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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Clinical and Experimental Immunology

Prospective Association Between Leukocyte Telomere Length and Mortality: Findings from the Black Women’s Experiences Living with Lupus (BeWELL) Study

David H Chae, Connor D Martz, Amani M Nuru-Jeter, Tiffany Yip, Jue Lin, Eloisa Bonfá, Elissa S Epel, Kenneth Saag, Cristina Lanata, Sofia Nadgauda, Jesus Ramirez-Valles, Jinoos Yazdany

Abstract Leukocyte telomere length (LTL) is a biomarker of replicative history of cells and has been posited to be an indicator of biological aging. LTL may yield insight into immunomodulatory disorders, including systemic lupus erythematosus (SLE), an immune-mediated inflammatory disease that disproportionately affects Black/African American women. This study examined the association between LTL and mortality among 422 Black/African American women in the Black Women’s Experiences Living with Lupus (BeWELL) Study. …

27.08.2026journal-article

SN Comprehensive Clinical Medicine

Effects of Exercise Training on Muscle and Functional Outcomes in Adults with Liver Cirrhosis: A Systematic Review

Priscila Meireles Calil Fontana, Rafael dos Santos Souza, Manuella Franco Cerqueira da Silva, Anete da Costa Medeiros, Yamana Dias de Matos, Laisa Liane Paineiras-Domingos

Abstract Objective To evaluate the efficacy and safety of physical exercise on muscle mass, strength, and functional capacity in adult patients with pre-transplant liver cirrhosis. Methods This systematic review (PROSPERO: CRD420261279439) followed PRISMA guidelines. We searched six databases (PubMed, EMBASE, Cochrane, VHL, Scopus, SciELO) for randomized controlled trials (RCTs) evaluating exercise in cirrhotic patients. Risk of bias and certainty of evidence were assessed using RoB 2 and GRADE, respectively. Resul …

27.08.2026journal-article

Journal of Hospital Medicine

The association between sociodemographic and clinical factors and outcomes among inpatients with community‐acquired pneumonia

Farhana Islam, Surain B. Roberts, Sarah L. Malecki, Anne Loffler, Leo Hersi, Anthony D. Bai, Amol A. Verma, Fahad Razak, Peter J. Gill, Sanjay Mahant

Abstract Background Community‐acquired pneumonia (CAP) is a leading cause of hospitalization and mortality. The influence of sociodemographic characteristics on adverse outcomes in adults hospitalized with CAP remains poorly understood, particularly for patients younger than 65. Objectives To evaluate associations between baseline sociodemographic characteristics and a composite outcome of intensive care unit (ICU) admission or in‐hospital mortality, and whether these differed across age strata (18–39, 40–64, and ≥ …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

IL-18 in atherosclerosis: context-dependent biology, human evidence, and translational challenges

Dongshuai Zhang, Shuai Wang, Yang Li, Huijie Zhang, Bing Wang

Atherosclerosis is a chronic inflammatory disease shaped by interactions among vascular cells, innate immunity, adaptive immunity, and metabolic stress. Interleukin-18 (IL-18), an IL-1 superfamily cytokine activated predominantly downstream of inflammasomes, links vascular injury to type 1 immune responses. This structured narrative review integrates mechanistic, plaque-tissue, epidemiological, genetic, and therapeutic evidence for IL-18 in atherosclerosis. Experimental studies generally support pro-atherogenic act …

27.08.2026journal-article

Andrology

Penile Cutaneous Nerve Distribution Pattern: An Anatomical Study to Guide Penile Surgery

Junxi Wu, Fei Xu, Ji Zhang, Linhu Zhang, Shengbo Yang

ABSTRACT Background The overall distribution pattern of penile cutaneous nerves (PCNs) is critical for sexual function and penile surgeries but remains incompletely characterized. Objective To systematically elucidate the overall innervation pattern of PCNs and provide an anatomical basis for surgical practices. Methods PCNs origins were examined in 24 formalin‐fixed adult male cadavers (12 incompletely covered prepuces, 12 completely covered prepuces) through dissection. Modified Sihler's staining with clock‑point …

27.08.2026journal-article

Razi Medical Journal

Efficacy of Methotrexate Treatment in Women with Tubal Ectopic Pregnancy, University Hospital, Tripoli, Libya

Noura Elawam

The use of methotrexate for the treatment of women with tubal ectopic pregnancies is now common practice. However, the clinical and hormonal determinants of the success of this treatment are not known. Methods: We studied 120 women with tubal ectopic pregnancies who were treated with methotrexate intramuscularly according to a single-dose protocol. Pretreatment serum concentrations of human chorionic gonadotropin and progesterone, the size and volume of the gestational mass, fetal cardiac activity, and the presence …

27.08.2026journal-article

Neuro-Oncology

57 The role of the Clinical Nurse Specialist in neuro-oncology: Insights from a UK-wide review of adult brain tumour services (2020-2026)

Catharine James, Charlotte Robinson, Jillian Sokratous, Andrew Wright, Eloise Lines, Shona Floyd, Camille Goetz, Nicky Huskens

Abstract Introduction Clinical Nurse Specialists (CNSs) are central to coordinating complex neuro-oncology pathways, yet national data on capacity and roles are lacking. We aimed to examine variation in CNS capacity, team structure, responsibilities, and training across UK adult brain tumour services. Method Data were collected from 25 NHS neuro-oncology centres (covering more than 90% of the UK population) in 2020–2026 through the Tessa Jowell Centre of Excellence programme, supplemented by national patient experi …

27.08.2026journal-article

Clinical Journal of Health Sciences

Dialectical Behavior Therapy for Borderline Personality Disorder: A Systematic Review

Damla Rana Altunay, Meryem Karaaziz

There are numerous studies in the literature examining the effects of Dialectical Behavior Therapy (DBT) on patients with Borderline Personality Disorder (BPD). The aim of this systematic review is to synthesize studies on DBT and Borderline Personality Disorder to examine the effects of Dialectical Behavior Therapy on patients with BPD and to observe how differences in the treatment process and content influence patient outcomes. This study was conducted using a systematic review methodology and did not involve pr …

27.08.2026journal-article

Veterinary Sciences

Keyhole Limpet Hemocyanin-Based Multimodal Management in Two Dogs with Presumptive Urothelial Carcinoma: Long-Term Clinical and Imaging Follow-Up

Ji-hee Hong, Jihyun Kim, Kun-Ho Song

Canine urothelial carcinoma (UC) is commonly managed with non-steroidal anti-inflammatory drugs (NSAIDs), alone or combined with cytotoxic chemotherapy. Evidence supporting subcutaneous keyhole limpet hemocyanin (KLH) in canine UC is lacking. We describe two client-owned dogs with presumptive lower urinary tract UC managed with NSAIDs, KLH, and selenium after cytotoxic chemotherapy was declined. Case 1 was an 11-year-7-month-old castrated male Maltese with bladder-neck/proximal-urethral thickening. A positive veter …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Preoperative C-reactive protein and textbook outcome following pancreaticoduodenectomy for pancreatic head adenocarcinoma

Ugur Topal, Burak Aydogan, Yunus Kaycı, Ishak Aydin, Mevlut Harun Agca, Serdar Gumus, Ahmet Gökhan Saritas, Abdullah Ulku, Atilgan Tolga Akcam

BACKGROUND Textbook outcome (TO) captures an ideal postoperative course after pancreaticoduodenectomy (PD) and is increasingly used for surgical quality assessment. However, standardized TO-based data after PD from Türkiye remain limited, restricting comparison with international benchmarks. We hypothesized that preoperative systemic inflammation, reflected by C-reactive protein (CRP), would be associated with TO achievement after PD for pancreatic head adenocarcinoma. AIM To determine the TO achievement and preope …

27.08.2026journal-article

Journal of Clinical Immunology & Microbiology

Immune Memory Based Classification of Human Herd (IMCHH)

Ibrahim MS Shnawa

Individual and population/herd immunity are at most depend on the nature of effector cells on first encounter and immune memory cells on re-infection or boost vaccination. The present opinion paper tempts to suggest human herd classification on the bases of immune memory cell nature. The immune memory stratification starts as; baseline immune memory function, innate immune memory, infection induced memory, pre-existing and current immune memory and vaccine induced memory. Based on this stratification and in accorda …

27.08.2026journal-article

BMJ Supportive & Palliative Care

Cost-effectiveness analysis of fosaprepitant versus aprepitant-based antiemetic regimens in children receiving highly emetogenic chemotherapy: individual patient-level analysis of a randomised trial

Rahul Kumar, Manraj Singh Sra, Azgar Abdul Rasheed, Archana Sasi, Deepam Pushpam, Atul Batra, Shuvadeep Ganguly, Sameer Bakhshi

Objectives To assess the trial-based cost-effectiveness of an intravenous fosaprepitant-based antiemetic regimen compared with oral aprepitant, in combination with ondansetron and dexamethasone, among children receiving highly emetogenic chemotherapy in India and the USA using individual patient-level data. Methods Costs were estimated from a private payer perspective in India and the USA. Health outcomes were expressed as quality-adjusted life-years (QALYs). Incremental cost-utility ratio (ICUR) and incremental ne …

27.08.2026journal-article

Brain

Could NQO1 genotypes impact the results of clinical trials with idebenone?

Valerio Carelli, Martina Romagnoli, Filippo Fortuna, Claudio Fiorini, Leonardo Caporali, Thomas Klopstock, Chiara La Morgia, Anna Maria Ghelli

Carelli et al. argue that new insights into how NQO1 influences the response to idebenone warrant reevaluating the results of previous clinical trials, including those in Friedreich ataxia and Duchenne muscular dystrophy, using patient stratification by NQO1 genotype.

27.08.2026journal-article

Medicina

Endocardial Left Atrial Appendage Occlusion in Atrial Fibrillation: Device Design, Clinical Evidence, and Postprocedural Antithrombotic Management

Grigory Matvienko, Mantė Agnė Rimkienė, Vilhelmas Bajoras, Agnė Drąsutienė, Rūta Masiulienė, Dovilė Gabartaitė, Monika Šalaševičienė, Mindaugas Matačiūnas, Diana Sudavičienė, Germanas Marinskis, Audrius Aidietis, Gediminas Račkauskas

Background and Objectives: Atrial fibrillation is a major cause of ischemic stroke, and in patients with non-valvular atrial fibrillation the left atrial appendage is the predominant site of thrombus formation. Although oral anticoagulation remains the standard strategy for stroke prevention, long-term therapy may be limited by bleeding risk, prior major bleeding, contraindications, intolerance, or difficulty maintaining stable anticoagulation. Endocardial left atrial appendage occlusion (LAAO) has therefore emerge …

27.08.2026journal-article

Frontiers in Endocrinology

A case report of young-onset type 2 diabetes patient with severe metabolic dysregulation carrying an LRP6 variant

Dan Xiang, Li Yuan, Shuaiju Liao, Yangtian Wang

Background The global epidemic of type 2 diabetes mellitus (T2D), along with its rising prevalence among younger populations, raises substantial public health concerns; severe hypertriglyceridemia (sHTG) is a major risk factor for acute pancreatitis. Insulin resistance in T2D often coincides with dyslipidemia, contributing to lipotoxicity, and insulin-resistant states may be linked to specific genetic variants. Case presentation This report presents a 27-year-old man with poor glycemic control, recurrent dizziness, …

27.08.2026journal-article

International Journal of Reproduction, Contraception, Obstetrics and Gynecology

Condyloma acuminata in pregnancy: clinical profile and management

Auxeelia P. D. R. Rathinasamy, Lalitha Karunamoorthy, Bhavadharani Nanthakumar

Condyloma acuminatum, also known as mucocutaneous external genital warts, is a benign neoplasm of the genital tract caused by human papillomavirus most commonly types 6 and 11. Here we present a case of 24-weeks unbooked primigravida who presented with complaints of vulval itching and a mass over the vulva for six months. Genital examination revealed multiple papillomatous growths arising from the vulva, no bleeding on touch. At 24 weeks of gestation vulval biopsy was performed and the report showed condyloma acumi …

27.08.2026journal-article

Frontiers in Public Health

Research progress on continuous nursing care for children after radical surgery for Hirschsprung’s disease

Dezhi Lu, Qingyu Xu, Xiaohan Yu, Yi Song, Honglian Xia, Yufeng Li

Hirschsprung’s disease is a common congenital gastrointestinal malformation in children, for which radical surgery remains the primary treatment modality. Postoperatively, patients are prone to complications such as Hirschsprung-associated enterocolitis, defecation dysfunction, anal stenosis, and psychological or behavioral abnormalities, all of which significantly impair growth, development, and quality of life. As a critical bridge linking inpatient treatment with home-based rehabilitation, continuous nursing car …

27.08.2026journal-article

Journal of Advanced Periodontology & Implant Dentistry

A comparative evaluation of implant stability and crestal bone loss in T-PRF-treated and conventional implants: A split-mouth clinical study

Anuraga Tejaswi Thotimpuri, Mohan Kumar Pasupuleti, Gautami Subhadra Penmetsa, Satyanarayana Raju Manthena, Naga Venkata Satya Sruthima Gottumukkala, Konathala Santosh Venkata Ramesh

Introduction: This study aimed to compare implant stability and crestal bone loss between titanium platelet-rich fibrin (T-PRF)-treated implants and conventional implants. Methods: A prospective, randomized, split-mouth clinical trial was conducted in 10 healthy patients, with 20 implants per mouth (test and control). Each patient received one T-PRF-treated implant and one conventional implant. Implant stability was assessed using implant stability quotient (ISQ) at placement and at 3 months. Crestal bone loss was …

27.08.2026journal-article

Frontiers in Psychiatry

RITA-T (rapid interactive screening test for autism in toddlers): a scoping review of psychometric properties, cross-cultural validation, and clinical applications

Huijuan Liu, Guiju Zhang, Ziyun Li, Ting Zhang, Li Zhang, Yan Li

Background The Rapid Interactive Screening Test for Autism in Toddlers (RITA-T) is a clinician-administered, interactive screening instrument for toddlers aged 18–36 months that directly assesses core social-communicative abilities through structured play. Since its introduction in 2015, validation studies have emerged across diverse populations and cultural contexts. Objective This scoping review systematically maps the evidence on RITA-T’s development, psychometric properties, cross-cultural validation, clinical …

27.08.2026journal-article

International Journal of Biology and Life Sciences

Machine Learning-Guided Design of Novel Janus Kinase Inhibitors for Rheumatoid Arthritis Treatment

Angela Wu

Attenuation of autoimmune responses by inhibiting immune activation pathways has been a common strategy for treating autoimmune diseases. The inhibition of JAK2 protein has proven effective in a clinical setting for treating RA. However, most of the JAK inhibitors have limited isoform selectivity, resulting in broad immune suppression that elevates the risk of infection, malignancy, and cardiovascular events. These concerns promote the development of novel JAK inhibitors with improved potency and selectivity. Focus …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Giant Meckel’s diverticulum with inflammation, ischemia, and adhesive obstruction: A case report

Berkan Acar, Ali Muhtaroğlu, Elif Yılmaz

BACKGROUND Adult Meckel diverticulum (MD) is an uncommon cause of acute abdomen, and preoperative diagnosis remains difficult because the presentation overlaps with more familiar right lower quadrant pathology. Giant lesions are particularly rare, with the literature using varying size thresholds. We report a 14-cm MD complicated by inflammation, ischemia, and adhesive small-bowel obstruction in an elderly man. CASE SUMMARY A 67-year-old man presented with 3 days of nausea, vomiting, abdominal distension, and obsti …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Non-surgical magnetic-electrical biofeedback improves anterior resection syndrome after sphincter-preserving surgery for low rectal cancer

Xia-Hui Weng, Yin Huang

BACKGROUND Sphincter-preserving surgery is a common procedure for rectal cancer, but anterior resection syndrome (ARS) remains a frequent complication. AIM To evaluate the efficacy of combined magnetic-electrical biofeedback therapy in patients with ARS after sphincter-preserving surgery for low rectal cancer. METHODS Sixty patients with ARS following sphincter-preserving surgery for low rectal cancer admitted to our hospital between August 2024 to March 2026, were selected. Based on the chronological order of surg …

27.08.2026journal-article

World Journal for Pediatric and Congenital Heart Surgery

Resection and Reimplantation of a Nearly Atretic Left Main Coronary Artery in an Adolescent

Robert McRae, Benjamin Hammond, Spencer Barfuss, Aaron Pennie, Collin Cowley, John Doty, Reilly Hobbs

Congenital coronary artery stenosis is a rare coronary anomaly with significant variability in presentation and management. We present a case of severe left main coronary artery stenosis in a young female. A 14-year-old female was referred to the Cardiology Clinic for multiple episodes of syncope and presyncope with activity that began in early childhood. Diagnostic imaging revealed near atresia of the proximal left main coronary artery. The patient underwent surgical repair with resection of the stenotic coronary …

27.08.2026journal-article

Cancers

Deconstructing Exceptional Responses to Immune Checkpoint Inhibition in Recurrent or Metastatic Head and Neck Carcinoma: A Site-Specific Clinical–Biological Synthesis

Giovanni Motta, Piero Giuseppe Meliante, Pasquale Capasso, Francesco Chiari, Giuseppe Tortoriello

Background: Recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is an aggressive malignancy with a historically poor prognosis. Although immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have established a new first-line standard of care, durable clinical benefit is restricted to a minority of patients, while primary or acquired resistance remains a major clinical challenge. This narrative review aims to provide a conceptual clinical–biological synthesis of immunotherapy in R/M …