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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Journal of Applied Clinical Medical Physics

Evaluating the preoperative diagnostic value of 99m Tc‐MIBI/ 99m TcO 4 − dual‐isotope SPECT/CT fusion imaging and ultrasonography in suspected primary hyperparathyroidism

Yanmei Li, Danna Hou, Zhehao Lyu, Xingrong Lan, Ziyue Zhang, Yu Lu, Peng Fu, Huiqi Gao

Abstract Background Primary hyperparathyroidism (PHPT) is a common endocrine disorder that often requires surgical intervention. Preoperative localization of parathyroid lesions is critical for successful surgery. This study compares the diagnostic value of 99m Tc‐MIBI/ 99m TcO 4 − dual‐isotope SPECT/CT fusion imaging and ultrasonography (US) in patients with suspected PHPT, and explores the correlation between lesion volume and preoperative serum biochemical markers. Objective This study aimed to assess the preope …

27.08.2026journal-article

SAS Journal of Surgery

Strangulated Rectal Prolapse in an Adult: A Case Report and Review of the Literature

Anzoua Kouakou Ibrahim, Assohoun Krahiboue Toussaint, Ekra Amos, Leh Bi Kalou Ismael, N'dri Ahou Bernadette, Bamba Inza, Diane Bamourou

Introduction: Strangulated rectal prolapse is a rare complication of complete rectal prolapse. Its course may be marked by necrosis, or even perforation, which requires prompt management. Case Report: A 44-year-old man with chronic constipation and a several-year history of episodes of reducible rectal prolapse was admitted with a large painful anal mass that had appeared suddenly after straining during defecation. On admission, he was hemodynamically stable. Proctological examination revealed a complete, large, ed …

27.08.2026journal-article

Frontiers in Medicine

Nanomaterials-enabled point-of-care diagnostics for pathogens

Jiao Wu, Dengchao Wang, Wanping Ye, Juan He, Yayun Jiang

Nanomaterials, with their unique physicochemical properties, have emerged as important enabling components for improving the performance of point-of-care testing (POCT) technologies for pathogen detection. Many conventional POCT methods still face challenges in sensitivity, specificity, multiplexing capability, and quantitative accuracy, particularly when applied to low-abundance pathogens in complex clinical samples. This review first summarizes the functional roles of representative nanomaterials in pathogen POCT …

27.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Effects of psychological interventions on competitive anxiety and athletic performance in golfers: a systematic review and meta-analysis

Longhui Li, Zilong Zhao, Xuewen Li, Yang Yi

Abstract Background Competitive anxiety is common in golf and can negatively affect athletic performance. Psychological interventions are widely used to manage competitive anxiety and enhance performance; however, evidence specific to golfers has not yet been systematically synthesized. This study aims to evaluate the effects of psychological interventions on competitive anxiety and athletic performance in golfers. In addition, subgroup analyses were conducted to explore potential sources of variation in interventi …

27.08.2026journal-article

Canadian Liver Journal

Impact of direct-acting antiviral treatment on time and out-of-pocket costs for hepatitis C patients

Yasmin A Saeed, Arcturus Phoon, Josephine F Wong, Kate Mason, Seff Pinch, Valérie Martel-Laferrière, Julie Bruneau, Jordan J Feld, Zeny Feng, Samuel S Lee, Jeff Powis, Beate Sander, William WL Wong

Abstract Background: Direct-acting antiviral (DAA) therapies have transformed care for chronic hepatitis C (CHC); however, the effect of DAA therapy on patient-borne costs is unclear. These costs can pose a substantial burden for patients and their families—even in a publicly funded health system. We estimated the patient-borne costs associated with CHC and the impact of DAA therapy on these costs. Methods: We recruited patients with CHC who were prescribed DAA therapy at two specialized liver clinics and five low- …

27.08.2026journal-article

Clinical Journal of the American Society of Nephrology

Proteinuria and Kidney Function Trajectories in Patients with Advanced CKD

Cheol Ho Park, Hyun Jun Hong, Hyung Woo Kim, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Sue K. Park, Jung Soon Kim, Kyu-Beck Lee, Jong Cheol Jeong, Kook-Hwan Oh, Amanda H. Anderson, Wei Yang, Jordana B. Cohen, Mahboob Rahman, Shin-Wook Kang, Seung Hyeok Han, on the behalf of CRIC Study and KNOW-CKD Investigators

Introduction: While urine protein-to-creatinine ratio (UPCR) is more commonly used than urine albumin-to-creatinine ratio in routine care, and particularly in low-resource settings; its association with kidney function decline and projected time to reach a kidney failure estimated glomerular filtration rate (eGFR) threshold in advanced chronic kidney disease (CKD) remains underexplored. Methods: We analyzed 2,727 participants with eGFR 15–45mL/min/1.73 m 2 without kidney replacement therapy (KRT) from the Chronic R …

27.08.2026journal-article

Clinical Cancer Research

Adrenergic regulation of cancer immunity

Jingjing Zhu, Pierre-Hubert Desimpel, Constance Gérard, Benoit J. Van den Eynde

Abstract The nervous and immune systems engage in extensive bidirectional crosstalk that shapes tumor progression and therapeutic response. Among the neuro-immune pathways involved in cancer, adrenergic receptor signaling has emerged as a key regulator of the tumor microenvironment. In this review, we summarize current understanding of the distinct roles of β- and α2-adrenergic receptor signaling in cancer immunity and their therapeutic implications. β2-adrenergic receptor signaling promotes immune suppression by i …

27.08.2026journal-article

Medicine & Science in Sports & Exercise

Knee Cartilage Composition, Morphology, and Function in Asymptomatic Recreational Runners, Non-Runners, and Obese Adults: A Matched 4HAIE MRI Study

Lukáš Slovák, Jan Plešek, Lucie Šustková, David Zahradník, Jaroslav Uchytil, Jan Šustek, Jiri Skypala, Jan Urbaczka, Miloš Golián, Miika T. Nieminen, Victor Casula, Daniel Jandačka

Introduction: Identifying early alterations in asymptomatic individuals with different physical activity levels and/or BMI is essential for understanding joint health before clinical symptoms develop. Purpose: The aim of this study was to compare cartilage composition, morphology, and subjective knee function among age- and sex-matched recreational runners (R), non-runners (NR), and obese individuals with BMI ≥ 30 kg/m²) (O). Methods: This cross-sectional study included 183 asymptomatic adults (61 age- and sex-matc …

27.08.2026journal-article

Journal of Clinical Medicine

Clinical and Functional Outcomes Following Repeat VA-ECMO in Adults: A Propensity Score–Matched Comparative Study

Kostiantyn Kozakov, Alois Philipp, Maik Foltan, Henrik Heuer, Walter Petermichl, Alexander Dietl, Bernhard Flörchinger, Leopold Rupprecht, Simon Schopka, Christof Schmid, Zdenek Provaznik

Background/Objectives: Evidence on outcomes after repeat VA-ECMO in adults remains limited. This study aimed to compare survival and post-discharge functional outcomes between adults requiring a second VA-ECMO run and propensity-matched patients supported with a single VA-ECMO run and to characterize the clinical course during repeat support. Methods: This is an observational, single-center, retrospective cohort study with a propensity score–matched comparative analysis, conducted at a university tertiary-care refe …

27.08.2026journal-article

Journal of Clinical Medicine

Frequency and Systemic Associations of Focal Low-Trabeculation/Low-Density Intramedullary Jawbone Findings: A Retrospective CBCT Study

Marzena Dominiak, Wojciech Niemczyk, Artur Pitułaj, Witold Świenc, Sebastian Dominiak, Konstanty Sławecki, Łucja Janek, Jacek Matys

Background: This exploratory study assessed the frequency of study-defined focal low-trabeculation/low-density intramedullary findings (FLDIFs) in a selected clinical cohort referred for cone-beam computed tomography (CBCT) and examined their associations with demographic, systemic, and radiographic variables. CBCT depicts mineralized trabecular architecture and relative attenuation but cannot directly demonstrate marrow fat or establish osteonecrosis; FDOJ/MFI were therefore considered only possible interpretation …

27.08.2026journal-article

Frontiers in Medicine

Machine learning prediction of adverse events during minutes 15–30 of recovery in patients event-free at 15 min after sedated gastrointestinal endoscopy

Siyuan Huang, Jiayao Zhang, Lu Yin, Meiyuan Luo, Anna Jia, Dihong Chen

Background Sedated gastrointestinal (GI) endoscopy is widely used for diagnosis and treatment but may be complicated by respiratory and hemodynamic adverse events (AEs) during post-anaesthesia recovery. Early risk identification may support targeted monitoring and efficient allocation of recovery-care resources. This study aimed to develop and internally evaluate machine-learning (ML) models for identifying respiratory and hemodynamic AEs occurring during 15–30 min after awakening following sedated GI endoscopy. Me …

27.08.2026journal-article

Technology and Health Care

Redefining coronary revascularization: The emergence of totally endoscopic robotic bypass surgery

Hamad Abdullah Shehab, Syed Mohammad Hussaini, Ibrahim Alabid, Wasim Iyad Alghoul, Mohamedanas Mohamedfaruk Patni

Abstract Totally endoscopic coronary artery bypass (TECAB) is regarded as the most advanced minimally invasive surgical coronary revascularization approach. The objective of this review is to discuss the current evidence on the feasibility, safety, clinical outcomes, and implementation challenges of TECAB, and to investigate whether TECAB can be considered a reproducible and effective alternative to traditional and other minimally invasive approaches for coronary artery bypass. A narrative review was conducted of s …

27.08.2026journal-article

Frontiers in Medicine

Advanced and underlying therapeutic strategies in transformed small cell lung cancer

Mingfeng Wei, Zheng Li, Kaiyuan Zhu, Shixiang Guo, Lefei Hu, Fuzhi Yang, Xiaoyu Chen, Xuelin Zhang, Shuai Jiang, Xunxia Zhu, Xiaoyong Shen

Transformed small-cell lung cancer (T-SCLC) is a clinically important form of histologic transformation and a mechanism of acquired resistance in non-small-cell lung cancer (NSCLC). It is associated with poor prognosis, with a median overall survival of only about 9–13 months. This review summarizes recent advances in the mechanisms, diagnosis, monitoring, and treatment of T-SCLC. Repeat biopsy remains the gold standard for confirming histologic transformation, whereas molecular profiling and liquid biopsy may faci …

27.08.2026journal-article

The Annals of The Royal College of Surgeons of England

Evaluating large language models in patient education: a comparative analysis addressing frequently asked questions in peri-acetabular osteotomy

TP Davis, B Guevel, K Logishetty, AG Dick, J Hutt

Introduction Large language models (LLMs) are increasingly used as sources of information across many fields, including healthcare. As patients turn to these models for health-related queries, evaluating the accuracy and reliability of their responses is essential. Peri-acetabular osteotomy (PAO) is performed on younger patients – a group more likely to use digital tools like LLMs for health information. This study assesses the accuracy and readability performance of two leading LLMs, ChatGPT and Google Gemini, in …

27.08.2026journal-article

PLOS Digital Health

Extracting adverse event nature, severity, timelines and resulting interventions from clinical notes of patients receiving CAR-T cell therapy using large language models

Jordan Guillot, Brenda Miao, Arvind Suresh, Madhumita Sushil, Christopher Y. K. Williams, Rohit Vashisht, Tomiko T. Oskotsky, Marina Sirota, Atul J. Butte

Chimeric Antigen Receptor T-cell (CAR‑T) therapy, genetically engineered patient T cells targeting tumor antigens, has transformed care for hematologic malignancies but requires careful tracking of adverse events (AEs) often documented only in unstructured electronic health record (EHR) notes. We evaluated a Large Language Model (LLM)–based approach in UCSF’s secure environment to extract AEs, dates, grades, and interventions within 30 days post‑infusion for six commercial CAR‑T products (2012–2023), benchmarking a …

27.08.2026journal-article

International Journal of Cosmetic Science

New insights from data analysis of 12 global clinical studies on hair shedding

Yingjie Li, Shengnan Lin, Sarah Paterson, Tony Dadd, Jiayin Gu, Ranjit K. Bhogal, Zulfa Hudaya, Hepsy Y. Selliah, Mingming Pu, Jianing N. Sun

Abstract Excessive hair shedding continues to be a major concern for individuals, negatively affecting their wellbeing and confidence. This research analysed 12 clinical studies involving 805 participants (323 males and 482 females) across eight countries (China, Indonesia, UK, India, Brazil, Thailand, Turkey and US) with concerns about hair loss. Two recent studies in China and a study in Indonesia were investigated in depth, focusing on hair shedding and breakage conditions, and age‐related differences in hair sh …

27.08.2026journal-article

Blood Coagulation & Fibrinolysis

Glycoprotein 1bM assay and von Willebrand disease: a change in diagnosis

David Lazris, Craig Seaman

The diagnosis of von Willebrand disease (VWD) is complicated by limitations of traditional laboratory tests, such as the VWF ristocetin cofactor (VWF:RCo) assay. Newer assays, such as the VWF glycoprotein 1bM (VWF:GP1bM) assay, are more reliable and not affected by the D1472H polymorphism; thus, current hematology societal guidelines recommend these newer assays for diagnosing VWD. This study aims to perform a descriptive analysis of the impact of the VWF:GP1bM assay on the diagnosis of VWD among previously diagnos …

27.08.2026journal-article

Head & Neck

Aggressive Mandibular Squamous Cell Carcinoma Mimicking Periodontal Disease in a Non‐Transplanted Patient With Fanconi Anemia

Cassius Carvalho Torres‐Pereira, Laura Grein Cavalcanti, Marta Aparecida Alberton Nuernberg, Juliana Lucena Schussel, José Miguel Amenábar Céspedes

ABSTRACT Background Fanconi anemia (FA) is associated with markedly increased risk for early‐onset oral squamous cell carcinoma (OSCC). Methods We report an aggressive mandibular squamous cell carcinoma in a 26‐year‐old non‐transplanted woman with FA initially interpreted as localized periodontal disease adjacent to a tongue leukoplakia. Results Initial examination demonstrated mild gingival inflammation and localized alveolar bone loss involving the right mandibular molars. Forty‐five days later, the patient retur …

27.08.2026journal-article

Journal of the Royal Society of Medicine

Alfred the Great: a diagnosis

Nicholas Summerton

Based on a re-analysis of the available evidence it seems likely that Alfred the Great suffered from a painful perianal swelling as a teenager termed, in Latin, ficus . After this problem had resolved he was then troubled by an intermittently painful abdominal condition that affected him for most of his adult life. Although it is tempting to equate Alfred`s condition to a specific modern-day gastrointestional or urological diagnosis – as opposed to appreciating the nature and significance of his pain – it is argued …

27.08.2026journal-article

npj Digital Medicine

Ensuring trustworthy AI assisted guideline development for clinical practice

Quan Zhang, Yuanyuan Fu

Abstract Li et al. introduce Quicker, an agentic large language model system that drafts clinical guideline recommendations through a GRADE-based workflow. Building on gaps in the authors’ own evaluation, we propose safeguards for trustworthy use: verifiable, design-aware evidence bundles with explicit scope; calibrated, uncertainty-aware deferral; targeted human validation and modular quality gates; and governance against contamination and over-reliance. Trustworthiness, however, is necessary but not sufficient fo …

27.08.2026journal-article

Aperture Neuro

Large-Scale Open Science Simulated Data to Study the Development of Brain and Behavior Relationships: Epidemiologic, Clinical, and Neuroimaging Characteristics

Tonya White, Neda Sadeghi, Luke Norman, Vince Calhoun, Philip Shaw

Both brain and behavior undergo considerable changes during adolescence, a time synonymous with the emergence several psychiatric disorders, including mood and psychotic disorders. Multiple studies have explored the interaction between brain and behavior during childhood and adolescence, with both mixed and convergent findings between the studies. One challenge is that different longitudinal models can be applied to both the same or similar dataset and yet yield different results. Without knowing the ground truth, …

27.08.2026journal-article

Clinical Spine Surgery

Revisiting the Incidence and Risk Factors for Cervical Postlaminectomy Kyphosis

Takashi Hirase, Colten Rowan, Thomas Jacob, Max Sadlowski, Sree M. Vemu, Austin Nguyen, Gregory S. Kazarian, Kevin J. DiSilvestro, Rex A.W. Marco, Todd J. Albert, Han J. Kim

Study Design: Systematic review. Objective: To perform a systematic review that investigates the incidence and risk factors for cervical postlaminectomy kyphosis. Summary of Background Data: There is a wide range of incidences and risk factors for cervical postlaminectomy kyphosis reported within the literature. Definitive recommendations on indications and technical considerations to minimize this complication remain elusive. Methods: A systematic review was registered with PROSPERO and conducted in accordance wit …

27.08.2026journal-article

Frontiers in Nuclear Medicine

Artificial intelligence across oncologic theranostics: evidence for patient stratification, dosimetry, and adaptive radiopharmaceutical therapy

Mallareddy Banala, Shabbir Ezuddin, Mark Foley, Russ Kuker

Artificial intelligence (AI) has been studied across radiopharmaceutical therapy (RPT); however, evidence for treatment-changing use remains limited. We conducted a structured narrative review with descriptive mapping of learned models for patient stratification, segmentation, tumor-burden quantification, quantitative preprocessing, dosimetry, toxicity prediction, response assessment, and radiation-safety/logistics support. The mapped set contained 73 direct full journal reports and eight direct conference abstract …

27.08.2026journal-article

Clinical Child Psychology and Psychiatry

Tree of Life Groups for Children and Young People With Long-Term Medical Conditions and Their Parents Led by Pre-Qualification Psychology Staff

Kristina Soon, Caitlin Cook, Emily Golding, Eseoghene Obukohwo, India Browne, Morgan Baynes Zolkwer, Ramisa Hasan, Tripti Gureta, Georgia Setchell

The Tree of Life group (Ncube, 2006) was designed to help children, young people (CYP), and adults who have experienced hard times or trauma to build resilience, restore hope, and connect with their strengths and social histories. A small number of publications have demonstrated a positive impact with CYP with long-term medical conditions (LTCs) (e.g., Casdagli et al., 2017) who are more likely to experience psychosocial challenges. In the context of increasing workforce pressures, the current study aimed to test i …