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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Canadian Diabetes & Endocrinology Today

Low Risk for Recurrence of Differentiated Thyroid Cancer: A Paradigm Shift to De-Escalation and Simplifying Care for Long Term Follow-up

Shivraj Singh Riar

The incidence of thyroid cancer in Canada increased from 1984 to 2013, followed by a subsequent decline; the most recent projections estimate 6,100 cases in 2026. Low-risk differentiated thyroid cancer (DTC), with an excellent treatment response, is associated with a recurrence risk of less than 2% and a 20-year disease specific mortality of less than 1%. In alignment with the 2025 American Thyroid Association DTC Guidelines and the Follow-up and Transition of Care for Low Recurrence Risk Thyroid Cancer Patients in …

26.08.2026journal-article

Otolaryngology–Head and Neck Surgery

Treatment Strategies and Outcome in Minimally Invasive, Gland‐Preserving Treatment for Multiple Sialolithiasis

Elisabeth Wimmer, Sophie Kansy, Moritz Allner, Robin Rupp, Antoniu‐Oreste Gostian, Sarina Mueller, Michael Koch

Abstract Objective(s) Minimally invasive procedures are well established for patients with sialolithiasis involving single stones. For patients with multiple sialolithiasis, few data are available regarding the treatment approaches and outcomes with gland‐preserving therapies. The aim of this study was to review current treatment concepts and postinterventional outcomes in these patients and to propose a treatment algorithm. Study Design Retrospective study. Setting University hospital and tertiary referral center. …

26.08.2026journal-article

Journal of Biochemical and Molecular Toxicology

Autocrine Control of CD276 by SPARC in Liver Cancer and Its Contribution to Immune Escape and Resistance to Immunotherapy

Mengying Tang, Jing Liu

ABSTRACT Hepatocellular carcinoma (HCC) frequently demonstrates resistance to immunotherapeutic interventions, a phenomenon largely linked to mechanisms of immune escape. Among the modulators of the tumor microenvironment, SPARC (Secreted Protein Acidic and Rich in Cysteine), a matricellular glycoprotein, has been associated with diverse oncogenic processes in multiple cancer types. However, the contribution of SPARC to immune regulation through CD276 signaling remains insufficiently characterized. To clarify this …

26.08.2026journal-article

Cancers

Comparative Outcomes of Open, Laparoscopic, and Robotic Right Colectomy for Colon Cancer: Postoperative Recovery, Surgical Quality, and 3-Year Survival—A Monocentric Retrospective Study

Krzysztof Nowakowski, Leonie Wesselmann, Michael Leitz, Fabian Nimczewski, Annika Hoyer, Kira Baginski, Wolfgang Hiller, Jens Hoeppner, Zsolt Madarasz

Background/Objectives: Minimally invasive approaches are increasingly used in right colectomy for colon cancer; however, comparative data, including open, laparoscopic, and robotic techniques, remain limited, particularly regarding postoperative recovery and oncological outcomes. Methods: This retrospective monocentric study included 89 patients undergoing elective right colectomy for colon cancer between July 2018 and December 2022. Of these, 30 patients underwent open, 29 laparoscopic, and 30 robotic-assisted sur …

26.08.2026journal-article

Biomedicines

Single-Cell RNA-Seq Reveals Chromosomal Instability-Associated Transcriptomic Profiles in Breast Cancer

María Paula Meléndez-Flórez, Nelson Rangel, Milena Rondón-Lagos, Oscar Ortega-Recalde

Background/Objectives: Breast cancer (BC) is the most frequently diagnosed malignancy and a leading cause of cancer-related mortality in women worldwide. This disease is highly heterogeneous and dynamic, and chromosomal instability (CIN) plays a key role in the acquisition of these traits by generating genetic diversity that promotes tumor adaptation and influences therapeutic response and prognosis. Although several methods have been developed to quantify CIN, they are not readily applicable to human tumors and ar …

26.08.2026journal-article

JCO Oncology Practice

Development of a Pediatric Oncology Financial Toxicity Outcome Measure With Content and Face Validity: The Parent-Reported Instrument of Costs and Experiences (PRICE)

Timothy J.D. Ohlsen, Grace Fredman, Jacqueline Burgara, Kristine A. Karvonen, M. Monica Gramatges, Eric J. Chow, Salene M.W. Jones, Arti D. Desai

PURPOSE To address a lack of validated outcome measures of financial toxicity in pediatric oncology settings, we developed a novel caregiver-reported instrument. METHODS We first conducted qualitative concept elicitation interviews with family caregivers, then drafted de novo survey items guided by salient content domains. Items were reviewed by an expert panel who provided numeric ratings of item relevance to calculate content validity index (CVI), along with feedback on clarity and content. Items were removed or …

26.08.2026journal-article

Frontiers in Immunology

Association between serum tumor necrosis factor-alpha levels and rheumatoid arthritis-associated interstitial lung disease: a cross-sectional study

Xiaoli Li, Lina Leng, Yaorong Han, Jinfeng Zhang, Xinfang Shang, Shusen Zhang, Dengxiang Liu, Yuhua Qiao

Background Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is one of the most severe extra-articular complications of rheumatoid arthritis (RA). Although tumor necrosis factor-α (TNF-α) plays a central role in RA pathogenesis, its relationship with RA-ILD remains uncertain. This study aimed to investigate the association between serum TNF-α levels and RA-ILD, with a focus on sex-stratified patterns. Methods We performed a cross-sectional study that initially included 1,191 consecutive RA inpatien …

26.08.2026journal-article

Frontiers in Public Health

A longitudinal analysis of symptom burden trajectories among breast cancer patients undergoing postoperative chemotherapy and related factors: a latent class growth model

Wanqin Tie, Xi Zhang, Liang Yue, Lingling Yang, Meng Niu, Jiayi Zhang

Background Symptom burden among breast cancer patients receiving postoperative chemotherapy shows marked individual variability, yet its longitudinal trajectory has not been fully characterized. Aim To delineate heterogeneous trajectories of symptom burden and identify their influencing factors in postoperative breast cancer patients undergoing chemotherapy. Methods We recruited postoperative breast cancer patients receiving chemotherapy from a tertiary hospital in Ningxia, China. Participants completed a general i …

26.08.2026journal-article

Current Oncology

Lenalidomide Exposure and TP53-Mutated Myelodysplastic Syndromes/Neoplasms

Bahga Katamesh, Rory M. Shallis

The benefits of lenalidomide, which leverages TP53-dependent apoptosis and promotion of megakaryocytic differentiation, in lower-risk MDS (LR-MDS) with del(5q) are well-established and drive its frequent use in clinical practice. In parallel, advances in molecular testing have elucidated the clear impact of TP53 mutations on response to therapies and prognosis, with diversity in the latter informed by variant allele frequency (VAF) and/or predicted allelic state. In this review, we discuss the converging pre-clinic …

26.08.2026journal-article

BMC Cancer

‘How can I take things as they happen?’ unveiling illness perceptions among patients with gastrointestinal tract cancer: a mixed-methods study

Yongfeng Chen, Carmen Wing Han Chan, Liuxin Zhang, Kai Chow Choi, Marques Shek Nam Ng

Abstract Background Illness perceptions are defined as patients’ cognitive and emotional representations of their disease. These perceptions influence how individuals engage in health-related behaviours, including treatment adherence, long-term surveillance, and healthy lifestyle adoption. Understanding of illness perceptions among patients with gastrointestinal (GI) tract cancer remains limited. This study aimed to describe illness perceptions, examine their associated factors, and achieve a comprehensive understa …

26.08.2026journal-article

Clinical Oral Investigations

Detection of oral potentially malignant disorders and oral cancer with white light through deep learning: a systematic review and meta-analysis

N. Soto Ayén, J. A. Rodríguez Molinero, P. J. Navarro Lorente, Juan Antonio Ruiz-Roca, P. López-Jornet

Abstract Objectives The research question was: How accurate is artificial intelligence (AI) in diagnosing Oral Potentially Malignant Disorders (OPMD)/oral cancer in patients of any age, using digital photographic images under white light? Materials and methods A systematic review was performed in the PubMed, Web of Science and Scopus databases. The inclusion criteria were: detection of OPMD or Oral Squamous Cell Carcinoma (OSCC). The risk of bias was assessed with the QUADAS-C tool. Forest plots were generated with …

26.08.2026journal-article

Visual Computing for Industry, Biomedicine, and Art

Hierarchical two-stage ensemble of dilated U-net models for brain tumor segmentation

Vladyslav Koniukhov

Abstract Ensemble methods for image segmentation improve performance by combining predictions from multiple models, yielding more accurate and reliable results. This study presents a two-stage hierarchical framework to enhance the accuracy and stability of brain tumor delineation in magnetic resonance imaging data. The proposed approach integrates ensemble strategies at different stages of the processing pipeline. The architecture operates in two stages: first, sub-ensembles resolve internal inconsistencies through …

26.08.2026journal-article

Plastic & Reconstructive Surgery

Ideas and Innovations: Successful Maintenance of Implant-Based Breast Reconstruction in Recurrent Breast Cancer Treatment Using Tailored Tissue Expander Conversion

Ryoko Hamaguchi, Kimberly S. Khouri, Nicholas Leung, Emily Lafleur, Yoon S. Chun

Patients with a prior mastectomy and implant-based breast reconstruction (IBR) who suffer breast cancer recurrence generally require wide excision followed by chest wall radiotherapy for definitive treatment. This typically results in poor cosmetic outcomes due to skin/soft tissue deficit, progressive capsular contracture of the irradiated implant, deformity, and asymmetry despite otherwise successful oncologic treatment. We describe a novel staged approach using tissue expander (TE) at the time of recurrence treat …

26.08.2026journal-article

Frontiers in Oncology

Clinical and ultrasound predictors of clinically significant endometrial pathology in women with histologically confirmed lesions: a retrospective case–control study

Xiao Yuhong, Wang Bolun, Wang Xiliang, Yan Li, Yu Tingting, Xiu Yinling, Yuexin Yu, Ma Xiangwei

Objective To identify clinical and ultrasound predictors of clinically significant endometrial pathology and to develop an internally validated clinicosonographic model in women with histologically confirmed endometrial or intracavitary lesions. Methods This unmatched retrospective case–control study included women with histologically confirmed lesions who had complete clinicosonographic data. All eligible women with clinically significant pathology during the study period were included (n=500), and a random 1:1 sa …

26.08.2026journal-article

Indian Journal of Cancer

Measurement of preoperative repair area of thyroid gland flap in patients with neck cancer by three-dimensional imaging

Bo Han, Ye Wang, Xiang Zhuang

Abstract Background: We aimed to explore a method to measure the preoperative repair area of the thyroid gland flap (TGF) in patients with neck cancer. Methods: A total of 82 patients with nonthyroid diseases were included in this study. The digital imaging and communications in medicine (DICOM) data of enhanced computed tomography (CT) of the neck were collected. Three-dimensional (3D) reconstruction was performed using Mimics software, and data on the thyroid gland was collected. The projected area of the unilate …

25.08.2026journal-article

Blood Journal

Phase 1 Trial with Soquelitinib, a Selective ITK Inhibitor for Treatment of Relapsed/Refractory T Cell Lymphomas

Richard A. Miller, Ning Ding, John C. Reneau, Yuqin Song, Dok Hyun Yoon, Tatyana A. Feldman, Costas K Yannakou, Won Seog Kim, Robin Gasiorowski, Youn H Kim, Michael S Khodadoust, Dejan Radeski, Pratyush Giri, Ho-Jin Shin, Sung-Soo Yoon, Neha Mehta-Shah, Oleg E Akilov, Amit S Khot, Nagendra Prasad Sungala, Suresh Mahabhashyam, Ryan A Wilcox

Despite advances in the molecular characterization of mature T and NK cell lymphomas, outcomes for these patients is poor especially those with relapsed/refractory (R/R) disease. These tumors possess mutations that often result in tonic T cell receptor (TCR) signaling and an immunosuppressive tumor microenvironment. Interleukin-2-inducible T cell kinase (ITK) plays an important role in TCR signaling and T cell differentiation. Soquelitinib is a covalent oral selective ITK inhibitor that blocks Th2 differentiation w …

25.08.2026journal-article

Pakistan Journal of Medical Sciences

Skin concerns and treatment seeking trends among patients visiting aesthetic clinics in Lahore, Pakistan

Muhammad Awais Arif, Shamsa Kanwal, Areesha Arif

Background & Objective: The increasing demand for aesthetic services, combined with the lucrative nature of the aesthetic industry, has led many healthcare providers to enter this field. This led to the rapid expansion of aesthetic clinics worldwide. However, many of these establishments face early closures. The primary objective of this study was to identify the most prevalent skin concerns among patients visiting dermatology and aesthetic clinics. In addition, the study aims to analyze patients’ treatment-seeking …

25.08.2026journal-article

Revista ft

Musculação terapêutica no tratamento da condropatia patelar: efeitos do método SCI sobre perímetros musculares, controle articular e sintomas clínicos.

Saulo de Tarso Silva

Introduction: Patellar chondropathy is a degenerative condition that generates significant pain and functional limitation. Conventional protocols often fail due to underloading and a lack of individualization. Objective: To evaluate the effects of the SCI Method on muscle circumferences, joint control, and symptoms in patients with patellar chondropathy. Methods: A longitudinal study with men and women (mean age 30–35 years) followed for 24 months. The protocol was based on uni- and bilateral leg extension exercise …

25.08.2026journal-article

Journal of Chittagong Medical College Teachers' Association

Effect of Intermittent Clamping of Chest Tubes on Reducing The Duration of Drainage and Length of Hospital Stay Following Lung Cancer Surgery

Sowrabh Biswas, Mohammad Karim Hossain, Yousuf Kabir, Md Ataur Rahman, Dashab Hannan, Mohammad Lutfor Rahman

Background: Chest tube management plays a vital role in postoperative recovery after lung cancer surgery. Intermittent clamping may facilitate earlier tube removal, reducing complications, hospital stay and costs. To evaluate the impact of intermittent chest tube clamping on drainage duration and hospital stay following lobectomy. Materials and methods: This comparative cross-sectional study included 40 lobectomy patients at the National Institute of Diseases of the Chest and Hospital, Dhaka (January 2023–August 20 …

25.08.2026journal-article

Frontiers in Pharmacology

MircoRNAs as regulators of regulated cell death in cancer progression: a focus on ferroptosis, anoikis and pyroptosis

Di Xiao, Yanzhou Luo, Liyuan Liu, Yajie Lu, Xiaofang Xie, Zhaokai Zhou, Bin Ma, Fu Peng

Cancer progression is shaped not only by genetic alterations but also by dynamic remodeling of regulated cell death. MicroRNAs (miRNAs) have emerged as central regulators of these processes by coordinating gene expression, metabolic balance, and stress responses. This review summarizes current understanding of how miRNAs modulate ferroptosis, anoikis, and pyroptosis across liver, lung, gastric, breast, and other cancers. They influence ferroptosis through lipid peroxidation and antioxidant systems, regulate anoikis …

25.08.2026journal-article

Physics in Medicine & Biology

Diagnosis of Clinically Significant Prostate Cancer in Multiparametric MRI with Pseudo-Localization of Suspected Lesion

Xijun Liu, Rongzong Liu, Xin Zhou, Yifei Yan, Haihao He, Quan Zhou, Limin Zhang, Qi Zhang

Abstract Objective. To develop a two-stage diagnostic framework using pseudo-localization for patient-level diagnosis of clinically significant prostate cancer (csPCa) on multiparametric MRI (mpMRI), enabling better utilization of examinations without manual lesion annotations.
Approach. We included 1494 mpMRI examinations from the PI-CAI dataset, partitioned at the patient level into 217 annotated csPCa, 202 unannotated csPCa, and 1075 non-csPCa cases. First, a prostate transformer U-Net (PTUnet) was trained o …

25.08.2026journal-article

JAAPA

Precision oncology in breast cancer

Whitney Tobin

ABSTRACT Recent advances in breast cancer management have transformed treatment across molecular subtypes and expanded the role of precision oncology. Hormone receptor–positive (HR-positive), human epidermal growth factor receptor 2–positive (HER2-positive), HER2-low, and triple-negative breast cancer (TNBC) each demonstrate distinct biologic behavior requiring tailored therapeutic strategies. In HR-positive disease, cyclin-dependent kinase 4/6 (CDK4/6) inhibitors and next-generation selective estrogen receptor deg …

25.08.2026journal-article

Saudi Endodontic Journal

Preliminary comparative analysis of faculty and self-assessment in evaluating root canal treatment quality performed by dental students in a preclinical setting: A cross-sectional study

Ahmad Jabali

Abstract Introduction: Self and staff assessments represent a recent approach to evaluating preclinical performance, though not yet widely adopted. This preliminary study aimed to compare faculty assessments with student self-assessments of root canal treatment (RCT) quality and evaluate the influence of gender on assessment accuracy across rubric parameters. Materials and Methods: This cross-sectional study evaluated dental students ( N = 40; 20 males, 20 females) in their final practical examination for the precl …

25.08.2026journal-article

Frontiers in Medicine

Fulminant development of a giant pelvic metastasis from microsatellite-stable early-onset sigmoid colon cancer with KRAS and TP53 co-mutations: a case report

Shouxin Wei, Sijia Yu, Yunsheng Lan

Background Early-onset colorectal cancer (EO-CRC) is often characterized by a highly aggressive nature and insidious onset. Herein, we report a rare case of fulminant, early-onset colon cancer presenting with a massive pelvic seeding metastasis driven by concurrent KRAS and TP53 mutations. This study aims to elucidate the molecular mechanisms underlying its hyper-progressive course and provide critical insights into clinical differential diagnosis. Case description A 44-year-old female presented with intermittent a …