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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Frontiers in Oncology

Galectin-9, FABP4 and pentraxin-3 are associated with myocardial dysfunction and discriminate chemotherapy-related cardiac dysfunction in anthracycline-treated breast cancer: a single-centre retrospective study

Jincheng Ma, Zhiqiang Ma, Yanhui Cheng, Xiaoyun Li, Huiqing Song, Shuai Wang

Background Anthracycline-based chemotherapy improves breast cancer outcomes but may cause cancer therapy-related cardiac dysfunction (CTRCD). Biomarkers reflecting inflammatory and metabolic myocardial stress may complement imaging surveillance, but the combined value of galectin-9 (Gal-9), fatty-acid-binding protein 4 (FABP4) and pentraxin-3 (PTX-3) is unclear. Objective This study aimed to evaluate whether serum Gal-9, FABP4 and PTX-3 are associated with myocardial dysfunction and discriminate CTRCD. Methods This …

26.08.2026journal-article

Frontiers in Oncology

EUS features and clinical outcomes of gastric calcifying fibrous tumor: a retrospective analysis of 20 cases

Bing Bai, Qiuyu Liu, Bingxi Zhou, Baosong Liang, Shengli Kuang

Objective To analyze the endoscopic ultrasonography (EUS) features and clinical characteristics of gastric calcifying fibrous tumor (GCFT) to improve the endoscopic recognition of this entity. Methods A retrospective analysis was conducted on 20 consecutive patients with pathologically confirmed GCFT at Henan Provincial People’s Hospital from January 2018 to May 2025. EUS findings and clinical data were reviewed to summarize the endoscopic and clinical features of this rare lesion. Results Of the 20 patients, 12 (6 …

26.08.2026journal-article

Frontiers in Digital Health

A comparative study on the credibility of ischemic stroke treatment information on social media platforms: evidence from Weibo and REDnote

Jiayan Gu, Zihan Li, Jiajun Yang, Sen Miao, Juan Li, Lijuan Gu

Background Social media is a key channel for public health information, but its open nature leads to mixed quality of information regarding Ischemic Stroke (IS) treatment, which may mislead patient decisions. This study aimed to systematically compare IS treatment information published by professional and lay sources on two major Chinese social media platforms, Weibo and REDnote, in terms of content, engagement, and quality. Methods This study employed computational social science and Natural Language Processing (N …

26.08.2026journal-article

Russian Bulletin of Obstetrician-Gynecologist

The influence of socio-psychological factors, adverse effects of hormone therapy on the refusal of patients from its implementation or interruption of therapy after surgical treatment of ovarian endometriosis

E.Yu. Zhilnio, I.A. Salov, V.M. Kuleshov, Yu.V. Naumova

Objective. To analyze the role of socio-psychological factors and undesirable effects of hormone therapy on the patient’s refusal to undergo it or discontinue therapy after surgical treatment for ovarian endometriosis. Materials and methods. A prospective study is presented in which the frequency of refusals of patients and the frequency of interruption of anti-relapse hormone therapy after surgical treatment for ovarian endometriosis in the gynecological department of Saratov City Clinical Hospital No. 8 during th …

26.08.2026journal-article

Frontiers in Oncology

Distal cholangiocarcinoma mimicking pancreatic ductal adenocarcinoma successfully converted to resection following PD-1/CTLA-4 bispecific immunotherapy (cadonilimab) combined with nab-paclitaxel–based chemotherapy: a case report providing preliminary real-world insight

Yongzhao Li, Xiyang Sheng, Chen Mi, Yongyue Du, Siyang Wang, Dongdong Wang, Wei Wang, Longbo Wang, Gengyuan Shi, Mancai Wang, Tianlong Ma, Xuechao Xu, Yun Wang, Hanteng Yang

Background Distal cholangiocarcinoma (dCCA) and pancreatic ductal adenocarcinoma (PDAC) share highly overlapping clinical presentations and radiological features, often leading to preoperative misdiagnosis. Therapeutic strategies for these malignancies differ substantially. While PDAC is commonly treated with gemcitabine plus nab-paclitaxel (AG regimen) or FOLFIRINOX as neoadjuvant or conversion therapy, first-line treatment for cholangiocarcinoma (CCA) typically consists of gemcitabine plus cisplatin (GC regimen), …

26.08.2026journal-article

Journal of Magnetic Resonance Imaging

Accuracy of Quantitative Chemical‐Exchange‐Saturation‐Transfer Imaging for Grading Prostate Cancer and Predicting Adverse Pathology

Huan Chang, Zhechuan Dai, Hao Cheng, Hongyue Ji, Jiajia Liu, Ming Liu, Wei Zhang, Huimin Hou, Miao Wang, Min Chen, Yi Zhang, Chunmei Li

ABSTRACT Background Preoperative quantitative chemical‐exchange‐saturation‐transfer (CEST) imaging may help prostate cancer (PCa) grading and adverse pathological prediction, including positive surgical margin (PSM), perineural invasion (PNI), and extracapsular extension (EPE), which are important for clinical decision‐making. Purpose To assess quantitative CEST imaging in grading PCa and predicting PSM, PNI, and EPE. Study Type Prospective. Population Seventy‐four male participants (74 ± 5 years) with 77 surgicall …

26.08.2026journal-article

Biosensors

Advances in Extracellular Vesicle-Based Surface-Enhanced Raman Spectroscopy for Cancer Diagnosis

Shuyuan Zhao, Wen Lei, Juan Li, Jingjing Xia

As a noninvasive liquid biopsy approach, extracellular vesicle (EV)-based detection offers significant advantages in reflecting real-time tumor dynamis and overcoming the limitations of conventional tissue biopsy. EVs, nanoscale vesicles secreted by cells, carry diverse biomolecules such as proteins and nucleic acids, playing key roles in tumor progression, metastasis, and immune evasion, and have emerged as promising biomarkers for cancer liquid biopsy. Surface-enhanced Raman spectroscopy (SERS), characterized by …

26.08.2026journal-article

Healthcare

Fear of Cancer Recurrence and Associated Factors Among Women with Female Cancer: A Cross-Sectional Study

Lovorka Brajković, Ivana Lozić, Dora Korać, Vanja Kopilaš

Background/Objectives: The emotional impact of a cancer diagnosis may become particularly salient during survivorship, as survivors continue to face fears and concerns related to recurrence. Fear of cancer recurrence (FCR) is one of the most prevalent psychological challenges and significant unmet need among women with female cancer. The aim of this study was to assess the presence of FCR in predominantly breast cancer survivors, and to examine its relationship with certain demographic, clinical, and psychosocial f …

26.08.2026journal-article

Journal of the American Podiatric Medical Association

Autologous Bone Grafting for the Treatment of Osteochondral Lesion of the Talus: A Systematic Review and Meta-Analysis

Katrina Hoi Kiu Law, Jin Hean Koh, Dexter Seow

Treatment of osteochondral lesions of the talus (OLTs) with bone grafting is an alternative option to osteochondral transplantation for larger OLTs. The purpose of this study is to evaluate treatment of OLTs with bone grafting with continuous functional outcome scores, return-to-play data, and meta-analyses of overall complication rates after bone graft treatment for OLT lesions as reported and best- and worst-case scenarios. A systematic review was conducted based on PRISMA guidelines using specific search terms o …

26.08.2026journal-article

Eurasian Journal of Medicine and Oncology

Сirculating DNA markers for assessing antitumor therapy efficacy and monitoring metastatic colorectal cancer

Anastasia Ponomaryova, Dmitry Kostromitsky, Anna Tarasova, Elena Rykova, Alexey Dobrodeev, Ulyana Zhilenkova, Sergey Afanasiev, Nadezhda Cherdyntseva

Introduction: Colorectal cancer remains one of the leading causes of oncological morbidity and mortality. Aberrant methylation patterns of tumor-suppressor genes and oncogenes have been detected in circulating DNA isolated from the blood of cancer patients, suggesting their potential utility as diagnostic and prognostic markers. Objective: To evaluate changes in the methylation levels of VIM, SEPTIN9, and DCC genes in cell-surface-bound cell-free DNA (csb-cfDNA) from the blood of metas …

26.08.2026journal-article

World Journal of Surgical Oncology

Early recurrence prediction after curative-intent surgery of intrahepatic cholangiocarcinoma using a novel weighted tumor burden score

Anna Mantas, Smiths S. Lueong, Sophia Mauerer, Antonia Krumm, Dieter P. Hoyer, Iakovos Amygdalos, Tom F. Ulmer, Jens Siveke, Florian W. R. Vondran, Ulf P. Neumann, Jan Bednarsch

Abstract Background Recurrence after curative-intent resection of patients with intrahepatic cholangiocarcinoma (ICC) remains common and difficult to predict. Tumor burden scores (TBS) incorporating tumor size and tumor nodule number have been proposed, but the relative contribution of multifocality remains unclear. Methods Patients undergoing curative-intent surgery for ICC in a large hepatobiliary center between 2009 and 2024 were retrospectively analyzed. A simplified weighted tumor burden score (wTBS) was devel …

26.08.2026journal-article

Endodontics Today

Comparative analysis of treatment of pulpal hyperemia

K. D. Kirsh, A. А. Adamchik, V. А. Ivashchenko, E. S. Zaporozhskaya-Abramova, S. Yu. Maksyukov, V. V. Tairov, I. A. Kovtun, I. V. Khromtsova

INTRODUCTION. The leading problem of modern dentistry is the treatment of caries and its complications: diseases of the pulp and periapical tissues, and as a result, these pathologies in the adult population make up the basis of therapeutic procedures in the daily dental appointment of a practicing doctor. Currently, in order to provide an effective treatment method during conservative therapy with a diagnosis of pulp hyperemia, a dentist should clearly interpret the algorithm of therapeutic procedures and the mean …

26.08.2026journal-article

Medicine and health care organization

Неопределенность в ситуации онкологического заболевания

Елена Викторовна Пестерева, Татьяна Владимировна Каурова

В статье рассматривается проблема неопределенности, которая включена в жизнь любого человека. Возможность справляться с неопределенностью бытия выражена в конструкте «толерантность к неопределенности», проявляемом в готовности человека действовать в условиях нехватки информации, отсутствия гарантий и устойчивых ориентиров. Когда человеку диагностируют онкологическое заболевание, он оказывается в ситуации угрозы жизни, отсутствия гарантий выздоровления, у него разрушаются представления и убеждения, которые имеются у …

26.08.2026journal-article

Frontiers in Public Health

A latent profile analysis of the pain-fatigue-sleep disturbance symptom clusters in postoperative cervical cancer patients: a multicenter cross-sectional study

Kaiyi Wang, Xinru Ma, Huan Wang

Objective To investigate the potential subtypes and influencing factors of the pain-fatigue-sleep disturbance (PFS) symptom cluster in postoperative cervical cancer patients, thereby providing a basis for developing targeted intervention measures. Methods A cross-sectional study design was adopted. Using convenience sampling, 374 postoperative cervical cancer patients admitted to three Grade A Level 3 hospitals in Liaoning Province between April 2025 and September 2025 were selected as study subjects. Questionnaire …

26.08.2026journal-article

Cognitive Therapy and Research

Investigating the Relationship Between Insight and Metacognition in Anxiety Treatment: Results from an Online Imagery Rescripting Intervention

Asala Halaj, Hila Sorka-Ella, Jonathan D. Huppert, Anthony S. David

Abstract Background Imagery Rescripting (IR) has shown promise in reducing anxiety symptoms and improving coping skills, but who benefits most may depend on individual factors. Insight refers to recognizing symptoms as abnormal and in need of treatment, while metacognitive beliefs are beliefs that people hold about their own thoughts, such as beliefs about their uncontrollability or danger. Both may shape treatment outcomes. Objective This study examined pre-post changes in insight and anxiety symptoms following an …

26.08.2026journal-article

MedComm

Metabolism in Tumor: Mechanisms and Therapeutic Perspectives

Jia‐Chen Cheng, Yi‐Xuan Hu, Xiang‐Chun Huang, Shan Jiang, Jie‐Lin Wang, Yang Zhao, Shuo Chen

ABSTRACT Tumor metabolic reprogramming now extends far beyond the Warburg effect, spanning glycolysis, mitochondrial oxidative phosphorylation (OXPHOS), de novo lipogenesis, cholesterol biosynthesis, and fatty acid oxidation. This network is shaped by cell‐intrinsic regulatory layers—transcriptional programs, histone lactylation and other posttranslational modifications, and m 6 A RNA modification—and by metabolic crosstalk with tumor‐associated macrophages (TAMs) and cancer‐associated fibroblasts (CAFs) that drive …

26.08.2026journal-article

Journal of Clinical Medicine

Preoperative Cervical Smear Cytology and Clinicopathologic Characteristics in Endometrial Cancer

Kubra Cakar Yilmaz, Kevser Arkan, Asli Tugce Sarisoy, Sunullah Soysal

Objectives: The endometrium and cervix share a common Müllerian origin and may exhibit overlapping biological responses to oncogenic stimuli. However, the clinical significance of preoperative cervical cytology in patients with endometrial cancer remains unclear. This study aimed to investigate the association between preoperative cervical smear cytology and clinicopathologic characteristics, with particular emphasis on advanced FIGO stage (III–IV) as the primary outcome. Methods: This retrospective cohort study in …

26.08.2026journal-article

Endocrine Oncology

Tumor Risks and Surveillance Outcomes in SDHA Variant Carriers

Kelsey Ellis, Daniel Christensen, Jacob Beiringer, Anne Naumer, Jennie Vagher, Richard Wiggins, Hilary Mccrary, Luke Buchmann

Abstract Objective SDHA germline pathogenic variants confer a lower paraganglioma risk compared to other hereditary paraganglioma genes. Reduced screening for carriers without a personal or family history of SDHA-associated tumors has been proposed; however, supporting data remains limited. This single-institution cohort study addresses this by characterizing SDHA carrier tumor features and long-term screening outcomes. Design Retrospective cohort study with longitudinal surveillance follow-up. Methods Clinical rec …

26.08.2026journal-article

International Journal of Molecular Sciences

Comprehensive Analyses of SOX7 Provide Novel Insights on Its Tumor Suppressor Role and Its Target Genes with Therapeutic Implications in Multiple Myeloma

Arda Ceylan, Xiaozhou Hu, Tevfik Hatipoğlu, Fenangi Chiara Nainkwi, Kadriye Bahriye Payzın, Güner Hayri Özsan, Itır Şirinoğlu Demiriz, Ömer Şeker, Merve Kakçı, Osman Can Öztürk, Bircan Yılmaz, Elif Yıldız, Athanasia Pavlopoulou, Can Küçük

Multiple myeloma (MM) is an incurable hematological malignancy. SOX7, located within the recurrently deleted 8p23.1 region in MM, is suggested to act as a tumor suppressor. We characterized SOX7 through genetic, epigenetic, and functional analyses in MM cell lines. SOX7 was frequently silenced due to deletion and/or promoter hypermethylation. Ectopic SOX7 expression in KMS-18 and MM.1S cell lines caused a progressive decline in SOX7-transduced cells and induced G1 cell cycle arrest and/or apoptosis. Although SOX7 r …

26.08.2026journal-article

Frontiers in Oncology

The electrical tumor microenvironment: abnormalities and opportunities

Alice Burchett Darantiere, Fionn Lay, Meenal Datta

Abnormal electrical properties in cancerous tumors have been observed for more than a century. Modern technological advances have enabled rapid improvements in our understanding of these electrical facets and our ability to leverage this information for diagnosis and treatment. Here, we outline the current knowledge of the electrical tumor microenvironment (eTME), including electrical abnormalities at the tissue, cell, and molecular scales. Of particular interest to solid tumors and immunotherapy, the innate immune …

26.08.2026journal-article

BMC Infectious Diseases

Seroprevalence update of Hepatitis B Virus, Hepatitis C Virus, and human immunodeficiency virus among people who inject drugs in Kuwait: a cross-sectional study at a national addiction treatment center

Haya Altawalah, Farah Altannak, Karima Abounouh, Sayeh Ezzikouri

Abstract Background People who inject drugs (PWID) represent a key population disproportionately affected by blood-borne viruses. Updated epidemiological data are crucial for informing public health interventions. This study provides a 2024 update on the seroprevalence and correlates of Hepatitis B (HBV), Hepatitis C (HCV), and Human Immunodeficiency Virus (HIV) among PWID at Kuwait’s national addiction treatment center, building on a previous 2017 baseline. Methods A cross-sectional study was conducted from Januar …

26.08.2026journal-article

Frontiers in Cardiovascular Medicine

Design and rationale for MICROFIT (Microvascular Coronary Rehabilitation For Improving Treatment)—a feasibility randomized trial of intensive lifestyle rehabilitation for symptomatic coronary microvascular dysfunction

Joanna Abramik, David Murphy, John Graby, Anna Lacey, Theresa Smith, Christopher Lawton, Faith Martin, Fiona Gillison, Matthias G. Friedrich, Amedeo Chiribiri, Mark Mariathas, Kevin Carson, Jonathan Carl Luis Rodrigues, Dylan Thompson, Ali Khavandi

Background Coronary microvascular dysfunction (CMD), a common endotype of angina with non-obstructed coronary arteries (ANOCA), is linked to poor cardiovascular outcomes, and can significantly impact quality of life, mental health, and functional capacity. CMD management strategies focus on symptom control with antianginal therapies, with limited effect and prognostic benefit. While lifestyle changes and risk factor modification are advocated by international guidelines, evidence supporting cardiac rehabilitation f …

26.08.2026journal-article

Ultrasound

Novel evaluation of the sternocleidomastoid muscle of head and neck cancer patients using shear wave elastography: A preliminary exploratory pilot study

Mei S. L. Lai, Chin C. Ooi, Ia C. C. Tan, Q. H. M. Leow, Zhan H. S. Quek, Mahalakshmi S. Rangabashyam, Wen L. J. Lau, Hiang K. Tan, Meng A. Png

Aim: Shear wave elastography is commonly used to evaluate muscle stiffness and thickness. This study aimed to evaluate the stiffness and thickness of the sternocleidomastoid muscle in patients diagnosed with head and neck cancer undergoing neck dissection (removal of lymph nodes). Materials and methods: Ten subjects with head and neck cancer were recruited. Two radiographers performed ultrasound and shear wave elastography scans to evaluate muscle stiffness and thickness in the sternocleidomastoid muscle pre-surger …

26.08.2026journal-article

Endodontics Today

Modern approaches to root canal irrigation in endodontic treatment: literature review

D. N. Kudryashov, M. A. Postnikov, I. A. Kostionova-Ovod, O. E. Simanovskaya, D. A. Mokshina

INTRODUCTION. The problem of persistent infection of the root canal system remains one of the key causes of failures in endodontic treatment. Despite the improvement of instrumental processing, the anatomical complexity of the root system and the stability of microbial biofilms necessitate effective drug treatment. AIM. The purpose of the review is to systematize data on the role of irrigation in endodontic treatment based on the analysis of modern domestic and foreign literature, to evaluate the effectiveness of b …