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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Microorganisms

Rich Efficient Short-Chain Phthalate Esters-Degrading Bacteria and Their Degradation Mechanisms in Recycled Plastic Wastewater Treatment Plant

Zhilian Gong, Lingshan Li, Yajie Li, Xiao Zhang, Sidan Gong, Yong Li

Microbial degradation of phthalate esters (PAEs) is regarded as a highly promising green remediation strategy for PAE-contamination, but it still remains constrained by the scarcity of efficient microbial resources capable of degrading PAEs completely under complex conditions. This study systematically explored microbial resources resistant to dimethyl phthalate (DMP)/dibutyl phthalate (DBP) stress along with the putative degradation mechanisms in recycled plastic sewage treatment plants through high-throughput seq …

26.08.2026journal-article

Radiation Sciences in Oncology

<i>Saprochaete capitata</i> superinfection mimicking steroid-refractory radiation pneumonitis after SBRT for oligometastatic lung lesion: A case report and literature review

Gülfem Güneş, Maksut Görkem Aksu, Emine Binnaz Sarper

Objective: Radiation pneumonitis (RP) is a well-recognized pulmonary complication of stereotactic body radiotherapy (SBRT). However, opportunistic fungal superinfection complicating RP remains exceedingly rare. This case report highlights the diagnostic challenges and clinical management considerations of a rare fungal superinfection that closely mimics steroid-refractory RP. Case Presentation: A 62-year-old man with locally advanced non-small cell lung cancer (NSCLC) developed Grade 2 RP after receiving stereotact …

26.08.2026journal-article

Angewandte Chemie International Edition

Bacteria‐Mediated Targeted Delivery and Deep Tumor Penetration of a Pt(IV)‐Drug Enables Synergistic Chemo‐Immunotherapy

He Meng, Jinhui Wang, Bing Shi, Tao Ouyang, Kai Lu, Wenkai Lin, Yuxiang Lu, Jing Wang, Xiyu Huang, Hailong Zhao, Yufang Xiong, Zilong Xu, Zong‐Wan Mao, Wei Xia

ABSTRACT Platinum‐based drugs are clinically vital for cancer treatment but suffer from off‐target cytotoxicity and poor tumor penetration. To overcome these limitations, we designed a tumor‐targeted Pt(IV) drug‐bacteria conjugate ( Pt‐EcN‐HER2 ). This conjugate exploits the inherent tumor tropism of probiotic bacterium Escherichia coli Nissle 1917 (EcN) to achieve targeted accumulation and deep penetration within the tumor microenvironment (TME). Once localized, elevated intratumoral hydrogen peroxide (H 2 O 2 ) a …

26.08.2026journal-article

Endodontics Today

Modern approaches to root canal irrigation in endodontic treatment: literature review

D. N. Kudryashov, M. A. Postnikov, I. A. Kostionova-Ovod, O. E. Simanovskaya, D. A. Mokshina

INTRODUCTION. The problem of persistent infection of the root canal system remains one of the key causes of failures in endodontic treatment. Despite the improvement of instrumental processing, the anatomical complexity of the root system and the stability of microbial biofilms necessitate effective drug treatment. AIM. The purpose of the review is to systematize data on the role of irrigation in endodontic treatment based on the analysis of modern domestic and foreign literature, to evaluate the effectiveness of b …

26.08.2026journal-article

Journal of Surgical Oncology

Prognostic Determinants of Overall Survival After Resection for Pancreatic Ductal Adenocarcinoma: A Consensus‐Based Conceptual Framework

Muhammad Maisam Ali, Kaleem S. Ahmed, Clayton T. Marcinak, Syed Ali Tayyeb Hasan, Anne D. Letocha, Noorain Ahmad, Haider bin Khalid, Kainat Fatima, Syed Nabeel Zafar

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis despite surgical resection, yet the prognostic literature remains fragmented across hundreds of single‐institution studies that vary in design, covariates, and analytical approaches. A synthesis of this evidence is needed to identify which factors most consistently predict overall survival (OS) after curative‐intent resection and standardize covariate selection for future outcomes research and trial design. Following PRISMA guidelines, we s …

26.08.2026journal-article

Frontiers in Psychology

Time-bounded uncertainty in childhood cancer survivorship: a psycho-oncology perspective on result communication

Christian Prinz

Follow-up after childhood cancer may be clinically routine, but it can still leave families in a poorly defined waiting period. A scan or blood test may be part of routine surveillance; however, the days that follow can feel far from ordinary. Families may not know when the results will arrive, who will interpret them, or whether silence has meaning. This Perspective proposes event-related distress windows (ERDWs) as an early service-design heuristic rather than a diagnosis or validated construct. The contribution …

26.08.2026journal-article

Frontiers in Public Health

Family-school-hospital collaboration model for urinary system tumor early screening education

Fen Zhou, Ping Yu, Xiaofen Yu, Xuyan Han, Zheng Wang

Objective To develop and validate a 3D printing-assisted family-school-hospital collaborative education model for urinary system tumor early screening, and to evaluate its association with changes in medical students’ knowledge and core competencies related to tumor early detection. Methods A non-randomized controlled pre-post study was conducted among 120 clinical medical interns (60 in each group). The intervention group received a 6-month family-school-hospital collaborative program via family WeChat groups, whi …

26.08.2026journal-article

Frontiers in Oncology

Umbilical cord blood infusion enhances hematopoietic recovery and improves survival in elderly AML patients with chemotherapy-induced myelosuppression: a retrospective study

Yimin Zhou, Yuye Ren, Lan Zhang, Wenya Hu, Jiao Ma, Xiaomin Wang

Elderly AML (Acute Myeloid Leukemia) patients exhibit increased mortality owing to chemotherapy-induced myelosuppression. Umbilical cord blood (UCB) contains hematopoietic stem/progenitor cells and a spectrum of regenerative cytokines that actively promote hematopoietic regeneration. We investigated whether umbilical cord blood (UCB) infusion enhances hematopoietic recovery in elderly AML patients who experience chemotherapy-induced myelosuppression during post-chemotherapy supportive care. Methods We retrospective …

26.08.2026journal-article

Journal of Leukocyte Biology

Zinc finger protein 600 is essential for the cytotoxic function of esophageal cancer-associated natural killer cells

Jiongming He, Shan Liu, Lingying Wang, Fei Xiong

Abstract Natural killer (NK) cells are active tumoricidal cells that inhibit esophageal cancer (EC) development, making them a prospective immunotherapeutic tool. Nonetheless, NK cells undergo both activation and exhaustion in the tumor microenvironment, but the related mechanisms have not been thoroughly understood. Using a chemical-induced EC model, we investigated the expression pattern and functional properties of zinc finger protein 600 (ZNF600) in EC-associated NK cells. For the first time, we revealed that Z …

26.08.2026journal-article

Frontiers in Cellular and Infection Microbiology

Risk factors, resistance profiles, and clinical outcomes of Klebsiella pneumoniae infection in cancer patients: a retrospective study

Shulei Zhang, Jingwen Wang, Shuo Zhang, Shuping Lu, Miaosu Chang, Wei Xu, Qingmei Zhang, Mei Zhu

Background Cancer patients are highly susceptible to Klebsiella pneumoniae (KP) infection, yet integrated analyses considering infection-site resistance patterns, cancer-type heterogeneity, and host risk factors remain limited. Methods We retrospectively analyzed 300 adult cancer patients treated between October 2023 and November 2024, including 153 with KP infection and 147 uninfected controls. Data on demographics, comorbidities, invasive procedures, laboratory findings, antimicrobial resistance, treatment patter …

26.08.2026journal-article

Frontiers in Oncology

Biologically effective doses for α/β = 10 (BED10) of <80 Gy versus ≥80 Gy in stereotactic body radiotherapy for pancreatic cancer: a retrospective single-center analysis

Qian Wang, Shaoyu Cao, Zheng Zheng, Changwen Bo, Na Li, Qiuning Li, Yao Fan

Background The optimal biologically effective dose (BED 10 ) for stereotactic body radiation therapy (SBRT) in pancreatic cancer remains debated. This study evaluated whether BED 10 ≥80 Gy improves outcomes compared with &lt;80 Gy in a heterogeneous patient population. Methods 46 patients with pancreatic cancer treated with SBRT (May 2021–December 2023) were retrospectively analyzed. Overall survival (OS), progression-free survival (PFS), and local control (LC) were estimated using the Kaplan–Meier method with log- …

26.08.2026journal-article

Frontiers in Urology

Microsatellite instability in penile cancer: comparative analysis of primary tumors and metastases

Hadson Silva Araujo, Gustavo Ramos Teixeira, Ana Carolina Laus, Gustavo Noriz Berardinelli, Daniel D Almeida Preto, Rui Manuel Reis, Flavio Mavignier Cárcano

Background Penile cancer (PeCA) presents high morbidity and mortality and is more prevalent in underdeveloped countries. The presence of nodal metastasis at diagnosis or as early recurrence carries a worse prognosis, making it important to determine whether clinically relevant biomarkers are maintained between primary tumors and corresponding lymph node metastases. We aim to describe the presence of DNA microsatellite instability (MSI) in primary PeCA tumors and locoregional lymph nodes affected by metastatic cells …

26.08.2026journal-article

Frontiers in Psychiatry

Perceived social support as a mediator of the relationship between fear of progression and post-traumatic growth in lung cancer patients undergoing chemotherapy: a structural equation model analysis

Fan Xu, Qiao Li, Jing Wang, Shaoju Xie, Jiquan Zhang

Background Post-traumatic growth (PTG), as a positive psychological adaptation mechanism, can significantly enhance patients’ psychological resilience and promote positive psychological transformation. However, among lung cancer patients undergoing chemotherapy, fear of progression (FoP) is associated with substantial psychological distress and lower levels of positive adaptation. Research on the association between FoP and PTG in this population remains limited. Objective To investigate the association between FoP …

26.08.2026journal-article

Journal of Cancer Research and Therapeutics

Advances and future perspectives in the treatment of small cell lung cancer: From chemotherapy and radiotherapy to the era of targeted therapy and immunotherapy

Xiangwei Cheng, Weibin Lv, Linfeng Wu, Yifan Wang, Yiping Zhu

ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignant tumor that mainly originates from pulmonary neuroendocrine cells and is characterized by rapid proliferation, high metastatic potential, and acquired therapeutic resistance. The therapeutic landscape for SCLC is largely confined to traditional modalities, such as surgery and chemoradiotherapy. However, 80–85% of patients are diagnosed with extensive-stage SCLC at initial presentation; surgical intervention and radiotherapy are often not applicable fo …

26.08.2026journal-article

Cancer Medicine

Development of a Prognostic Survival Risk Score for Lung Cancer Patients With Type 2 Diabetes Mellitus: A Territory‐Wide Retrospective Cohort Study

Claire Chenwen Zhong, Junjie Huang, Zhaojun Li, Yu Jiang, Zehuan Yang, Jinqiu Yuan, Xiaodan Huang, Xiaofang Liu, Han Wang, Jonathan Poon, Qi Dou, Arthur Sung, Martin C. S. Wong

ABSTRACT Background Lung cancer is a leading cause of cancer‐related mortality, and its prognosis is often affected by comorbidities such as type 2 diabetes mellitus (T2DM). This study aimed to identify survival risk factors for lung cancer patients with T2DM, evaluate the predictive models, and develop a risk score system for survival prediction. Study Design and Methods We analyzed data from 5491 lung cancer patients with T2DM from the Hong Kong Hospital Authority Data Collaboration Laboratory (HADCL) (2000–2020) …

26.08.2026journal-article

Nutrients

Personalised Nutraceutical Treatment Guided by MTHFR Genotype in Mental Health: A Retrospective Cohort Study

Cristina Beer, Fiona Rae, Mikayla Watt, Maciej Trzaskowski, Clarissa Yates, Annalese Semmler, Joanne Voisey

Background & Aims: One-carbon metabolism plays a central role in neurotransmitter synthesis, methylation capacity, and neurobiological resilience. Variants in the methylenetetrahydrofolate reductase (MTHFR) gene can reduce enzymatic activity, affecting folate- and methionine-cycle functions and potentially influencing biological pathways relevant to mood and anxiety disorders. Personalised nutraceutical treatment strategies, particularly those addressing methylation capacity through targeted B-vitamin, folate, and …

26.08.2026journal-article

Intensive Care Medicine Experimental

Low preoperative adiponectin levels are associated with postoperative systemic inflammatory response following major colorectal cancer surgery

Sonja Škiljić, Ines Šahinović, Gordana Kristek, Hrvoje Vinković, Ivana Haršanji-Drenjančević, Dino Budrovac, Bojan Trogrlić, Josip Kocur, Nenad Nešković, Slavica Kvolik

Abstract Background Adiponectin is an adipokine secreted by adipose tissue that plays an important role in colorectal oncogenesis and the response to surgical stress through its anti-inflammatory effects. However, it remains unclear whether perioperative alterations in circulating adiponectin in patients undergoing colorectal cancer surgery are associated with early postoperative systemic inflammation. The aim of this study was to investigate the predictive value of perioperative adiponectin levels, interleukin-6 ( …

26.08.2026journal-article

Drugs and Drug Candidates

Deep Learning-Based Molecular Generation for Lung Cancer Therapeutics

Mohavia Ben Amid Sinon, Uche A. K. Chude-Okonkwo

Background: The leading cause of cancer-related deaths globally is lung cancer, and the P2X7 receptor (P2X7R) is a promising therapeutic target due to its role in the disease progression. Methods: A deep learning-based molecular generation framework that integrates a fragment-based drug method with Relational Graph Convolutional Networks (RGCNs) and a Wasserstein Generative Adversarial Network (WGAN) was employed. Known P2X7R targeting drugs were fragmented to construct a fragment library, which was used to generat …

26.08.2026journal-article

Clinical Cancer Research

Neoadjuvant Botensilimab/Balstilimab for localized mismatch repair proficient and deficient colon cancer: Results of the NEST phase 2 clinical trial

Manish A. Shah, Erika Hissong, Mehraneh D. Jafari, Pashtoon Murtaza. Kasi, Maider Astorkia, Sahrish Khan, Casey Owens, Zhengming Chen, Heather Yeo, Fabio Socciarelli, Sandipto Sarkar, Alana Nguyen, Despina Siolas, Allyson Ocean, Kelly Garrett, Lea Lowenfeld, Alessio Pigazzi, Preethi Guniganti, Sanjay Patel, Doron Betel, Manuel Hidalgo

Abstract Purpose: Effective immunotherapy for mismatch repair proficient colorectal cancer (CRC) is lacking. We examined the safety and efficacy of the novel next-generation immune activator/Fc-enhanced CTLA-4 inhibitor botensilimab (BOT) plus PD-1 inhibitor balstilimab (BAL) in the neoadjuvant setting for patients with resectable CRC. Patients and Methods: Patients 18 years of age or older with non-metastatic CRC awaiting surgical resection were eligible. BOT/BAL was administered followed by surgical resection. In …

26.08.2026journal-article

Frontiers in Oncology

Capturing fine-grained spatial details in brain tumor MRI via multi-module feature enhancement

Jianle Chen, Yuanyong Zhou, Hailin Cao, YuYan Lin, Jianyu Zhu, Huilian Liao

Existing object detection models often face challenges in medical imaging, including limited feature fusion capabilities, constrained receptive fields, and the prevalent issue of class imbalance. To address these limitations, this paper proposes FDANet (Fine-Grained Detail Aggregation Network), a novel multi-module feature enhancement network built upon the YOLOv11 architecture. Specifically, FDANet integrates a Mixed Aggregation Network (MANet) to capture fine-grained spatial details of tumor regions. The FasterCG …

26.08.2026journal-article

Journal of Inherited Metabolic Disease

Cobalamin‐Related Remethylation Disorders: Pregnancy Outcomes and Prenatal Treatment‐New Cases and a Literature Study

Karolina M. Stepien, Jolanta Sykut‐Cegielska, Jennifer Sloan, Flavia Piazzon, Sarah Bick, Juliette Bouchereau, Edwin C. Ferren, Nina Gold, Apolline Imbard, Mirian C. H. Janssen, Pavel Jesina, Lisa A. Joseph, Amanda Krzywdzińska‐Rogowska, Louise Lapagesse, Fanny Mochel, Carol Van Ryzin, Manuel Schiff, Ida Vanessa Schwartz, Audrey Thurm, Wadih M. Zein, Charles P. Venditti, Martina Huemer, Irini Manoli

ABSTRACT Cobalamin‐related remethylation disorders (cbl‐RD) are rare, heterogenous conditions with a wide phenotypic spectrum, including prenatal and early infantile manifestations. Data on pregnancy outcomes in affected women and the efficacy and safety of prenatal treatment of affected fetuses remain limited. Here we report (1) five women with cbl‐RDs (3 cblC/epi‐cblC, 1 cblD, 1 cblE) who had in total nine pregnancies and (2) eight fetuses with cbl‐RD (7 cblC, 1 cblF) diagnosed and treated prenatally. All affecte …

26.08.2026journal-article

Cell Biology International

Tumor‐Associated Macrophages in the Chemoresistant Microenvironment of Gastric Cancer: Key Mechanisms and Intercellular Crosstalk

Saeb Younis Abdul‐Rahman, Abdulkareem Shareef, S. Renuka Jyothi, Priya Priyadarshini Nayak, J. Bethanney Janney, Gurjant Singh, Aashna Sinha, Munisa Ergasheva, Hayder Naji Sameer, Ahmed Yaseen, Rasim M. Salih, Mohaned Adil

ABSTRACT Gastric cancer (GC) remains a leading cause of cancer‐related mortality, with chemoresistance posing a critical barrier to effective treatment. Tumor‐associated macrophages (TAMs), particularly the immunosuppressive M2‐polarized subset, are emerging as pivotal mediators of chemoresistance within the tumor microenvironment (TME). TAMs promote resistance through multifaceted mechanisms, including activation of pro‐survival signaling pathways, induction of epithelial–mesenchymal transition (EMT), and enhancem …

26.08.2026journal-article

World Journal of Stem Cells

Cellular hypoxia reprograms drug response and reveals curcumin-driven cancer stem-cell-associated marker enrichment in oral squamous cell carcinoma

Hazar S Alharbi, Ishrat Rahman, Manal A AlSheddi, Hanan Henidi, Manal Mubarak Alkahtani, Zaha Al Makhlafi, Sahar ElRefai, Shams A Altwaim, Hourya Sanat Alnofaie, Hend M Salem, Maha Galal Omar, Alia Alturki, Hiba Talic, Ghada Aladhyani, Fotoon Alotaibi, Hadeel Basuhail, Rasil Alotaibi, Nada Alturki, Aljawhara Alharbi, Rafa Alsultan, Sara Khalid Albassam

BACKGROUND Oral squamous cell carcinoma is a deadly cancer often detected late, contributing to high mortality and treatment failure. The efficacy of first-line chemotherapeutic agents is limited by resistance and a narrow therapeutic index. Naturally derived compounds, including curcumin, are increasingly being explored for their anti-inflammatory and anticancer potential. AIM To determine whether curcumin retains cytotoxicity under hypoxia compared with carboplatin and assess apoptosis, reactive oxygen species (R …

26.08.2026journal-article

Journal of Clinical Oncology

Medical Therapy for Hormone Receptor-Positive, HER2-Negative Stage I-III Breast Cancer: ASCO Living Guideline, Version 2026.1.0

Jennifer L. Caswell-Jin, Mark R. Somerfield, Muhammad Ali Khan, Gretchen G. Kimmick, Shilpi Gupta, Kara Kenan, Namrata Peswani, Dawn L. Hershman, Brenda J. Ernst, Brittany E. Harvey, Gregor Krings, Nicholas P. McAndrew, Irbaz Bin Riaz, Ines Vaz-Luis, Cynthia Villarreal-Garza, Japneet Kaur Oberoi, Muhammad Hussnain Sadiq, Huan He, Ramaa Chitale, Michael J. Hassett

PURPOSE To provide recommendations on use of medical therapies for patients with stage I-III hormone receptor-positive, HER2-negative breast cancer. METHODS An Expert Panel including patient representation completed a systematic review of the evidence and formulated recommendations for practice. Eligible studies included patients with stage I-III hormone receptor-positive, HER2-negative breast cancer and evaluated neoadjuvant or adjuvant chemotherapy, endocrine therapy, immunotherapy, or targeted therapy. Outcomes …