensive geriatric assessment (CGA) outputs, participation in oncological multidisciplinary team (MDT) meetings, and involvement in treatment decision-making were explored. Results A to …

28.08.2026journal-article

Public Health Reports®

Social Media Use and Cardiovascular Health Among US High School Students

Ryan Saelee, Izraelle I. McKinnon, Sandra J. Kiplagat, Jelonia T. Rumph, Caitlin L. Merlo, Kelly Cornett, Sandra Leonard, Ahlia Sekkarie, Kathleen H. Krause, Jonetta Mpofu

Objectives: Cardiovascular health during adolescence can shape cardiovascular disease risk later in life. We examined the association between frequent social media use and cardiovascular health among US high school students. Methods: We used data from the 2023 national Youth Risk Behavior Survey to create cardiovascular health metrics based on the American Heart Association’s Life’s Essential 8 construct (range, 0-100), with a higher score representing better cardiovascular health. Metrics included diet, physical a …

28.08.2026journal-article

Scientific Notes of Junior Academy of Sciences of Ukraine

Management of documentation support for public informatization projects in the archival and library sectors

I. V. Bakum, I. V. Zakharova

The article examines the theoretical and practical foundations of managing documentation support for public informatization projects in the archival and library sectors in the context of digital transformation of public administration. The relevance of the research is substantiated by the active implementation of electronic archives, digital repositories, automated library and information systems, and other components of the digital infrastructure of documentary and cultural heritage. It is established that the eff …

28.08.2026journal-article

Journal of Orthopaedic & Sports Physical Therapy

Rehabilitation of Athletes With Hamstring Strain Injury: SONAFE-Brazil Clinical Practice Guideline

Bruno Manfredini Baroni, Rodrigo Ribeiro de Oliveira, Albino Luciano Abreu Pereira, Felipe Coimbra Meira, Filipe Abdalla dos Reis, Flavio Fernandes Bryk, Luiz Hespanhol, Katherinne Ferro Moura Franco, Larissa Santos Pinto Pinheiro, Natalia Franco Neto Bittencourt, Aline Carla Araújo Carvalho, Daniel Ferreira Moreira Lobato, Fábio Carlos Lucas de Oliveira, Rodolfo Borges Parreira, Verônica Colpani, Cynthia Gobbi Alves Araújo

The National Society of Sports Physical Therapy (SONAFE-Brazil), the official organization representing sports physical therapists in Brazil, developed this Clinical Practice Guideline to support clinicians and athletes in managing hamstring strain injury. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was employed to address the clinical question: “Which interventions provided by physical therapists improve rehabilitation outcomes in athletes with hamstring strain injury?” …

28.08.2026journal-article

International Journal of Social Sciences and Public Administration

The Role of Immersive Murder Mystery Games in Preventing Telecom Fraud among College Students

Sirui Xu

Telecom fraud represents a typical security risk on university campuses, severely undermining campus stability and safety. As fraudulent tactics continue to evolve, traditional anti-fraud models struggle to keep pace with the increasingly severe landscape. Exploring efficient anti-fraud education methods tailored to college students has thus become a priority for higher education institutions, with immersive murder mystery games offering a novel approach to innovating campus anti-fraud initiatives. Grounded in the …

28.08.2026journal-article

Nutrition in Clinical Practice

A proposal for individualized administration of energy and protein in the critically ill with obesity

K. Georg Kreymann, Geraldine de Heer, Arved Weimann

Abstract The increasing prevalence of obesity has transformed intensive care and nutritional therapy of patients with obesity from a specialized problem to standard care. The dilemma in providing nutrition to critically ill patients with obesity is that current and historical nutritional guideline recommendations are based on expert opinion, are divergent, and are sometimes contradictory. None has been evaluated in a clinical trial. All but one are based on body weight, which results in a sex difference in the prot …

28.08.2026journal-article

Hacettepe University Faculty of Health Sciences Journal

Hemodiyaliz Hastalarının Öz Bakım Gücünün Günlük Yaşam Aktivitelerine ve Egzersiz Engellerine Etkisi

Esra Saraçoğlu, Dilek Kıymaz, Ümmühan Kılıç

Amaç: Araştırma Samsun Eğitim ve Araştırma Hastanesi Diyaliz Ünitesi’nde hemodiyaliz tedavisi alan hastaların öz bakım gücünün, günlük yaşam aktivitelerine ve egzersiz engellerine etkisini belirlemek amacıyla yapıldı.Yöntem: Kesitsel-tanımlayıcı türde yürütülen araştırma diyaliz ünitesine kayıtlı, araştırmaya katılmayı kabul eden 97 hemodiyaliz hastası ile tamamlandı. Araştırmanın verileri Kişisel Bilgi Formu, Öz-bakım Gücü Ölçeği (ÖBGÖ), Katz Günlük Yaşam Aktiviteleri İndeksi (GYA) ve Diyaliz Hastalarında Egzersiz …

28.08.2026journal-article

BMC Infectious Diseases

An international multicentre observational cohort study of the clinical presentation of acute arboviral infection (ARIA): a study protocol

Josephine Bourner, Giselle Duarte, Leonardo S. L. Bastos, Timo Tolppa, Janice Caoili, Madiha Hashmi, Jose Cerbino-Neto, Priscilla Soares Filgueiras, Arishay Hussaini, Elise Pesonel, John Amuasi, Joseph Bonney, Piero Olliaro, Daniel Schubert, Otavio T Ranzani, Andre Siqueira, Fernando A Bozza

Abstract Background Despite the growing global burden of diseases caused by arboviruses, there remain substantial gaps in our understanding of the clinical presentation and natural history of arboviral infections, especially in the acute phase. There is a critical need for robust, multicentre, and internationally harmonised data to characterise the clinical features of arboviral infections, identify early predictors of severe disease, and inform the development of diagnostic algorithms, case definitions and researc …

28.08.2026journal-article

Nordic Wittgenstein Review

Two Types of Philosophical Therapy: Wittgenstein’s Late Discovery of Freud

Thomas J. Spiegel

A variety of influential readers of Wittgenstein endorse the view that Wittgenstein consistently held onto one conception philosophical therapy (the ‘singularity assumption’). This article argues against the singularity assumption such that there are two fundamentally different types of philosophical therapy present in the early and later Wittgenstein. This change is elicited by Wittgenstein ‘discovering’ the idea of psychoanalysis after the Tractatus, this discovery’s impact being more fundamentally than is usuall …

28.08.2026journal-article

Izmir Katip Celebi University Faculty of Medicine

Intraoperative Suspicion of Squamous Cell Carcinoma in a Presumed Giant Scalp Cyst: A Case Report

Şükrü Kasap, Muhammed Said Aydin, Gökay Özler, Mustafa Nişancı

Squamous cell carcinoma (SCC) arising in an epidermal cyst is rare and may be overlooked when a large scalp lesion appears clinically benign. An elderly woman presented with a 19 × 8 cm occipital mass thought to be a giant cyst. Ultrasonography and computed tomography showed a predominantly cystic lesion with internal solid components, but the overlying skin had no obvious malignant features. During surgery, abnormal tissue was noted over the lesion, in the subdermal plane, and at its base. The planned cyst excisio …

28.08.2026journal-article

Health Research Journal of Indonesia

Hubungan Pengetahuan Dan Sikap Mahasiswa Praktik Klinik Infeksi Nosokomial Dengan Kepatuhan Kebersihan Tangan Di RSD Idaman Banjar Baru

Sopia, Ika Lestiani, Hj Rusdiana, Martini Nur Sukmawaty

Latar Belakang: Infeksi nosokomial merupakan masalah kesehatan yang meningkatkan risiko penularan infeksi di rumah sakit. Salah satu upaya pencegahannya adalah penerapan kebersihan tangan sesuai standar Five Moments for Hand Hygiene. Kepatuhan kebersihan tangan dapat dipengaruhi oleh pengetahuan dan sikap mahasiswa praktik klinik tentang infeksi nosokomial. Tujuan: Mengetahui hubungan pengetahuan dan sikap mahasiswa praktik klinik tentang infeksi nosokomial dengan kepatuhan kebersihan tangan di RSD Idaman Banjarbar …

28.08.2026journal-article

Journal of Epidemiology and Community Health

Natural experiments: should we define them broadly or narrowly?

Peter Craig

The recently updated UK Medical Research Council’s guidance on the use of natural experiments to evaluate population health interventions, published in 2025, adopted a broad definition of natural experiments as any event or process that divides a population into groups that differ in their exposure to the intervention of interest and that is not under the control of a researcher. Many authors adopt narrower definitions that only include cases where exposure is determined in an ‘as-if random’ or ‘plausibly exogenous …

28.08.2026journal-article

Odovtos - International Journal of Dental Sciences

Clinical Knowledge of Final-Year Dental Students Regarding the Dental Management of Pregnant Women: A Cross-Sectional Study in Public Universities of São Paulo, Brazil

Ana Laura Martins Ferreira, Luis Eduardo Genaro, Fernanda Lopez Rosell

This study aimed to evaluate the clinical knowledge of final-year dental students from public universities in the state of São Paulo regarding the management of pregnant women in dental care. An observational, cross-sectional study was conducted with 63 final-year dental students from six public universities. A structured and self-administered questionnaire assessed sociodemographic variables, aspects of undergraduate training, and specific domains of clinical knowledge related to pregnancy management in dentistry …

28.08.2026journal-article

Frontiers in Nutrition

Effects of salivary amylase gene copy number on metabolic health

Sri Lakshmi Sravani Devarakonda, Kalem D. Hanlon, Alex P. Loinard-González, Bethany P. Cummings, Angela C. Poole

Precision nutrition is the personalization of dietary recommendations based on characteristics such as genetics, the microbiome, lifestyle, environment, and baseline metabolic state. One potential basis for the development of guidelines is the characterization of gene-diet interactions. In this narrative review, we evaluate the published literature reporting associations between salivary amylase gene copy number and metabolic health. The salivary amylase enzyme facilitates starch digestion and is encoded by AMY1 , …

28.08.2026journal-article

Frontiers in Public Health

AI-related measures and self-reported lesson-aim attainment: an explainable machine-learning analysis of TALIS 2024

ZhuFang Mao

Introduction Artificial intelligence (AI) is increasingly used to support teachers' lesson planning, feedback, assessment, and learning-material adaptation in school settings. Effective teaching practices may also support health literacy, social-emotional development, and health-promoting learning environments, although TALIS does not directly measure public-health education outcomes. Existing studies often treat AI use as a simple adoption variable and provide limited cross-national evidence on whether AI-related …

28.08.2026journal-article

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

Cross-National Comparison of the Association between Adult Child Educational Attainment and Older Parents’ Functional Health

Yulin Yang, Karla Renata Flores Romero, Sirena Gutierrez, Ah-Reum Lee, Emma Nichols, Jacqueline Torres

Abstract Background Mounting evidence points to the protective role of adult child education in older parents' health, including their risk of ADL and IADL difficulties. Yet, little is known whether this association varies cross-nationally due to contextual differences in intergenerational transfers, family dynamics, and other factors. This study examines the relationship between adult child education and parents’ functional health outcomes across countries, using comparable population-based datasets. Methods We us …